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Select item 76680351.

PtdIns(3,4,5)P₃-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, Christina A. Mitchell

Proc Natl Acad Sci U S A. 2020 Nov 10; 117(45): 28056–28067. Published online 2020 Oct 23. doi: 10.1073/pnas.2006445117

PMCID:: PMC7668035

Abstract Article PDF–2.7M

Select item 48657572.

Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis

Qing Liang, Ni Cheng, Gufang Zhang, Yurong Liang, Feng Qian, Dianqing Wu, Richard D. Ye

Sci Rep. 2016; 6: 25785. Published online 2016 May 13. doi: 10.1038/srep25785

PMCID:: PMC4865757

Abstract Article PDF–2.1M

Select item 36779603.

A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability

Ram P. Naikawadi, Ni Cheng, Stephen M. Vogel, Feng Qian, Dianqing Wu, Asrar B. Malik, Richard D. Ye

Circ Res. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Circ Res. 2012 Dec 7; 111(12): 1517–1527. Published online 2012 Sep 10. doi: 10.1161/CIRCRESAHA.112.273078

PMCID:: PMC3677960

Abstract Article PDF–4.8M

Select item 67251234.

Involvement of a Rac Activator, P-Rex1, in Neurotrophin-Derived Signaling and Neuronal Migration

Masato Yoshizawa, Takeshi Kawauchi, Masaki Sone, Yoshiaki V. Nishimura, Mami Terao, Kaori Chihama, Yo-ichi Nabeshima, Mikio Hoshino

J Neurosci. 2005 Apr 27; 25(17): 4406–4419. doi: 10.1523/JNEUROSCI.4955-04.2005

PMCID:: PMC6725123

Abstract Article PDF–824K

Select item 46875395.

Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior

Jun Li, Anping Chai, Lifang Wang, Yuanlin Ma, Zhiliu Wu, Hao Yu, Liwei Mei, Lin Lu, Chen Zhang, Weihua Yue, Lin Xu, Yi Rao, Dai Zhang

Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50): E6964–E6972. Published online 2015 Nov 30. doi: 10.1073/pnas.1512913112

PMCID:: PMC4687539

Abstract Article PDF–2.2M

Select item 42698076.

A Rac1-Independent Role for P-Rex1 in Melanoblasts

Colin R Lindsay, Ang Li, William Faller, Brad Ozanne, Heidi Welch, Laura M Machesky, Owen J Sansom

J Invest Dermatol. 2015 Jan; 135(1): 314–318. Prepublished online 2014 Jul 30. Published online 2014 Sep 11. doi: 10.1038/jid.2014.323

PMCID:: PMC4269807

Article PDF–1.6M

Select item 38762547.

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

Hiromichi Ebi, Carlotta Costa, Anthony C. Faber, Madhuri Nishtala, Hiroshi Kotani, Dejan Juric, Patricia Della Pelle, Youngchul Song, Seiji Yano, Mari Mino-Kenudson, Cyril H. Benes, Jeffrey A. Engelman

Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52): 21124–21129. Published online 2013 Dec 10. doi: 10.1073/pnas.1314124110

PMCID:: PMC3876254

Abstract Article PDF–1.2M

Select item 36448628.

Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis

Zhenglong Wang, Xuemei Dong, Zhong Li, Jonathan D. Smith, Dianqing Wu

Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2013 May 6.

Published in final edited form as: Prostaglandins Other Lipid Mediat. 2008 Dec; 87(0): 9–13. Published online 2008 Apr 23. doi: 10.1016/j.prostaglandins.2008.04.001

PMCID:: PMC3644862

Abstract Article PDF–927K

Select item 34000579.

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C Norman, Laura M Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom

Nat Commun. Author manuscript; available in PMC 2012 Jul 19.

Published in final edited form as: Nat Commun. 2011 Nov 22; 2: 555. Published online 2011 Nov 22. doi: 10.1038/ncomms1560

PMCID:: PMC3400057

Abstract Article PDF–4.4M

Select item 328865810.

Role for the guanine nucleotide exchange factor P-Rex1 in platelet secretion and aggregation

Feng Qian, Guy C. Le Breton, Jia Chen, Jing Deng, John W. Christman, Dianqing Wu, Richard D. Ye

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3): 768–777. Published online 2011 Dec 29. doi: 10.1161/ATVBAHA.111.243675

PMCID:: PMC3288658

Abstract Article PDF–578K

Select item 323484511.

Identification of P-Rex1 as a Novel Rac1-Guanine Nucleotide Exchange Factor (GEF) That Promotes Actin Remodeling and GLUT4 Protein Trafficking in Adipocytes

Demis Balamatsias, Anne M. Kong, Joanne E. Waters, Absorn Sriratana, Rajendra Gurung, Charles G. Bailey, John E. J. Rasko, Tony Tiganis, S. Lance Macaulay, Christina A. Mitchell

J Biol Chem. 2011 Dec 16; 286(50): 43229–43240. Published online 2011 Oct 15. doi: 10.1074/jbc.M111.306621

PMCID:: PMC3234845

Abstract Article PDF–2.3M

Select item 291591912.

Control of Cerebellar Long-Term Potentiation by P-Rex-Family Guanine-Nucleotide Exchange Factors and Phosphoinositide 3-Kinase

Claire Jackson, Heidi C. Welch, Tomas C. Bellamy

PLoS One. 2010; 5(8): e11962. Published online 2010 Aug 4. doi: 10.1371/journal.pone.0011962

PMCID:: PMC2915919

Abstract Article PDF–561K

Select item 300187313.

A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation

Marlon R. Schneider, Maik Dahlhoff, David Horst, Benjamin Hirschi, Konrad Trülzsch, Josef Müller-Höcker, Roger Vogelmann, Michael Allgäuer, Markus Gerhard, Sylvia Steininger, Eckhard Wolf, Frank T. Kolligs

PLoS One. 2010; 5(12): e14325. Published online 2010 Dec 14. doi: 10.1371/journal.pone.0014325

PMCID:: PMC3001873

Abstract Article PDF–20M

Select item 239378614.

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination

Sarah Donald, Trevor Humby, Ian Fyfe, Anne Segonds-Pichon, Simon A. Walker, Simon R. Andrews, W. John Coadwell, Piers Emson, Lawrence S. Wilkinson, Heidi C. E. Welch

Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11): 4483–4488. Published online 2008 Mar 11. doi: 10.1073/pnas.0712324105

PMCID:: PMC2393786

Abstract Article PDF–1.2M

Select item 1029374115.

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis

Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch

Front Immunol. 2023; 14: 1180886. Published online 2023 Jun 13. doi: 10.3389/fimmu.2023.1180886

PMCID:: PMC10293741

Abstract Article PDF–22M

Select item 475962716.

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Macek, Angeliki Malliri

Nat Commun. 2016; 7: 10664. Published online 2016 Feb 18. doi: 10.1038/ncomms10664

PMCID:: PMC4759627

Abstract Article PDF–7.6M

Select item 432677417.

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation

Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, Heidi C. E. Welch

Blood. 2015 Feb 12; 125(7): 1146–1158. Prepublished online 2014 Dec 23. doi: 10.1182/blood-2014-07-591040

PMCID:: PMC4326774

Abstract Article

Select item 481354518.

Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1

Dingxin Pan, Mark A. Barber, Kirsti Hornigold, Martin J. Baker, Judit M. Toth, David Oxley, Heidi C. E. Welch

J Biol Chem. 2016 Mar 18; 291(12): 6359–6375. Published online 2016 Jan 20. doi: 10.1074/jbc.M115.686592

PMCID:: PMC4813545

Abstract Article PDF–3.1M

Select item 504520019.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355

PMCID:: PMC5045200

Abstract Article PDF–2.9M

Select item 359383320.

The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

Gina E. Elsen, Rebecca D. Hodge, Francesco Bedogni, Ray A. M. Daza, Branden R. Nelson, Naoko Shiba, Steven L. Reiner, Robert F. Hevner

Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10): 4081–4086. Published online 2013 Feb 19. doi: 10.1073/pnas.1209076110

PMCID:: PMC3593833

Abstract Article PDF–1.0M

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