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Select item 104355221.

Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3

Pragya Rampuria, Lidia Mosyak, Adam R. Root, Kristine Svenson, Michael J. Agostino, Edward R. LaVallie

Sci Rep. 2023; 13: 13408. Published online 2023 Aug 17. doi: 10.1038/s41598-023-40467-0

PMCID:: PMC10435522

Abstract Article PDF–2.7M

Select item 76114792.

Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations

Avipsa Bose, Sanghita Banerjee, Sandhya S. Visweswariah

IUBMB Life. Author manuscript; available in PMC 2021 Aug 11.

Published in final edited form as: IUBMB Life. 2020 Jun 1; 72(6): 1145–1159. Published online 2020 Apr 15. doi: 10.1002/iub.2283

PMCID:: PMC7611479

Abstract Article PDF–2.1M

Select item 75154553.

Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity

Amanda M. Pattison, Joshua R. Barton, Ariana A. Entezari, Alicja Zalewski, Jeff A. Rappaport, Adam E. Snook, Scott A. Waldman

Cancer Biol Ther. 2020; 21(9): 799–805. Published online 2020 Jun 28. doi: 10.1080/15384047.2020.1779005

PMCID:: PMC7515455

Abstract Article PDF–3.4M

Select item 59322074.

Human GUCY2C-targeted chimeric antigen receptor (CAR)-expressing T cells eliminate colorectal cancer metastases

Michael S. Magee, Tara S. Abraham, Trevor R. Baybutt, John C. Flickinger, Jr., Natalie A. Ridge, Glen P. Marszalowicz, Priyanka Prajapati, Adam R. Hersperger, Scott A. Waldman, Adam E. Snook

Cancer Immunol Res. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Cancer Immunol Res. 2018 May; 6(5): 509–516. Published online 2018 Apr 3. doi: 10.1158/2326-6066.CIR-16-0362

PMCID:: PMC5932207

Abstract Article PDF–1.3M

Select item 57362185.

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

Hadi Danaee, Thea Kalebic, Timothy Wyant, Matteo Fassan, Claudia Mescoli, Feng Gao, William L. Trepicchio, Massimo Rugge

PLoS One. 2017; 12(12): e0189953. Published online 2017 Dec 19. doi: 10.1371/journal.pone.0189953

PMCID:: PMC5736218

Abstract Article PDF–12M

Select item 56197826.

Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation

Hilde L. von Volkmann, Ingeborg Brønstad, Odd Helge Gilja, Rune R. Tronstad, Dag Andre Sangnes, Ragnar Nortvedt, Trygve Hausken, Georg Dimcevski, Torunn Fiskerstrand, Kim Nylund

PLoS One. 2017; 12(9): e0185496. Published online 2017 Sep 28. doi: 10.1371/journal.pone.0185496

PMCID:: PMC5619782

Abstract Article PDF–9.4M

Select item 55035767.

Expression of guanylyl cyclase C in tissue samples and the circulation of rectal cancer patients

Yong Liu, Guoping Cheng, Jun Qian, HaiXing Ju, YuPing Zhu, Meucci Stefano, Ulrich Keilholz, DeChuan Li

Oncotarget. 2017 Jun 13; 8(24): 38841–38849. Published online 2017 Mar 21. doi: 10.18632/oncotarget.16406

PMCID:: PMC5503576

Abstract Article PDF–4.5M

Select item 51754238.

Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope

Adam E. Snook, Trevor R. Baybutt, Terry Hyslop, Scott A. Waldman

Hum Gene Ther Methods. 2016 Dec 1; 27(6): 238–250. Published online 2016 Dec 1. doi: 10.1089/hgtb.2016.114

PMCID:: PMC5175423

Abstract Article PDF–781K

Select item 49758299.

Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C

Thomas Müller, Insha Rasool, Peter Heinz-Erian, Eva Mildenberger, Christian Hülstrunk, Andreas Müller, Laurent Michaud, Bart G P Koot, Antje Ballauff, Julia Vodopiutz, Stefan Rosipal, Britt-Sabina Petersen, Andre Franke, Irene Fuchs, Heiko Witt, Heinz Zoller, Andreas R Janecke, Sandhya S Visweswariah

Gut. 2016 Aug; 65(8): 1306–1313. Published online 2015 May 20. doi: 10.1136/gutjnl-2015-309441

PMCID:: PMC4975829

Abstract Article PDF–3.6M

Select item 446351110.

Meconium ileus in a Lebanese family secondary to mutations in the GUCY2C gene

Amanda Smith, Dennis E Bulman, Claire Goldsmith, Eric Bareke, FORGE Canada Consortium, Jacek Majewski, Kym M Boycott, Sarah M Nikkel

Eur J Hum Genet. 2015 Jul; 23(7): 990–992. Published online 2014 Nov 5. doi: 10.1038/ejhg.2014.236

PMCID:: PMC4463511

Abstract Article PDF–439K

Select item 337648611.

Meconium Ileus Caused by Mutations in GUCY2C, Encoding the CFTR-Activating Guanylate Cyclase 2C

Hila Romi, Idan Cohen, Daniella Landau, Suliman Alkrinawi, Baruch Yerushalmi, Reli Hershkovitz, Nitza Newman-Heiman, Garry R. Cutting, Rivka Ofir, Sara Sivan, Ohad S. Birk

Am J Hum Genet. 2012 May 4; 90(5): 893–899. doi: 10.1016/j.ajhg.2012.03.022

PMCID:: PMC3376486

Abstract Article PDF–898K

Select item 314001712.

Guanylyl Cyclase C Is a Specific Marker for Differentiating Primary and Metastatic Ovarian Mucinous Neoplasms

Vincenzo Ciocca, Alessandro Bombonati, Juan P. Palazzo, Stephanie Schulz, Scott A. Waldman

Histopathology. Author manuscript; available in PMC 2011 Jul 20.

Published in final edited form as: Histopathology. 2009 Aug; 55(2): 182–188. doi: 10.1111/j.1365-2559.2009.03358.x

PMCID:: PMC3140017

Abstract Article PDF–3.3M

Select item 309673013.

Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer

Terry Hyslop, David S. Weinberg, Stephanie Schulz, Alan Barkun, Scott A. Waldman

Clin Cancer Res. Author manuscript; available in PMC 2012 May 15.

Published in final edited form as: Clin Cancer Res. 2011 May 15; 17(10): 3293–3303. Published online 2011 Feb 9. doi: 10.1158/1078-0432.CCR-10-3113

PMCID:: PMC3096730

Abstract Article PDF–1.0M

Select item 281039914.

GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients

Alex Mejia, Stephanie Schulz, Terry Hyslop, David S Weinberg, Scott A Waldman

Expert Rev Mol Diagn. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Expert Rev Mol Diagn. 2009 Nov; 9(8): 777–785. doi: 10.1586/erm.09.67

PMCID:: PMC2810399

Abstract Article PDF–80K

Select item 122412115.

Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.

Yashoda Ghanekar, Akhila Chandrashaker, Utpal Tatu, Sandhya S Visweswariah

Biochem J. 2004 May 1; 379(Pt 3): 653–663. doi: 10.1042/BJ20040001

PMCID:: PMC1224121

Summary PDF–413K

Select item 2622116.

Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues

S. L. Carrithers, M. T. Barber, S. Biswas, S. J. Parkinson, P. K. Park, S. D. Goldstein, S. A. Waldman

Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25): 14827–14832. doi: 10.1073/pnas.93.25.14827

PMCID:: PMC26221

Abstract Article PDF–350K

Select item 825192517.

Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach

Rachel M. Wolfe, Al‐Walid Mohsen, Cate Walsh Vockley, Carol A. Bertrand, Robert D. Nicholls, Paige Heiman, Leah M. Seibold, Jerry Vockley, Lina Ghaloul‐Gonzalez

Am J Med Genet A. 2021 Jul; 185(7): 2046–2055. Published online 2021 May 5. doi: 10.1002/ajmg.a.62207