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Select item 102359931.

Primary cilia TRP channel regulates hippocampal excitability

Thuy N. Vien, My C. Ta, Louise F. Kimura, Tuncer Onay, Paul G. DeCaen

Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2219686120. Published online 2023 May 22. doi: 10.1073/pnas.2219686120

PMCID:: PMC10235993

Article PDF–7.0M

Select item 87752492.

Enhanced β-adrenergic response in mice with dominant-negative expression of the PKD2L1 channel

Manabu Murakami, Agnieszka M. Murakami, Takayuki Nemoto, Takayoshi Ohba, Manabu Yonekura, Yuichi Toyama, Hirofumi Tomita, Yasushi Matsuzaki, Daisuke Sawamura, Kazuyoshi Hirota, Shirou Itagaki, Yujiro Asada, Ichiro Miyoshi

PLoS One. 2022; 17(1): e0261668. Published online 2022 Jan 20. doi: 10.1371/journal.pone.0261668

PMCID:: PMC8775249

Article PDF–1.4M

Select item 47639203.

A proton current associated with sour taste: distribution and functional properties

Jeremy D. Bushman, Wenlei Ye, Emily R. Liman

FASEB J. 2015 Jul; 29(7): 3014–3026. Published online 2015 Apr 9. doi: 10.1096/fj.14-265694

PMCID:: PMC4763920

Article

Select item 34766304.

Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem

Adeline Orts-Del'Immagine, Nicolas Wanaverbecq, Catherine Tardivel, Vanessa Tillement, Michel Dallaporta, Jérôme Trouslard

J Physiol. 2012 Aug 15; 590(Pt 16): 3719–3741. Published online 2012 May 8. doi: 10.1113/jphysiol.2012.227959

PMCID:: PMC3476630

Article PDF–2.2M

Select item 26426775.

The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse

Shinji Kataoka, Ruibiao Yang, Yoshiro Ishimaru, Hiroaki Matsunami, John C. Kinnamon, Thomas E. Finger

Chem Senses. Author manuscript; available in PMC 2009 Mar 1.

Published in final edited form as: Chem Senses. 2008 Mar; 33(3): 243–254. Published online 2007 Dec 21. doi: 10.1093/chemse/bjm083

PMCID:: PMC2642677

Article PDF–2.1M

Select item 104880766.

A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting Neurons in Spinal Cords of Rodents, Carnivores, and Primates

Xiaohe Liu, Karen Rich, Sohail M. Nasseri, Guifa Li, Simone Hjæresen, Bente Finsen, Hansjörg Scherberger, Åsa Svenningsen, Mengliang Zhang

Int J Mol Sci. 2023 Sep; 24(17): 13582. Published online 2023 Sep 1. doi: 10.3390/ijms241713582

PMCID:: PMC10488076

Article PDF–12M

Select item 65206437.

Physiological and Behavioral Responses to Optogenetic Stimulation of PKD2L1⁺ Type III Taste Cells

Courtney E. Wilson, Aurelie Vandenbeuch, Sue C. Kinnamon

eNeuro. 2019 Mar-Apr; 6(2): ENEURO.0107-19.2019. Prepublished online 2019 Apr 25. Published online 2019 May 9. doi: 10.1523/ENEURO.0107-19.2019

PMCID:: PMC6520643

Article PDF–2.1M

Select item 55863978.

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

Takahiro Shimizu, Taiga Higuchi, Toshihiro Toba, Chie Ohno, Takuto Fujii, Bernd Nilius, Hideki Sakai

FEBS Open Bio. 2017 Sep; 7(9): 1392–1401. Published online 2017 Aug 14. doi: 10.1002/2211-5463.12273

PMCID:: PMC5586397

Article PDF–1.0M

Select item 24753329.

Off-response property of an acid-activated cation channel complex PKD1L3–PKD2L1

Hitoshi Inada, Fuminori Kawabata, Yoshiro Ishimaru, Tohru Fushiki, Hiroaki Matsunami, Makoto Tominaga

EMBO Rep. 2008 Jul; 9(7): 690–697. Published online 2008 Jun 6. doi: 10.1038/embor.2008.89

PMCID:: PMC2475332

Article PDF–291K

Select item 157104710.

The Cells and Logic for Mammalian Sour Taste detection

Angela L. Huang, Xiaoke Chen, Mark A. Hoon, Jayaram Chandrashekar, Wei Guo, Dimitri Tränkner, Nicholas J. P. Ryba, Charles S. Zuker

Nature. Author manuscript; available in PMC 2007 Feb 24.

Published in final edited form as: Nature. 2006 Aug 24; 442(7105): 934–938. doi: 10.1038/nature05084

PMCID:: PMC1571047

Article PDF–2.1M

Select item 1001782111.

Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine

Takahiro Shimizu, Takuto Fujii, Keisuke Hanita, Ryo Shinozaki, Yusaku Takamura, Yoshiro Suzuki, Teppei Kageyama, Mizuki Kato, Hisao Nishijo, Makoto Tominaga, Hideki Sakai

Sci Rep. 2023; 13: 4271. Published online 2023 Mar 15. doi: 10.1038/s41598-023-31322-3

PMCID:: PMC10017821

Article PDF–4.1M

Select item 586475412.

Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang, Xiaodong Liu, Tingliang Wang

Nat Commun. 2018; 9: 1192. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03606-0

PMCID:: PMC5864754

Article PDF–2.5M

Select item 473101913.

Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability

Gang Yao, Chong Luo, Michael Harvey, Maoqing Wu, Taylor H. Schreiber, Yanjun Du, Nuria Basora, Xuefeng Su, Diego Contreras, Jing Zhou

Hum Mol Genet. 2016 Feb 1; 25(3): 448–458. Published online 2015 Nov 26. doi: 10.1093/hmg/ddv484

PMCID:: PMC4731019

Article PDF–1.0M

Select item 317603714.

Polycystin-2 Expression and Function in Adult Mouse Lacrimal Acinar Cells

Simon Kaja, Jill D. Hilgenberg, Volodymyr Rybalchenko, Wanda E. Medina-Ortiz, Elaine V. Gregg, Peter Koulen

Invest Ophthalmol Vis Sci. 2011 Jul; 52(8): 5605–5611. Published online 2011 Jul 27. doi: 10.1167/iovs.10-7114

PMCID:: PMC3176037

Article PDF–1.7M

Select item 309827715.

Sour Taste Responses in Mice Lacking PKD Channels

Nao Horio, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, Hiroaki Matsunami, Yuzo Ninomiya

PLoS One. 2011; 6(5): e20007. Published online 2011 May 19. doi: 10.1371/journal.pone.0020007

PMCID:: PMC3098277

Article PDF–813K

Select item 472031916.

The K⁺ channel K_IR2.1 functions in tandem with proton influx to mediate sour taste transduction

Wenlei Ye, Rui B. Chang, Jeremy D. Bushman, Yu-Hsiang Tu, Eric M. Mulhall, Courtney E. Wilson, Alexander J. Cooper, Wallace S. Chick, David C. Hill-Eubanks, Mark T. Nelson, Sue C. Kinnamon, Emily R. Liman

Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2): E229–E238. Published online 2015 Dec 1. doi: 10.1073/pnas.1514282112

PMCID:: PMC4720319

Article PDF–3.8M

Select item 411273717.

Primary cilia are specialized calcium signaling organelles

Markus Delling, Paul G. DeCaen, Julia F. Doerner, Sebastien Febvay, David E. Clapham

Nature. Author manuscript; available in PMC 2014 Jul 28.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 311–314. doi: 10.1038/nature12833

PMCID:: PMC4112737

Article PDF–4.3M

Select item 153164318.

Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor

Yoshiro Ishimaru, Hitoshi Inada, Momoka Kubota, Hanyi Zhuang, Makoto Tominaga, Hiroaki Matsunami

Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33): 12569–12574. Published online 2006 Aug 4. doi: 10.1073/pnas.0602702103

PMCID:: PMC1531643

Article PDF–1.9M

Select item 287849019.

Activation of Polycystic Kidney Disease-2-like 1 (PKD2L1)-PKD1L3 Complex by Acid in Mouse Taste Cells

Hitoshi Kawaguchi, Akihiro Yamanaka, Kunitoshi Uchida, Koji Shibasaki, Takaaki Sokabe, Yutaka Maruyama, Yuchio Yanagawa, Shingo Murakami, Makoto Tominaga

J Biol Chem. 2010 Jun 4; 285(23): 17277–17281. Published online 2010 Apr 20. doi: 10.1074/jbc.C110.132944