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Select item 99833581.

Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men

Jason Garcia, Kirsten D. Krieger, Candice Loitz, Lillian M. Perez, Zachary A. Richards, Yves Helou, Steve Kregel, Sasha Celada, Clementina A. Mesaros, Maarten Bosland, Peter H. Gann, Thomas E. Willnow, Donald Vander Griend, Rick Kittles, Gail S. Prins, Trevor Penning, Larisa Nonn

Cancer Res Commun. 2023 Mar; 3(3): 371–382. Published online 2023 Mar 3. doi: 10.1158/2767-9764.CRC-22-0362

PMCID:: PMC9983358

Abstract Article PDF–11M

Select item 86474142.

Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus

Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu, Hu Liu

J Transl Med. 2021; 19: 495. Published online 2021 Dec 6. doi: 10.1186/s12967-021-03155-z

PMCID:: PMC8647414

Abstract Article PDF–5.3M

Select item 70806763.

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population

Airi Akashi, Akiyoshi Nakayama, Yoichiro Kamatani, Toshihide Higashino, Seiko Shimizu, Yusuke Kawamura, Misaki Imoto, Mariko Naito, Asahi Hishida, Makoto Kawaguchi, Mikiya Takao, Michinori Matsuo, Tappei Takada, Kimiyoshi Ichida, Hiroshi Ooyama, Nariyoshi Shinomiya, Hirotaka Matsuo

Hum Cell. 2020; 33(2): 303–307. Published online 2020 Jan 24. doi: 10.1007/s13577-019-00318-5

PMCID:: PMC7080676

Abstract Article PDF–533K

Select item 69807334.

Megalin: A Bridge Connecting Kidney, the Renin-angiotensin System, and Atherosclerosis

Masayoshi Kukida, Hisashi Sawada, Alan Daugherty, Hong S. Lu

Pharmacol Res. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Pharmacol Res. 2020 Jan; 151: 104537. Published online 2019 Nov 7. doi: 10.1016/j.phrs.2019.104537

PMCID:: PMC6980733

Abstract Article PDF–573K

Select item 51317445.

Megalin Is Predominantly Observed in Vesicular Structures in First and Third Trimester Cytotrophoblasts of the Human Placenta

Tina Storm, Erik I. Christensen, Julie Nelly Christensen, Tine Kjaergaard, Niels Uldbjerg, Agnete Larsen, Bent Honoré, Mette Madsen

J Histochem Cytochem. 2016 Dec; 64(12): 769–784. Published online 2016 Oct 21. doi: 10.1369/0022155416672210

PMCID:: PMC5131744

Abstract Article PDF–2.6M

Select item 42647616.

Significance of Urinary Full-Length Megalin in Patients with IgA Nephropathy

Takuto Seki, Katsuhiko Asanuma, Rin Asao, Kanae Nonaka, Yu Sasaki, Juan Alejandro Oliva Trejo, Hiroyuki Kurosawa, Yoshiaki Hirayama, Satoshi Horikoshi, Yasuhiko Tomino, Akihiko Saito

PLoS One. 2014; 9(12): e114400. Published online 2014 Dec 12. doi: 10.1371/journal.pone.0114400

PMCID:: PMC4264761

Abstract Article PDF–1.3M

Select item 39790387.

Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption

Humaira Rasheed, Amanda Phipps-Green, Ruth Topless, Jade E Hollis-Moffatt, Jennie Harré Hindmarsh, Christopher Franklin, Nicola Dalbeth, Peter B Jones, Douglas HN White, Lisa K Stamp, Tony R Merriman

Arthritis Res Ther. 2013; 15(6): R177. Published online 2013 Nov 4. doi: 10.1186/ar4366

PMCID:: PMC3979038

Abstract Article PDF–343K

Select item 39535478.

Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility

Akiyoshi Nakayama, Hirotaka Matsuo, Toru Shimizu, Yuzo Takada, Takahiro Nakamura, Seiko Shimizu, Toshinori Chiba, Masayuki Sakiyama, Mariko Naito, Emi Morita, Kimiyoshi Ichida, Nariyoshi Shinomiya

Rheumatol Int. 2014; 34(4): 473–476. Published online 2013 Dec 24. doi: 10.1007/s00296-013-2924-8

PMCID:: PMC3953547

Abstract Article PDF–218K

Select item 33702759.

Scan-Statistic Approach Identifies Clusters of Rare Disease Variants in LRP2, a Gene Linked and Associated with Autism Spectrum Disorders, in Three Datasets

Iuliana Ionita-Laza, Vlad Makarov, the ARRA Autism Sequencing Consortium, Joseph D. Buxbaum

Am J Hum Genet. 2012 Jun 8; 90(6): 1002–1013. doi: 10.1016/j.ajhg.2012.04.010

PMCID:: PMC3370275

Abstract Article PDF–598K

Select item 323517410.

Association between Low Density Lipoprotein Receptor-Related Protein 2 Gene Polymorphisms and Bone Mineral Density Variation in Chinese Population

Chun Wang, Yi-Ming Hu, Jin-Wei He, Jie-Mei Gu, Hao Zhang, Wei-Wei Hu, Hua Yue, Gao Gao, Wen-Jin Xiao, Jin-Bo Yu, Yao-Hua Ke, Yun-Qiu Hu, Miao Li, Yu-Juan Liu, Wen-Zhen Fu, Ying Ren, Zhen-Lin Zhang

PLoS One. 2011; 6(12): e28874. Published online 2011 Dec 9. doi: 10.1371/journal.pone.0028874

PMCID:: PMC3235174

Abstract Article PDF–243K

Select item 289172811.

Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes

Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi, Maria Loscertales, Caroline Robson, Tianming Liu, David T MacLaughlin, Kristin M Noonan, Meaghan K Russell, Christopher A Walsh, Patricia K Donahoe, Barbara R Pober

Nat Genet. Author manuscript; available in PMC 2010 Jun 24.

Published in final edited form as: Nat Genet. 2007 Aug; 39(8): 957–959. Published online 2007 Jul 15. doi: 10.1038/ng2063

PMCID:: PMC2891728

Abstract Article PDF–624K

Select item 267588312.

Association of Megalin Genetic Polymorphisms with Prostate Cancer Risk and Prognosis

Sarah K. Holt, Danielle M. Karyadi, Erika M. Kwon, Janet L. Stanford, Peter S. Nelson, Elaine A. Ostrander

Clin Cancer Res. Author manuscript; available in PMC 2009 Jun 15.

Published in final edited form as: Clin Cancer Res. 2008 Jun 15; 14(12): 3823–3831. doi: 10.1158/1078-0432.CCR-07-4566

PMCID:: PMC2675883

Abstract Article PDF–323K

Select item 18573613.

The unfolding story of megalin (gp330): now recognized as a drug receptor.

M G Farquhar

J Clin Invest. 1995 Sep; 96(3): 1184. doi: 10.1172/JCI118149

PMCID:: PMC185736

Summary Page Browse PDF–242K

Select item 16504914.

Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases

Seido Ooka, Toshihiro Matsui, Kusuki Nishioka, Tomohiro Kato

Arthritis Res Ther. 2003; 5(3): R174–R180. Published online 2003 Apr 4. doi: 10.1186/ar754

PMCID:: PMC165049

Abstract Article PDF–509K

Select item 3872115.

Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.

S K Moestrup, H Birn, P B Fischer, C M Petersen, P J Verroust, R B Sim, E I Christensen, E Nexø

Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16): 8612–8617. doi: 10.1073/pnas.93.16.8612

PMCID:: PMC38721

Summary Page Browse PDF–1.7M

Select item 999384216.

Structures of LRP2 reveal a molecular machine for endocytosis

Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y Robbins-Juarez, Estefania Y Chavez, Goran Ahlsen, Phinikoula S Katsamba, Thomas A. Neubert, Anthony W.P. Fitzpatrick, Jonathan Barasch, Lawrence Shapiro

Cell. Author manuscript; available in PMC 2023 Mar 8.

Published in final edited form as: Cell. 2023 Feb 16; 186(4): 821–836.e13. Published online 2023 Feb 6. doi: 10.1016/j.cell.2023.01.016