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Select item 98406851.

MTAP deficiency contributes to immune landscape remodeling and tumor evasion

Wen-Hsin Chang, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C. Yang, Chih-Wei Chu, Estelle H. Yoo, Weici Zhang, Sung-Liang Yu, Ching-Hsien Chen

Immunology. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Immunology. 2023 Feb; 168(2): 331–345. Published online 2022 Oct 11. doi: 10.1111/imm.13587

PMCID:: PMC9840685

Abstract Article PDF–4.2M

Select item 90164822.

Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase

YUSUKE AOKI, YASUNORI TOME, QINGHONG HAN, JUN YAMAMOTO, KAZUYUKI HAMADA, NORIYUKI MASAKI, YUTARO KUBOTA, MICHAEL BOUVET, KOTARO NISHIDA, ROBERT M. HOFFMAN

Cancer Genomics Proteomics. 2022 May-Jun; 19(3): 299–304. Published online 2022 May 3. doi: 10.21873/cgp.20321

PMCID:: PMC9016482

Abstract Article PDF–591K

Select item 82709123.

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller

Nat Commun. 2021; 12: 4228. Published online 2021 Jul 9. doi: 10.1038/s41467-021-24240-3

PMCID:: PMC8270912

Abstract Article PDF–7.0M

Select item 70727584.

Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness

Weder Pereira de Menezes, Viviane Aline Oliveira Silva, Izabela Natália Faria Gomes, Marcela Nunes Rosa, Maria Luisa Corcoll Spina, Adriana Cruvinel Carloni, Ana Laura Vieira Alves, Matias Melendez, Gisele Caravina Almeida, Luciane Sussuchi da Silva, Carlos Clara, Isabela Werneck da Cunha, Glaucia Noeli Maroso Hajj, Chris Jones, Lucas Tadeu Bidinotto, Rui Manuel Reis

Cells. 2020 Feb; 9(2): 492. Published online 2020 Feb 20. doi: 10.3390/cells9020492

PMCID:: PMC7072758

Abstract Article PDF–5.9M

Select item 69728925.

MTAP-deficiency could predict better treatment response in advanced lung adenocarcinoma patients initially treated with pemetrexed-platinum chemotherapy and bevacizumab

Wang Jing, Hui Zhu, Wenjuan Liu, Xiaoyang Zhai, Hairong Tian, Jinming Yu

Sci Rep. 2020; 10: 843. Published online 2020 Jan 21. doi: 10.1038/s41598-020-57812-2

PMCID:: PMC6972892

Abstract Article PDF–1.4M

Select item 68105956.

MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation

Landon J. Hansen, Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, Carlee Hemphill, Austin B. Carpenter, Patrick Healy, Ryan C. Ruger, Chin-Pu J. Chen, Paula K. Greer, Fangping Zhao, Ivan Spasojevic, Carole Grenier, Zhiqing Huang, Susan K. Murphy, Roger E. McLendon, Henry S. Friedman, Allan H. Friedman, James E. Herndon, II, John H. Sampson, Stephen T. Keir, Darell D. Bigner, Hai Yan, Yiping He

Cancer Res. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Cancer Res. 2019 Jul 1; 79(13): 3383–3394. Published online 2019 Apr 30. doi: 10.1158/0008-5472.CAN-18-1010

PMCID:: PMC6810595

Abstract Article PDF–1.2M

Select item 59997657.

非小细胞肺癌中MTAP蛋白及基因表达水平的检测

李莎莎, 张义军, 李洪利, 丁保清

Zhongguo Fei Ai Za Zhi. 2011 Feb 20; 14(2): 151–155. Chinese. doi: 10.3779/j.issn.1009-3419.2011.02.09

PMCID:: PMC5999765

Abstract Article PDF–1.3M

Select item 59270148.

Deletion of Dinucleotide Repeat (Δ14 Allele) in the Methylthioadenosine Phosphorylase (MTAP) Promoter and the Allelotype of MTAP Promoter in the Japanese Population

Yuwaraj Kadariya, Junji Nishioka, Kaname Nakatani, Kunio Nakashima, Tsutomu Nobori

Jpn J Cancer Res. 2002 Apr; 93(4): 369–373. doi: 10.1111/j.1349-7006.2002.tb01266.x

PMCID:: PMC5927014

Abstract Article PDF–176K

Select item 50085219.

Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma

Hong-Lin He, Ying-En Lee, Yow-Ling Shiue, Sung-Wei Lee, Tzu-Ju Chen, Chien-Feng Li

Medicine (Baltimore) 2015 Dec; 94(49): e2271. Published online 2015 Dec 11. doi: 10.1097/MD.0000000000002271

PMCID:: PMC5008521

Abstract Article PDF–791K

Select item 496879810.

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma

Katharina Limm, Katja Dettmer, Jörg Reinders, Peter J. Oefner, Anja-Katrin Bosserhoff

PLoS One. 2016; 11(8): e0160348. Published online 2016 Aug 1. doi: 10.1371/journal.pone.0160348

PMCID:: PMC4968798

Abstract Article PDF–575K

Select item 492472211.

The essential role of methylthioadenosine phosphorylase in prostate cancer

Gaia Bistulfi, Hayley C. Affronti, Barbara A. Foster, Ellen Karasik, Bryan Gillard, Carl Morrison, James Mohler, James G. Phillips, Dominic J. Smiraglia

Oncotarget. 2016 Mar 22; 7(12): 14380–14393. Published online 2016 Feb 18. doi: 10.18632/oncotarget.7486

PMCID:: PMC4924722

Abstract Article PDF–4.5M

Select item 470909912.

Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines

Sarah Franco Vieira de Oliveira, Monica Ganzinelli, Rosaria Chilà, Leandro Serino, Marcos Euzébio Maciel, Cícero de Andrade Urban, Rubens Silveira de Lima, Iglenir João Cavalli, Daniele Generali, Massimo Broggini, Giovanna Damia, Enilze Maria de Souza Fonseca Ribeiro

PLoS One. 2016; 11(1): e0145647. Published online 2016 Jan 11. doi: 10.1371/journal.pone.0145647

PMCID:: PMC4709099

Abstract Article PDF–1.1M

Select item 429434213.

Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance

Chien-Feng Li, Fu-Min Fang, Hsing-Jien Kung, Li-Tzong Chen, Jun-Wen Wang, Jen-Wei Tsai, Shih Chen Yu, Yu-Hui Wang, Shau-Hsuan Li, Hsuan-Ying Huang

Oncotarget. 2014 Nov; 5(22): 11428–11441. Published online 2014 Oct 24. doi: 10.18632/oncotarget.2552

PMCID:: PMC4294342

Abstract Article PDF–4.6M

Select item 332222114.

Primate Genome Gain and Loss: A Bone Dysplasia, Muscular Dystrophy, and Bone Cancer Syndrome Resulting from Mutated Retroviral-Derived MTAP Transcripts

Olga Camacho-Vanegas, Sandra Catalina Camacho, Jacob Till, Irene Miranda-Lorenzo, Esteban Terzo, Maria Celeste Ramirez, Vern Schramm, Grace Cordovano, Giles Watts, Sarju Mehta, Virginia Kimonis, Benjamin Hoch, Keith D. Philibert, Carsten A. Raabe, David F. Bishop, Marc J. Glucksman, John A. Martignetti

Am J Hum Genet. 2012 Apr 6; 90(4): 614–627. doi: 10.1016/j.ajhg.2012.02.024

PMCID:: PMC3322221

Abstract Article PDF–1.5M

Select item 326685615.

Polymorphisms in naevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma

Marina Kvaskoff, David C. Whiteman, Zhen Z. Zhao, Grant W. Montgomery, Nicholas G. Martin, Nicholas K. Hayward, David L. Duffy

Twin Res Hum Genet. Author manuscript; available in PMC 2012 Jan 26.

Published in final edited form as: Twin Res Hum Genet. 2011 Oct; 14(5): 422–432. doi: 10.1375/twin.14.5.422

PMCID:: PMC3266856

Abstract Article PDF–334K

Select item 322273716.

Entropy-Driven Binding of Picomolar Transition State Analogue Inhibitors to Human 5′-Methylthioadenosine Phosphorylase

Rong Guan, Meng-Chiao Ho, Michael Brenowitz, Peter C. Tyler, Gary B. Evans, Steven C. Almo, Vern L. Schramm

Biochemistry. Author manuscript; available in PMC 2012 Nov 29.

Published in final edited form as: Biochemistry. 2011 Nov 29; 50(47): 10408–10417. Published online 2011 Nov 7. doi: 10.1021/bi201321x

PMCID:: PMC3222737

Abstract Article PDF–2.3M

Select item 306991617.

Down-Regulation of Methylthioadenosine Phosphorylase (MTAP) Induces Progression of Hepatocellular Carcinoma via Accumulation of 5′-Deoxy-5′-Methylthioadenosine (MTA)

Georgi Kirovski, Axel P. Stevens, Barbara Czech, Katja Dettmer, Thomas S. Weiss, Peter Wild, Arndt Hartmann, Anja K. Bosserhoff, Peter J. Oefner, Claus Hellerbrand

Am J Pathol. 2011 Mar; 178(3): 1145–1152. doi: 10.1016/j.ajpath.2010.11.059

PMCID:: PMC3069916

Abstract Article PDF–1.0M

Select item 303933918.

Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase

Indranil Basu, Joseph Locker, Maria B. Cassera, Thomas J. Belbin, Emilio F. Merino, Xinyuan Dong, Ivan Hemeon, Gary B. Evans, Chandan Guha, Vern L. Schramm

J Biol Chem. 2011 Feb 11; 286(6): 4902–4911. Published online 2010 Dec 6. doi: 10.1074/jbc.M110.198374

PMCID:: PMC3039339

Abstract Article PDF–1.6M

Select item 186821319.

Characterization of Methylthioadenosin Phosphorylase (MTAP) Expression in Malignant Melanoma

Iris Behrmann, Susanne Wallner, Waraporn Komyod, Peter C. Heinrich, Marion Schuierer, Reinhard Buettner, Anja-Katrin Bosserhoff

Am J Pathol. 2003 Aug; 163(2): 683–690. doi: 10.1016/S0002-9440(10)63695-4

PMCID:: PMC1868213

Abstract Article PDF–621K

Select item 182967720.

Abnormality of the Long Bones and Progressive Muscular Dystrophy in a Family

E. W. Henry, N. L. Auckland, H. W. McIntosh, D. E. Starr

Can Med Assoc J. 1958 Mar 1; 78(5): 331–336.

PMCID:: PMC1829677

Summary Page Browse PDF–2.3M

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