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Select item 88053211.

Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study

Xinli Song, Qiongxuan Li, Jingyi Diao, Jinqi Li, Yihuan Li, Senmao Zhang, Lijuan Zhao, Letao Chen, Jianhui Wei, Jing Shu, Yiping Liu, Mengting Sun, Peng Huang, Tingting Wang, Jiabi Qin

BMC Pregnancy Childbirth. 2022; 22: 88. Published online 2022 Jan 31. doi: 10.1186/s12884-022-04419-2

PMCID:: PMC8805321

Article PDF–861K

Select item 84886692.

Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

Danielle E. Anderson, Jin Cui, Qian Ye, Baoying Huang, Ya Tan, Chao Jiang, Wenhong Zu, Jing Gong, Weiqiang Liu, So Young Kim, Biao Guo Yan, Kristmundur Sigmundsson, Xiao Fang Lim, Fei Ye, Peihua Niu, Aaron T. Irving, Haoyu Zhang, Yefeng Tang, Xuming Zhou, Yu Wang, Wenjie Tan, Lin-Fa Wang, Xu Tan

Proc Natl Acad Sci U S A. 2021 Sep 28; 118(39): e2104759118. Published online 2021 Sep 20. doi: 10.1073/pnas.2104759118

PMCID:: PMC8488669

Article PDF–1.9M

Select item 72848303.

Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels

Patrice Jones, Mark Lucock, Charlotte Martin, Rohith Thota, Manohar Garg, Zoe Yates, Christopher J. Scarlett, Martin Veysey, Emma Beckett

Nutrients. 2020 May; 12(5): 1455. Published online 2020 May 18. doi: 10.3390/nu12051455

PMCID:: PMC7284830

Article PDF–500K

Select item 69522694.

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans Michael Maric, Robert Kralovics, Keiryn L. Bennett, Andre C. Müller, Karl Mechtler, Jörg Menche, James E. Bradner, Georg E. Winter, Kristaps Klavins, Emilio Casanova, Christoph Bock, Johannes Zuber, Stefan Kubicek

Nat Genet. Author manuscript; available in PMC 2020 Jan 9.

Published in final edited form as: Nat Genet. 2019 Dec 23; 51(6): 990–998. Published online 2019 May 27. doi: 10.1038/s41588-019-0413-z

PMCID:: PMC6952269

Article PDF–2.4M

Select item 62595765.

Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis

Donglin He, Zhihai Yu, Sheng Liu, Hong Dai, Qing Xu, Feng Li

Med Sci Monit. 2018; 24: 8391–8400. Published online 2018 Nov 21. doi: 10.12659/MSM.911124

PMCID:: PMC6259576

Article PDF–918K

Select item 62068136.

Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation

Ke Ding, Jianyang Jiang, Liang Chen, Xiaohua Xu

Med Sci Monit. 2018; 24: 7499–7507. Published online 2018 Oct 21. doi: 10.12659/MSM.910265

PMCID:: PMC6206813

Article PDF–666K

Select item 56246427.

One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation

Sara Moruzzi, Patrizia Guarini, Silvia Udali, Andrea Ruzzenente, Alfredo Guglielmi, Simone Conci, Patrizia Pattini, Nicola Martinelli, Oliviero Olivieri, Stephanie A. Tammen, Sang-Woon Choi, Simonetta Friso

PLoS One. 2017; 12(10): e0185792. Published online 2017 Oct 2. doi: 10.1371/journal.pone.0185792

PMCID:: PMC5624642

Article PDF–2.6M

Select item 48992848.

MTHFD1 Regulates Nuclear de novo Thymidylate Biosynthesis and Genome Stability

Martha S. Field, Elena Kamynina, Patrick J. Stover

Biochimie. Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: Biochimie. 2016 Jul; 126: 27–30. Published online 2016 Feb 4. doi: 10.1016/j.biochi.2016.02.001

PMCID:: PMC4899284

Article PDF–275K

Select item 45669459.

Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels

Jian Wu, Yihua Bao, Xiaolin Lu, Lihua Wu, Ting Zhang, Jin Guo, Jian Yang

Med Sci Monit. 2015; 21: 2630–2637. Published online 2015 Sep 4. doi: 10.12659/MSM.895155

PMCID:: PMC4566945

Article PDF–543K

Select item 429920010.

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis

Martha S. Field, Elena Kamynina, David Watkins, David S. Rosenblatt, Patrick J. Stover

Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2): 400–405. Published online 2014 Dec 29. doi: 10.1073/pnas.1414555112

PMCID:: PMC4299200

Article PDF–1.0M

Select item 407626411.

Association between MTHFD1 G1958A Polymorphism and Neural Tube Defects Susceptibility: A Meta-Analysis

Jianxin Jiang, Yanfei Zhang, Liang Wei, Zhiyang Sun, Zhongmin Liu

PLoS One. 2014; 9(6): e101169. Published online 2014 Jun 30. doi: 10.1371/journal.pone.0101169

PMCID:: PMC4076264

Article PDF–1.0M

Select item 371664312.

Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis

Hongtuan Zhang, Hui Ma, Liang Li, Zhihong Zhang, Yong Xu

PLoS One. 2013; 8(7): e69366. Published online 2013 Jul 19. doi: 10.1371/journal.pone.0069366

PMCID:: PMC3716643

Article PDF–149K

Select item 301907913.

Methylenetetrahydrofolate dehydrogenase (MTHFD) enzyme polymorphism as a maternal risk factor for trisomy 21: a clinical study

D Neagos, R Cretu, A Tutulan–Cunita, V Stoian, LC Bohiltea

J Med Life. 2010 Nov 15; 3(4): 454–457. Published online 2010 Nov 25.

PMCID:: PMC3019079

Article PDF–348K

Select item 273299514.

Analysis of the MTHFD1 promoter and risk of neural tube defects

Nicola Carroll, Faith Pangilinan, Anne M. Molloy, James Troendle, James L. Mills, Peadar N. Kirke, Lawrence C. Brody, John M. Scott, Anne Parle-McDermott

Hum Genet. Author manuscript; available in PMC 2010 Apr 1.

Published in final edited form as: Hum Genet. 2009 Apr; 125(3): 247–256. Published online 2009 Jan 8. doi: 10.1007/s00439-008-0616-3

PMCID:: PMC2732995

Article PDF–215K

Select item 171566915.

Chromosomal localization of the gene for the human trifunctional enzyme, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.

R Rozen, D Barton, J Du, D W Hum, R E MacKenzie, U Francke

Am J Hum Genet. 1989 Jun; 44(6): 781–786.

PMCID:: PMC1715669

Summary Page Browse PDF–882K

Select item 38509916.

A Polymorphism, R653Q, in the Trifunctional Enzyme Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase/Formyltetrahydrofolate Synthetase Is a Maternal Genetic Risk Factor for Neural Tube Defects: Report of the Birth Defects Research Group

Lawrence C. Brody, Mary Conley, Christopher Cox, Peadar N. Kirke, Mary P. McKeever, James L. Mills, Anne M. Molloy, Valerie B. O’Leary, Anne Parle-McDermott, John M. Scott, Deborah A. Swanson

Am J Hum Genet. 2002 Nov; 71(5): 1207–1215. Published online 2002 Oct 16. doi: 10.1086/344213