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Select item 105892721.

Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding

George Kefalas, Daniela Rotin

Sci Rep. 2023; 13: 17903. Published online 2023 Oct 20. doi: 10.1038/s41598-023-44761-9

PMCID:: PMC10589272

Abstract Article PDF–1.9M

Select item 96041692.

Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer

Sujitha Jayaprakash, Mangala Hegde, Bandari BharathwajChetty, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara

Int J Mol Sci. 2022 Oct; 23(20): 12380. Published online 2022 Oct 16. doi: 10.3390/ijms232012380

PMCID:: PMC9604169

Abstract Article PDF–2.7M

Select item 89994223.

The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration

Shanez Haouari, Patrick Vourc’h, Médéric Jeanne, Sylviane Marouillat, Charlotte Veyrat-Durebex, Débora Lanznaster, Frédéric Laumonnier, Philippe Corcia, Hélène Blasco, Christian R. Andres

Int J Mol Sci. 2022 Apr; 23(7): 3882. Published online 2022 Mar 31. doi: 10.3390/ijms23073882

PMCID:: PMC8999422

Abstract Article PDF–1.6M

Select item 69239564.

NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis

Lingfeng Wan, Tao Liu, Zhipeng Hong, You Pan, Steven T. Sizemore, Junran Zhang, Zhefu Ma

Breast Cancer Res. 2019; 21: 148. Published online 2019 Dec 19. doi: 10.1186/s13058-019-1236-7

PMCID:: PMC6923956

Abstract Article PDF–2.4M

Select item 69186125.

Association between polymorphism of the NEDD4 gene and cognitive dysfunction of schizophrenia patients in Chinese Han population

Chao Han, Kaiyan Cui, Xiaojiao Bi, Lina Wang, Mengmeng Sun, Limin Yang, Lanfen Liu

BMC Psychiatry. 2019; 19: 405. Published online 2019 Dec 18. doi: 10.1186/s12888-019-2386-y

PMCID:: PMC6918612

Abstract Article PDF–505K

Select item 66390526.

NEDD4: The founding member of a family of ubiquitin-protein ligases

Natasha Boase, Sharad Kumar

Gene. Author manuscript; available in PMC 2019 Jul 18.

Published in final edited form as: Gene. 2015 Feb 25; 557(2): 113–122. Published online 2014 Dec 17. doi: 10.1016/j.gene.2014.12.020

PMCID:: PMC6639052

Abstract Article PDF–502K

Select item 59695577.

NEDD4 promotes cell growth and motility in hepatocellular carcinoma

Hailun Zheng, Xiquan Ke, Dapeng Li, Qiangwu Wang, Jianchao Wang, Xiaoyang Liu, Min Deng, Xiaojing Deng, Yongju Xue, Yu Zhu, Qizhi Wang

Cell Cycle. 2018; 17(6): 728–738. Published online 2018 Apr 10. doi: 10.1080/15384101.2018.1440879

PMCID:: PMC5969557

Abstract Article PDF–1.5M

Select item 57549538.

Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma

Ying-Hua Song, Cai-Qing Zhang, Fang-Fang Chen, Xiao-Yan Lin

Chin Med J (Engl) 2018 Jan 5; 131(1): 16–24. doi: 10.4103/0366-6999.221262

PMCID:: PMC5754953

Abstract Article PDF–2.9M

Select item 55848559.

Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells

Wu Wen, Jingying Li, Longwang Wang, Yifei Xing, Xuechao Li, Hailong Ruan, Xiaoqing Xi, Jianhua Xiong, Renrui Kuang

Cell Cycle. 2017; 16(16): 1509–1514. Published online 2017 Jul 26. doi: 10.1080/15384101.2017.1338220

PMCID:: PMC5584855

Abstract Article PDF–905K

Select item 544435210.

NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells

Shaoyan Feng, Guangwei Yang, Haidi Yang, Zibin Liang, Rongkai Zhang, Yunping Fan, Gehua Zhang

Cell Cycle. 2017; 16(9): 869–878. Published online 2017 Apr 5. doi: 10.1080/15384101.2017.1308617

PMCID:: PMC5444352

Abstract Article PDF–1.1M

Select item 538676211.

The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer

Min Weng, Zhu-Lin Luo, Xiao-Ling Wu, Wei-Zheng Zeng

Oncotarget. 2017 Mar 21; 8(12): 20288–20296. Published online 2017 Feb 17. doi: 10.18632/oncotarget.15446

PMCID:: PMC5386762

Abstract Article PDF–2.8M

Select item 458640512.

NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling

Yuping Zhang, Renee Goodfellow, Yujun Li, Shujie Yang, Christopher J. Winters, Kristina W. Thiel, Kimberly K. Leslie, Baoli Yang

Gynecol Oncol. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Gynecol Oncol. 2015 Oct; 139(1): 127–133. Published online 2015 Jul 17. doi: 10.1016/j.ygyno.2015.07.098

PMCID:: PMC4586405

Abstract Article PDF–976K

Select item 449622113.

A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis

Chia-Jung Liao, Hsiang-Cheng Chi, Chung-Ying Tsai, Chi-De Chen, Sheng-Ming Wu, Yi-Hsin Tseng, Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen, Syuan-Ling Lin, Shiu-Feng Huang, Ya-Hui Huang, Kwang-Huei Lin

Oncotarget. 2015 Apr 20; 6(11): 9341–9354. Published online 2015 Mar 20. doi: 10.18632/oncotarget.3322

PMCID:: PMC4496221

Abstract Article PDF–7.3M

Select item 423932414.

Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis

Aiqin Sun, Guanzhen Yu, Xiaoyan Dou, Xiaowei Yan, Wannian Yang, Qiong Lin

Mol Cancer. 2014; 13: 248. Published online 2014 Nov 14. doi: 10.1186/1476-4598-13-248

PMCID:: PMC4239324

Abstract Article PDF–2.2M

Select item 411669615.

Abnormal Splicing of NEDD4 in Myotonic Dystrophy Type 2: Possible Link to Statin Adverse Reactions

Mark Screen, Per Harald Jonson, Olayinka Raheem, Johanna Palmio, Reijo Laaksonen, Terho Lehtimäki, Mario Sirito, Ralf Krahe, Peter Hackman, Bjarne Udd

Am J Pathol. 2014 Aug; 184(8): 2322–2332. doi: 10.1016/j.ajpath.2014.04.013

PMCID:: PMC4116696

Abstract Article PDF–1.6M

Select item 285296716.

Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition

Jian Wang, Qisheng Peng, Qiong Lin, Chandra Childress, David Carey, Wannian Yang

J Biol Chem. 2010 Apr 16; 285(16): 12279–12288. Published online 2010 Feb 19. doi: 10.1074/jbc.M109.086405

PMCID:: PMC2852967

Abstract Article PDF–1.7M

Select item 1102468417.

DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage

Bingchen Lv, Ping Fu, Miao Wang, Likun Cui, Lei Bao, Xingzhi Wang, Lu Yu, Chao Zhou, Mengxin Zhu, Fei Wang, Ye Pang, Suhua Qi, Zuohui Zhang, Guiyun Cui

CNS Neurosci Ther. 2024 Apr; 30(4): e14685. Published online 2024 Apr 18. doi: 10.1111/cns.14685