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Select item 99325701.

Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis

Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner

Redox Biol. 2023 Apr; 60: 102616. Published online 2023 Feb 1. doi: 10.1016/j.redox.2023.102616

PMCID:: PMC9932570

Abstract Article PDF–5.3M

Select item 95408082.

Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia

Simona Maria Di Modica, Emanuele Tanzi, Violante Olivari, Maria Rosa Lidonnici, Mariateresa Pettinato, Alessia Pagani, Francesca Tiboni, Valeria Furiosi, Laura Silvestri, Giuliana Ferrari, Stefano Rivella, Antonella Nai

Am J Hematol. 2022 Oct; 97(10): 1324–1336. Published online 2022 Aug 10. doi: 10.1002/ajh.26673

PMCID:: PMC9540808

Abstract Article PDF–8.5M

Select item 70860283.

Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload

Aaron M. Wortham, Devorah C. Goldman, Juxing Chen, William H. Fleming, An-Sheng Zhang, Caroline A. Enns

J Biol Chem. 2020 Mar 20; 295(12): 3906–3917. Published online 2020 Feb 13. doi: 10.1074/jbc.RA119.010535

PMCID:: PMC7086028

Abstract Article PDF–2.3M

Select item 54334194.

Altered Erythropoiesis in Mouse Models of Type 3 Hemochromatosis

R. M. Pellegrino, F. Riondato, L. Ferbo, M. Boero, A. Palmieri, L. Osella, P. Pollicino, B. Miniscalco, G. Saglio, A. Roetto

Biomed Res Int. 2017; 2017: 2408941. Published online 2017 May 2. doi: 10.1155/2017/2408941

PMCID:: PMC5433419

Abstract Article PDF–2.2M

Select item 49679015.

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse

Rosa Maria Pellegrino, Enrica Boda, Francesca Montarolo, Martina Boero, Mariarosa Mezzanotte, Giuseppe Saglio, Annalisa Buffo, Antonella Roetto

Sci Rep. 2016; 6: 30725. Published online 2016 Aug 1. doi: 10.1038/srep30725

PMCID:: PMC4967901

Abstract Article PDF–2.8M

Select item 43997536.

The second transferrin receptor regulates red blood cell production in mice

Antonella Nai, Maria Rosa Lidonnici, Marco Rausa, Giacomo Mandelli, Alessia Pagani, Laura Silvestri, Giuliana Ferrari, Clara Camaschella

Blood. 2015 Feb 12; 125(7): 1170–1179. Prepublished online 2014 Dec 11. doi: 10.1182/blood-2014-08-596254

PMCID:: PMC4399753

Abstract Article

Select item 40409057.

The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice

Antonella Nai, Rosa M. Pellegrino, Marco Rausa, Alessia Pagani, Martina Boero, Laura Silvestri, Giuseppe Saglio, Antonella Roetto, Clara Camaschella

Haematologica. 2014 Jun; 99(6): 1016–1021. doi: 10.3324/haematol.2013.103143

PMCID:: PMC4040905

Abstract Article PDF–751K

Select item 33865588.

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

Paul J. Schmidt, Mark D. Fleming

Am J Hematol. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Am J Hematol. 2012 Jun; 87(6): 588–595. Published online 2012 Mar 28. doi: 10.1002/ajh.23173

PMCID:: PMC3386558

Abstract Article PDF–1.1M

Select item 28808079.

Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis

Anita C.G. Chua, Roheeth D. Delima, Evan H. Morgan, Carly E. Herbison, Janina E.E. Tirnitz-Parker, Ross M. Graham, Robert E. Fleming, Robert S. Britton, Bruce R. Bacon, John K. Olynyk, Debbie Trinder

J Hepatol. Author manuscript; available in PMC 2011 Mar 1.

Published in final edited form as: J Hepatol. 2010 Mar; 52(3): 425–431. Published online 2010 Jan 6. doi: 10.1016/j.jhep.2009.12.010

PMCID:: PMC2880807

Abstract Article PDF–1.3M

Select item 283474710.

Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection

Cameron J. McDonald, Malcolm K. Jones, Daniel F. Wallace, Lesa Summerville, Sujeevi Nawaratna, V. Nathan Subramaniam

PLoS One. 2010; 5(3): e9594. Published online 2010 Mar 9. doi: 10.1371/journal.pone.0009594

PMCID:: PMC2834747

Abstract Article PDF–891K

Select item 257461211.

Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2

Vladimir Lesnikov, Nicholas Gorden, Nelson Fausto, Emily Spaulding, Jean Campbell, Howard Shulman, Robert E. Fleming, H. Joachim Deeg

Apoptosis. Author manuscript; available in PMC 2009 Aug 1.

Published in final edited form as: Apoptosis. 2008 Aug; 13(8): 1005–1012. doi: 10.1007/s10495-008-0233-6

PMCID:: PMC2574612

Abstract Article PDF–1014K

Select item 177462912.

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

D F Wallace, L Summerville, P E Lusby, V N Subramaniam

Gut. 2005 Jul; 54(7): 980–986. doi: 10.1136/gut.2004.062018

PMCID:: PMC1774629

Abstract Article PDF–247K

Select item 630228113.

Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model

Irene Artuso, Maria Rosa Lidonnici, Sandro Altamura, Giacomo Mandelli, Mariateresa Pettinato, Martina U. Muckenthaler, Laura Silvestri, Giuliana Ferrari, Clara Camaschella, Antonella Nai

Blood. 2018 Nov 22; 132(21): 2286–2297. Prepublished online 2018 Sep 12. doi: 10.1182/blood-2018-05-852277

Correction in:: Blood. 2019 Jul 4; 134(1): 94.

PMCID:: PMC6302281

Abstract Article

Select item 473101514.

Gene co-expression networks shed light into diseases of brain iron accumulation

Conceição Bettencourt, Paola Forabosco, Sarah Wiethoff, Moones Heidari, Daniel M. Johnstone, Juan A. Botía, Joanna F. Collingwood, John Hardy, for the UK Brain Expression Consortium (UKBEC), Elizabeth A. Milward, Mina Ryten, Henry Houlden

Neurobiol Dis. 2016 Mar; 87: 59–68. doi: 10.1016/j.nbd.2015.12.004

PMCID:: PMC4731015

Abstract Article

Select item 379646615.

In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact

Gautam Rishi, Emily M. Crampton, Daniel F. Wallace, V. Nathan Subramaniam

PLoS One. 2013; 8(10): e77267. Published online 2013 Oct 14. doi: 10.1371/journal.pone.0077267

PMCID:: PMC3796466

Abstract Article PDF–1.5M

Select item 12500316.

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

Robert E. Fleming, John R. Ahmann, Mary C. Migas, Abdul Waheed, H. Phillip Koeffler, Hiroshi Kawabata, Robert S. Britton, Bruce R. Bacon, William S. Sly

Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16): 10653–10658. Published online 2002 Jul 19. doi: 10.1073/pnas.162360699

PMCID:: PMC125003

Abstract Article PDF–271K

Select item 1578017.

Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

Robert E. Fleming, Mary C. Migas, Christopher C. Holden, Abdul Waheed, Robert S. Britton, Shunji Tomatsu, Bruce R. Bacon, William S. Sly

Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5): 2214–2219. Published online 2000 Feb 18. doi: 10.1073/pnas.040548097

PMCID:: PMC15780

Abstract Article PDF–562K

Select item 469221418.

Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver

Shunsuke Matsuo, Masayuki Ogawa, Martina U. Muckenthaler, Yumiko Mizui, Shota Sasaki, Takafumi Fujimura, Masayuki Takizawa, Nagayuki Ariga, Hiroaki Ozaki, Masakiyo Sakaguchi, Frank J. Gonzalez, Yusuke Inoue

J Biol Chem. 2015 Dec 25; 290(52): 30855–30865. Published online 2015 Nov 2. doi: 10.1074/jbc.M115.694414