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Select item 90122631.

PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay

Archna Ravi, Lavinia Palamiuc, Ryan M. Loughran, Joanna Triscott, Gurpreet K. Arora, Avi Kumar, Vivian Tieu, Chantal Pauli, Matthias Reist, Rachel J. Lew, Shauna L. Houlihan, Christof Fellmann, Christian Metallo, Mark A. Rubin, Brooke M. Emerling

Dev Cell. Author manuscript; available in PMC 2022 Jun 7.

Published in final edited form as: Dev Cell. 2021 Jun 7; 56(11): 1661–1676.e10. Published online 2021 May 12. doi: 10.1016/j.devcel.2021.04.019

PMCID:: PMC9012263

Abstract Article PDF–3.0M

Select item 85355042.

Association of PIP4K2A Polymorphisms with Alcohol Use Disorder

Olga Yu. Fedorenko, Ekaterina V. Mikhalitskaya, Valentina A. Toshchakova, Anton J. M. Loonen, Nikolay A. Bokhan, Svetlana A. Ivanova

Genes (Basel) 2021 Oct; 12(10): 1642. Published online 2021 Oct 19. doi: 10.3390/genes12101642

PMCID:: PMC8535504

Abstract Article PDF–443K

Select item 75798683.

Genetic polymorphisms of PIP5K2A and course of schizophrenia

Evgeniya G. Poltavskaya, Olga Yu. Fedorenko, Natalya M. Vyalova, Elena G. Kornetova, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova

BMC Med Genet. 2020; 21(Suppl 1): 171. Published online 2020 Oct 22. doi: 10.1186/s12881-020-01107-w

PMCID:: PMC7579868

Abstract Article PDF–651K

Select item 72865484.

Targeting the PI5P4K lipid kinase family in cancer using covalent inhibitors

Sindhu Carmen Sivakumaren, Hyeseok Shim, Tinghu Zhang, Fleur M. Ferguson, Mark R. Lundquist, Christopher M. Browne, Hyuk-Soo Seo, Marcia N. Paddock, Theresa D. Manz, Baishan Jiang, Ming-Feng Hao, Pranav Krishnan, Diana G. Wang, T. Jonathan Yang, Nicholas P. Kwiatkowski, Scott B. Ficarro, James M. Cunningham, Jarrod A. Marto, Sirano Dhe-Paganon, Lewis C. Cantley, Nathanael S. Gray

Cell Chem Biol. Author manuscript; available in PMC 2021 May 21.

Published in final edited form as: Cell Chem Biol. 2020 May 21; 27(5): 525–537.e6. Published online 2020 Mar 3. doi: 10.1016/j.chembiol.2020.02.003

PMCID:: PMC7286548

Abstract Article PDF–1.9M

Select item 70781665.

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase

Anita N. Kremer, Judith Bausenwein, Ellie Lurvink, Andreas E. Kremer, Caroline E. Rutten, Cornelis A. M. van Bergen, Sascha Kretschmann, Edith van der Meijden, Maria W. Honders, Daniela Mazzeo, Colin Watts, Andreas Mackensen, J. H. Frederik Falkenburg, Marieke Griffioen

Front Immunol. 2020; 11: 381. Published online 2020 Mar 11. doi: 10.3389/fimmu.2020.00381

PMCID:: PMC7078166

Abstract Article PDF–965K

Select item 65042096.

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

Yong Jae Shin, Jason K. Sa, Yeri Lee, Donggeon Kim, Nakho Chang, Hee Jin Cho, Miseol Son, Michael Y.T. Oh, Kayoung Shin, Jin-Ku Lee, Jiwon Park, Yoon Kyung Jo, Misuk Kim, Patrick J. Paddison, Vinay Tergaonkar, Jeongwu Lee, Do-Hyun Nam

J Exp Med. 2019 May 6; 216(5): 1120–1134. Published online 2019 Mar 21. doi: 10.1084/jem.20172170

PMCID:: PMC6504209

Abstract Article PDF–3.9M

Select item 58329307.

PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P₂ homeostasis

Ao Hu, Xue-Tong Zhao, Heng Tu, Ting Xiao, Ting Fu, Yan Wang, Yong Liu, Xiong-Jie Shi, Jie Luo, Bao-Liang Song

J Lipid Res. 2018 Mar; 59(3): 507–514. Published online 2018 Jan 20. doi: 10.1194/jlr.M082149

PMCID:: PMC5832930

Abstract Article PDF–1.3M

Select item 48637808.

Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility

Fei Liao, Dandan Yin, Yan Zhang, Qianqian Hou, Zhaoyue Zheng, Li Yang, Yang Shu, Heng Xu, Yu Li

Medicine (Baltimore) 2016 May; 95(18): e3542. Published online 2016 May 6. doi: 10.1097/MD.0000000000003542

PMCID:: PMC4863780

Abstract Article PDF–823K

Select item 44385439.

Association Study Indicates a Protective Role of Phosphatidylinositol-4-Phosphate-5-Kinase against Tardive Dyskinesia

Olga Yu Fedorenko, Anton J. M. Loonen, Florian Lang, Valentina A. Toshchakova, Evgenia G. Boyarko, Arkadiy V. Semke, Nikolay A. Bokhan, Nikolay V. Govorin, Lyubomir I. Aftanas, Svetlana A. Ivanova

Int J Neuropsychopharmacol. 2015 Apr; 18(6): pyu098. Published online 2015 Jan 29. doi: 10.1093/ijnp/pyu098

PMCID:: PMC4438543

Abstract Article PDF–726K

Select item 409937810.

Genetic Variations of PIP4K2A Confer Vulnerability to Poor Antipsychotic Response in Severely Ill Schizophrenia Patients

Harpreet Kaur, Ajay Jajodia, Sandeep Grover, Ruchi Baghel, Meenal Gupta, Sanjeev Jain, Ritushree Kukreti

PLoS One. 2014; 9(7): e102556. Published online 2014 Jul 15. doi: 10.1371/journal.pone.0102556

PMCID:: PMC4099378

Abstract Article PDF–645K

Select item 382561111.

Enzyme activity of the PIP4K2A gene product polymorphism that is implicated in schizophrenia

Jonathan H. Clarke, Robin F. Irvine

Psychopharmacology (Berl) 2013; 230(2): 329–331. Published online 2013 Oct 1. doi: 10.1007/s00213-013-3299-y

PMCID:: PMC3825611

Article PDF–146K

Select item 378244312.

Tamoxifen Inhibition of Kv7.2/Kv7.3 Channels

Tania Ferrer, Ivan Arael Aréchiga-Figueroa, Mark S. Shapiro, Martin Tristani-Firouzi, José A. Sanchez-Chapula

PLoS One. 2013; 8(9): e76085. Published online 2013 Sep 24. doi: 10.1371/journal.pone.0076085

PMCID:: PMC3782443

Abstract Article PDF–1.3M

Select item 298880413.

In Silico Ascription of Gene Expression Differences to Tumor and Stromal Cells in a Model to Study Impact on Breast Cancer Outcome

Simen Myhre, Hayat Mohammed, Trine Tramm, Jan Alsner, Greg Finak, Morag Park, Jens Overgaard, Anne-Lise Børresen-Dale, Arnoldo Frigessi, Therese Sørlie

PLoS One. 2010; 5(11): e14002. Published online 2010 Nov 19. doi: 10.1371/journal.pone.0014002

PMCID:: PMC2988804

Abstract Article PDF–2.8M

Select item 113569014.

The cloning and sequence of the C isoform of PtdIns4P 5-kinase.

N Divecha, O Truong, J J Hsuan, K A Hinchliffe, R F Irvine

Biochem J. 1995 Aug 1; 309(Pt 3): 715–719. doi: 10.1042/bj3090715

PMCID:: PMC1135690

Summary Page Browse PDF–1.2M

Select item 623569515.

BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia

Adam J. de Smith, Kyle M. Walsh, Stephen S. Francis, Chenan Zhang, Helen M. Hansen, Ivan Smirnov, Libby Morimoto, Todd P. Whitehead, Alice Kang, Xiaorong Shao, Lisa F. Barcellos, Roberta McKean-Cowdin, Luoping Zhang, Cecilia Fu, Rong Wang, Herbert Yu, Josephine Hoh, Andrew T. Dewan, Catherine Metayer, Xiaomei Ma, Joseph L. Wiemels

Int J Cancer. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Int J Cancer. 2018 Dec 1; 143(11): 2647–2658. Published online 2018 Oct 3. doi: 10.1002/ijc.31622

PMCID:: PMC6235695

Abstract Article PDF–619K

Select item 413065916.

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

Julian G Jude, Gary J Spencer, Xu Huang, Tim D D Somerville, David R Jones, Nullin Divecha, Tim C P Somervaille

Oncogene. Author manuscript; available in PMC 2015 Sep 5.

Published in final edited form as: Oncogene. 2015 Mar 5; 34(10): 1253–1262. Published online 2014 Mar 31. doi: 10.1038/onc.2014.77

PMCID:: PMC4130659

Abstract Article PDF–2.2M

Select item 401117617.

Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case-control study of schizophrenia (ICCSS)

D.L. Thiselton, B.S. Maher, B.T. Webb, T.B. Bigdeli, F.A. O’Neill, D. Walsh, K.S. Kendler, B.P. Riley

Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2014 May 6.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5; 0(1): 323–331. doi: 10.1002/ajmg.b.30982

PMCID:: PMC4011176

Abstract Article PDF–408K

Select item 1083736018.

Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre‐mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis

Dan Nie, Xin Tang, Haijun Deng, Xiaojun Yang, Junji Tao, Fengli Xu, Yi Liu, Kang Wu, Kai Wang, Zhechuan Mei, Ailong Huang, Ni Tang

Adv Sci (Weinh) 2024 Feb; 11(5): 2305374. Published online 2023 Dec 7. doi: 10.1002/advs.202305374

PMCID:: PMC10837360

Abstract Article PDF–12M

Select item 816619319.

Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells

Song Chen, Caroline Chandra Tjin, Xiang Gao, Yi Xue, Haoyan Jiao, Ruilin Zhang, Mengnan Wu, Zunyu He, Jonathan Ellman, Ya Ha

Proc Natl Acad Sci U S A. 2021 May 25; 118(21): e2002486118. Published online 2021 May 17. doi: 10.1073/pnas.2002486118

Correction in:: Proc Natl Acad Sci U S A. 2021 Nov 23; 118(47): e2118029118.

PMCID:: PMC8166193

Abstract Article PDF–1.7M

Select item 474765720.

The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis

Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd, Yuxiang Zheng, Emily Rose Kahoud, Takehiro Yokota, Brooke M. Emerling, John M. Asara, Tetsuo Ishida, Jason W. Locasale, Takiko Daikoku, Dimitrios Anastasiou, Toshiya Senda, Atsuo T. Sasaki

Mol Cell. Author manuscript; available in PMC 2017 Jan 21.

Published in final edited form as: Mol Cell. 2016 Jan 21; 61(2): 187–198. Published online 2016 Jan 7. doi: 10.1016/j.molcel.2015.12.011

PMCID:: PMC4747657

Abstract Article PDF–2.7M

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