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Select item 106066011.

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences

Alessia Finotti, Jessica Gasparello, Cristina Zuccato, Lucia Carmela Cosenza, Enrica Fabbri, Nicoletta Bianchi, Roberto Gambari

Genes (Basel) 2023 Oct; 14(10): 1927. Published online 2023 Oct 11. doi: 10.3390/genes14101927

PMCID:: PMC10606601

Abstract Article PDF–2.7M

Select item 99007002.

BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway

Qianya Jin, Yanmin Chen, Shibei Du, Dongqing Xu, Juanqing Yue, Lei Cai, Xiaojun Yuan

Curr Cancer Drug Targets. 2022 Oct 14; 22(11): 919–930. Published online 2022 Oct 14. doi: 10.2174/1568009622666220728123748

PMCID:: PMC9900700

Abstract Article PDF–5.7M

Select item 92192463.

Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A

Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai, Surapol Issaragrisil

Stem Cell Res Ther. 2022; 13: 274. Published online 2022 Jun 23. doi: 10.1186/s13287-022-02954-5

Correction in:: Stem Cell Res Ther. 2022; 13: 396.

PMCID:: PMC9219246

Abstract Article PDF–4.5M

Select item 89414734.

BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes

Yoshitaka Sunami, Takashi Yokoyama, Seiko Yoshino, Tomoko Takahara, Yukari Yamazaki, Hironori Harada, Takuro Nakamura

Blood Adv. 2022 Mar 22; 6(6): 1827–1843. Published online 2022 Mar 16. doi: 10.1182/bloodadvances.2021004558

PMCID:: PMC8941473

Abstract Article PDF–3.4M

Select item 85303015.

Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing

Yong Shen, Rick Li, Kristian Teichert, Kara E. Montbleau, Jeffrey M. Verboon, Richard A. Voit, Vijay G. Sankaran

PLoS Genet. 2021 Oct; 17(10): e1009835. Published online 2021 Oct 11. doi: 10.1371/journal.pgen.1009835

PMCID:: PMC8530301

Abstract Article PDF–2.7M

Select item 74501256.

The transcriptional repressor BCL11A promotes breast cancer metastasis

Darcie D. Seachrist, Molly M. Hannigan, Natasha N. Ingles, Bryan M. Webb, Kristen L. Weber-Bonk, Peng Yu, Gurkan Bebek, Salendra Singh, Steven T. Sizemore, Vinay Varadan, Donny D. Licatalosi, Ruth A. Keri

J Biol Chem. 2020 Aug 14; 295(33): 11707–11719. Published online 2020 Jun 23. doi: 10.1074/jbc.RA120.014018

PMCID:: PMC7450125

Abstract Article PDF–1.9M

Select item 68515057.

BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases

Jiawei Yin, Xiaoli Xie, Yufu Ye, Lijuan Wang, Fengyuan Che

Biosci Rep. 2019 Nov 29; 39(11): BSR20190604. Published online 2019 Nov 13. doi: 10.1042/BSR20190604

PMCID:: PMC6851505

Abstract Article PDF–827K

Select item 63771918.

The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching

Sayed Abdulazeez, Shaheen Sultana, Noor B. Almandil, Dana Almohazey, B. Jesvin Bency, J. Francis Borgio

PLoS One. 2019; 14(2): e0212492. Published online 2019 Feb 15. doi: 10.1371/journal.pone.0212492

PMCID:: PMC6377191

Abstract Article PDF–4.0M

Select item 57654019.

BCL11A frameshift mutation associated with dyspraxia and hypotonia affecting the fine, gross, oral, and speech motor systems

Julie Soblet, Ivan Dimov, Clemens Graf von Kalckreuth, Julie Cano‐Chervel, Simon Baijot, Karin Pelc, Martine Sottiaux, Catheline Vilain, Guillaume Smits, Nicolas Deconinck

Am J Med Genet A. 2018 Jan; 176(1): 201–208. Published online 2017 Sep 27. doi: 10.1002/ajmg.a.38479

PMCID:: PMC5765401

Abstract Article PDF–624K

Select item 532149810.

Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma

Jian Zhou, Yue Yang, Duo Zhang, Liang Zhou, Lei Tao, Li-Ming Lu

PLoS One. 2017; 12(2): e0171116. Published online 2017 Feb 22. doi: 10.1371/journal.pone.0171116

PMCID:: PMC5321498

Abstract Article PDF–897K

Select item 509682411.

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype

Christian Brendel, Swaroopa Guda, Raffaele Renella, Daniel E. Bauer, Matthew C. Canver, Young-Jo Kim, Matthew M. Heeney, Denise Klatt, Jonathan Fogel, Michael D. Milsom, Stuart H. Orkin, Richard I. Gregory, David A. Williams

J Clin Invest. 2016 Oct 3; 126(10): 3868–3878. Published online 2016 Sep 6. doi: 10.1172/JCI87885

PMCID:: PMC5096824

Abstract Article PDF–1016K

Select item 492855112.

Association of BCL11A genetic variant (rs11886868) with severity in β-thalassaemia major & sickle cell anaemia

Sneha Dadheech, D. Madhulatha, Suman Jain, James Joseph, A. Jyothy, Anjana Munshi

Indian J Med Res. 2016 Apr; 143(4): 449–454. doi: 10.4103/0971-5916.184285

PMCID:: PMC4928551

Abstract Article PDF–615K

Select item 467090413.

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin

Alessia Finotti, Jessica Gasparello, Giulia Breveglieri, Lucia Carmela Cosenza, Giulia Montagner, Alberto Bresciani, Sergio Altamura, Nicoletta Bianchi, Elisa Martini, Eleonora Gallerani, Monica Borgatti, Roberto Gambari

Exp Hematol. 2015 Dec; 43(12): 1062–1071.e3. doi: 10.1016/j.exphem.2015.08.011

PMCID:: PMC4670904

Abstract Article

Select item 461577314.

Association between Variants at BCL11A Erythroid-Specific Enhancer and Fetal Hemoglobin Levels among Sickle Cell Disease Patients in Cameroon: Implications for Future Therapeutic Interventions

Gift Dineo Pule, Valentina Josiane Ngo Bitoungui, Bernard Chetcha Chemegni, Andre Pascal Kengne, Stylianos Antonarakis, Ambroise Wonkam

OMICS. 2015 Oct 1; 19(10): 627–631. doi: 10.1089/omi.2015.0124

PMCID:: PMC4615773

Abstract Article PDF–142K

Select item 434190215.

BCL11A Enhancer Haplotypes and Fetal Hemoglobin in Sickle Cell Anemia: BCL11A Enhancers and HbF

P. Sebastiani, J.J. Farrell, A. Alsultan, S. Wang, H. L. Edward, H. Shappell, H. Bae, J. N. Milton, C.T. Baldwin, A.M. Al-Rubaish, Z. Naserullah, F. Al-Muhanna, A. Alsuliman, P. K. Patra, L.A. Farrer, D. Ngo, V. Vathipadiekal, D.H.K. Chui, A.K. Al-Ali, M.H. Steinberg

Blood Cells Mol Dis. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Blood Cells Mol Dis. 2015 Mar; 54(3): 224–230. Published online 2015 Jan 30. doi: 10.1016/j.bcmd.2015.01.001

PMCID:: PMC4341902

Abstract Article PDF–625K

Select item 410060616.

BCL11A IS A MAJOR HbF QUANTITATIVE TRAIT LOCUS IN THREE DIFFERENT POPULATIONS WITH β-HEMOGLOBINOPATHIES

Amanda E. Sedgewick, Nadia Timofeev, Paola Sebastiani, Jason C.C. So, Edmond S.K. Ma, Li Chong Chan, Goonnapa Fucharoen, Supan Fucharoen, Cynara G. Barbosa, Badri N. Vardarajan, Lindsay A. Farrer, Clinton T. Baldwin, Martin H. Steinberg, David H.K. Chui

Blood Cells Mol Dis. Author manuscript; available in PMC 2014 Jul 16.

Published in final edited form as: Blood Cells Mol Dis. 2008 Nov-Dec; 41(3): 255–258. Published online 2008 Aug 8. doi: 10.1016/j.bcmd.2008.06.007

PMCID:: PMC4100606

Abstract Article PDF–536K

Select item 401882617.

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

Daniel E. Bauer, Sophia C. Kamran, Samuel Lessard, Jian Xu, Yuko Fujiwara, Carrie Lin, Zhen Shao, Matthew C. Canver, Elenoe C. Smith, Luca Pinello, Peter J. Sabo, Jeff Vierstra, Richard A. Voit, Guo-Cheng Yuan, Matthew H. Porteus, John A. Stamatoyannopoulos, Guillaume Lettre, Stuart H. Orkin

Science. Author manuscript; available in PMC 2014 May 13.

Published in final edited form as: Science. 2013 Oct 11; 342(6155): 253–257. doi: 10.1126/science.1242088

PMCID:: PMC4018826

Abstract Article PDF–906K

Select item 392244118.

Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach

Pavlos Fanis, Ioanna Kousiappa, Marios Phylactides, Marina Kleanthous

BMC Genomics. 2014; 15: 108. Published online 2014 Feb 6. doi: 10.1186/1471-2164-15-108

PMCID:: PMC3922441

Abstract Article PDF–909K

Select item 339666719.

Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion

Fabrice Danjou, Franco Anni, Lucia Perseu, Stefania Satta, Carlo Dessì, Maria Eliana Lai, Paolo Fortina, Marcella Devoto, Renzo Galanello

Haematologica. 2012 Jul; 97(7): 989–993. doi: 10.3324/haematol.2011.053504

PMCID:: PMC3396667

Abstract Article PDF–801K

Select item 994063420.

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

Peng Huang, Scott A. Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A. Keller, Belinda Giardine, Henry W. Bell, Xianjiang Lan, Malini Sharma, John R. Horton, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Merlin Crossley, Ross C. Hardison, Xiaodong Cheng, Gerd A. Blobel

Nat Genet. Author manuscript; available in PMC 2023 Feb 20.

Published in final edited form as: Nat Genet. 2022 Sep; 54(9): 1417–1426. Published online 2022 Aug 8. doi: 10.1038/s41588-022-01152-6

Correction in:: Nat Genet. 2023 Jul 31

PMCID:: PMC9940634

Abstract Article PDF–5.3M

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