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Select item 101218941.

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

Dylan V Neel, Himanish Basu, Georgia Gunner, Matthew D Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza Brody, Xin Jiang, Edward Lee, Michelle E Watts, Christine Marques, Aaron Held, Brian Wainger, Clotilde Lagier-Tourenne, Yong-Jie Zhang, Leonard Petrucelli, Tracey L. Young-Pearse, Alice S Chen-Plotkin, Lee L. Rubin, Judy Lieberman, Isaac M Chiu

Neuron. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: Neuron. 2023 Apr 19; 111(8): 1222–1240.e9. Published online 2023 Mar 13. doi: 10.1016/j.neuron.2023.02.019

PMCID:: PMC10121894

Abstract Article PDF–4.5M

Select item 95267472.

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils

Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu, Xu Chen

Cell Death Dis. 2022 Oct; 13(10): 841. Published online 2022 Oct 1. doi: 10.1038/s41419-022-05276-9

PMCID:: PMC9526747

Abstract Article PDF–7.5M

Select item 88001163.

Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina

Binxiang Cai, Chunyan Liao, Danxue He, Jingmeng Chen, Jiahuai Han, Jiaying Lu, Kaiqi Qin, Wenxu Liang, Xiaoling Wu, Zuguo Liu, Yalin Wu

J Biol Chem. 2022 Feb; 298(2): 101553. Published online 2021 Dec 29. doi: 10.1016/j.jbc.2021.101553

PMCID:: PMC8800116

Abstract Article PDF–5.7M

Select item 87200794.

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De Schutter, Jana Ramon, Benjamin Pfeuty, Caroline De Tender, Stephan Stremersch, Koen Raemdonck, Ken Op de Beeck, Wim Declercq, Franck B. Riquet, Kevin Braeckmans, Peter Vandenabeele

Cell Mol Life Sci. 2022 Jan; 79(1): 19. Published online 2021 Dec 31. doi: 10.1007/s00018-021-04078-0

PMCID:: PMC8720079

Abstract Article PDF–4.6M

Select item 85670745.

Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction

Mengying Wu, Weiwei Xia, Qianqian Jin, Anning Zhou, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Yuanyuan Li, Zhanjun Jia

Front Cell Dev Biol. 2021; 9: 754134. Published online 2021 Oct 21. doi: 10.3389/fcell.2021.754134

PMCID:: PMC8567074

Abstract Article PDF–3.0M

Select item 93052126.

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis

Zeqing Zhai, Fangyuan Yang, Wenchao Xu, Jiaochan Han, Guihu Luo, Yehao Li, Jian Zhuang, Hongyu Jie, Xing Li, Xingliang Shi, Xinai Han, Xiaoqing Luo, Rui Song, Yonghong Chen, Jianheng Liang, Shufan Wu, Yi He, Erwei Sun

Arthritis Rheumatol. 2022 Mar; 74(3): 427–440. Published online 2022 Jan 18. doi: 10.1002/art.41963

PMCID:: PMC9305212

Abstract Article PDF–7.8M

Select item 90357237.

Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection

Siwen Dong, Yujin Shi, Xiaojing Dong, Xia Xiao, Jianli Qi, Lili Ren, Zichun Xiang, Zhuo Zhou, Jianwei Wang, Xiaobo Lei

J Biol Chem. 2022 May; 298(5): 101850. Published online 2022 Mar 23. doi: 10.1016/j.jbc.2022.101850

PMCID:: PMC9035723

Abstract Article PDF–3.0M

Select item 78626998.

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia

Cell Death Dis. 2021 Feb; 12(2): 139. Published online 2021 Feb 1. doi: 10.1038/s41419-021-03431-2

PMCID:: PMC7862699

Abstract Article PDF–4.0M

Select item 76489399.

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Gao Tan, Chongyang Huang, Jiaye Chen, Fachao Zhi

J Hematol Oncol. 2020; 13: 149. Published online 2020 Nov 7. doi: 10.1186/s13045-020-00985-0

PMCID:: PMC7648939

Abstract Article PDF–2.1M

Select item 672163010.

Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model

Lieselot Croes, Erik Fransen, Marieke Hylebos, Kimberly Buys, Christophe Hermans, Glenn Broeckx, Marc Peeters, Patrick Pauwels, Ken Op de Beeck, Guy Van Camp

Cancers (Basel) 2019 Aug; 11(8): 1214. Published online 2019 Aug 20. doi: 10.3390/cancers11081214

PMCID:: PMC6721630

Abstract Article PDF–3.2M

Select item 645983611.

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, Emad S. Alnemri

Nat Commun. 2019; 10: 1689. Published online 2019 Apr 11. doi: 10.1038/s41467-019-09397-2

PMCID:: PMC6459836

Abstract Article PDF–2.9M

Select item 892366412.

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling

Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele

eLife. 2022; 11: e75753. Published online 2022 Mar 4. doi: 10.7554/eLife.75753

PMCID:: PMC8923664

Abstract Article PDF–7.4M

Select item 651782713.

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz

EMBO J. 2019 May 15; 38(10): e101638. Published online 2019 Mar 22. doi: 10.15252/embj.2019101638

PMCID:: PMC6517827

Abstract Article PDF–1.2M

Select item 1090769114.

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen

Cell Death Dis. 2024 Mar; 15(3): 180. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06545-5

PMCID:: PMC10907691

Abstract Article PDF–9.3M

Select item 1036264315.

Iron induces B cell pyroptosis through Tom20–Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury

Chengjie Wu, Lining Wang, Sixian Chen, Lei Shi, Mengmin Liu, Pengcheng Tu, Jie Sun, Ruihua Zhao, Yafeng Zhang, Jianwei Wang, Yalan Pan, Yong Ma, Yang Guo

J Neuroinflammation. 2023; 20: 171. Published online 2023 Jul 22. doi: 10.1186/s12974-023-02848-0

PMCID:: PMC10362643

Abstract Article PDF–17M

Select item 985979816.

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation

Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Naoto Watamura, Hiroki Sasaguri, Yuhei Takado, Yoshihiro Yoshihara, Takashi Saito, Takaomi C. Saido

Sci Rep. 2023; 13: 1109. Published online 2023 Jan 20. doi: 10.1038/s41598-023-27653-w

PMCID:: PMC9859798

Abstract Article PDF–3.1M

Select item 853582217.

NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J. Ulevitch, Jiahuai Han

Sci Adv. 2021 Oct; 7(43): eabi9471. Published online 2021 Oct 22. doi: 10.1126/sciadv.abi9471

PMCID:: PMC8535822

Abstract Article PDF–8.9M

Select item 832927518.

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy

Yinshuang Li, Ying Yuan, Zhong-xing Huang, Hui Chen, Ruilong Lan, Zeng Wang, Kunmei Lai, Hong Chen, Zhimin Chen, Zhenhuan Zou, Hua-bin Ma, Hui-Yao Lan, Tak W. Mak, Yanfang Xu

Cell Death Differ. 2021 Aug; 28(8): 2333–2350. Published online 2021 Mar 4. doi: 10.1038/s41418-021-00755-6

PMCID:: PMC8329275

Abstract Article PDF–11M

Select item 828595719.

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling

Kaiwen W. Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P. Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D. Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E. Brodsky, Petr Broz

Proc Natl Acad Sci U S A. 2021 Jul 13; 118(28): e2101189118. Published online 2021 Jul 6. doi: 10.1073/pnas.2101189118

PMCID:: PMC8285957

Abstract Article PDF–1.8M

Select item 712379420.

Gasdermin E suppresses tumor growth by activating anti-tumor immunity

Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, Karla F. Meza-Sosa, Mo Yin Temy Mok, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu, Judy Lieberman

Nature. Author manuscript; available in PMC 2020 Sep 11.

Published in final edited form as: Nature. 2020 Mar; 579(7799): 415–420. Published online 2020 Mar 11. doi: 10.1038/s41586-020-2071-9

PMCID:: PMC7123794

Abstract Article PDF–4.1M

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