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Select item 109665251.

RNF43 Inactivation Enhances the B‐RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells

Shih‐Han Hsu, Ya‐Li Tsai, Yeng‐Tseng Wang, Che‐Hung Shen, Yu‐Hsuan Hung, Li‐Tzong Chen, Wen‐Chun Hung

Adv Sci (Weinh) 2024 Mar; 11(12): 2304820. Published online 2024 Jan 15. doi: 10.1002/advs.202304820

PMCID:: PMC10966525

Abstract Article PDF–5.4M

Select item 105805502.

Pan-cancer analysis identifies RNF43 as a prognostic, therapeutic and immunological biomarker

Yingting Xu, Zhengjun Lin, Yuqiao Ji, Chen Zhang, Xianzhe Tang, Chuan Li, Tang Liu

Eur J Med Res. 2023; 28: 438. Published online 2023 Oct 17. doi: 10.1186/s40001-023-01383-1

PMCID:: PMC10580550

Abstract Article PDF–13M

Select item 102080193.

RNF43 is a novel tumor-suppressor and prognostic indicator in clear cell renal cell carcinoma

DAWEI ZHU, LEI ZHANG, XIAOKAI SHI, SHENGLIN GAO, CHUANG YUE, LIFENG ZHANG, YU BAI, QIFENG WANG, ATSUSHI OKADA, TAKAHIRO YASUI, CHAO WANG, XINGANG CUI, LI ZUO

Oncol Res. 2021; 29(3): 159–174. Published online 2022 Aug 1. doi: 10.32604/or.2022.03458

PMCID:: PMC10208019

Abstract Article PDF–17M

Select item 95563334.

RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAF^V600E metastatic colorectal cancer

Elena Elez, Javier Ros, Jose Fernández, Guillermo Villacampa, Ana Belén Moreno-Cárdenas, Carlota Arenillas, Kinga Bernatowicz, Raquel Comas, Shanshan Li, David Philip Kodack, Roberta Fasani, Ariadna Garcia, Javier Gonzalo-Ruiz, Alejandro Piris-Gimenez, Paolo Nuciforo, Grainne Kerr, Rossana Intini, Aldo Montagna, Marco Maria Germani, Giovanni Randon, Ana Vivancos, Ron Smits, Diana Graus, Raquel Perez-Lopez, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Rodrigo Dienstmann, Josep Tabernero, Rodrigo A. Toledo

Nat Med. 2022; 28(10): 2162–2170. Published online 2022 Sep 12. doi: 10.1038/s41591-022-01976-z

PMCID:: PMC9556333

Abstract Article PDF–4.1M

Select item 93148655.

Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer

Daisuke Yamamoto, Hiroko Oshima, Dong Wang, Haruna Takeda, Kenji Kita, Xuelian Lei, Mizuho Nakayama, Kazuhiro Murakami, Takashi Ohama, Hirofumi Takemura, Mutsumi Toyota, Hiromu Suzuki, Noriyuki Inaki, Masanobu Oshima

J Pathol. 2022 May; 257(1): 39–52. Published online 2022 Mar 4. doi: 10.1002/path.5868

PMCID:: PMC9314865

Abstract Article PDF–30M

Select item 90648976.

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, Jeff Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John L. Marshall, Benjamin A. Weinberg, Paul E. Sackstein, Kiat Hon Lim, Gek San Tan, Chadi Nabhan, W. Michael Korn, Arno Amann, Zlatko Trajanoski, Martin D. Berger, Emil Lou, Dominik Wolf, Heinz-Josef Lenz

Clin Cancer Res. 2022 May 2; 28(9): 1863–1870. Published online 2022 Feb 16. doi: 10.1158/1078-0432.CCR-21-3018

PMCID:: PMC9064897

Abstract Article PDF–631K

Select item 85477087.

Oligodendroglial Ring Finger Protein Rnf43 is an essential injury specific regulator of oligodendrocyte maturation

Jianqin Niu, Guangdan Yu, Xiaorui Wang, Wenlong Xia, Yuxin Wang, Kimberly K. Hoi, Feng Mei, Lan Xiao, Jonah R. Chan, Stephen P.J. Fancy

Neuron. Author manuscript; available in PMC 2022 Oct 6.

Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3104–3118.e6. Published online 2021 Aug 13. doi: 10.1016/j.neuron.2021.07.018

PMCID:: PMC8547708

Abstract Article PDF–2.1M

Select item 80488178.

RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps

Yasmijn J van Herwaarden, Lieke M Koggel, Femke Simmer, Elisa M. Vink‐Börger, Polat Dura, Gerrit A Meijer, Fokko M Nagengast, Nicoline Hoogerbrugge, Tanya M Bisseling, Iris D Nagtegaal

Histopathology. 2021 Apr; 78(5): 749–758. Published online 2020 Dec 25. doi: 10.1111/his.14286

PMCID:: PMC8048817

Abstract Article PDF–847K

Select item 72917199.

Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells

Tomasz Radaszkiewicz, Vítězslav Bryja

Cell Commun Signal. 2020; 18: 91. Published online 2020 Jun 11. doi: 10.1186/s12964-020-00559-0

PMCID:: PMC7291719

Abstract Article PDF–2.7M

Select item 689835610.

The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis

Jianghua Tu, Soohyun Park, Wangsheng Yu, Sheng Zhang, Ling Wu, Kendra Carmon, Qingyun J. Liu

Sci Rep. 2019; 9: 18557. Published online 2019 Dec 6. doi: 10.1038/s41598-019-54931-3

PMCID:: PMC6898356

Abstract Article PDF–3.7M

Select item 608682311.

RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers

Lochlan J. Fennell, Mark Clendenning, Diane M. McKeone, Saara H. Jamieson, Samanthy Balachandran, Jennifer Borowsky, John Liu, Futoshi Kawamata, Catherine E. Bond, Christophe Rosty, Matthew E. Burge, Daniel D. Buchanan, Barbara A. Leggett, Vicki L. J. Whitehall

Fam Cancer. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Fam Cancer. 2018 Jan; 17(1): 63–69. doi: 10.1007/s10689-017-0003-0

PMCID:: PMC6086823

Abstract Article PDF–506K

Select item 373297012.

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

Xiaomo Jiang, Huai-Xiang Hao, Joseph D. Growney, Steve Woolfenden, Cindy Bottiglio, Nicholas Ng, Bo Lu, Mindy H. Hsieh, Linda Bagdasarian, Ronald Meyer, Timothy R. Smith, Monika Avello, Olga Charlat, Yang Xie, Jeffery A. Porter, Shifeng Pan, Jun Liu, Margaret E. McLaughlin, Feng Cong

Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31): 12649–12654. Published online 2013 Jul 11. doi: 10.1073/pnas.1307218110

PMCID:: PMC3732970

Abstract Article PDF–1.1M

Select item 1086937013.

Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family

James M. Chan, Mark Clendenning, Sharelle Joseland, Peter Georgeson, Khalid Mahmood, Jihoon E. Joo, Romy Walker, Julia Como, Susan Preston, Shuyi Marci Chai, Yen Lin Chu, Aaron L. Meyers, Bernard J. Pope, David Duggan, J. Lynn Fink, Finlay A. Macrae, Christophe Rosty, Ingrid M. Winship, Mark A. Jenkins, Daniel D. Buchanan

Fam Cancer. 2024; 23(1): 9–21. Published online 2023 Dec 8. doi: 10.1007/s10689-023-00351-2

PMCID:: PMC10869370

Abstract Article PDF–2.7M

Select item 933893314.

Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer

Abdul Khalid Siraj, Rong Bu, Tariq Masoodi, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Wael Al-Haqawi, Hassan Al-Dossari, Saud Azam, Zeeshan Qadri, Padmanaban Annaiyappanaidu, Fouad Al-Dayel, Khawla Sami Al-Kuraya

Sci Rep. 2022; 12: 13098. Published online 2022 Jul 30. doi: 10.1038/s41598-022-17449-9

PMCID:: PMC9338933

Abstract Article PDF–1.5M

Select item 905484815.

RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface

A-Ri Cho, Hee Jung Sul, Yoo Jin Kim, Bohyun Kim, Dae Young Zang

Sci Rep. 2022; 12: 7013. Published online 2022 Apr 29. doi: 10.1038/s41598-022-10868-8

PMCID:: PMC9054848

Abstract Article PDF–1.6M

Select item 876407316.

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch

Nat Commun. 2022; 13: 334. Published online 2022 Jan 17. doi: 10.1038/s41467-021-27923-z