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Select item 100219891.

Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly

Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng

Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y

PMCID:: PMC10021989

Abstract Article PDF–1.5M

Select item 33566302.

Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses

Surinder Kaur, Antonella Sassano, Beata Majchrzak-Kita, Darren P. Baker, Bing Su, Eleanor N. Fish, Leonidas C. Platanias

Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7723–7728. Published online 2012 May 1. doi: 10.1073/pnas.1118122109

PMCID:: PMC3356630

Abstract Article PDF–1.7M

Select item 28448243.

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

Partha Chakrabarti, Taylor English, Jun Shi, Cynthia M. Smas, Konstantin V. Kandror

Diabetes. 2010 Apr; 59(4): 775–781. Published online 2010 Jan 12. doi: 10.2337/db09-1602

PMCID:: PMC2844824

Abstract Article PDF–325K

Select item 27037824.

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

Hui H. Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M. Squillace, Chin-Lee Wu, Brendan D. Manning

PLoS One. 2009; 4(7): e6189. Published online 2009 Jul 10. doi: 10.1371/journal.pone.0006189

PMCID:: PMC2703782

Abstract Article PDF–3.6M

Select item 53949875.

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton, David M. Sabatini

Cell. Author manuscript; available in PMC 2018 Mar 9.

Published in final edited form as: Cell. 2017 Mar 9; 168(6): 960–976. doi: 10.1016/j.cell.2017.02.004

Correction in:: Cell. 2017 Apr 6; 169(2): 361–371.

PMCID:: PMC5394987

Abstract Article PDF–1.1M

Select item 44080216.

mLST8 Promotes mTOR-Mediated Tumor Progression

Kyoko Kakumoto, Jun-ichiro Ikeda, Masato Okada, Eiichi Morii, Chitose Oneyama

PLoS One. 2015; 10(4): e0119015. Published online 2015 Apr 23. doi: 10.1371/journal.pone.0119015

PMCID:: PMC4408021

Abstract Article PDF–6.9M

Select item 33240897.

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Dudley W. Lamming, Lan Ye, Pekka Katajisto, Marcus D. Goncalves, Maki Saitoh, Deanna M. Stevens, James G. Davis, Adam B. Salmon, Arlan Richardson, Rexford S. Ahima, David A. Guertin, David M. Sabatini, Joseph A. Baur

Science. Author manuscript; available in PMC 2012 Apr 11.

Published in final edited form as: Science. 2012 Mar 30; 335(6076): 1638–1643. doi: 10.1126/science.1215135

PMCID:: PMC3324089

Abstract Article PDF–797K

Select item 27013818.

The mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

David A. Guertin, Deanna M. Stevens, Maki Saitoh, Stephanie Kinkel, Katherine Crosby, Joon-Ho Sheen, David J. Mullholland, Mark A. Magnuson, Hong Wu, David M. Sabatini

Cancer Cell. Author manuscript; available in PMC 2009 Aug 3.

Published in final edited form as: Cancer Cell. 2009 Feb 3; 15(2): 148–159. doi: 10.1016/j.ccr.2008.12.017

PMCID:: PMC2701381

Abstract Article PDF–2.8M

Select item 29467869.

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Alex I. Lipovsky, Amanda L. Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver, Matthew G. Vander Heiden, Jeffrey P. MacKeigan, Peter M. Finan, Clary B. Clish, Leon O. Murphy, Brendan D. Manning

Mol Cell. Author manuscript; available in PMC 2011 Jul 30.

Published in final edited form as: Mol Cell. 2010 Jul 30; 39(2): 171–183. doi: 10.1016/j.molcel.2010.06.022

PMCID:: PMC2946786

Abstract Article PDF–2.6M

Select item 267600810.

Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein

Tatsuhiro Sato, Akio Nakashima, Lea Guo, Fuyuhiko Tamanoi

J Biol Chem. 2009 May 8; 284(19): 12783–12791. doi: 10.1074/jbc.M809207200

PMCID:: PMC2676008

Abstract Article PDF–610K

Select item 492686111.

Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival

Laura J. Smithson, David H. Gutmann

Genes Dev. 2016 Jun 15; 30(12): 1383–1388. doi: 10.1101/gad.279661.116

PMCID:: PMC4926861

Abstract Article PDF–500K

Select item 257883112.

Syndecan-4 regulates subcellular localization of mTOR complex2 and Akt activation in a PKCα-dependent manner in endothelial cells

Chohreh Partovian, Rong Ju, Zhen W. Zhuang, Kathleen Martin, Michael Simons

Mol Cell. Author manuscript; available in PMC 2009 Oct 10.

Published in final edited form as: Mol Cell. 2008 Oct 10; 32(1): 140–149. doi: 10.1016/j.molcel.2008.09.010

PMCID:: PMC2578831

Abstract Article PDF–2.7M

Select item 248627513.

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou, Kun-Liang Guan

EMBO J. 2008 Jul 23; 27(14): 1919–1931. Published online 2008 Jun 19. doi: 10.1038/emboj.2008.119

Correction in:: EMBO J. 2008 Aug 20; 27(16): 2270.

PMCID:: PMC2486275

Abstract Article PDF–858K

Select item 803465114.

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Anouk M Olthof, Alisa K White, Stephen Mieruszynski, Karen Doggett, Madisen F Lee, Almahdi Chakroun, Alice K Abdel Aleem, Justine Rousseau, Cinzia Magnani, Chaim M Roifman, Philippe M Campeau, Joan K Heath, Rahul N Kanadia

Nucleic Acids Res. 2021 Apr 6; 49(6): 3524–3545. Published online 2021 Feb 28. doi: 10.1093/nar/gkab118

PMCID:: PMC8034651

Abstract Article PDF–7.2M

Select item 333167915.

mTOR signaling in growth control and disease

Mathieu Laplante, David M. Sabatini

Cell. Author manuscript; available in PMC 2013 Apr 13.

Published in final edited form as: Cell. 2012 Apr 13; 149(2): 274–293. doi: 10.1016/j.cell.2012.03.017

PMCID:: PMC3331679

Abstract Article PDF–3.8M

Select item 293936416.

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

Hiroyuki Takai, Yihu Xie, Titia de Lange, Nikola P. Pavletich

Genes Dev. 2010 Sep 15; 24(18): 2019–2030. doi: 10.1101/gad.1956410

PMCID:: PMC2939364

Abstract Article PDF–875K

Select item 909121717.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Abstract Article PDF–7.2M

Select item 141356818.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

Select item 793877019.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 255627020.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

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