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Items: 20

Select item 102902751.

Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer

Mélanie A. Dacheux, Derek D. Norman, Gábor J. Tigyi, Sue Chin Lee

Pharmacol Ther. Author manuscript; available in PMC 2023 Jun 24.

Published in final edited form as: Pharmacol Ther. 2023 May; 245: 108414. Published online 2023 Apr 13. doi: 10.1016/j.pharmthera.2023.108414

PMCID:: PMC10290275

Abstract Article PDF–1.8M

Select item 100860522.

Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer

Ben Zhang, Lixi Zhang, Peng Qi, Renzhu Pang, Ziming Wang, Xuyao Liu, Qi Shi, Qiang Zhang

Sci Rep. 2023; 13: 5850. Published online 2023 Apr 10. doi: 10.1038/s41598-023-32733-y

PMCID:: PMC10086052

Abstract Article PDF–11M

Select item 97976023.

Infiltration of LPAR5⁺ macrophages in osteosarcoma tumor microenvironment predicts better outcomes

Yi He, Haiting Zhou, Xiaojian Huang, Yunkun Qu, Yingguang Wang, Wenbin Pei, Rui Zhang, Sheng Chen, Hongbo You

Front Immunol. 2022; 13: 909932. Published online 2022 Dec 15. doi: 10.3389/fimmu.2022.909932

PMCID:: PMC9797602

Abstract Article PDF–43M

Select item 95334964.

LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway

Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai, Ping-Kun Zhou

J Transl Med. 2022; 20: 456. Published online 2022 Oct 5. doi: 10.1186/s12967-022-03673-4

PMCID:: PMC9533496

Abstract Article PDF–9.6M

Select item 80192275.

LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β

Wei‐Jun Zhao, Liu‐Lian Zhu, Wei‐Qiang Yang, Shuai‐Jun Xu, Jie Chen, Xiao‐Fei Ding, Yong Liang, Guang Chen

Cancer Sci. 2021 Apr; 112(4): 1624–1632. Published online 2021 Mar 6. doi: 10.1111/cas.14837

PMCID:: PMC8019227

Abstract Article PDF–1.4M

Select item 78107446.

Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5

Li Lei, Bei Yan, Panpan Liu, Jie Li, Chao Chen, Wu Zhu, Yehong Kuang, Xiang Chen, Cong Peng

Signal Transduct Target Ther. 2021; 6: 19. Published online 2021 Jan 15. doi: 10.1038/s41392-020-00379-1

PMCID:: PMC7810744

Article PDF–1.1M

Select item 69776157.

Lysophosphatidic Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (mTOR) Pathway

Cheng-Yong Wu, Chen Zheng, Er-Jie Xia, Rui-Da Quan, Jing Hu, Xiao-Hua Zhang, Ru-Tian Hao

Med Sci Monit. 2020; 26: e919820-1–e919820-12. Published online 2020 Jan 6. doi: 10.12659/MSM.919820

PMCID:: PMC6977615

Abstract Article PDF–3.6M

Select item 27193668.

Unique Ligand Selectivity of the GPR92/LPA₅ Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

Jesica R. Williams, Anna L. Khandoga, Pankaj Goyal, James I. Fells, Donna H. Perygin, Wolfgang Siess, Abby L. Parrill, Gabor Tigyi, Yuko Fujiwara

J Biol Chem. 2009 Jun 19; 284(25): 17304–17319. Published online 2009 Apr 14. doi: 10.1074/jbc.M109.003194

PMCID:: PMC2719366

Abstract Article PDF–1.4M

Select item 24757059.

Identification of Farnesyl Pyrophosphate and N-Arachidonylglycine as Endogenous Ligands for GPR92

Da Young Oh, Jung Min Yoon, Mi Jin Moon, Jong-Ik Hwang, Han Choe, Ju Yeon Lee, Jae Il Kim, Sunoh Kim, Hyewhon Rhim, David K. O'Dell, J. Michael Walker, Heung Sik Na, Min Goo Lee, Hyuk Bang Kwon, Kyungjin Kim, Jae Young Seong

J Biol Chem. 2008 Jul 25; 283(30): 21054–21064. doi: 10.1074/jbc.M708908200

PMCID:: PMC2475705

Abstract Article PDF–730K

Select item 880690910.

Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling

Ling Xu, Chaoxiang Xu, Xiaoxin Lin, Huiyao Lu, Yinlian Cai

Bioengineered. 2021; 12(1): 8089–8099. Published online 2021 Oct 18. doi: 10.1080/21655979.2021.1983975

PMCID:: PMC8806909

Abstract Article PDF–2.8M

Select item 835007211.

Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5

Mo Wang, Peijian He, Yiran Han, Lei Dong, C. Chris Yun

Cell Mol Gastroenterol Hepatol. 2021; 12(3): 1073–1092. Published online 2021 May 8. doi: 10.1016/j.jcmgh.2021.05.003

PMCID:: PMC8350072

Abstract Article PDF–5.8M

Select item 655841412.

LPA₅ Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling

Divij Mathew, Kimberly N. Kremer, Pamela Strauch, Gabor Tigyi, Roberta Pelanda, Raul M. Torres

Front Immunol. 2019; 10: 1159. Published online 2019 May 28. doi: 10.3389/fimmu.2019.01159

PMCID:: PMC6558414

Abstract Article PDF–2.7M

Select item 306547013.

LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release

Anders Lundequist, Joshua A. Boyce

PLoS One. 2011; 6(3): e18192. Published online 2011 Mar 28. doi: 10.1371/journal.pone.0018192

PMCID:: PMC3065470

Abstract Article PDF–384K

Select item 321392114.

Lysophosphatidic acid 5 receptor induces activation of Na⁺/H⁺ exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells

Byong Kwon Yoo, Peijian He, Sei-Jung Lee, C. Chris Yun

Am J Physiol Cell Physiol. 2011 Nov; 301(5): C1008–C1016. Published online 2011 Aug 10. doi: 10.1152/ajpcell.00231.2011

PMCID:: PMC3213921

Abstract Article

Select item 412805815.

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Yasuyuki Kihara, Michael Maceyka, Sarah Spiegel, Jerold Chun

Br J Pharmacol. 2014 Aug; 171(15): 3575–3594. Published online 2014 Jul 12. doi: 10.1111/bph.12678

PMCID:: PMC4128058

Abstract Article PDF–1.2M

Select item 773761016.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 926261417.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538