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Select item 96714541.

Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption

Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi

PLoS One. 2022; 17(11): e0277307. Published online 2022 Nov 17. doi: 10.1371/journal.pone.0277307

PMCID:: PMC9671454

Abstract Article PDF–2.0M

Select item 41033702.

Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury

Jung-Sub Park, Seo-Jun Kang, Mi-kyoung Seo, Ilo Jou, Hyun Goo Woo, Sang Myun Park

Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27): 9911–9916. Published online 2014 Jun 23. doi: 10.1073/pnas.1402261111

PMCID:: PMC4103370

Abstract Article PDF–1.2M

Select item 40757493.

Cysteinyl leukotriene receptor 1 mediates LTD₄-induced activation of mouse microglial cells in vitro

Shu-ying Yu, Xia-yan Zhang, Xiao-rong Wang, Dong-min Xu, Lu Chen, Li-hui Zhang, San-hua Fang, Yun-bi Lu, Wei-ping Zhang, Er-qing Wei

Acta Pharmacol Sin. 2014 Jan; 35(1): 33–40. Published online 2013 Oct 21. doi: 10.1038/aps.2013.130

PMCID:: PMC4075749

Abstract Article PDF–1.3M

Select item 37040564.

Lung Type 2 innate lymphoid cells express CysLT1R that regulates Th2 cytokine production

Taylor A. Doherty, Naseem Khorram, Sean Lund, Amit Kumar Mehta, Michael Croft, David H. Broide

J Allergy Clin Immunol. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: J Allergy Clin Immunol. 2013 Jul; 132(1): 205–213. Published online 2013 May 17. doi: 10.1016/j.jaci.2013.03.048

PMCID:: PMC3704056

Abstract Article PDF–2.1M

Select item 36175605.

Enhanced Fracture Repair by Leukotriene Antagonism Is Characterized by Increased Chondrocyte Proliferation and Early Bone Formation: A Novel Role of the Cysteinyl LT-1 Receptor

JOHN J. WIXTED, PAUL J. FANNING, TRIPTI GAUR, SHANNON L. O’CONNELL, JASON SILVA, APRIL MASON-SAVAS, DAVID C. AYERS, GARY S. STEIN, JANE B. LIAN

J Cell Physiol. Author manuscript; available in PMC 2013 Apr 5.

Published in final edited form as: J Cell Physiol. 2009 Oct; 221(1): 31–39. doi: 10.1002/jcp.21809

PMCID:: PMC3617560

Abstract Article PDF–3.0M

Select item 88068406.

Montelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2)

Zongwei Li, Jianming Wang, Yumin Ma

Bioengineered. 2021; 12(1): 8476–8484. Published online 2021 Oct 25. doi: 10.1080/21655979.2021.1984003

PMCID:: PMC8806840

Abstract Article PDF–2.0M

Select item 63205077.

Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis

Ernest Duah, Lakshminarayan Reddy Teegala, Vinay Kondeti, Ravi K. Adapala, Venkateshwar G. Keshamouni, Yoshihide Kanaoka, K. Frank Austen, Charles K. Thodeti, Sailaja Paruchuri

Proc Natl Acad Sci U S A. 2019 Jan 2; 116(1): 199–204. Published online 2018 Dec 17. doi: 10.1073/pnas.1817325115

PMCID:: PMC6320507

Abstract Article PDF–1.5M

Select item 58390978.

Leukotriene D₄ and prostaglandin E₂ signals synergize and potentiate vascular inflammation in a mast cell–dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3

Vinay Kondeti, Nosayba Al-Azzam, Ernest Duah, Charles K. Thodeti, Joshua A. Boyce, Sailaja Paruchuri

J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Mar 6.

Published in final edited form as: J Allergy Clin Immunol. 2016 Jan; 137(1): 289–298. Published online 2015 Aug 5. doi: 10.1016/j.jaci.2015.06.030

PMCID:: PMC5839097

Abstract Article PDF–964K

Select item 54710109.

Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer

Janina Osman, Sayeh Savari, Naveen Kumar Chandrashekar, Kishan Bellamkonda, Desiree Douglas, Anita Sjölander

Oncotarget. 2017 May 23; 8(21): 34773–34786. Published online 2017 Mar 30. doi: 10.18632/oncotarget.16718

PMCID:: PMC5471010

Abstract Article PDF–12M

Select item 424494510.

Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma

Daniela Masid-de-Brito, Túlio Queto, Maria Ignez C. Gaspar-Elsas, Pedro Xavier-Elsas

Mediators Inflamm. 2014; 2014: 403970. Published online 2014 Nov 11. doi: 10.1155/2014/403970

PMCID:: PMC4244945

Abstract Article PDF–1.0M

Select item 271063111.

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D₄

Akiko Maekawa, Barbara Balestrieri, K. Frank Austen, Yoshihide Kanaoka

Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28): 11685–11690. Published online 2009 Jun 26. doi: 10.1073/pnas.0905364106

PMCID:: PMC2710631

Abstract Article PDF–1.9M

Select item 3012512.

Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing

Akiko Maekawa, Yoshihide Kanaoka, Bing K. Lam, K. Frank Austen

Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5): 2256–2261. Published online 2001 Feb 13. doi: 10.1073/pnas.041624398

PMCID:: PMC30125

Abstract Article PDF–321K

Select item 556181813.

Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice

Wen-Zhen Shi, Chun-Zhen Zhao, Bing Zhao, Qiao-Juan Shi, Li-Hui Zhang, Yan-Fang Wang, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing Wei

Neurosci Bull. 2012 Dec; 28(6): 680–692. Published online 2012 Nov 6. doi: 10.1007/s12264-012-1281-z

PMCID:: PMC5561818

Abstract Article PDF–956K

Select item 553160114.

Leukotriene C4 potentiates IL-33 induced ILC2 activation and lung inflammation

Sean J. Lund, Alex Portillo, Kellen Cavagnero, Rachel E. Baum, Luay H. Naji, Jana H. Badrani, Amit Mehta, Michael Croft, David H. Broide, Taylor A. Doherty

J Immunol. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: J Immunol. 2017 Aug 1; 199(3): 1096–1104. Published online 2017 Jun 30. doi: 10.4049/jimmunol.1601569

PMCID:: PMC5531601

Abstract Article PDF–1.1M

Select item 363086615.

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E₄ Ligand

Yoshihide Kanaoka, Akiko Maekawa, K. Frank Austen

J Biol Chem. 2013 Apr 19; 288(16): 10967–10972. Published online 2013 Mar 15. doi: 10.1074/jbc.C113.453704

PMCID:: PMC3630866

Abstract Article PDF–778K

Select item 305858716.

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes

Nora A. Barrett, Opu M. Rahman, James M. Fernandez, Matthew W. Parsons, Wei Xing, K. Frank Austen, Yoshihide Kanaoka

J Exp Med. 2011 Mar 14; 208(3): 593–604. doi: 10.1084/jem.20100793

PMCID:: PMC3058587

Abstract Article PDF–1.6M

Select item 261539517.

P2Y6 Receptors Require an Intact Cysteinyl Leukotriene Synthetic and Signaling System to Induce Survival and Activation of Mast Cells¹

Yongfeng Jiang, Laura Borrelli, Brian J. Bacskai, Yoshihide Kanaoka, Joshua A. Boyce

J Immunol. Author manuscript; available in PMC 2010 Jan 15.

Published in final edited form as: J Immunol. 2009 Jan 15; 182(2): 1129–1137. doi: 10.4049/jimmunol.182.2.1129

PMCID:: PMC2615395

Abstract Article PDF–1.2M

Select item 257548218.

Functional recognition of a distinct receptor preferential for leukotriene E₄ in mice lacking the cysteinyl leukotriene 1 and 2 receptors

Akiko Maekawa, Yoshihide Kanaoka, Wei Xing, K. Frank Austen

Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43): 16695–16700. Published online 2008 Oct 17. doi: 10.1073/pnas.0808993105

PMCID:: PMC2575482

Abstract Article PDF–1.1M

Select item 36574219.

Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis

Thomas C. Beller, Daniel S. Friend, Akiko Maekawa, Bing K. Lam, K. Frank Austen, Yoshihide Kanaoka

Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9): 3047–3052. Published online 2004 Feb 17. doi: 10.1073/pnas.0400235101

PMCID:: PMC365742

Abstract Article PDF–642K

Select item 933897020.

RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R

Jana H. Badrani, Allyssa N. Strohm, Lee Lacasa, Blake Civello, Kellen Cavagnero, Yung-An Haung, Michael Amadeo, Luay H. Naji, Sean J. Lund, Anthea Leng, Hyojoung Kim, Rachel E. Baum, Naseem Khorram, Monalisa Mondal, Grégory Seumois, Julie Pilotte, Peter W. Vanderklish, Heather M. McGee, Taylor A. Doherty

Nat Commun. 2022; 13: 4435. Published online 2022 Jul 30. doi: 10.1038/s41467-022-32176-5