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Select item 109320211.

The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages

Sayonara Ivana Santos de Assis, Leonardo Szalo Amendola, Maristela Mitiko Okamoto, Guilherme da Silva Ferreira, Rodrigo Tallada Iborra, Danielle Ribeiro Santos, Monique de Fátima Mello Santana, Kelly Gomes Santana, Maria Lucia Correa-Giannella, Denise Frediani Barbeiro, Francisco Garcia Soriano, Ubiratan Fabres Machado, Marisa Passarelli

Int J Mol Sci. 2024 Mar; 25(5): 2713. Published online 2024 Feb 27. doi: 10.3390/ijms25052713

PMCID:: PMC10932021

Article PDF–2.4M

Select item 102424112.

Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity

Kunihiko Moriya, Tomohiro Nakano, Yoshitaka Honda, Miyuki Tsumura, Masato Ogishi, Motoshi Sonoda, Masahiko Nishitani-Isa, Takashi Uchida, Mohamed Hbibi, Yoko Mizoguchi, Masataka Ishimura, Kazushi Izawa, Takaki Asano, Fumihiko Kakuta, Daiki Abukawa, Darawan Rinchai, Peng Zhang, Naotomo Kambe, Aziz Bousfiha, Takahiro Yasumi, Bertrand Boisson, Anne Puel, Jean-Laurent Casanova, Ryuta Nishikomori, Shouichi Ohga, Satoshi Okada, Yoji Sasahara, Shigeo Kure

J Exp Med. 2023 Sep 4; 220(9): e20212276. Published online 2023 Jun 5. doi: 10.1084/jem.20212276

PMCID:: PMC10242411

Article PDF–6.4M

Select item 101737823.

Epstein–Barr virus envelope glycoprotein 110 inhibits NF-κB activation by interacting with NF-κB subunit p65

Mingsheng Cai, Bin Xiao, Yuanfang Wang, Kezhen Wang, Wenqi Luo, Jiangqin Fu, Shuai Wang, Shenyu Deng, Bolin Li, Lan Gong, Jiayi Zhong, Li Hu, Lingxia Pan, Liding Wang, Yintao Liu, Chen Huang, Xiaoqing Li, Qiyuan Zeng, Haoran Kang, Linhai Li, Jie Zan, Tao Peng, Haidi Yang, Meili Li

J Biol Chem. 2023 May; 299(5): 104613. Published online 2023 Mar 16. doi: 10.1016/j.jbc.2023.104613

PMCID:: PMC10173782

Article PDF–4.2M

Select item 100114804.

Case report: Novel variants in RELA associated with familial Behcet’s-like disease

Jason W. An, Pallavi Pimpale-Chavan, Deborah L. Stone, Marcia Bandeira, Fatma Dedeoglu, Jeffrey Lo, John Bohnsack, Sofia Rosenzweig, Oskar Schnappauf, Dilan Dissanayake, Linda T. Hiraki, Daniel L. Kastner, Christina Pelajo, Ronald M. Laxer, Ivona Aksentijevich

Front Immunol. 2023; 14: 1127085. Published online 2023 Feb 28. doi: 10.3389/fimmu.2023.1127085

PMCID:: PMC10011480

Article PDF–2.6M

Select item 99989655.

RELA tunes innate-like interferon I/III responses in human T cells

Nadia Jeremiah, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas Manel

J Exp Med. 2023 May 1; 220(5): e20220666. Published online 2023 Feb 23. doi: 10.1084/jem.20220666

PMCID:: PMC9998965

Article PDF–7.2M

Select item 80381096.

Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

Rocío Mato-Basalo, Miriam Morente-López, Onno J Arntz, Fons A. J. van de Loo, Juan Fafián-Labora, María C. Arufe

Int J Mol Sci. 2021 Apr; 22(7): 3367. Published online 2021 Mar 25. doi: 10.3390/ijms22073367

PMCID:: PMC8038109

Article PDF–10M

Select item 73795877.

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging

Mélanie Pagès, Kristian W. Pajtler, Stéphanie Puget, David Castel, Nathalie Boddaert, Arnault Tauziède‐Espariat, Stéphanie Picot, Marie‐Anne Debily, Marcel Kool, David Capper, Christian Sainte‐Rose, Fabrice Chrétien, Stefan M. Pfister, Torsten Pietsch, Jacques Grill, Pascale Varlet, Felipe Andreiuolo

Brain Pathol. 2019 May; 29(3): 325–335. Published online 2018 Nov 28. doi: 10.1111/bpa.12664

PMCID:: PMC7379587

Article PDF–588K

Select item 72600718.

The overexpression of long intergenic ncRNA00162 induced by RelA/p65 promotes growth of pancreatic ductal adenocarcinoma

Yu Lu, Min Wu, Jie Fu, Yichen Sun, Kenei Furukawa, Jianhua Ling, Xue Qin, Paul J. Chiao

Cell Prolif. 2020 May; 53(5): e12805. Published online 2020 May 4. doi: 10.1111/cpr.12805

PMCID:: PMC7260071

Article PDF–1.7M

Select item 72579119.

Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis

Jun Zhao, Mao Tian, Shu Zhang, Alireza Delfarah, Ruoyun Gao, Youliang Rao, Ali Can Savas, Anjie Lu, Larissa Bubb, Xiao Lei, Rosa Moshirian, Wenjie Zhu, Cheng Peng, Taijiao Jiang, Lin Chen, Nicholas A. Graham, Pinghui Feng

Cell Metab. Author manuscript; available in PMC 2020 May 29.

Published in final edited form as: Cell Metab. 2020 May 5; 31(5): 937–955.e7. Published online 2020 Apr 22. doi: 10.1016/j.cmet.2020.04.006

PMCID:: PMC7257911

Article PDF–2.6M

Select item 700027210.

RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model

Shayna E. Thomas-Jardin, Haley Dahl, Mohammed S. Kanchwala, Freedom Ha, Joan Jacob, Reshma Soundharrajan, Monica Bautista, Afshan F. Nawas, Dexter Robichaux, Ragini Mistry, Vanessa Anunobi, Chao Xing, Nikki A. Delk

Prostate. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Prostate. 2020 Feb; 80(2): 133–145. Published online 2019 Nov 15. doi: 10.1002/pros.23925

PMCID:: PMC7000272

Article PDF–3.4M

Select item 688647711.

Optical pooled screens in human cells

David Feldman, Avtar Singh, Jonathan L. Schmid-Burgk, Rebecca J. Carlson, Anja Mezger, Anthony J. Garrity, Feng Zhang, Paul C. Blainey

Cell. Author manuscript; available in PMC 2020 Oct 17.

Published in final edited form as: Cell. 2019 Oct 17; 179(3): 787–799.e17. doi: 10.1016/j.cell.2019.09.016

PMCID:: PMC6886477

Article PDF–2.6M

Select item 674984512.

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert

Front Immunol. 2019; 10: 2168. Published online 2019 Sep 11. doi: 10.3389/fimmu.2019.02168

PMCID:: PMC6749845

Article PDF–1.3M

Select item 669603913.

Methylation of the RELA Gene is Associated with Expression of NF-κB1 in Response to TNF-α in Breast Cancer

Young Ju Jeong, Hoon Kyu Oh, Hye Ryeon Choi

Molecules. 2019 Aug; 24(15): 2834. Published online 2019 Aug 4. doi: 10.3390/molecules24152834

PMCID:: PMC6696039

Article PDF–740K

Select item 666861114.

Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues

Fatima Qaiser, Janeen H. Trembley, Sarah Sadiq, Iqbal Muhammad, Rubina Younis, Shoaib Naiyar Hashmi, Badar Murtaza, Thomas S. Rector, Abdul Khaliq Naveed, Khalil Ahmed

Mol Cell Biochem. Author manuscript; available in PMC 2019 Jul 31.

Published in final edited form as: Mol Cell Biochem. 2016 Sep; 420(1-2): 43–51. Published online 2016 Jul 19. doi: 10.1007/s11010-016-2765-3

PMCID:: PMC6668611

Article PDF–1.1M

Select item 660564015.

Validation of the prognostic value of NF-κB p65 in prostate cancer: A retrospective study using a large multi-institutional cohort of the Canadian Prostate Cancer Biomarker Network

Andrée-Anne Grosset, Véronique Ouellet, Christine Caron, Gabriela Fragoso, Véronique Barrès, Nathalie Delvoye, Mathieu Latour, Armen Aprikian, Alain Bergeron, Simone Chevalier, Ladan Fazli, Neil Fleshner, Martin Gleave, Pierre Karakiewicz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Dominique Trudel, Anne-Marie Mes-Masson, Fred Saad, for the Canadian Prostate Cancer Biomarker Network

PLoS Med. 2019 Jul; 16(7): e1002847. Published online 2019 Jul 2. doi: 10.1371/journal.pmed.1002847

PMCID:: PMC6605640

Article PDF–1.6M

Select item 653349816.

NF‐κB p65 promotes ovarian cancer cell proliferation and migration via regulating mortalin

Shan Li, Mengyuan Lv, Shi Qiu, Jiaqi Meng, Wen Liu, Ji Zuo, Ling Yang

J Cell Mol Med. 2019 Jun; 23(6): 4338–4348. Published online 2019 Apr 14. doi: 10.1111/jcmm.14325

PMCID:: PMC6533498

Article PDF–1.4M

Select item 638295817.

Fold-Change Detection of NF-κB at Target Genes with Different Transcript Outputs

Victor C. Wong, Shibin Mathew, Ramesh Ramji, Suzanne Gaudet, Kathryn Miller-Jensen

Biophys J. 2019 Feb 19; 116(4): 709–724. Published online 2019 Jan 12. doi: 10.1016/j.bpj.2019.01.011

PMCID:: PMC6382958

Article PDF–2.6M

Select item 635321118.

Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation

Andrea Callegari, Christian Sieben, Alexander Benke, David M. Suter, Beat Fierz, Davide Mazza, Suliana Manley

PLoS Genet. 2019 Jan; 15(1): e1007891. Published online 2019 Jan 17. doi: 10.1371/journal.pgen.1007891

PMCID:: PMC6353211

Article PDF–2.5M

Select item 620847919.

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

Ping Wang, Zunpeng Liu, Xiaoqian Zhang, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi Song, Jing Qu

Protein Cell. 2018 Nov; 9(11): 945–965. Published online 2018 Jul 2. doi: 10.1007/s13238-018-0560-5

PMCID:: PMC6208479

Article PDF–5.4M

Select item 620766120.

NF-κB p65 directs sex-specific neuroprotection in human neurons

Lucia M. Ruiz-Perera, Lennart Schneider, Beatrice A. Windmöller, Janine Müller, Johannes F. W. Greiner, Christian Kaltschmidt, Barbara Kaltschmidt

Sci Rep. 2018; 8: 16012. Published online 2018 Oct 30. doi: 10.1038/s41598-018-34394-8

PMCID:: PMC6207661

Article PDF–4.7M

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