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Select item 50611011.

The Toxoplasma gondii rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7

Thomas Hermanns, Urs B. Müller, Stephanie Könen‐Waisman, Jonathan C. Howard, Tobias Steinfeldt

Cell Microbiol. 2016 Feb; 18(2): 244–259. Published online 2015 Oct 30. doi: 10.1111/cmi.12499

PMCID:: PMC5061101

Article PDF–1.4M

Select item 47740192.

Kathrin Schulte, Nikolaus Pawlowski, Katja Faelber, Chris Fröhlich, Jonathan Howard, Oliver Daumke

BMC Biol. 2016; 14: 14. Published online 2016 Mar 2. doi: 10.1186/s12915-016-0236-7

PMCID:: PMC4774019

Article PDF–1.7M

Select item 41838193.

The Toxoplasma Pseudokinase ROP5 Is an Allosteric Inhibitor of the Immunity-related GTPases

Michael L. Reese, Niket Shah, John C. Boothroyd

J Biol Chem. 2014 Oct 3; 289(40): 27849–27858. Published online 2014 Aug 12. doi: 10.1074/jbc.M114.567057

PMCID:: PMC4183819

Article PDF–3.9M

Select item 33936714.

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

Martin C. Fleckenstein, Michael L. Reese, Stephanie Könen-Waisman, John C. Boothroyd, Jonathan C. Howard, Tobias Steinfeldt

PLoS Biol. 2012 Jul; 10(7): e1001358. Published online 2012 Jul 10. doi: 10.1371/journal.pbio.1001358

PMCID:: PMC3393671

Article PDF–2.1M

Select item 31177895.

The IFN-γ-Inducible GTPase, Irga6, Protects Mice against Toxoplasma gondii but Not against Plasmodium berghei and Some Other Intracellular Pathogens

Oliver Liesenfeld, Iana Parvanova, Jens Zerrahn, Seong-Ji Han, Frederik Heinrich, Melba Muñoz, Frank Kaiser, Toni Aebischer, Thorsten Buch, Ari Waisman, Gaby Reichmann, Olaf Utermöhlen, Esther von Stebut, Friederike D. von Loewenich, Christian Bogdan, Sabine Specht, Michael Saeftel, Achim Hoerauf, Maria M. Mota, Stephanie Könen-Waisman, Stefan H. E. Kaufmann, Jonathan C. Howard

PLoS One. 2011; 6(6): e20568. Published online 2011 Jun 17. doi: 10.1371/journal.pone.0020568

PMCID:: PMC3117789

Article PDF–501K

Select item 30429886.

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii

Nikolaus Pawlowski, Aliaksandr Khaminets, Julia P Hunn, Natasa Papic, Andreas Schmidt, Revathy C Uthaiah, Rita Lange, Gabriela Vopper, Sascha Martens, Eva Wolf, Jonathan C Howard

BMC Biol. 2011; 9: 7. Published online 2011 Jan 28. doi: 10.1186/1741-7007-9-7

PMCID:: PMC3042988

Article PDF–3.4M

Select item 30063847.

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

Tobias Steinfeldt, Stephanie Könen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L. David Sibley, Julia P. Hunn, Jonathan C. Howard

PLoS Biol. 2010 Dec; 8(12): e1000576. Published online 2010 Dec 21. doi: 10.1371/journal.pbio.1000576

Correction in:: PLoS Biol. 2015 Jul; 13(7): e1002199.

PMCID:: PMC3006384

Article PDF–955K

Select item 28488668.

A Dedicated Promoter Drives Constitutive Expression of the Cell-Autonomous Immune Resistance GTPase, Irga6 (IIGP1) in Mouse Liver

Jia Zeng, Iana Angelova Parvanova, Jonathan C. Howard

PLoS One. 2009; 4(8): e6787. Published online 2009 Aug 26. doi: 10.1371/journal.pone.0006787

PMCID:: PMC2848866

Article PDF–781K

Select item 26438469.

IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via Autophagy

Munir A. Al-Zeer, Hesham M. Al-Younes, Peter R. Braun, Jens Zerrahn, Thomas F. Meyer

PLoS One. 2009; 4(2): e4588. Published online 2009 Feb 26. doi: 10.1371/journal.pone.0004588

PMCID:: PMC2643846

Article PDF–2.1M

Select item 258159010.

Inactive and Active States of the Interferon-inducible Resistance GTPase, Irga6, in Vivo

Natasa Papic, Julia P. Hunn, Nikolaus Pawlowski, Jens Zerrahn, Jonathan C. Howard

J Biol Chem. 2008 Nov 14; 283(46): 32143–32151. doi: 10.1074/jbc.M804846200

PMCID:: PMC2581590

Article PDF–1.3M

Select item 756561911.

Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication

Bin Tian, Yueming Yuan, Yu Yang, Zhaochen Luo, Baokun Sui, Ming Zhou, Zhen F. Fu, Ling Zhao

J Virol. 2020 Nov; 94(21): e01203-20. Prepublished online 2020 Aug 12. Published online 2020 Oct 14. doi: 10.1128/JVI.01203-20

PMCID:: PMC7565619

Article PDF–3.6M

Select item 128790712.

Disruption of Toxoplasma gondii Parasitophorous Vacuoles by the Mouse p47-Resistance GTPases

Sascha Martens, Iana Parvanova, Jens Zerrahn, Gareth Griffiths, Gudrun Schell, Gaby Reichmann, Jonathan C Howard

PLoS Pathog. 2005 Nov; 1(3): e24. Published online 2005 Nov 18. doi: 10.1371/journal.ppat.0010024

PMCID:: PMC1287907

Article PDF–942K

Select item 421479913.

Identification of the Microsporidian Encephalitozoon cuniculi as a New Target of the IFNγ-Inducible IRG Resistance System

Marialice da Fonseca Ferreira-da-Silva, Helen Maria Springer-Frauenhoff, Wolfgang Bohne, Jonathan C. Howard

PLoS Pathog. 2014 Oct; 10(10): e1004449. Published online 2014 Oct 30. doi: 10.1371/journal.ppat.1004449

Correction in:: PLoS Pathog. 2014 Dec; 10(12): e1004590.

PMCID:: PMC4214799

Article PDF–2.0M

Select item 253278514.

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

Julia P Hunn, Stephanie Koenen-Waisman, Natasa Papic, Nina Schroeder, Nikolaus Pawlowski, Rita Lange, Frank Kaiser, Jens Zerrahn, Sascha Martens, Jonathan C Howard

EMBO J. 2008 Oct 8; 27(19): 2495–2509. Published online 2008 Sep 4. doi: 10.1038/emboj.2008.176

PMCID:: PMC2532785

Article PDF–1.6M

Select item 316240715.

Maria K. Traver, Stanley C. Henry, Viviana Cantillana, Tim Oliver, Julia P. Hunn, Jonathan C. Howard, Sandra Beer, Klaus Pfeffer, Jörn Coers, Gregory A. Taylor

J Biol Chem. 2011 Sep 2; 286(35): 30471–30480. Published online 2011 Jul 12. doi: 10.1074/jbc.M111.251967

Correction in:: J Biol Chem. 2013 Apr 19; 288(16): 11504.

PMCID:: PMC3162407

Article PDF–3.5M

Select item 320699316.

Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning

Henrik Fagman, Elena Amendola, Luca Parrillo, Pietro Zoppoli, Pina Marotta, Marzia Scarfò, Pasquale De Luca, Denise Pires de Carvalho, Michele Ceccarelli, Mario De Felice, Roberto Di Lauro

Dev Biol. 2011 Nov 15; 359(2): 163–175. doi: 10.1016/j.ydbio.2011.08.015

PMCID:: PMC3206993

Article

Select item 173522817.

Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays

W Lemon, H Bernert, H Sun, Y Wang, M You

J Med Genet. 2002 Sep; 39(9): 644–655. doi: 10.1136/jmg.39.9.644

PMCID:: PMC1735228

Summary PDF–257K

Select item 9908318.

The human (PEDB) and mouse (mPEDB) Prostate Expression Databases

Peter S. Nelson, Colin Pritchard, Denise Abbott, Nigel Clegg

Nucleic Acids Res. 2002 Jan 1; 30(1): 218–220. doi: 10.1093/nar/30.1.218

PMCID:: PMC99083

Article PDF–152K

Select item 347860619.

Impact of lactobacilli on orally acquired listeriosis

Cristel Archambaud, Marie-Anne Nahori, Guillaume Soubigou, Christophe Bécavin, Laure Laval, Pierre Lechat, Tamara Smokvina, Philippe Langella, Marc Lecuit, Pascale Cossart

Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41): 16684–16689. Published online 2012 Sep 24. doi: 10.1073/pnas.1212809109

PMCID:: PMC3478606

Article PDF–772K

Select item 901455920.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Article PDF–6.6M

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