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Select item 101543891.

N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2

Haibo Xia, Yan Wu, Jing Zhao, Cheng Cheng, Jiaheng Lin, Yi Yang, Lu Lu, Quanyong Xiang, Tao Bian, Qizhan Liu

Cell Death Differ. 2023 May; 30(5): 1293–1304. Published online 2023 Feb 24. doi: 10.1038/s41418-023-01138-9

PMCID:: PMC10154389

Abstract Article PDF–8.0M

Select item 49940412.

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

Eunjeong Seo, Wan-Young Kim, Jeongmi Hur, Hanbyul Kim, Sun Ah Nam, Arum Choi, Yu-Mi Kim, Sang Hee Park, Chaeuk Chung, Jin Kim, Soohong Min, Seung-Jae Myung, Dae-Sik Lim, Yong Kyun Kim

Sci Rep. 2016; 6: 31931. Published online 2016 Aug 23. doi: 10.1038/srep31931

PMCID:: PMC4994041

Abstract Article PDF–2.5M

Select item 54527233.

Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis

Janet Y. Leung, Harper L. Wilson, Kristin J. Voltzke, Lindsay A. Williams, Hyo Jin Lee, Sara E. Wobker, William Y. Kim

Mol Cell Biol. 2017 Jun 15; 37(12): e00565-16. Prepublished online 2017 Mar 20. Published online 2017 May 31. doi: 10.1128/MCB.00565-16

PMCID:: PMC5452723

Abstract Article PDF–8.1M

Select item 29647484.

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

Jing Cai, Nailing Zhang, Yonggang Zheng, Roeland F. de Wilde, Anirban Maitra, Duojia Pan

Genes Dev. 2010 Nov 1; 24(21): 2383–2388. doi: 10.1101/gad.1978810

PMCID:: PMC2964748

Abstract Article PDF–1.3M

Select item 28895585.

The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

Kwang-Pyo Lee, Joo-Hyeon Lee, Tae-Shin Kim, Tack-Hoon Kim, Hee-Dong Park, Jin-Seok Byun, Min-Chul Kim, Won-Il Jeong, Diego F. Calvisi, Jin-Man Kim, Dae-Sik Lim

Proc Natl Acad Sci U S A. 2010 May 4; 107(18): 8248–8253. Published online 2010 Apr 19. doi: 10.1073/pnas.0912203107

PMCID:: PMC2889558

Abstract Article PDF–1005K

Select item 95324386.

Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

Letizia De Chiara, Carolina Conte, Roberto Semeraro, Paula Diaz-Bulnes, Maria Lucia Angelotti, Benedetta Mazzinghi, Alice Molli, Giulia Antonelli, Samuela Landini, Maria Elena Melica, Anna Julie Peired, Laura Maggi, Marta Donati, Gilda La Regina, Marco Allinovi, Fiammetta Ravaglia, Daniele Guasti, Daniele Bani, Luigi Cirillo, Francesca Becherucci, Francesco Guzzi, Alberto Magi, Francesco Annunziato, Laura Lasagni, Hans-Joachim Anders, Elena Lazzeri, Paola Romagnani

Nat Commun. 2022; 13: 5805. Published online 2022 Oct 4. doi: 10.1038/s41467-022-33110-5

PMCID:: PMC9532438

Abstract Article PDF–5.5M

Select item 66456887.

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte De-Differentiation During Pressure Overload

Shohei Ikeda, Wataru Mizushima, Sebastiano Sciarretta, Maha Abdellatif, Peiyong Zhai, Risa Mukai, Nadezhda Fefelova, Shin-ichi Oka, Michinari Nakamura, Dominic P. Del Re, Iain Farrance, Ji Yeon Park, Bin Tian, Lai-Hua Xie, Mohit Kumar, Chiao-Po Hsu, Sakthivel Sadayappan, Hiroaki Shimokawa, Dae-Sik Lim, Junichi Sadoshima

Circ Res. Author manuscript; available in PMC 2020 Jan 18.

Published in final edited form as: Circ Res. 2019 Jan 18; 124(2): 292–305. doi: 10.1161/CIRCRESAHA.118.314048

PMCID:: PMC6645688

Abstract Article PDF–1.9M

Select item 64475408.

MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu

Nat Commun. 2019; 10: 1515. Published online 2019 Apr 3. doi: 10.1038/s41467-019-09233-7

PMCID:: PMC6447540

Abstract Article PDF–1.8M

Select item 48733659.

Analysis of liver tumor-prone mouse models of the Hippo kinase scaffold proteins RASSF1A and SAV1

Xiaoying Zhang, Cai Guo, Xiwei Wu, Arthur X. Li, Limin Liu, Walter Tsark, Reinhard Dammann, Hui Shen, Steven L. Vonderfecht, Gerd P. Pfeifer

Cancer Res. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Cancer Res. 2016 May 1; 76(9): 2824–2835. Published online 2016 Mar 15. doi: 10.1158/0008-5472.CAN-15-3010

PMCID:: PMC4873365

Abstract Article PDF–1.4M

Select item 621742510.

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

Takahiro Kodama, Jing Yi, Justin Y. Newberg, Jean C. Tien, Hao Wu, Milton J. Finegold, Michiko Kodama, Zhubo Wei, Takeshi Tamura, Tetsuo Takehara, Randy L. Johnson, Nancy A. Jenkins, Neal G. Copeland

Proc Natl Acad Sci U S A. 2018 Oct 30; 115(44): E10417–E10426. Published online 2018 Oct 16. doi: 10.1073/pnas.1808968115

PMCID:: PMC6217425

Abstract Article PDF–2.1M

Select item 448918211.

Mouse Hepatic Tumor Vascular Imaging by Experimental Selective Angiography

Sang Kyum Kim, Honsoul Kim, Gou Young Koh, Dae-Sik Lim, Dae-Yeul Yu, Man Deuk Kim, Mi-Suk Park, Joon Seok Lim

PLoS One. 2015; 10(7): e0131687. Published online 2015 Jul 1. doi: 10.1371/journal.pone.0131687

PMCID:: PMC4489182

Abstract Article PDF–3.1M

Select item 444212812.

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

Yuka Morikawa, Min Zhang, Todd Heallen, John Leach, Ge Tao, Yang Xiao, Yan Bai, Wei Li, James T. Willerson, James F. Martin

Sci Signal. Author manuscript; available in PMC 2015 May 25.

Published in final edited form as: Sci Signal. 2015; 8(375): ra41. Published online 2015 May 5. doi: 10.1126/scisignal.2005781

PMCID:: PMC4442128

Abstract Article PDF–2.2M

Select item 893050313.

YAP/TAZ drives cell proliferation and tumor growth via a polyamine-eIF5A hypusination-LSD1 axis

Hongde Li, Bo-Kuan Wu, Mohammed Kanchwala, Jing Cai, Li Wang, Chao Xing, Yonggang Zheng, Duojia Pan

Nat Cell Biol. Author manuscript; available in PMC 2022 Aug 17.

Published in final edited form as: Nat Cell Biol. 2022 Mar; 24(3): 373–383. Published online 2022 Feb 17. doi: 10.1038/s41556-022-00848-5

PMCID:: PMC8930503

Abstract Article PDF–6.6M

Select item 572974314.

Hippo Pathway Deficiency Reverses Systolic Heart Failure Post-Infarction

John P. Leach, Todd Heallen, Min Zhang, Mahdis Rahmani, Yuka Morikawa, Matthew C. Hill, Ana Segura, James T. Willerson, James F. Martin

Nature. Author manuscript; available in PMC 2018 Apr 4.

Published in final edited form as: Nature. 2017 Oct 12; 550(7675): 260–264. Published online 2017 Oct 4. doi: 10.1038/nature24045

PMCID:: PMC5729743

Abstract Article PDF–2.1M

Select item 552885315.

Dystrophin Glycoprotein Complex Sequesters Yap to Inhibit Cardiomyocyte Proliferation

Yuka Morikawa, Todd Heallen, John Leach, Yang Xiao, James F. Martin

Nature. Author manuscript; available in PMC 2017 Dec 5.

Published in final edited form as: Nature. 2017 Jul 13; 547(7662): 227–231. Published online 2017 Jun 5. doi: 10.1038/nature22979

PMCID:: PMC5528853

Abstract Article PDF–4.3M

Select item 499925116.

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury

Ge Tao, Peter C. Kahr, Yuka Morikawa, Min Zhang, Mahdis Rahmani, Todd R. Heallen, Lele Li, Zhao Sun, Eric N. Olson, Brad A. Amendt, James F. Martin

Nature. Author manuscript; available in PMC 2016 Dec 2.

Published in final edited form as: Nature. 2016 Jun 2; 534(7605): 119–123. Published online 2016 May 25. doi: 10.1038/nature17959

PMCID:: PMC4999251

Abstract Article PDF–2.6M

Select item 604951417.

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

Jing Cai, Xuewen Song, Wei Wang, Terry Watnick, York Pei, Feng Qian, Duojia Pan

Genes Dev. 2018 Jun 1; 32(11-12): 781–793. doi: 10.1101/gad.315127.118

PMCID:: PMC6049514

Abstract Article PDF–7.8M

Select item 582486118.

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer

Sun-Hye Jeong, Han-Byul Kim, Min-Chul Kim, Ji-min Lee, Jae Ho Lee, Jeong-Hwan Kim, Jin-Woo Kim, Woong-Yang Park, Seon-Young Kim, Jae Bum Kim, Haeryoung Kim, Jin-Man Kim, Hueng-Sik Choi, Dae-Sik Lim

J Clin Invest. 2018 Mar 1; 128(3): 1010–1025. Published online 2018 Feb 5. doi: 10.1172/JCI95802

PMCID:: PMC5824861

Abstract Article PDF–34M

Select item 452673419.

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

Jing Cai, Anirban Maitra, Robert A. Anders, Makoto M. Taketo, Duojia Pan

Genes Dev. 2015 Jul 15; 29(14): 1493–1506. doi: 10.1101/gad.264515.115

PMCID:: PMC4526734

Abstract Article PDF–706K

Select item 383342820.

Hippo signaling impedes adult heart regeneration

Todd Heallen, Yuka Morikawa, John Leach, Ge Tao, James T. Willerson, Randy L. Johnson, James F. Martin

Development. 2013 Dec 1; 140(23): 4683–4690. doi: 10.1242/dev.102798

PMCID:: PMC3833428

Abstract Article

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