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Select item 79653581.

Differential activity and expression of human 5β-reductase (AKR1D1) splice variants

Nathan Appanna, Hylton Gibson, Elena Gangitano, Niall J Dempster, Karen Morris, Sherly George, Anastasia Arvaniti, Laura L Gathercole, Brian Keevil, Trevor M Penning, Karl-Heinz Storbeck, Jeremy W Tomlinson, Nikolaos Nikolaou

J Mol Endocrinol. 2021 Mar; 66(3): 181–194. Published online 2021 Jan 12. doi: 10.1530/JME-20-0160

PMCID:: PMC7965358

Abstract Article PDF–3.3M

Select item 73899312.

先天性胆汁酸合成障碍2型一家系临床和遗传学分析:两个AKR1D1新突变的识别

程映, 郭丽, 邓梅, 宋元宗

Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jul 25; 19(7): 734–740. Chinese. doi: 10.7499/j.issn.1008-8830.2017.07.002

PMCID:: PMC7389931

Abstract Article PDF–2.8M

Select item 67443723.

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Nikolaos Nikolaou, Laura L. Gathercole, Lea Marchand, Sara Althari, Niall J. Dempster, Charlotte J. Green, Martijn van de Bunt, Catriona McNeil, Anastasia Arvaniti, Beverly A. Hughes, Bruno Sgromo, Richard S. Gillies, Hanns-Ulrich Marschall, Trevor M. Penning, John Ryan, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson

Metabolism. 2019 Oct; 99: 67–80. doi: 10.1016/j.metabol.2019.153947

PMCID:: PMC6744372

Abstract Article

Select item 58913894.

Dysregulation of Δ⁴-3-oxosteroid 5β-reductase in Diabetic Patients: Implications and Mechanisms

Leila Valanejad, Mwlod Ghareeb, Stephanie Shiffka, Christina Nadolny, Yuan Chen, Liangran Guo, Ruchi Verma, Sangmin You, Fatemeh Akhlaghi, Ruitang Deng

Mol Cell Endocrinol. Author manuscript; available in PMC 2019 Jul 15.

Published in final edited form as: Mol Cell Endocrinol. 2018 Jul 15; 470: 127–141. Published online 2017 Oct 9. doi: 10.1016/j.mce.2017.10.005

PMCID:: PMC5891389

Abstract Article PDF–923K

Select item 46967695.

In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency

Mo Chen, Yi Jin, Trevor M. Penning

Biochemistry. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Biochemistry. 2015 Oct 20; 54(41): 6343–6351. Published online 2015 Oct 6. doi: 10.1021/acs.biochem.5b00816

PMCID:: PMC4696769

Abstract Article PDF–986K

Select item 44146916.

The Rate-determining Steps of Aldo-keto Reductases (AKRs), a Study on Human Steroid 5β-Reductase (AKR1D1)

Mo Chen, Yi Jin, Trevor M. Penning

Chem Biol Interact. Author manuscript; available in PMC 2016 Jun 5.

Published in final edited form as: Chem Biol Interact. 2015 Jun 5; 234: 360–365. Published online 2014 Dec 11. doi: 10.1016/j.cbi.2014.12.004

PMCID:: PMC4414691

Abstract Article PDF–910K

Select item 41638387.

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Yi Jin, Mo Chen, Trevor M. Penning

Biochem J. Author manuscript; available in PMC 2015 Aug 15.

Published in final edited form as: Biochem J. 2014 Aug 15; 462(1): 163–171. doi: 10.1042/BJ20140220

PMCID:: PMC4163838

Abstract Article PDF–961K

Select item 41620058.

Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s

Amarjit S. Chaudhry, Ranjit K. Thirumaran, Kazuto Yasuda, Xia Yang, Yiping Fan, Stephen C. Strom, Erin G. Schuetz

Drug Metab Dispos. 2013 Aug; 41(8): 1538–1547. Published online 2013 Aug. doi: 10.1124/dmd.113.051672

Correction in:: Drug Metab Dispos. 2014 May; 42(5): 917.

PMCID:: PMC4162005

Abstract Article PDF–906K

Select item 39714739.

5β-Reduced Steroids and Human Δ⁴-3-Ketosteroid 5β-Reductase (AKR1D1)

Mo Chen, Trevor M. Penning

Steroids. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Steroids. 2014 May; 83: 17–26. Published online 2014 Feb 8. doi: 10.1016/j.steroids.2014.01.013

PMCID:: PMC3971473

Abstract Article PDF–2.6M

Select item 335132510.

Conversion of Human Steroid 5β-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING

Mo Chen, Jason E. Drury, David W. Christianson, Trevor M. Penning

J Biol Chem. 2012 May 11; 287(20): 16609–16622. Published online 2012 Mar 20. doi: 10.1074/jbc.M111.338780

PMCID:: PMC3351325

Abstract Article PDF–2.6M

Select item 310129211.

The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function

Rebekka Mindnich, Jason E. Drury, Trevor M. Penning

Chem Biol Interact. Author manuscript; available in PMC 2012 May 30.

Published in final edited form as: Chem Biol Interact. 2011 May 30; 191(1-3): 250–254. Published online 2010 Dec 24. doi: 10.1016/j.cbi.2010.12.020

PMCID:: PMC3101292

Abstract Article PDF–460K

Select item 305688212.

Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)

Mo Chen, Jason E. Drury, Trevor M. Penning

Steroids. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: Steroids. 2011 Apr; 76(5): 484–490. Published online 2011 Jan 19. doi: 10.1016/j.steroids.2011.01.003

PMCID:: PMC3056882

Abstract Article PDF–584K

Select item 291568913.

Characterization of Disease-related 5β-Reductase (AKR1D1) Mutations Reveals Their Potential to Cause Bile Acid Deficiency

Jason E. Drury, Rebekka Mindnich, Trevor M. Penning

J Biol Chem. 2010 Aug 6; 285(32): 24529–24537. Published online 2010 Jun 3. doi: 10.1074/jbc.M110.127779

PMCID:: PMC2915689

Abstract Article PDF–1.7M

Select item 267519014.

Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)

Luigi Di Costanzo, Jason E. Drury, David W. Christianson, Trevor M. Penning

Mol Cell Endocrinol. Author manuscript; available in PMC 2010 Mar 25.

Published in final edited form as: Mol Cell Endocrinol. 2009 Mar 25; 301(1-2): 191–198. Published online 2008 Sep 19. doi: 10.1016/j.mce.2008.09.013

PMCID:: PMC2675190

Abstract Article PDF–3.3M

Select item 242325115.

Crystal Structure of Human Liver Δ⁴-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

Luigi Di Costanzo, Jason E. Drury, Trevor M. Penning, David W. Christianson

J Biol Chem. 2008 Jun 13; 283(24): 16830–16839. doi: 10.1074/jbc.M801778200

PMCID:: PMC2423251

Abstract Article PDF–942K

Select item 790615516.

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma

Pengfei Zhu, Ruo Feng, Xu Lu, Yuan Liao, Zhicheng Du, Wenlong Zhai, Kunlun Chen

Aging (Albany NY) 2021 Feb 15; 13(3): 4138–4156. Published online 2021 Jan 20. doi: 10.18632/aging.202380

PMCID:: PMC7906155

Abstract Article PDF–2.3M

Select item 737583517.

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

Nikolaos Nikolaou, Laura L. Gathercole, Lucy Kirkwood, James E. Dunford, Beverly A. Hughes, Lorna C. Gilligan, Udo Oppermann, Trevor M. Penning, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2020 Jul 22.

Published in final edited form as: J Steroid Biochem Mol Biol. 2019 May; 189: 218–227. Published online 2019 Feb 12. doi: 10.1016/j.jsbmb.2019.02.002

PMCID:: PMC7375835

Abstract Article PDF–1.1M

Select item 365903118.

A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease

Neil V Morgan, Jane L Hartley, Kenneth DR Setchell, Michael A Simpson, Rachel Brown, Louise Tee, Sian Kirkham, Shanaz Pasha, Richard C Trembath, Eamonn R Maher, Paul Gissen, Deirdre A Kelly

Orphanet J Rare Dis. 2013; 8: 74. Published online 2013 May 16. doi: 10.1186/1750-1172-8-74

PMCID:: PMC3659031

Abstract Article PDF–344K

Select item 387046819.

Role of Aldo-Keto Reductase Family 1 (AKR1) Enzymes in Human Steroid Metabolism

Tea Lanišnik Rižner, Trevor M. Penning

Steroids. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Steroids. 2014 Jan; 79: 10.1016/j.steroids.2013.10.012. Published online 2013 Nov 1. doi: 10.1016/j.steroids.2013.10.012

PMCID:: PMC3870468

Abstract Article PDF–1.3M

Select item 356581420.

Genome-wide association of mood-incongruent psychotic bipolar disorder

F S Goes, M L Hamshere, F Seifuddin, M Pirooznia, P Belmonte-Mahon, R Breuer, T Schulze, M Nöthen, S Cichon, M Rietschel, P Holmans, P P Zandi, Bipolar Genome Study (BiGS), N Craddock, J B Potash

Transl Psychiatry. 2012 Oct; 2(10): e180. Published online 2012 Oct 23. doi: 10.1038/tp.2012.106