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Select item 109704741.

TRIM21 Promotes Oxidative Stress and Ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly Pathogenic Avian Influenza Virus

Yifan Wei, Yongxia Gu, Ziwei Zhou, Changrong Wu, Yanwei Liu, Hailiang Sun

Int J Mol Sci. 2024 Mar; 25(6): 3315. Published online 2024 Mar 14. doi: 10.3390/ijms25063315

PMCID:: PMC10970474

Article PDF–4.2M

Select item 105610072.

TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy

Jing Chen, Wen Cao, Xi Huang, Qingxiao Chen, Shuting Ye, Jianwei Qu, Yang Liu, Xing Guo, Shunnan Yao, Enfan Zhang, Jingsong He, Anqi Li, Li Yang, Zhen Cai

Blood Adv. 2023 Oct 10; 7(19): 5752–5770. Published online 2023 Apr 24. doi: 10.1182/bloodadvances.2022008241

PMCID:: PMC10561007

Article PDF–9.0M

Select item 100489173.

TRIM21 Expression as a Prognostic Biomarker for Progression-Free Survival in HNSCC

Amelie von Bernuth, Julika Ribbat-Idel, Luise Klapper, Tobias Jagomast, Dirk Rades, Anke Leichtle, Ralph Pries, Karl-Ludwig Bruchhage, Sven Perner, Anne Offermann, Verena Sailer, Christian Idel

Int J Mol Sci. 2023 Mar; 24(6): 5140. Published online 2023 Mar 7. doi: 10.3390/ijms24065140

PMCID:: PMC10048917

Article PDF–2.4M

Select item 99355464.

TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models

Jun-Yan Li, Yin Zhao, Sha Gong, Miao-Miao Wang, Xu Liu, Qing-Mei He, Ying-Qin Li, Sheng-Yan Huang, Han Qiao, Xi-Rong Tan, Ming-Liang Ye, Xun-Hua Zhu, Shi-Wei He, Qian Li, Ye-Lin Liang, Kai-Lin Chen, Sai-Wei Huang, Qing-Jie Li, Jun Ma, Na Liu

Nat Commun. 2023; 14: 865. Published online 2023 Feb 16. doi: 10.1038/s41467-023-36523-y

PMCID:: PMC9935546

Article PDF–5.8M

Select item 98670905.

Multiple Roles of TRIM21 in Virus Infection

Xue Li, Lin Yang, Si Chen, Jiawei Zheng, Huimin Zhang, Linzhu Ren

Int J Mol Sci. 2023 Jan; 24(2): 1683. Published online 2023 Jan 14. doi: 10.3390/ijms24021683

PMCID:: PMC9867090

Article PDF–3.9M

Select item 95066796.

The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

Xintian Chen, Menghan Cao, Pengfei Wang, Sufang Chu, Minle Li, Pingfu Hou, Junnian Zheng, Zhongwei Li, Jin Bai

Front Immunol. 2022; 13: 968755. Published online 2022 Sep 9. doi: 10.3389/fimmu.2022.968755

PMCID:: PMC9506679

Article PDF–1.3M

Select item 85337767.

A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment

Gang Chen, Yu Kong, You Li, Ailing Huang, Chunyu Wang, Shanshan Zhou, Zhenlin Yang, Yanling Wu, Jianke Ren, Tianlei Ying

Biomolecules. 2021 Oct; 11(10): 1512. Published online 2021 Oct 14. doi: 10.3390/biom11101512

PMCID:: PMC8533776

Article PDF–4.1M

Select item 82778458.

Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting

Jie Jin, Xianbin Meng, Yi Huo, Haiteng Deng

Cell Death Dis. 2021 Jul; 12(7): 697. Published online 2021 Jul 13. doi: 10.1038/s41419-021-03989-x

PMCID:: PMC8277845

Article PDF–3.1M

Select item 82417789.

TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients

Chun-Yi Chuang, Yi-Chung Chien, Chiao-Wen Lin, Chia-Hsuan Chou, Shuo-Chueh Chen, Chun-Lin Liu, Li-Yuan Bai, Shun-Fa Yang, Yung-Luen Yu

Int J Med Sci. 2021; 18(13): 2997–3003. Published online 2021 Jun 11. doi: 10.7150/ijms.56614

PMCID:: PMC8241778

Article PDF–451K

Select item 807435110.

TRIM21 inhibits porcine epidemic diarrhea virus proliferation by proteasomal degradation of the nucleocapsid protein

Hua Wang, Xiaoyong Chen, Ning Kong, Yajuan Jiao, Dage Sun, Sujie Dong, Wenzhen Qin, Huanjie Zhai, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Guangzhi Tong, Tongling Shan

Arch Virol. 2021; 166(7): 1903–1911. Published online 2021 Apr 26. doi: 10.1007/s00705-021-05080-4

PMCID:: PMC8074351

Article PDF–1.8M

Select item 743191511.

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity

Maarten R Hillen, Katia Urso, Emma Koppe, Ana Pinheiro Lopes, Sofie L M Blokland, Aridaman Pandit, Tom Slocombe, André van Maurik, Joel A G van Roon, Timothy R D J Radstake

RMD Open. 2020; 6(2): e001184. Published online 2020 Jun 15. doi: 10.1136/rmdopen-2020-001184

PMCID:: PMC7431915

Article PDF–737K

Select item 679409112.

Rare missense variants in the human cytosolic antibody receptor preserve antiviral function

Jingwei Zeng, Greg Slodkowicz, Leo C James

eLife. 2019; 8: e48339. Published online 2019 Oct 15. doi: 10.7554/eLife.48339

PMCID:: PMC6794091

Article PDF–1.9M

Select item 623099813.

The Sjögren’s syndrome‐associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production

S. Brauner, M. Ivanchenko, G. E. Thorlacius, A. Ambrosi, M. Wahren‐Herlenius

Clin Exp Immunol. 2018 Dec; 194(3): 315–326. Published online 2018 Oct 16. doi: 10.1111/cei.13211

PMCID:: PMC6230998

Article PDF–537K

Select item 582028114.

Autoantibodies against the Immunoglobulin-Binding Region of Ro52 Link its Autoantigenicity with Pathogen Neutralization

Peter D. Burbelo, Leyla Y. Teos, Jesse L. Herche, Michael J. Iadarola, Ilias Alevizos

Sci Rep. 2018; 8: 3345. Published online 2018 Feb 20. doi: 10.1038/s41598-018-21522-7

PMCID:: PMC5820281

Article PDF–1.4M

Select item 534334615.

Ro52/TRIM21‐deficient expression and function in different subsets of peripheral blood mononuclear cells is associated with a proinflammatory cytokine response in patients with idiopathic inflammatory myopathies

D. Gómez‐Martín, A. S. Galindo‐Feria, A. Barrera‐Vargas, J. Merayo‐Chalico, G. Juárez‐Vega, J. Torres‐Ruiz, J. Alcocer‐Varela

Clin Exp Immunol. 2017 Apr; 188(1): 154–162. Published online 2017 Jan 22. doi: 10.1111/cei.12914

PMCID:: PMC5343346

Article PDF–287K

Select item 453865016.

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

Adam J. Fletcher, Donna L. Mallery, Ruth E. Watkinson, Claire F. Dickson, Leo C. James

Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32): 10014–10019. Published online 2015 Jul 6. doi: 10.1073/pnas.1507534112

PMCID:: PMC4538650

Article PDF–945K

Select item 408917317.

Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjögren's syndrome

L A Aqrawi, M Kvarnström, K A Brokstad, R Jonsson, K Skarstein, M Wahren-Herlenius

Clin Exp Immunol. 2014 Jul; 177(1): 244–252. Published online 2014 Jun 9. doi: 10.1111/cei.12341

PMCID:: PMC4089173

Article PDF–1.3M

Select item 344641618.

Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis

Marie Hudson, Janet Pope, Michael Mahler, Solène Tatibouet, Russell Steele, Murray Baron, Marvin J Fritzler

Arthritis Res Ther. 2012; 14(2): R50. Published online 2012 Mar 6. doi: 10.1186/ar3763

PMCID:: PMC3446416

Article PDF–239K

Select item 342172619.

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

W. A. McEwan, F. Hauler, C. R. Williams, S. R. Bidgood, D. L. Mallery, R. A. Crowther, L. C. James

J Virol. 2012 Aug; 86(16): 8482–8491. doi: 10.1128/JVI.00728-12

PMCID:: PMC3421726

Article PDF–1.4M

Select item 319611220.

Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface

Alexander Espinosa, Janosch Hennig, Aurélie Ambrosi, Madhanagopal Anandapadmanaban, Martina Sandberg Abelius, Yi Sheng, Filippa Nyberg, Cheryl H. Arrowsmith, Maria Sunnerhagen, Marie Wahren-Herlenius

J Biol Chem. 2011 Oct 21; 286(42): 36478–36491. Published online 2011 Aug 23. doi: 10.1074/jbc.M111.241786