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Items: 1 to 20 of 292

1.
G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity
Hui-ting Liang, Jiang-yu Yan, Hao-jun Yao, Xue-nan Zhang, Zhi-ming Xing, Lin Liu, Yao-qing Chen, Guo-rui Li, Jing Huang, Yi-de He, Ke-wei Zheng
Nucleic Acids Res. 2024 Mar 21; 52(5): 2142–2156. Published online 2024 Feb 10. doi: 10.1093/nar/gkae073
PMCID:
PMC10954455
AbstractArticlePDF–2.4M
2.
Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states
Diane T. Takahashi, Danièle Gadelle, Keli Agama, Evgeny Kiselev, Hongliang Zhang, Emilie Yab, Stephanie Petrella, Patrick Forterre, Yves Pommier, Claudine Mayer
Nat Commun. 2022; 13: 59. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27686-7
PMCID:
PMC8748870
AbstractArticlePDF–2.9M
3.
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier
Nat Commun. 2021; 12: 5010. Published online 2021 Aug 18. doi: 10.1038/s41467-021-25252-9
PMCID:
PMC8373905
AbstractArticlePDF–4.8M
4.
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
Agnese Cristini, Giulia Ricci, Sébastien Britton, Simona Salimbeni, Shar-yin Naomi Huang, Jessica Marinello, Patrick Calsou, Yves Pommier, Gilles Favre, Giovanni Capranico, Natalia Gromak, Olivier Sordet
Cell Rep. Author manuscript; available in PMC 2021 Jul 12.
Published in final edited form as: Cell Rep. 2019 Sep 17; 28(12): 3167–3181.e6. doi: 10.1016/j.celrep.2019.08.041
PMCID:
PMC8274950
AbstractArticlePDF–3.0M
5.
TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation
Jessica Sook Yuin Ho, Bobo Wing-Yee Mok, Laura Campisi, Tristan Jordan, Soner Yildiz, Sreeja Parameswaran, Joseph A. Wayman, Natasha N. Gaudreault, David A. Meekins, Sabarish V. Indran, Igor Morozov, Jessie D. Trujillo, Yesai S. Fstkchyan, Raveen Rathnasinghe, Zeyu Zhu, Simin Zheng, Nan Zhao, Kris White, Helen Ray-Jones, Valeriya Malysheva, Michiel J. Thiecke, Siu-Ying Lau, Honglian Liu, Anna Junxia Zhang, Andrew Chak-Yiu Lee, Wen-Chun Liu, Sonia Jangra, Alba Escalera, Teresa Aydillo, Betsaida Salom Melo, Ernesto Guccione, Robert Sebra, Elaine Shum, Jan Bakker, David A. Kaufman, Andre L. Moreira, Mariano Carossino, Udeni B.R. Balasuriya, Minji Byun, Randy A. Albrecht, Michael Schotsaert, Adolfo Garcia-Sastre, Sumit K. Chanda, Emily R. Miraldi, Anand D. Jeyasekharan, Benjamin R. TenOever, Mikhail Spivakov, Matthew T. Weirauch, Sven Heinz, Honglin Chen, Christopher Benner, Juergen A. Richt, Ivan Marazzi
Cell. 2021 May 13; 184(10): 2618–2632.e17. Published online 2021 Mar 30. doi: 10.1016/j.cell.2021.03.051
PMCID:
PMC8008343
AbstractArticlePDF–7.3M
6.
Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero
Nat Commun. 2020; 11: 3940. Published online 2020 Aug 7. doi: 10.1038/s41467-020-17858-2
PMCID:
PMC7414224
AbstractArticlePDF–2.9M
7.
Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells
Liton Kumar Saha, Mitsuo Wakasugi, Salma Akter, Rajendra Prasad, Samuel H. Wilson, Naoto Shimizu, Hiroyuki Sasanuma, Shar-yin Naomi Huang, Keli Agama, Yves Pommier, Tsukasa Matsunaga, Kouji Hirota, Shigenori Iwai, Yuka Nakazawa, Tomoo Ogi, Shunichi Takeda
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14412–14420. Published online 2020 Jun 8. doi: 10.1073/pnas.1920165117
PMCID:
PMC7321995
AbstractArticlePDF–1.5M
8.
Analysis of topoisomerase I expression and identification of predictive markers for efficacy of topotecan chemotherapy in small cell lung cancer
Chunxin Lv, Xiuju Liu, Qiwen Zheng, Hanxiao Chen, Xue Yang, Jia Zhong, Yuyan Wang, Jianchun Duan, Zhijie Wang, Hua Bai, Meina Wu, Jun Zhao, Jie Wang, Ziping Wang, Tongtong An, Minglei Zhuo
Thorac Cancer. 2018 Sep; 9(9): 1166–1173. Published online 2018 Jul 30. doi: 10.1111/1759-7714.12819
PMCID:
PMC6119620
AbstractArticlePDF–1.0M
9.
DNA Topoisomerase I differentially modulates R-loops across the human genome
Stefano G. Manzo, Stella R. Hartono, Lionel A. Sanz, Jessica Marinello, Sara De Biasi, Andrea Cossarizza, Giovanni Capranico, Frederic Chedin
Genome Biol. 2018; 19: 100. Published online 2018 Jul 30. doi: 10.1186/s13059-018-1478-1
PMCID:
PMC6066927
AbstractArticlePDF–2.7M
10.
CPT‐11 May Provide Therapeutic Efficacy for Esophageal Squamous Cell Cancer and the Effects Correlate with the Level of DNA Topoisomerase I Protein
Yasuaki Nakajima, Satoshi Miyake, Kagami Nagai, Tatsuyuki Kawano, Takehisa Iwai
Jpn J Cancer Res. 2001 Dec; 92(12): 1335–1341. doi: 10.1111/j.1349-7006.2001.tb02158.x
PMCID:
PMC5926676
SummaryPDF–170K
11.
Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells
Subhendu K. Das, Ishita Rehman, Arijit Ghosh, Souvik Sengupta, Papiya Majumdar, Biman Jana, Benu Brata Das
Nucleic Acids Res. 2016 Sep 30; 44(17): 8363–8375. Published online 2016 Jul 27. doi: 10.1093/nar/gkw665
PMCID:
PMC5041477
AbstractArticlePDF–4.4M
12.
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations
Niels Frank Jensen, Keli Agama, Amit Roy, David Hersi Smith, Thomas D. Pfister, Maria Unni Rømer, Hong-Liang Zhang, James H. Doroshow, Birgitta R. Knudsen, Jan Stenvang, Nils Brünner, Yves Pommier
J Exp Clin Cancer Res. 2016; 35: 56. Published online 2016 Mar 31. doi: 10.1186/s13046-016-0335-x
PMCID:
PMC4815242
AbstractArticlePDF–3.5M
13.
Single-molecule supercoil-relaxation assay as a screening tool to determine the mechanism and efficacy of human topoisomerase IB inhibitors
Yeonee Seol, Hongliang Zhang, Keli Agama, Nicholas Lorence, Yves Pommier, Keir C. Neuman
Mol Cancer Ther. Author manuscript; available in PMC 2016 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2015 Nov; 14(11): 2552–2559. Published online 2015 Sep 8. doi: 10.1158/1535-7163.MCT-15-0454
PMCID:
PMC4636450
AbstractArticlePDF–841K
14.
Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells
Nilesh K. Sharma, Ashutosh Kumar, Amrita Kumari, Erik J. Tokar, Michael P. Waalkes, Carl D. Bortner, Jason Williams, Marilyn Ehrenshaft, Ronald P. Mason, Birandra K. Sinha
PLoS One. 2015; 10(11): e0141897. Published online 2015 Nov 5. doi: 10.1371/journal.pone.0141897
PMCID:
PMC4635000
AbstractArticlePDF–1.9M
15.
Topoisomerase I Alone Is Sufficient to Produce Short DNA Deletions and Can Also Reverse Nicks at Ribonucleotide Sites
Shar-yin Naomi Huang, Sanchari Ghosh, Yves Pommier
J Biol Chem. 2015 May 29; 290(22): 14068–14076. Published online 2015 Apr 17. doi: 10.1074/jbc.M115.653345
PMCID:
PMC4447978
AbstractArticlePDF–2.2M
16.
Ligand-dependent Enhancer Activation Regulated by Topoisomerase-I Activity
Janusz Puc, Piotr Kozbial, Wenbo Li, Yuliang Tan, Zhijie Liu, Tom Suter, Kenneth A. Ohgi, Jie Zhang, Aneel K. Aggarwal, Michael G. Rosenfeld
Cell. Author manuscript; available in PMC 2016 Jan 29.
Published in final edited form as: Cell. 2015 Jan 29; 160(3): 367–380. Published online 2015 Jan 22. doi: 10.1016/j.cell.2014.12.023
Correction in:
volume 163 on page 520
PMCID:
PMC4422651
AbstractArticlePDF–1.4M
17.
Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
Cinzia Tesauro, Grazia Graziani, Barbara Arnò, Laura Zuccaro, Alessia Muzi, Ilda D’Annessa, Elettra Santori, Lucio Tentori, Carlo Leonetti, Paola Fiorani, Alessandro Desideri
J Exp Clin Cancer Res. 2014; 33(1): 71. Published online 2014 Sep 17. doi: 10.1186/s13046-014-0071-z
PMCID:
PMC4172901
AbstractArticlePDF–1.0M
18.
Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site
Ilda D'Annessa, Andrea Coletta, Thana Sutthibutpong, Jonathan Mitchell, Giovanni Chillemi, Sarah Harris, Alessandro Desideri
Nucleic Acids Res. 2014 Aug 18; 42(14): 9304–9312. Published online 2014 Jul 23. doi: 10.1093/nar/gku654
PMCID:
PMC4132758
AbstractArticlePDF–2.7M
19.
Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines
YASUHIRO ARAKAWA, KOJI OZAKI, YUTAKA OKAWA, HISASHI YAMADA
Oncol Rep. 2013 Sep; 30(3): 1053–1058. Published online 2013 Jul 5. doi: 10.3892/or.2013.2594
PMCID:
PMC3783056
AbstractArticlePDF–576K
20.
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
Cinzia Tesauro, Blasco Morozzo della Rocca, Alessio Ottaviani, Andrea Coletta, Laura Zuccaro, Barbara Arnò, Ilda D'Annessa, Paola Fiorani, Alessandro Desideri
Mol Cancer. 2013; 12: 100. Published online 2013 Sep 3. doi: 10.1186/1476-4598-12-100
PMCID:
PMC3766703
AbstractArticlePDF–2.8M

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