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Select item 74042741.

Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

Sultan Alanazi, Mirjana Grujic, Maria Lampinen, Ola Rollman, Christian P. Sommerhoff, Gunnar Pejler, Fabio Rabelo Melo

Int J Mol Sci. 2020 Jul; 21(14): 5065. Published online 2020 Jul 17. doi: 10.3390/ijms21145065

PMCID:: PMC7404274

Article PDF–2.4M

Select item 71167802.

Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis

Georg Greiner, Bettina Sprinzl, Aleksandra Górska, Franz Ratzinger, Michael Gurbisz, Nadine Witzeneder, Klaus G. Schmetterer, Bettina Gisslinger, Goekhan Uyanik, Emir Hadzijusufovic, Harald Esterbauer, Karoline V. Gleixner, Maria T. Krauth, Michael Pfeilstöcker, Felix Keil, Heinz Gisslinger, Boguslaw Nedoszytko, Marek Niedoszytko, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann

Blood. Author manuscript; available in PMC 2022 Jan 14.

Published in final edited form as: Blood. 2021 Jan 14; 137(2): 238–247. doi: 10.1182/blood.2020006157

PMCID:: PMC7116780

Article PDF–1.1M

Select item 53972973.

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

Jonathan J Lyons, Xiaomin Yu, Jason D Hughes, Quang T Le, Ali Jamil, Yun Bai, Nancy Ho, Ming Zhao, Yihui Liu, Michael P O’Connell, Neil N Trivedi, Celeste Nelson, Thomas DiMaggio, Nina Jones, Helen Matthews, Katie L Lewis, Andrew J Oler, Ryan J Carlson, Peter D Arkwright, Celine Hong, Sherene Agama, Todd M Wilson, Sofie Tucker, Yu Zhang, Joshua J McElwee, Maryland Pao, Sarah C Glover, Marc E Rothenberg, Robert J Hohman, Kelly D Stone, George H Caughey, Theo Heller, Dean D Metcalfe, Leslie G Biesecker, Lawrence B Schwartz, Joshua D Milner

Nat Genet. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Nat Genet. 2016 Dec; 48(12): 1564–1569. Published online 2016 Oct 17. doi: 10.1038/ng.3696

PMCID:: PMC5397297

Article PDF–484K

Select item 49845384.

Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis

Melody C. Carter, Sarah T. Clayton, Hirsh D. Komarow, Erica H. Brittain, Linda M. Scott, Daly Cantave, Donna M. Gaskins, Irina Maric, Dean D. Metcalfe

J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: J Allergy Clin Immunol. 2015 Dec; 136(6): 1673–79.e1-3. Published online 2015 Jun 1. doi: 10.1016/j.jaci.2015.04.024

PMCID:: PMC4984538

Article PDF–636K

Select item 42823355.

Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma

A M Abdelmotelb, M J Rose-Zerilli, S J Barton, S T Holgate, A F Walls, J W Holloway

Clin Exp Allergy. 2013 Jun; 44(6): 822–830. Published online 2013 May 24. doi: 10.1111/cea.12259

PMCID:: PMC4282335

Article PDF–300K

Select item 40517536.

Correlation between Serum Tryptase, Mast Cells Positive to Tryptase and Microvascular Density in Colo-Rectal Cancer Patients: Possible Biological-Clinical Significance

Michele Ammendola, Rosario Sacco, Giuseppe Sammarco, Giuseppe Donato, Severino Montemurro, Eustachio Ruggieri, Rosa Patruno, Ilaria Marech, Marica Cariello, Angelo Vacca, Cosmo Damiano Gadaleta, Girolamo Ranieri

PLoS One. 2014; 9(6): e99512. Published online 2014 Jun 10. doi: 10.1371/journal.pone.0099512

PMCID:: PMC4051753

Article PDF–1.0M

Select item 40226307.

Circulating Tryptase as a Marker for Subclinical Atherosclerosis in Obese Subjects

María Moreno, Josep Puig, Marta Serrano, José María Moreno-Navarrete, Francisco Ortega, Wifredo Ricart, Jose Manuel Fernandez-Real

PLoS One. 2014; 9(5): e97014. Published online 2014 May 15. doi: 10.1371/journal.pone.0097014

PMCID:: PMC4022630

Article PDF–380K

Select item 39223658.

Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium

Domenico Ribatti, Beatrice Nico, Cristina Maxia, Vito Longo, Daniela Murtas, Domenica Mangieri, M Teresa Perra, Michela De Giorgis, Franca Piras, Enrico Crivellato, Paola Sirigu

J Cell Mol Med. 2007 May; 11(3): 585–589. Published online 2007 Jul 13. doi: 10.1111/j.1582-4934.2007.00050.x

PMCID:: PMC3922365

Article PDF–119K

Select item 37965179.

Serum Tryptase Monitoring in Indolent Systemic Mastocytosis: Association with Disease Features and Patient Outcome

Almudena Matito, José Mario Morgado, Iván Álvarez-Twose, Laura Sánchez-Muñoz, Carlos Eduardo Pedreira, María Jara-Acevedo, Cristina Teodosio, Paula Sánchez-López, Elisa Fernández-Núñez, Ricardo Moreno-Borque, Andrés García-Montero, Alberto Orfao, Luis Escribano

PLoS One. 2013; 8(10): e76116. Published online 2013 Oct 14. doi: 10.1371/journal.pone.0076116

PMCID:: PMC3796517

Article PDF–449K

Select item 264324710.

β-Tryptase Regulates IL-8 Expression in Airway Smooth Muscle Cells by a PAR-2–Independent Mechanism

Charlotte S. Mullan, Michael Riley, Deborah Clarke, Amanda Tatler, Amy Sutcliffe, Alan J. Knox, Linhua Pang

Am J Respir Cell Mol Biol. 2008 May; 38(5): 600–608. Published online 2007 Dec 13. doi: 10.1165/rcmb.2007-0082OC

PMCID:: PMC2643247

Article PDF–320K

Select item 50794711.

Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts.

J A Cairns, A F Walls

J Clin Invest. 1997 Mar 15; 99(6): 1313–1321. doi: 10.1172/JCI119290

PMCID:: PMC507947

Summary PDF–238K

Select item 32977712.

Cloning and characterization of complementary DNA for human tryptase.

J S Miller, E H Westin, L B Schwartz

J Clin Invest. 1989 Oct; 84(4): 1188–1195. doi: 10.1172/JCI114284

PMCID:: PMC329777

Summary Page Browse PDF–1.5M

Select item 18597713.

The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis.

L B Schwartz, K Sakai, T R Bradford, S Ren, B Zweiman, A S Worobec, D D Metcalfe

J Clin Invest. 1995 Dec; 96(6): 2702–2710. doi: 10.1172/JCI118337

PMCID:: PMC185977

Summary Page Browse PDF–1.9M

Select item 678099814.

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

Quang T. Le, Jonathan J. Lyons, Andrea N. Naranjo, Ana Olivera, Robert A. Lazarus, Dean D. Metcalfe, Joshua D. Milner, Lawrence B. Schwartz

J Exp Med. 2019 Oct 7; 216(10): 2348–2361. Published online 2019 Jul 23. doi: 10.1084/jem.20190701

PMCID:: PMC6780998

Article PDF–2.2M

Select item 657277915.

Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold

Brian S. Finlin, Amy L. Confides, Beibei Zhu, Mary C. Boulanger, Hasiyet Memetimin, Kyle W. Taylor, Zachary R. Johnson, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern

Sci Rep. 2019; 9: 8658. Published online 2019 Jun 17. doi: 10.1038/s41598-019-45136-9

PMCID:: PMC6572779

Article PDF–2.0M

Select item 601645416.

Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer

Henry R. Maun, Peter S. Liu, Yvonne Franke, Charles Eigenbrot, William F. Forrest, Lawrence B. Schwartz, Robert A. Lazarus

J Biol Chem. 2018 Jun 22; 293(25): 9614–9628. Published online 2018 Apr 16. doi: 10.1074/jbc.M117.812016

PMCID:: PMC6016454

Article PDF–1.4M

Select item 445210417.

Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report

Lukasz Lewicki, Janusz Siebert, Natalia Marek-Trzonkowska, Emilia Masiewicz, Tomasz Kolinski, Magdalena Reiwer-Gostomska, Radoslaw Targonski, Piotr Trzonkowski

Mediators Inflamm. 2015; 2015: 395173. Published online 2015 May 18. doi: 10.1155/2015/395173

PMCID:: PMC4452104

Article PDF–634K

Select item 378054118.

High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression

Andrea Malfettone, Nicola Silvestris, Concetta Saponaro, Girolamo Ranieri, Antonio Russo, Stefano Caruso, Ondina Popescu, Giovanni Simone, Angelo Paradiso, Anita Mangia

J Cell Mol Med. 2013 Aug; 17(8): 1025–1037. Published online 2013 Aug 29. doi: 10.1111/jcmm.12073

PMCID:: PMC3780541

Article PDF–1.2M

Select item 266223519.

Alternate mRNA Splicing in Multiple Human Tryptase Genes Is Predicted to Regulate Tetramer Formation

Nicole E. Jackson, Hong-Wei Wang, Katherine J. Bryant, H. Patrick McNeil, Ahsan Husain, Ke Liu, Nicodemus Tedla, Paul S. Thomas, Garry C. King, Anusha Hettiaratchi, Jennifer Cairns, John E. Hunt

J Biol Chem. 2008 Dec 5; 283(49): 34178–34187. doi: 10.1074/jbc.M807553200

PMCID:: PMC2662235

Article PDF–3.1M

Select item 258489120.

Tryptase activates calcium-independent phospholipase A₂ and releases PGE₂ in airway epithelial cells

Prerna Rastogi, Dawn M. Young, Jane McHowat

Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5): L925–L932. Published online 2008 Sep 12. doi: 10.1152/ajplung.90230.2008

PMCID:: PMC2584891

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