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Select item 108579711.

METTL16 inhibits papillary thyroid cancer tumorigenicity through m⁶A/YTHDC2/SCD1-regulated lipid metabolism

Qiang Li, Yaju Wang, Xiangshu Meng, Wenjing Wang, Feifan Duan, Shuya Chen, Yukun Zhang, Zhiyong Sheng, Yu Gao, Lei Zhou

Cell Mol Life Sci. 2024; 81(1): 81. Published online 2024 Feb 9. doi: 10.1007/s00018-024-05146-x

PMCID:: PMC10857971

Article PDF–17M

Select item 108358882.

METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation

Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang, Lili Ren, Hongjie Bi, Lu Yang, Chao Shen, Zhenhua Chen, Laleh Melstrom, Hongzhi Li, Nikolai Timchenko, Xiaolan Deng, Wendong Huang, Steven T. Rosen, Jingyan Tian, Lin Xu, Jiajie Diao, Chun-Wei Chen, Jianjun Chen, Baiyong Shen, Hao Chen, Rui Su

J Hematol Oncol. 2024; 17: 7. Published online 2024 Feb 1. doi: 10.1186/s13045-024-01526-9

PMCID:: PMC10835888

Article PDF–15M

Select item 106254883.

METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/β-Catenin Axis

Changshu Li, Ji Liu, Yuanyuan Lyu, Shizhang Ling, Yonghong Luo

Anal Cell Pathol (Amst) 2023; 2023: 9952234. Published online 2023 Oct 28. doi: 10.1155/2023/9952234

PMCID:: PMC10625488

Article PDF–7.2M

Select item 102808574.

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression

Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang, Hao Wang

J Exp Clin Cancer Res. 2023; 42: 151. Published online 2023 Jun 20. doi: 10.1186/s13046-023-02732-y

Correction in:: J Exp Clin Cancer Res. 2024; 43: 26.

PMCID:: PMC10280857

Article PDF–12M

Select item 98509205.

Elucidating the Kinetic Mechanism of Human METTL16

Kurtis Breger, Jessica A. Brown

Biochemistry. 2023 Jan 17; 62(2): 494–506. Published online 2022 Dec 30. doi: 10.1021/acs.biochem.2c00601

PMCID:: PMC9850920

Article PDF–6.1M

Select item 98381876.

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

Li Han, Lei Dong, Keith Leung, Zhicong Zhao, Yangchan Li, Lei Gao, Zhenhua Chen, Jianhuang Xue, Ying Qing, Wei Li, Sheela Pangeni Pokharel, Min Gao, Meiling Chen, Chao Shen, Brandon Tan, Andrew Small, Kitty Wang, Zheng Zhang, Xi Qin, Lu Yang, Mark Wunderlich, Bin Zhang, James C. Mulloy, Guido Marcucci, Chun-Wei Chen, Minjie Wei, Rui Su, Jianjun Chen, Xiaolan Deng

Cell Stem Cell. Author manuscript; available in PMC 2024 Jan 5.

Published in final edited form as: Cell Stem Cell. 2023 Jan 5; 30(1): 52–68.e13. doi: 10.1016/j.stem.2022.12.006

PMCID:: PMC9838187

Article PDF–3.0M

Select item 92864147.

RNA methyltransferase METTL16: Targets and function

Emily R. Satterwhite, Kyle D. Mansfield

Wiley Interdiscip Rev RNA. 2022 Mar-Apr; 13(2): e1681. Published online 2021 Jul 6. doi: 10.1002/wrna.1681

PMCID:: PMC9286414

Article PDF–3.0M

Select item 90704138.

METTL16 exerts an m⁶A-independent function to facilitate translation and tumorigenesis

Rui Su, Lei Dong, Yangchan Li, Min Gao, P. Cody He, Wei Liu, Jiangbo Wei, Zhicong Zhao, Lei Gao, Li Han, Xiaolan Deng, Chenying Li, Emily Prince, Brandon Tan, Ying Qing, Xi Qin, Chao Shen, Meilin Xue, Keren Zhou, Zhenhua Chen, Jianhuang Xue, Wei Li, Hanjun Qin, Xiwei Wu, Miao Sun, Yunsun Nam, Chun-Wei Chen, Wendong Huang, David Horne, Steven T. Rosen, Chuan He, Jianjun Chen

Nat Cell Biol. Author manuscript; available in PMC 2022 Aug 10.

Published in final edited form as: Nat Cell Biol. 2022 Feb; 24(2): 205–216. Published online 2022 Feb 10. doi: 10.1038/s41556-021-00835-2

PMCID:: PMC9070413

Article PDF–7.6M

Select item 84749879.

Systematic analysis of molecular characterization and clinical relevance of m6A regulators in digestive system pan-cancers

Tiankuo Kou, Ruizhi Chai, Lan Jin, Zhigang Bai, Yun Yang, Yongtian Zhao, Dongfang Wu, Zhongtao Zhang, Yingchi Yang

Exp Biol Med (Maywood) 2021 Sep; 246(18): 2007–2018. Published online 2021 Jun 8. doi: 10.1177/15353702211019681

PMCID:: PMC8474987

Article PDF–2.8M

Select item 792707310.

METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function

Agnieszka Ruszkowska

Int J Mol Sci. 2021 Feb; 22(4): 2176. Published online 2021 Feb 22. doi: 10.3390/ijms22042176

PMCID:: PMC7927073

Article PDF–4.7M

Select item 722981311.

Mechanistic insights into m⁶A modification of U6 snRNA by human METTL16

Tomohiko Aoyama, Seisuke Yamashita, Kozo Tomita

Nucleic Acids Res. 2020 May 21; 48(9): 5157–5168. Published online 2020 Apr 8. doi: 10.1093/nar/gkaa227

PMCID:: PMC7229813

Article PDF–4.0M

Select item 696192912.

Characterization of METTL16 as a cytoplasmic RNA binding protein

Daniel J. Nance, Emily R. Satterwhite, Brinda Bhaskar, Sway Misra, Kristen R. Carraway, Kyle D. Mansfield

PLoS One. 2020; 15(1): e0227647. Published online 2020 Jan 15. doi: 10.1371/journal.pone.0227647

PMCID:: PMC6961929

Article PDF–2.3M

Select item 587188013.

Structural insights into the RNA methyltransferase domain of METTL16

Agnieszka Ruszkowska, Milosz Ruszkowski, Zbigniew Dauter, Jessica A. Brown

Sci Rep. 2018; 8: 5311. Published online 2018 Mar 28. doi: 10.1038/s41598-018-23608-8

PMCID:: PMC5871880

Article PDF–4.0M

Select item 1087815314.

METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway

Hao Yu, Juntao Zhuang, Zijian Zhou, Qiang Song, Jiancheng Lv, Xiao Yang, Haiwei Yang, Qiang Lu

Int J Biol Sci. 2024; 20(4): 1471–1491. Published online 2024 Feb 4. doi: 10.7150/ijbs.86719

PMCID:: PMC10878153

Article PDF–9.0M

Select item 1048289115.

METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle

Xinquan Zhang, Wen Meng, Jian Feng, Xinghong Gao, Chao Qin, Pinghui Feng, Yufei Huang, Shou-Jiang Gao

Cell Death Dis. 2023 Sep; 14(9): 591. Published online 2023 Sep 6. doi: 10.1038/s41419-023-06121-3

PMCID:: PMC10482891

Article PDF–6.8M

Select item 912370916.

METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m⁶A-dependent manner

Yun-zhang Dai, Yong-da Liu, Jie Li, Mei-ting Chen, Mei Huang, Fang Wang, Qing-song Yang, Ji-hang Yuan, Shu-han Sun

Cell Mol Biol Lett. 2022; 27: 41. Published online 2022 May 20. doi: 10.1186/s11658-022-00342-8

PMCID:: PMC9123709

Article PDF–6.1M

Select item 827809017.

METTL16 promotes cell proliferation by up‐regulating cyclin D1 expression in gastric cancer

Xiao‐Kun Wang, Ya‐Wei Zhang, Chun‐Ming Wang, Bo Li, Tian‐Zhi Zhang, Wen‐Jie Zhou, Lyu‐jia Cheng, Ming‐Yu Huo, Chang‐Hua Zhang, Yu‐Long He

J Cell Mol Med. 2021 Jul; 25(14): 6602–6617. Published online 2021 Jun 2. doi: 10.1111/jcmm.16664

PMCID:: PMC8278090

Article PDF–2.9M

Select item 682132218.

METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis

Lindsey Van Haute, Alan G Hendrick, Aaron R D’Souza, Christopher A Powell, Pedro Rebelo-Guiomar, Michael E Harbour, Shujing Ding, Ian M Fearnley, Byron Andrews, Michal Minczuk

Nucleic Acids Res. 2019 Nov 4; 47(19): 10267–10281. Published online 2019 Sep 6. doi: 10.1093/nar/gkz735

PMCID:: PMC6821322

Article PDF–4.0M

Select item 636793419.

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

Katelyn A. Doxtader, Ping Wang, Anna M. Scarborough, Dahee Seo, Nicholas K. Conrad, Yunsun Nam

Mol Cell. Author manuscript; available in PMC 2019 Feb 8.

Published in final edited form as: Mol Cell. 2018 Sep 20; 71(6): 1001–1011.e4. Published online 2018 Sep 6. doi: 10.1016/j.molcel.2018.07.025

PMCID:: PMC6367934

Article PDF–2.4M

Select item 566660220.

Human METTL16 is a N⁶‐methyladenosine (m⁶A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs

Ahmed S Warda, Jens Kretschmer, Philipp Hackert, Christof Lenz, Henning Urlaub, Claudia Höbartner, Katherine E Sloan, Markus T Bohnsack

EMBO Rep. 2017 Nov; 18(11): 2004–2014. Published online 2017 Oct 19. doi: 10.15252/embr.201744940

PMCID:: PMC5666602

Article PDF–1.0M

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