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Items: 1 to 20 of 58

1.
Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury
Zhengping Hou, Qiuying Ding, Yuqi Li, Zhibo Zhao, Fang Yan, Yanping Li, Xingxing Wang, Jingyuan Xu, Weiting Chen, Guicheng Wu, Xiongzhong Ruan, Lei Zhao
eBioMedicine. 2022 Aug; 82: 104181. Published online 2022 Jul 28. doi: 10.1016/j.ebiom.2022.104181
PMCID:
PMC9352463
AbstractArticlePDF–6.2M
2.
Glucagon receptor signaling regulates weight loss via central KLB receptor complexes
Shelly R. Nason, Jessica Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H. Pierre, Teayoun Kim, Jodi R. Paul, Cassie Holleman, Martin E. Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S. Hunter, Alexei Kharitonenkov, Kirk M. Habegger
JCI Insight. 2021 Feb 22; 6(4): e141323. Published online 2021 Feb 22. doi: 10.1172/jci.insight.141323
PMCID:
PMC7934938
AbstractArticlePDF–1.4M
3.
Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice
Karlton R Larson, Aki T-B Chaffin, Michael L Goodson, Yanbin Fang, Karen K Ryan
Endocrinology. 2019 May; 160(5): 1069–1080. Published online 2019 Feb 25. doi: 10.1210/en.2018-01056
PMCID:
PMC6469953
AbstractArticle
4.
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
Kathleen R. Markan, Meghan C. Naber, Sarah M. Small, Lila Peltekian, Rachel L. Kessler, Matthew J. Potthoff
Mol Metab. 2017 Jun; 6(6): 602–610. Published online 2017 Mar 27. doi: 10.1016/j.molmet.2017.03.009
PMCID:
PMC5444074
AbstractArticlePDF–900K
5.
FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure and Weight Loss
Bryn M. Owen, Xunshan Ding, Donald A. Morgan, Katie Colbert Coate, Angie L. Bookout, Kamal Rahmouni, Steven A. Kliewer, David J. Mangelsdorf
Cell Metab. Author manuscript; available in PMC 2015 Oct 7.
Published in final edited form as: Cell Metab. 2014 Oct 7; 20(4): 670–677. Published online 2014 Aug 14. doi: 10.1016/j.cmet.2014.07.012
PMCID:
PMC4192037
AbstractArticlePDF–642K
6.
Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands
Regina Goetz, Mutsuko Ohnishi, Xunshan Ding, Hiroshi Kurosu, Lei Wang, Junko Akiyoshi, Jinghong Ma, Weiming Gai, Yisrael Sidis, Nelly Pitteloud, Makoto Kuro-o, Mohammed S. Razzaque, Moosa Mohammadi
Mol Cell Biol. 2012 May; 32(10): 1944–1954. doi: 10.1128/MCB.06603-11
PMCID:
PMC3347405
AbstractArticlePDF–2.3M
7.
Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho
Shinji Ito, Toshihiko Fujimori, Akiko Furuya, Junko Satoh, Yoko Nabeshima, Yo-ichi Nabeshima
J Clin Invest. 2005 Aug 1; 115(8): 2202–2208. doi: 10.1172/JCI23076
PMCID:
PMC1180526
AbstractArticlePDF–909K
8.
FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
Cristal M. Hill, Thomas Laeger, Madeleine Dehner, Diana C. Albarado, Blaise Clarke, Desiree Wanders, Susan J. Burke, J. Jason Collier, Emily Qualls-Creekmore, Samantha M. Solon-Biet, Stephen J. Simpson, Hans-Rudolf Berthoud, Heike Munzberg, Christopher D. Morrison
Cell Rep. Author manuscript; available in PMC 2019 Jun 17.
Published in final edited form as: Cell Rep. 2019 Jun 4; 27(10): 2934–2947.e3. doi: 10.1016/j.celrep.2019.05.022
PMCID:
PMC6579533
AbstractArticlePDF–1.7M
9.
Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat
Huating Li, Guangyu Wu, Qichen Fang, Mingliang Zhang, Xiaoyan Hui, Bin Sheng, Liang Wu, Yuqian Bao, Peng Li, Aimin Xu, Weiping Jia
Nat Commun. 2018; 9: 272. Published online 2018 Jan 18. doi: 10.1038/s41467-017-02677-9
PMCID:
PMC5773530
AbstractArticlePDF–3.3M
10.
FGF19, FGF21 and an FGFR1/β-Klotho-activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Tian Lan, Donald A. Morgan, Kamal Rahmouni, Junichiro Sonoda, Xiaorong Fu, Shawn C. Burgess, William L. Holland, Steven A. Kliewer, David J. Mangelsdorf
Cell Metab. Author manuscript; available in PMC 2018 Nov 7.
Published in final edited form as: Cell Metab. 2017 Nov 7; 26(5): 709–718.e3. Published online 2017 Oct 5. doi: 10.1016/j.cmet.2017.09.005
PMCID:
PMC5679468
AbstractArticlePDF–1.8M
11.
β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue
Emmanuel Somm, Hugues Henry, Stephen J. Bruce, Sébastien Aeby, Marta Rosikiewicz, Gerasimos P. Sykiotis, Mohammed Asrih, François R. Jornayvaz, Pierre Damien Denechaud, Urs Albrecht, Moosa Mohammadi, Andrew Dwyer, James S. Acierno, Jr., Kristina Schoonjans, Lluis Fajas, Gilbert Greub, Nelly Pitteloud
JCI Insight. 2017 Apr 20; 2(8): e91809. Published online 2017 Apr 20. doi: 10.1172/jci.insight.91809
PMCID:
PMC5396514
AbstractArticlePDF–1.9M
12.
FGF21 is an Exocrine Pancreas Secretagogue
Katie C. Coate, Genaro Hernandez, Curtis A. Thorne, Shengyi Sun, Thao D. V. Le, Kevin Vale, Steven A. Kliewer, David J. Mangelsdorf
Cell Metab. Author manuscript; available in PMC 2018 Feb 7.
Published in final edited form as: Cell Metab. 2017 Feb 7; 25(2): 472–480. Published online 2017 Jan 12. doi: 10.1016/j.cmet.2016.12.004
PMCID:
PMC5299054
AbstractArticlePDF–1.4M
13.
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Gunter Schumann, Chunyu Liu, Paul O’Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, Stefan Enroth, Krista Fischer, Jenni Hällfors, Sarah E. Harris, Saskia Hieber, Edith Hofer, Jouke-Jan Hottenga, Åsa Johansson, Peter K. Joshi, Niina Kaartinen, Jaana Laitinen, Rozenn Lemaitre, Anu Loukola, Jian’an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Hamdi Mbarek, Yuri Milaneschi, Alireza Moayyeri, Kenneth Mukamal, Christopher Nelson, Jennifer Nettleton, Eemil Partinen, Rajesh Rawal, Antonietta Robino, Lynda Rose, Cinzia Sala, Takashi Satoh, Reinhold Schmidt, Katharina Schraut, Robert Scott, Albert Vernon Smith, John M. Starr, Alexander Teumer, Stella Trompet, André G. Uitterlinden, Cristina Venturini, Anne-Claire Vergnaud, Niek Verweij, Veronique Vitart, Dragana Vuckovic, Juho Wedenoja, Loic Yengo, Bing Yu, Weihua Zhang, Jing Hua Zhao, Dorret I. Boomsma, John Chambers, Daniel I. Chasman, Toniolo Daniela, Eco de Geus, Ian Deary, Johan G. Eriksson, Tõnu Esko, Volker Eulenburg, Oscar H. Franco, Philippe Froguel, Christian Gieger, Hans J. Grabe, Vilmundur Gudnason, Ulf Gyllensten, Tamara B. Harris, Anna-Liisa Hartikainen, Andrew C. Heath, Lynne Hocking, Albert Hofman, Cornelia Huth, Marjo-Riitta Jarvelin, J. Wouter Jukema, Jaakko Kaprio, Jaspal S. Kooner, Zoltan Kutalik, Jari Lahti, Claudia Langenberg, Terho Lehtimäki, Yongmei Liu, Pamela A. F. Madden, Nicholas Martin, Alanna Morrison, Brenda Penninx, Nicola Pirastu, Bruce Psaty, Olli Raitakari, Paul Ridker, Richard Rose, Jerome I. Rotter, Nilesh J. Samani, Helena Schmidt, Tim D. Spector, David Stott, David Strachan, Ioanna Tzoulaki, Pim van der Harst, Cornelia M. van Duijn, Pedro Marques-Vidal, Peter Vollenweider, Nicholas J. Wareham, John B. Whitfield, James Wilson, Bruce Wolffenbuttel, Georgy Bakalkin, Evangelos Evangelou, Yun Liu, Kenneth M. Rice, Sylvane Desrivières, Steven A. Kliewer, David J. Mangelsdorf, Christian P. Müller, Daniel Levy, Paul Elliott
Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50): 14372–14377. Published online 2016 Nov 28. doi: 10.1073/pnas.1611243113
PMCID:
PMC5167198
AbstractArticlePDF–829K
14.
FGF21 Regulates Sweet and Alcohol Preference
Saswata Talukdar, Bryn M. Owen, Parkyong Song, Genaro Hernandez, Yuan Zhang, Yingjiang Zhou, William T. Scott, Bhavna Paratala, Tod Turner, Andrew Smith, Barbara Bernardo, Christian P. Müller, Hao Tang, David J. Mangelsdorf, Bryan Goodwin, Steven A. Kliewer
Cell Metab. Author manuscript; available in PMC 2017 Feb 9.
Published in final edited form as: Cell Metab. 2016 Feb 9; 23(2): 344–349. Published online 2015 Dec 24. doi: 10.1016/j.cmet.2015.12.008
PMCID:
PMC4749404
AbstractArticlePDF–989K
15.
FGF21 contributes to neuroendocrine control of female reproduction
Bryn M. Owen, Angie L. Bookout, Xunshan Ding, Vicky Y. Lin, Stan D. Atkin, Laurent Gautron, Steven A. Kliewer, David J. Mangelsdorf
Nat Med. Author manuscript; available in PMC 2014 Mar 1.
Published in final edited form as: Nat Med. 2013 Sep; 19(9): 1153–1156. Published online 2013 Aug 11. doi: 10.1038/nm.3250
PMCID:
PMC3769455
AbstractArticlePDF–993K
16.
FGF21 regulates circadian behavior and metabolism by acting on the nervous system
Angie L. Bookout, Marleen H. M. de Groot, Bryn M. Owen, Syann Lee, Laurent Gautron, Heather L. Lawrence, Xunshan Ding, Joel K. Elmquist, Joseph S. Takahashi, David J. Mangelsdorf, Steven A. Kliewer
Nat Med. Author manuscript; available in PMC 2014 Mar 1.
Published in final edited form as: Nat Med. 2013 Sep; 19(9): 1147–1152. Published online 2013 Aug 11. doi: 10.1038/nm.3249
PMCID:
PMC3769420
AbstractArticlePDF–956K
17.
FGF21 Requires βklotho to Act In Vivo
Andrew C. Adams, Christine C. Cheng, Tamer Coskun, Alexei Kharitonenkov
PLoS One. 2012; 7(11): e49977. Published online 2012 Nov 27. doi: 10.1371/journal.pone.0049977
PMCID:
PMC3507945
AbstractArticlePDF–501K
18.
βKlotho Is Required for Fibroblast Growth Factor 21 Effects On Growth and Metabolism
Xunshan Ding, Jamie Boney-Montoya, Bryn M. Owen, Angie L. Bookout, Katie Colbert Coate, David J. Mangelsdorf, Steven A. Kliewer
Cell Metab. Author manuscript; available in PMC 2013 Mar 5.
Published in final edited form as: Cell Metab. 2012 Sep 5; 16(3): 387–393. doi: 10.1016/j.cmet.2012.08.002
PMCID:
PMC3447537
AbstractArticlePDF–2.8M
19.
Relevant use of Klotho in FGF19 subfamily signaling system in vivo
Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito, Yoko Nabeshima, Tsutomu Tomita, Shinji Odori, Kiminori Hosoda, Kazuwa Nakao, Akihiro Imura, Yo-ichi Nabeshima
Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4): 1666–1671. Published online 2010 Jan 8. doi: 10.1073/pnas.0913986107
PMCID:
PMC2824417
AbstractArticlePDF–546K
20.
β-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
Jyoti Sinha, Frank Chen, Tamir Miloh, Robert C. Burns, Zhisheng Yu, Benjamin L. Shneider
Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5): G996–G1003. Published online 2008 Sep 4. doi: 10.1152/ajpgi.90343.2008
PMCID:
PMC2584833
AbstractArticle

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