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Select item 73467201.

Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Activity Reverses Behavioral Deficits in a Rodent Model of Autism

Manavi Chatterjee, Priya Singh, Jian Xu, Paul J. Lombroso, Pradeep K. Kurup

Behav Brain Res. Author manuscript; available in PMC 2021 Aug 5.

Published in final edited form as: Behav Brain Res. 2020 Aug 5; 391: 112713. Published online 2020 May 24. doi: 10.1016/j.bbr.2020.112713

PMCID:: PMC7346720

Abstract Article PDF–703K

Select item 67035972.

A Critical Role for Protein Tyrosine Phosphatase Nonreceptor Type 5 in Determining Individual Susceptibility to Develop Stress-Related Cognitive and Morphological Changes

Chih-Hao Yang, Chiung-Chun Huang, Kuei-Sen Hsu

J Neurosci. 2012 May 30; 32(22): 7550–7562. doi: 10.1523/JNEUROSCI.5902-11.2012

PMCID:: PMC6703597

Abstract Article PDF–3.2M

Select item 47524973.

Missense Variant in MAPK Inactivator PTPN5 Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring

Ravi F. Sood, Saman Arbabi, Shari Honari, Nicole S. Gibran

PLoS One. 2016; 11(2): e0149206. Published online 2016 Feb 12. doi: 10.1371/journal.pone.0149206

PMCID:: PMC4752497

Abstract Article PDF–434K

Select item 43646244.

STEP Levels Are Unchanged in Pre-Frontal Cortex and Associative Striatum in Post-Mortem Human Brain Samples from Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder

Thomas A. Lanz, J. Julie Joshi, Veronica Reinhart, Kjell Johnson, Lonnie E. Grantham II, Dmitri Volfson

PLoS One. 2015; 10(3): e0121744. Published online 2015 Mar 18. doi: 10.1371/journal.pone.0121744

PMCID:: PMC4364624

Abstract Article PDF–352K

Select item 42598355.

Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders

Takatoshi Karasawa, Paul J. Lombroso

Neurosci Res. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Neurosci Res. 2014 Dec; 0: 1–9. Published online 2014 Sep 10. doi: 10.1016/j.neures.2014.08.018

PMCID:: PMC4259835

Abstract Article PDF–475K

Select item 40656186.

Alterations in Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Expression, Activation and Downstream Signaling in Early and Late Stages of the YAC128 Huntington’s Disease Mouse Model

Clare M. Gladding, Jing Fan, Lily Y. J. Zhang, Liang Wang, Jian Xu, Edward H. Y. Li, Paul J. Lombroso, Lynn A. Raymond

J Neurochem. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: J Neurochem. 2014 Jul; 130(1): 145–159. Published online 2014 Apr 2. doi: 10.1111/jnc.12700

PMCID:: PMC4065618

Abstract Article PDF–1.2M

Select item 37603437.

Involvement of PTPN5, the gene encoding the STriatal-Enriched protein tyrosine Phosphatase (STEP), in schizophrenia and cognition

Ilana Pelov, Omri Teltsh, Lior Greenbaum, Amihai Rigbi, Kyra Kanyas-Sarner, Bernard Lerer, Paul Lombroso, Yoav Kohn

Psychiatr Genet. Author manuscript; available in PMC 2013 Sep 3.

Published in final edited form as: Psychiatr Genet. 2012 Aug; 22(4): 168–176. doi: 10.1097/YPG.0b013e3283518586

PMCID:: PMC3760343

Abstract Article PDF–401K

Select item 32305118.

The role of STEP in Alzheimer disease

Pradeep Kurup, Yongfang Zhang, Deepa V Venkitaramani, Jian Xu, Paul J Lombroso

Channels (Austin) 2010 Sep-Oct; 4(5): 347–350. Published online 2010 Sep 1. doi: 10.4161/chan.4.5.12910

PMCID:: PMC3230511

Abstract Article PDF–429K

Select item 98402889.

Tyrosine phosphatase STEP₆₁ in human dementia and in animal models with amyloid and tau pathology

Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Götz

Mol Brain. 2023; 16: 6. Published online 2023 Jan 13. doi: 10.1186/s13041-023-00994-3

PMCID:: PMC9840288

Abstract Article PDF–1.0M

Select item 653691510.

Loss of STEP₆₁ couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing

Annemarie Dedek, Jian Xu, Chaya M Kandegedara, Louis-Étienne Lorenzo, Antoine G Godin, Yves De Koninck, Paul J Lombroso, Eve C Tsai, Michael E Hildebrand

Brain. 2019 Jun; 142(6): 1535–1546. Published online 2019 May 28. doi: 10.1093/brain/awz105

PMCID:: PMC6536915

Abstract Article PDF–5.9M

Select item 372564411.

THE TYROSINE PHOSPHATASE STEP CONSTRAINS AMYGDALA-DEPENDENT MEMORY FORMATION AND NEUROPLASTICITY

P. OLAUSSON, D. V. VENKITARAMANI, T. D. MORAN, M. W. SALTER, J. R. TAYLOR, P. J. LOMBROSO

Neuroscience. Author manuscript; available in PMC 2013 Jul 29.

Published in final edited form as: Neuroscience. 2012 Dec 6; 225: 1–8. Published online 2012 Aug 9. doi: 10.1016/j.neuroscience.2012.07.069

PMCID:: PMC3725644

Abstract Article PDF–1.0M

Select item 5227012.

Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.

P J Lombroso, G Murdoch, M Lerner

Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16): 7242–7246. doi: 10.1073/pnas.88.16.7242

PMCID:: PMC52270

Summary Page Browse PDF–1.5M

Select item 258602813.

Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability

Sebastian Korff, Stefan M Woerner, Yan P Yuan, Peer Bork, Magnus von Knebel Doeberitz, Johannes Gebert

BMC Cancer. 2008; 8: 329. Published online 2008 Nov 10. doi: 10.1186/1471-2407-8-329

PMCID:: PMC2586028

Abstract Article PDF–500K

Select item 146269814.

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases

Jeyanthy Eswaran, Jens Peter von Kries, Brian Marsden, Emma Longman, Judit É. Debreczeni, Emilie Ugochukwu, Andrew Turnbull, Wen Hwa Lee, Stefan Knapp, Alastair J. Barr

Biochem J. 2006 May 1; 395(Pt 3): 483–491. Prepublished online 2006 Jan 30. Published online 2006 Apr 11. doi: 10.1042/BJ20051931