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Items: 1 to 20 of 77

1.
Three-Dimensional Visualization of APEX2-Tagged Erg11 in Saccharomyces cerevisiae Using Focused Ion Beam Scanning Electron Microscopy
Winnie Kerstens, Anneke Kremer, Michelle Holtappels, Peter Borghgraef, Saskia Lippens, Patrick Van Dijck
mSphere. 2020 Jan-Feb; 5(1): e00981-19. Published online 2020 Feb 5. doi: 10.1128/mSphere.00981-19
PMCID:
PMC7002314
ArticlePDF–1.6M
2.
Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
Brian C. Monk, Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, Danyon O. Graham, Harith F. Hassan, Danni Chen, Joel D. A. Tyndall
Antimicrob Agents Chemother. 2019 Jan; 63(1): e02114-18. Prepublished online 2018 Nov 5. Published online 2018 Dec 21. doi: 10.1128/AAC.02114-18
PMCID:
PMC6325177
ArticlePDF–4.1M
3.
Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase
Alia A. Sagatova, Mikhail V. Keniya, Rajni K. Wilson, Manya Sabherwal, Joel D. A. Tyndall, Brian C. Monk
Sci Rep. 2016; 6: 26213. Published online 2016 May 18. doi: 10.1038/srep26213
PMCID:
PMC4870556
ArticlePDF–1.4M
4.
Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase
Alia A. Sagatova, Mikhail V. Keniya, Rajni K. Wilson, Brian C. Monk, Joel D. A. Tyndall
Antimicrob Agents Chemother. 2015 Aug; 59(8): 4982–4989. Prepublished online 2015 Jun 8. Published online 2015 Jul 16. doi: 10.1128/AAC.00925-15
PMCID:
PMC4505223
ArticlePDF–1.3M
5.
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer
Brian C. Monk, Thomas M. Tomasiak, Mikhail V. Keniya, Franziska U. Huschmann, Joel D. A. Tyndall, Joseph D. O’Connell, III, Richard D. Cannon, Jeffrey G. McDonald, Andrew Rodriguez, Janet S. Finer-Moore, Robert M. Stroud
Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10): 3865–3870. Published online 2014 Feb 3. doi: 10.1073/pnas.1324245111
PMCID:
PMC3956205
ArticlePDF–1.3M
6.
An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p
Dominic Hoepfner, Shantanu Karkare, Stephen B. Helliwell, Martin Pfeifer, Markus Trunzer, Sophie De Bonnechose, Alfred Zimmerlin, Jianshi Tao, Daryl Richie, Andreas Hofmann, Stefan Reinker, Mathias Frederiksen, N. Rao Movva, Jeffrey A. Porter, Neil S. Ryder, Christian N. Parker
Antimicrob Agents Chemother. 2012 Aug; 56(8): 4233–4240. doi: 10.1128/AAC.06332-11
PMCID:
PMC3421618
ArticlePDF–1.5M
7.
Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B
Claire M. Hull, Josie E. Parker, Oliver Bader, Michael Weig, Uwe Gross, Andrew G. S. Warrilow, Diane E. Kelly, Steven L. Kelly
Antimicrob Agents Chemother. 2012 Aug; 56(8): 4223–4232. doi: 10.1128/AAC.06253-11
PMCID:
PMC3421581
ArticlePDF–2.0M
8.
Potent Synergistic Effect of Doxycycline with Fluconazole against Candida albicans Is Mediated by Interference with Iron Homeostasis
Alessandro Fiori, Patrick Van Dijck
Antimicrob Agents Chemother. 2012 Jul; 56(7): 3785–3796. doi: 10.1128/AAC.06017-11
PMCID:
PMC3393430
ArticlePDF–1.5M
9.
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B
Claire M. Martel, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Steven L. Kelly, Diane E. Kelly
Antimicrob Agents Chemother. 2010 Nov; 54(11): 4920–4923. Published online 2010 Aug 23. doi: 10.1128/AAC.00349-10
PMCID:
PMC2976139
ArticlePDF–141K
10.
Molecular Basis for Enhanced Activity of Posaconazole against Absidia corymbifera and Rhizopus oryzae
Andrew S. Chau, Guodong Chen, Paul M. McNicholas, Paul A. Mann
Antimicrob Agents Chemother. 2006 Nov; 50(11): 3917–3919. Published online 2006 Sep 11. doi: 10.1128/AAC.00747-06
PMCID:
PMC1635193
ArticlePDF–54K
11.
Cytochromes P-450 of yeasts.
O Käppeli
Microbiol Rev. 1986 Sep; 50(3): 244–258. doi: 10.1128/mr.50.3.244-258.1986
PMCID:
PMC373070
SummaryPage BrowsePDF–2.8M
12.
Overexpression of Erg11p by the Regulatable GAL1 Promoter Confers Fluconazole Resistance in Saccharomyces cerevisiae
Dimitrios P. Kontoyiannis, Namita Sagar, Kendal D. Hirschi
Antimicrob Agents Chemother. 1999 Nov; 43(11): 2798–2800. doi: 10.1128/aac.43.11.2798
PMCID:
PMC89564
ArticlePDF–186K
13.
Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast
Sabine Ottilie, Gregory M. Goldgof, Claudia Magalhaes Calvet, Gareth K. Jennings, Greg LaMonte, Jake Schenken, Edgar Vigil, Prianka Kumar, Laura-Isobel McCall, Eduardo Soares Constantino Lopes, Felicia Gunawan, Jennifer Yang, Yo Suzuki, Jair L. Siqueira-Neto, James H. McKerrow, Rommie E. Amaro, Larissa M. Podust, Jacob D. Durrant, Elizabeth A. Winzeler
ACS Chem Biol. Author manuscript; available in PMC 2017 Oct 20.
Published in final edited form as: ACS Chem Biol. 2017 Feb 17; 12(2): 422–434. Published online 2016 Dec 23. doi: 10.1021/acschembio.6b01037
PMCID:
PMC5649375
ArticlePDF–2.0M
14.
Determination of the Heme Affinity for Yeast Dap1p, and its Importance in Cellular Function
Alisha M. Thompson, Amit R. Reddi, Xiaoli Shi, Robert A. Goldbeck, Pierre Moënne-Loccoz, Brian R. Gibney, Theodore R. Holman
Biochemistry. Author manuscript; available in PMC 2009 Apr 16.
Published in final edited form as: Biochemistry. 2007 Dec 18; 46(50): 14629–14637. Published online 2007 Nov 22. doi: 10.1021/bi7013739
PMCID:
PMC2669782
ArticlePDF–1.4M
15.
Dap1p, a Heme-Binding Protein That Regulates the Cytochrome P450 Protein Erg11p/Cyp51p in Saccharomyces cerevisiae
Julia C. Mallory, Gerard Crudden, Ben L. Johnson, Caiqing Mo, Charles A. Pierson, Martin Bard, Rolf J. Craven
Mol Cell Biol. 2005 Mar; 25(5): 1669–1679. doi: 10.1128/MCB.25.5.1669-1679.2005
PMCID:
PMC549369
ArticlePDF–469K
16.
Requirement for a second sterol biosynthetic mutation for viability of a sterol C-14 demethylation defect in Saccharomyces cerevisiae.
F R Taylor, R J Rodriguez, L W Parks
J Bacteriol. 1983 Jul; 155(1): 64–68. doi: 10.1128/jb.155.1.64-68.1983
PMCID:
PMC217652
SummaryPage BrowsePDF–681K
17.
Relationship between antifungal activity and inhibition of sterol biosynthesis in miconazole, clotrimazole, and 15-azasterol.
F R Taylor, R J Rodriguez, L W Parks
Antimicrob Agents Chemother. 1983 Apr; 23(4): 515–521. doi: 10.1128/aac.23.4.515
PMCID:
PMC184691
SummaryPage BrowsePDF–896K
18.
Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli.
K Venkateswarlu, D E Kelly, S L Kelly
Antimicrob Agents Chemother. 1997 Apr; 41(4): 776–780. doi: 10.1128/aac.41.4.776
PMCID:
PMC163793
SummaryPDF–206K
19.
Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase
Alia A. Sagatova, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Antimicrob Agents Chemother. 2018 Mar; 62(3): e02242-17. Prepublished online 2017 Dec 20. Published online 2018 Feb 23. doi: 10.1128/AAC.02242-17
PMCID:
PMC5826108
ArticlePDF–1.4M
20.
Discovering hotspots in functional genomic data superposed on 3D chromatin configuration reconstructions
Daniel Capurso, Henrik Bengtsson, Mark R. Segal
Nucleic Acids Res. 2016 Mar 18; 44(5): 2028–2035. Published online 2016 Feb 10. doi: 10.1093/nar/gkw070
PMCID:
PMC4797302
ArticlePDF–1.0M

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