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Select item 83497961.

Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast

Joseph L. Sottnik, Evelyn K. Bordeaux, Sanjana Mehrotra, Sarah E. Ferrara, Andrew E. Goodspeed, James C. Costello, Matthew J. Sikora

Mol Cancer Res. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Mol Cancer Res. 2021 Aug; 19(8): 1270–1282. Published online 2021 May 4. doi: 10.1158/1541-7786.MCR-21-0025

PMCID:: PMC8349796

Article PDF–2.3M

Select item 83191432.

Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study

Kenta Nishi, Hisako Matsumoto, Noriyuki Tashima, Satoru Terada, Natsuko Nomura, Mariko Kogo, Chie Morimoto, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Yoshinari Nakatsuka, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Kazuhiro Sonomura, Fumihiko Matsuda, Kazuo Chin, Toyohiro Hirai

Sci Rep. 2021; 11: 15373. Published online 2021 Jul 28. doi: 10.1038/s41598-021-94835-9

PMCID:: PMC8319143

Article PDF–1.5M

Select item 78407713.

Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53–ROS–Mitochondrial Pathway

Zhihai Wang, Kui Liao, Wenqi Zuo, Xueliang Liu, Zhili Qiu, Zhitao Gong, Chuan Liu, Quan Zeng, Yi Qian, Liang Jiang, Youquan Bu, Suling Hong, Guohua Hu

Oncol Res. 2017; 25(1): 123–136. Published online 2017 Jan 2. doi: 10.3727/096504016X14732772150226

PMCID:: PMC7840771

Article PDF–23M

Select item 70668454.

MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells

Neeru Singh, Rashmi Bhakuni, Dimple Chhabria, Sivapriya Kirubakaran

BMC Res Notes. 2020; 13: 146. Published online 2020 Mar 11. doi: 10.1186/s13104-020-04996-5

PMCID:: PMC7066845

Article PDF–2.8M

Select item 41578005.

A Newfound Association between MDC1 Functional Polymorphism and Lung Cancer Risk in Chinese

Bo Wang, Lisha Zhang, Fuman Qiu, Wenxiang Fang, Jieqiong Deng, Yifeng Zhou, Jiachun Lu, Lei Yang

PLoS One. 2014; 9(9): e106794. Published online 2014 Sep 8. doi: 10.1371/journal.pone.0106794

Correction in:: PLoS One. 2015; 10(1): e0117882.

PMCID:: PMC4157800

Article PDF–198K

Select item 29634036.

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

S. Mehdi Belgnaoui, Kimberly A. Fryrear, Julius O. Nyalwidhe, Xin Guo, O. John Semmes

J Biol Chem. 2010 Oct 22; 285(43): 32897–32905. Published online 2010 Aug 20. doi: 10.1074/jbc.M110.146373

PMCID:: PMC2963403

Article PDF–1.7M

Select item 89231287.

Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci

Jian Xu, Mayrel Palestino Dominguez, Christine Alewine

Cancer Commun (Lond) 2022 Mar; 42(3): 269–272. Published online 2021 Dec 8. doi: 10.1002/cac2.12243

PMCID:: PMC8923128

Article PDF–774K

Select item 68583078.

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson

Nat Commun. 2019; 10: 5191. Published online 2019 Nov 15. doi: 10.1038/s41467-019-12929-5

PMCID:: PMC6858307

Article PDF–2.8M

Select item 64110109.

The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms

Alexander J. Garvin, Alexandra K. Walker, Ruth M. Densham, Anoop Singh Chauhan, Helen R. Stone, Hannah L. Mackay, Mohammed Jamshad, Katarzyna Starowicz, Manuel Daza-Martin, George E. Ronson, Alexander J. Lanz, James F. Beesley, Joanna R. Morris

Genes Dev. 2019 Mar 1; 33(5-6): 333–347. doi: 10.1101/gad.321125.118

PMCID:: PMC6411010

Article PDF–7.7M

Select item 563890810.

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You

Nat Commun. 2017; 8: 903. Published online 2017 Oct 12. doi: 10.1038/s41467-017-01051-z

Correction in:: Nat Commun. 2018; 9: 2284.

PMCID:: PMC5638908

Article PDF–3.3M

Select item 455850611.

Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition

Z Wang, Q Zeng, T Chen, K Liao, Y Bu, S Hong, G Hu

Cell Death Dis. 2015 Aug; 6(8): e1849. Published online 2015 Aug 6. doi: 10.1038/cddis.2015.214

PMCID:: PMC4558506

Article PDF–2.4M

Select item 444644312.

MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer

Chunyu Wang, Hongmiao Sun, Renlong Zou, Tingting Zhou, Shengli Wang, Shiying Sun, Changci Tong, Hao Luo, Yanshu Li, Zhenhua Li, Enhua Wang, Yuhua Chen, Liu Cao, Feng Li, Yue Zhao

Nucleic Acids Res. 2015 May 26; 43(10): 4893–4908. Published online 2015 Apr 30. doi: 10.1093/nar/gkv394

PMCID:: PMC4446443

Article PDF–7.5M

Select item 438160913.

A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer

Yao Xue, Gaoxiang Ma, Zhensheng Zhang, Qiuhan Hua, Haiyan Chu, Na Tong, Lin Yuan, Chao Qin, Changjun Yin, Zhengdong Zhang, Meilin Wang

Oncotarget. 2015 Jan; 6(1): 484–493. Published online 2014 Nov 6. doi: 10.18632/oncotarget.2861

PMCID:: PMC4381609

Article PDF–3.4M

Select item 396164714.

Interplay between the DNA Damage Proteins MDC1 and ATM in the Regulation of the Spindle Assembly Checkpoint

Yifat Eliezer, Liron Argaman, Maya Kornowski, Maayan Roniger, Michal Goldberg

J Biol Chem. 2014 Mar 21; 289(12): 8182–8193. Published online 2014 Feb 7. doi: 10.1074/jbc.M113.532739

PMCID:: PMC3961647

Article PDF–2.3M

Select item 376028015.

Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control

Charles Chung Yun Leung, Luxin Sun, Zihua Gong, Michael Burkat, Ross Edwards, Mark Assmus, Junjie Chen, J.N. Mark Glover

Structure. Author manuscript; available in PMC 2014 Aug 6.

Published in final edited form as: Structure. 2013 Aug 6; 21(8): 1450–1459. Published online 2013 Jul 25. doi: 10.1016/j.str.2013.06.015

PMCID:: PMC3760280

Article PDF–3.4M

Select item 348816616.

CDK1 Regulates Mediator of DNA Damage Checkpoint 1 (MDC1) During Mitotic DNA Damage

Bing Yu, W. Brian Dalton, Vincent W. Yang

Cancer Res. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Cancer Res. 2012 Nov 1; 72(21): 5448–5453. Published online 2012 Sep 7. doi: 10.1158/0008-5472.CAN-12-2354

PMCID:: PMC3488166

Article PDF–2.3M

Select item 339509917.

Sumoylation of MDC1 is important for proper DNA damage response

Kuntian Luo, Haoxing Zhang, Liewei Wang, Jian Yuan, Zhenkun Lou

EMBO J. 2012 Jun 29; 31(13): 3008–3019. Published online 2012 May 25. doi: 10.1038/emboj.2012.158

PMCID:: PMC3395099

Article PDF–2.4M

Select item 335116118.

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

Stephanie Jungmichel, Julie A. Clapperton, Janette Lloyd, Flurina J. Hari, Christoph Spycher, Lucijana Pavic, Jiejin Li, Lesley F. Haire, Mario Bonalli, Dorthe H. Larsen, Claudia Lukas, Jiri Lukas, Derek MacMillan, Michael L. Nielsen, Manuel Stucki, Stephen J. Smerdon

Nucleic Acids Res. 2012 May; 40(9): 3913–3928. Published online 2012 Jan 10. doi: 10.1093/nar/gkr1300