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Select item 108073571.

CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses

Hao Lou, Zelai Wu, Guangyou Wei

Oncol Rep. 2024 Feb; 51(2): 35. Published online 2024 Jan 3. doi: 10.3892/or.2024.8694

PMCID:: PMC10807357

Article PDF–14M

Select item 93163282.

CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma

Feng Wang, Fen Zhao, Li Zhang, Lai Xiong, Qing Mao, Yanhui Liu, Xiaoguang Qiu, Xiang Wang, Lin Shui, Xi Chen, Kexing Ren, Pixian Shui, Qiongwen Zhang, Yifei Deng, Weimin Li, Xiaoqi Xie, Dengbin Wu, Tao Li, Jinyi Lang, Lei Liu, Huaying Chen, Jianguo Xu, Sen Bai, Zhiping Li, Qiang Yue, Ni Chen, Bingwen Zhou, Cheng Yi, Yuquan Wei, Yuchuan Fu, Yong Luo, Qiheng Gou, Lunxu Liu, Yuanzhao Liu, Jingbo Kang, Junjie Wang, Dongcun Jing, Fuquan Zhang, Xiaoyan Yang, Xianfeng Li, Tao Jiang, Zongcun Zhang, Yizhi Zhou, Junlin Yi

Mol Cancer. 2022; 21: 153. Published online 2022 Jul 25. doi: 10.1186/s12943-022-01623-8

PMCID:: PMC9316328

Article PDF–2.1M

Select item 74963463.

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation

Nicholas Lim, Paul A. Townsend

Int J Cancer. 2020 Sep 15; 147(6): 1528–1534. Published online 2020 Feb 17. doi: 10.1002/ijc.32900

PMCID:: PMC7496346

Article PDF–516K

Select item 73073574.

A pilot study of cdc6 as a biomarker for circulating tumor cells in patients with lung cancer

Cheng An, Guijian Liu, Shi Cheng, Bo Pang, Shipeng Sun, Yaying Zhang, Zhongdai Pan, Xixiong Kang

J Clin Lab Anal. 2020 Jun; 34(6): e23245. Published online 2020 Apr 6. doi: 10.1002/jcla.23245

PMCID:: PMC7307357

Article PDF–774K

Select item 63456735.

Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition

Xiaohui Yu, Youhong Liu, Linglong Yin, Yongbo Peng, Yuchong Peng, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Bowen Xie, Lunquan Sun, Yan Chen, Zhicheng Gong, Yuanzheng Qiu, Xuegong Fan, Xiong Li

Oncogene. 2019; 38(4): 549–563. Published online 2018 Aug 29. doi: 10.1038/s41388-018-0460-4

PMCID:: PMC6345673

Article PDF–5.6M

Select item 57507116.

The Replication Protein Cdc6 Suppresses Centrosome Over-Duplication in a Manner Independent of Its ATPase Activity

Gwang Su Kim, Inyoung Lee, Ji Hun Kim, Deog Su Hwang

Mol Cells. 2017 Dec 31; 40(12): 925–934. Published online 2017 Dec 12. doi: 10.14348/molcells.2017.0191

PMCID:: PMC5750711

Article PDF–2.1M

Select item 56250567.

The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome

Inyoung Lee, Gwang Su Kim, Jun Sung Bae, Jaeyoun Kim, Kunsoo Rhee, Deog Su Hwang

J Biol Chem. 2017 Sep 29; 292(39): 16267–16276. Published online 2017 Aug 21. doi: 10.1074/jbc.M116.763680

PMCID:: PMC5625056

Article PDF–2.9M

Select item 54141748.

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang

Nat Commun. 2017; 8: 15164. Published online 2017 Apr 27. doi: 10.1038/ncomms15164

PMCID:: PMC5414174

Article PDF–3.0M

Select item 51300139.

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells

Sansan Chen, Xinglu Chen, Gui'e Xie, Yue He, Daoyu Yan, Dianpeng Zheng, Shi Li, Xinyang Fu, Yeping Li, Xiang Pang, Zhiming Hu, Hongwei Li, Wanlong Tan, Jinlong Li

Oncotarget. 2016 Jun 28; 7(26): 40362–40376. Published online 2016 May 26. doi: 10.18632/oncotarget.9616

PMCID:: PMC5130013

Article PDF–6.2M

Select item 461485810.

Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis

Faiza M Kalfalah, Elke Berg, Morten O Christensen, René M Linka, Wilhelm G Dirks, Fritz Boege, Christian Mielke

Cell Cycle. 2015 Jun 3; 14(11): 1704–1715. Published online 2015 Apr 15. doi: 10.1080/15384101.2014.1000182

PMCID:: PMC4614858

Article PDF–1.2M

Select item 344291611.

CDC6 expression is regulated by lineage-specific transcription factor GATA1

Bárbara Fernández-Morales, Leticia Pavón, Carmela Calés

Cell Cycle. 2012 Aug 15; 11(16): 3055–3066. doi: 10.4161/cc.21471

PMCID:: PMC3442916

Article PDF–3.1M

Select item 337023912.

HBx Protein of Hepatitis B Virus Promotes Reinitiation of DNA Replication by Regulating Expression and Intracellular Stability of Replication Licensing Factor CDC6

Vijaya Pandey, Vijay Kumar

J Biol Chem. 2012 Jun 8; 287(24): 20545–20554. Published online 2012 Apr 20. doi: 10.1074/jbc.M112.359760

PMCID:: PMC3370239

Article PDF–2.5M

Select item 331509413.

Cdc6 is required for meiotic spindle assembly in Xenopus oocytes

Yadushyla Narasimhachar, Daniel R Webster, David L Gard, Martine Coué

Cell Cycle. 2012 Feb 1; 11(3): 524–531. Published online 2012 Feb 1. doi: 10.4161/cc.11.3.19033

PMCID:: PMC3315094

Article PDF–36M

Select item 272430114.

A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression

Feng Jin, Joseph D. Fondell

Nucleic Acids Res. 2009 Aug; 37(14): 4826–4838. Published online 2009 Jun 11. doi: 10.1093/nar/gkp510

PMCID:: PMC2724301

Article PDF–1.8M

Select item 206416615.

Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase–mediated apoptosis of HeLa cells

Hyungshin Yim, In Sun Hwang, Joon-Seok Choi, Kwang-Hoon Chun, Ying Hua Jin, Young-Mi Ham, Kwang Youl Lee, Seung Ki Lee

J Cell Biol. 2006 Jul 3; 174(1): 77–88. doi: 10.1083/jcb.200509141

PMCID:: PMC2064166

Article PDF–3.3M

Select item 145692116.

The functional role of Cdc6 in S–G2/M in mammalian cells

Eric Lau, Changjun Zhu, Robert T Abraham, Wei Jiang

EMBO Rep. 2006 Apr; 7(4): 425–430. Published online 2006 Jan 27. doi: 10.1038/sj.embor.7400624

PMCID:: PMC1456921

Article PDF–193K

Select item 117106817.

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

K Stoeber, A D Mills, Y Kubota, T Krude, P Romanowski, K Marheineke, R A Laskey, G H Williams

EMBO J. 1998 Dec 15; 17(24): 7219–7229. doi: 10.1093/emboj/17.24.7219

PMCID:: PMC1171068

Summary PDF–530K

Select item 53568918.

A novel E2 box-GATA element modulates Cdc6 transcription during human cells polyploidization

Nuria Vilaboa, Rodrigo Bermejo, Pilar Martinez, Rafael Bornstein, Carmela Calés

Nucleic Acids Res. 2004; 32(21): 6454–6467. Published online 2004 Dec 8. doi: 10.1093/nar/gkh981

PMCID:: PMC535689

Article PDF–809K

Select item 20701619.

Caspase-3-mediated Cleavage of Cdc6 Induces Nuclear Localization of p49-truncated Cdc6 and Apoptosis

Hyungshin Yim, Ying Hua Jin, Byoung Duck Park, Hye Jin Choi, Seung Ki Lee

Mol Biol Cell. 2003 Oct; 14(10): 4250–4259. doi: 10.1091/mbc.E03-01-0029

PMCID:: PMC207016

Article PDF–669K

Select item 14073120.

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1

Lorena Clay-Farrace, Cristina Pelizon, David Santamaria, Jonathon Pines, Ronald A. Laskey

EMBO J. 2003 Feb 3; 22(3): 704–712. doi: 10.1093/emboj/cdg046

PMCID:: PMC140731

Article PDF–271K

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