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Select item 60536571.

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

Hidetoshi Tsushima, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, Benjamin A. Alman

Development. 2018 Jul 1; 145(13): dev162396. Published online 2018 Jul 9. doi: 10.1242/dev.162396

PMCID:: PMC6053657

Article

Select item 54571412.

Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia

Xin Heng, Qiuxia Guo, Alan W Leung, James YH Li

eLife. 2017; 6: e23253. Published online 2017 May 10. doi: 10.7554/eLife.23253

PMCID:: PMC5457141

Article PDF–11M

Select item 53777603.

Normalization of Hepatic Homeostasis in the Npc1^nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat

Andrew B. Munkacsi, Natalie Hammond, Remy T. Schneider, Dinindu S. Senanayake, Katsumi Higaki, Kirill Lagutin, Stephen J. Bloor, Daniel S. Ory, Robert A. Maue, Fannie W. Chen, Antonio Hernandez-Ono, Nicole Dahlson, Joyce J. Repa, Henry N. Ginsberg, Yiannis A. Ioannou, Stephen L. Sturley

J Biol Chem. 2017 Mar 17; 292(11): 4395–4410. Published online 2016 Dec 28. doi: 10.1074/jbc.M116.770578

PMCID:: PMC5377760

Article PDF–2.8M

Select item 51579844.

Chardonnay Grape Seed Flour Ameliorates Hepatic Steatosis and Insulin Resistance via Altered Hepatic Gene Expression for Oxidative Stress, Inflammation, and Lipid and Ceramide Synthesis in Diet-Induced Obese Mice

Kun-Ho Seo, Glenn E. Bartley, Christina Tam, Hong-Seok Kim, Dong-Hyeon Kim, Jung-Whan Chon, Hyunsook Kim, Wallace Yokoyama

PLoS One. 2016; 11(12): e0167680. Published online 2016 Dec 15. doi: 10.1371/journal.pone.0167680

PMCID:: PMC5157984

Article PDF–1.4M

Select item 50452005.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355

PMCID:: PMC5045200

Article PDF–2.9M

Select item 48879516.

Skeletal muscle insulin resistance in hamsters with diabetes developed from obesity is involved in abnormal skeletal muscle LXR, PPAR and SREBP expression

GUO-SHENG LI, XU-HAN LIU, HUA ZHU, LAN HUANG, YA-LI LIU, CHUN-MEI MA

Exp Ther Med. 2016 Jun; 11(6): 2259–2269. Published online 2016 Mar 31. doi: 10.3892/etm.2016.3209

PMCID:: PMC4887951

Article PDF–648K

Select item 47669907.

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

Laurent Vergnes, Robert G. Chin, Thomas de Aguiar Vallim, Loren G. Fong, Timothy F. Osborne, Stephen G. Young, Karen Reue

J Lipid Res. 2016 Mar; 57(3): 410–421. doi: 10.1194/jlr.M064022

PMCID:: PMC4766990

Article PDF–1.7M

Select item 47010418.

The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice

Ornella de Bari, Helen H. Wang, Piero Portincasa, Min Liu, David Q.-H. Wang

Biochim Biophys Acta. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2015 Oct; 1852(10 0 0): 2161–2169. Published online 2015 Jul 30. doi: 10.1016/j.bbadis.2015.07.020

PMCID:: PMC4701041

Article PDF–1.7M

Select item 45289179.

Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters

Minhao Wu, Bin Dong, Aiqin Cao, Hai Li, Jingwen Liu

Atherosclerosis. Author manuscript; available in PMC 2015 Aug 7.

Published in final edited form as: Atherosclerosis. 2012 Oct; 224(2): 401–410. Published online 2012 Aug 24. doi: 10.1016/j.atherosclerosis.2012.08.012

PMCID:: PMC4528917

Article PDF–1.2M

Select item 414205310.

DIETARY PROCYANIDINS ENHANCE TRANSCRIPTIONAL ACTIVITY OF BILE ACID-ACTIVATED FXR IN VITRO AND REDUCE TRIGLYCERIDEMIA IN VIVO IN A FXR-DEPENDENT MANNER

Josep Maria Del Bas, Marie-Louise Ricketts, Montserrat Vaqué, Esther Sala, Helena Quesada, Anna Ardevol, M. Josepa Salvadó, Mayte Blay, Lluís Arola, David D. Moore, Gerard Pujadas, Juan Fernandez-Larrea, Cinta Bladé

Mol Nutr Food Res. Author manuscript; available in PMC 2014 Aug 23.

Published in final edited form as: Mol Nutr Food Res. 2009 Jul; 53(7): 805–814. doi: 10.1002/mnfr.200800364

PMCID:: PMC4142053

Article PDF–540K

Select item 403511511.

Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1

Dorothy I. Mundy, Adam M. Lopez, Kenneth S. Posey, Jen-Chieh Chuang, Charina M. Ramirez, Philipp E. Scherer, Stephen D. Turley

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Jul; 1841(7): 995–1002. Published online 2014 Apr 18. doi: 10.1016/j.bbalip.2014.04.002

PMCID:: PMC4035115

Article PDF–1.2M

Select item 398990012.

Sustained and Selective Suppression of Intestinal Cholesterol Synthesis by Ro 48-8071, an Inhibitor of 2,3-Oxidosqualene:Lanosterol Cyclase, in the BALB/c Mouse

Jen-Chieh Chuang, Mark A. Valasek, Adam M. Lopez, Kenneth S. Posey, Joyce J. Repa, Stephen D. Turley

Biochem Pharmacol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Biochem Pharmacol. 2014 Apr 1; 88(3): 351–363. Published online 2014 Jan 31. doi: 10.1016/j.bcp.2014.01.031

PMCID:: PMC3989900

Article PDF–5.2M

Select item 385363213.

α-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression

Satoshi Fukumitsu, Myra O. Villareal, Shoko Onaga, Kazuhiko Aida, Junkyu Han, Hiroko Isoda

Cytotechnology. 2013 Dec; 65(6): 899–907. Published online 2012 Nov 9. doi: 10.1007/s10616-012-9510-x

PMCID:: PMC3853632

Article PDF–363K

Select item 380887014.

Candidate genes for limiting cholestatic intestinal injury identified by gene expression profiling

Samuel M Alaish, Jennifer Timmons, Alexis Smith, Marguerite S Buzza, Ebony Murphy, Aiping Zhao, Yezhou Sun, Douglas J Turner, Terez Shea-Donahue, Toni M Antalis, Alan Cross, Susan G Dorsey

Physiol Rep. 2013 Sep; 1(4): e00073. Published online 2013 Sep 17. doi: 10.1002/phy2.73