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Select item 69806851.

PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

Julian Naipauer, Santas Rosario, Sachin Gupta, Courtney Premer, Omayra Méndez-Solís, Mariana Schlesinger, Virginia Ponzinibbio, Vaibhav Jain, Lauren Gay, Rolf Renne, Ho Lam Chan, Lluis Morey, Daria Salyakina, Martin Abba, Sion Williams, Joshua M. Hare, Pascal J. Goldschmidt-Clermont, Enrique A. Mesri

PLoS Pathog. 2019 Dec; 15(12): e1008221. Published online 2019 Dec 27. doi: 10.1371/journal.ppat.1008221

PMCID:: PMC6980685

Article PDF–6.5M

Select item 69328162.

A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment

Thomas Günther, Jacqueline Fröhlich, Christina Herrde, Shinji Ohno, Lia Burkhardt, Heiko Adler, Adam Grundhoff

PLoS Pathog. 2019 Oct; 15(10): e1007838. Published online 2019 Oct 31. doi: 10.1371/journal.ppat.1007838

PMCID:: PMC6932816

Article PDF–5.3M

Select item 66758863.

Kaposi Sarcoma-Associated Herpesvirus Glycoprotein H Is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types

Murali Muniraju, Lorraine Z. Mutsvunguma, Joslyn Foley, Gabriela M. Escalante, Esther Rodriguez, Romina Nabiee, Jennifer Totonchy, David H. Mulama, Joshua Nyagol, Felix Wussow, Anne K. Barasa, Michael Brehm, Javier Gordon Ogembo

J Virol. 2019 Aug 15; 93(16): e00630-19. Prepublished online 2019 May 29. Published online 2019 Jul 30. doi: 10.1128/JVI.00630-19

PMCID:: PMC6675886

Article PDF–3.2M

Select item 66493144.

Kaposi Sarcoma in Mantled Guereza

Anna Grewer, Martina Bleyer, Kerstin Mätz-Rensing, Alexander S. Hahn, Tim Rüggeberg, Gregor Babaryka, Andre Zimmermann, Stefan Pöhlmann, Artur Kaul

Emerg Infect Dis. 2019 Aug; 25(8): 1552–1555. doi: 10.3201/eid2508.181804

PMCID:: PMC6649314

Article PDF–2.0M

Select item 65908365.

The landscape of transcription initiation across latent and lytic KSHV genomes

Xiang Ye, Yang Zhao, John Karijolich

PLoS Pathog. 2019 Jun; 15(6): e1007852. Published online 2019 Jun 12. doi: 10.1371/journal.ppat.1007852

PMCID:: PMC6590836

Article PDF–4.3M

Select item 65413086.

An integrative approach identifies direct targets of the late viral transcription complex and an expanded promoter recognition motif in Kaposi’s sarcoma-associated herpesvirus

Divya Nandakumar, Britt Glaunsinger

PLoS Pathog. 2019 May; 15(5): e1007774. Published online 2019 May 16. doi: 10.1371/journal.ppat.1007774

PMCID:: PMC6541308

Article PDF–2.8M

Select item 65022527.

Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO)

Christian M. Zmasek, David M. Knipe, Philip E. Pellett, Richard H. Scheuermann

Virology. 2019 Mar; 529: 29–42. Published online 2019 Jan 6. doi: 10.1016/j.virol.2019.01.005

PMCID:: PMC6502252

Article PDF–2.1M

Select item 64727598.

KSHV lytic proteins K-RTA and K8 bind to cellular and viral chromatin to modulate gene expression

Rajeev Kaul, Pravinkumar Purushothaman, Timsy Uppal, Subhash C. Verma

PLoS One. 2019; 14(4): e0215394. Published online 2019 Apr 18. doi: 10.1371/journal.pone.0215394

PMCID:: PMC6472759

Article PDF–1.7M

Select item 64014409.

Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs

Nathan A. Ungerleider, Vaibhav Jain, Yiping Wang, Nicholas J. Maness, Robert V. Blair, Xavier Alvarez, Cecily Midkiff, Dennis Kolson, Shanshan Bai, Claire Roberts, Walter N. Moss, Xia Wang, Jacqueline Serfecz, Michael Seddon, Terri Lehman, Tianfang Ma, Yan Dong, Rolf Renne, Scott A. Tibbetts, Erik K. Flemington

J Virol. 2019 Mar 15; 93(6): e01952-18. Prepublished online 2018 Dec 19. Published online 2019 Mar 5. doi: 10.1128/JVI.01952-18

PMCID:: PMC6401440

Article PDF–2.0M

Select item 639694510.

Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system

Dajiang Li, Sankar Swaminathan

PLoS Pathog. 2019 Feb; 15(2): e1007609. Published online 2019 Feb 19. doi: 10.1371/journal.ppat.1007609

PMCID:: PMC6396945

Article PDF–2.8M

Select item 638407311.

Genome-Wide Identification of Direct RTA Targets Reveals Key Host Factors for Kaposi’s Sarcoma-Associated Herpesvirus Lytic Reactivation

Bernadett Papp, Naeem Motlagh, Richard J. Smindak, Seung Jin Jang, Aria Sharma, Juan D. Alonso, Zsolt Toth

J Virol. 2019 Mar 1; 93(5): e01978-18. Prepublished online 2018 Dec 12. Published online 2019 Feb 19. doi: 10.1128/JVI.01978-18

PMCID:: PMC6384073

Article PDF–3.7M

Select item 637174912.

Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesviruses

Teresa Martinez, Maxwell Shapiro, Sumita Bhaduri-McIntosh, Thomas MacCarthy

Virus Evol. 2019 Jan; 5(1): vey040. Published online 2019 Feb 11. doi: 10.1093/ve/vey040

PMCID:: PMC6371749

Article PDF–450K

Select item 636494613.

LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency

Alessandra De Leo, Zhong Deng, Olga Vladimirova, Horng-Shen Chen, Jayaraju Dheekollu, Abram Calderon, Kenneth A. Myers, James Hayden, Frederick Keeney, Benedikt B. Kaufer, Yan Yuan, Erle Robertson, Paul M. Lieberman

PLoS Pathog. 2019 Jan; 15(1): e1007489. Published online 2019 Jan 25. doi: 10.1371/journal.ppat.1007489

PMCID:: PMC6364946

Article PDF–3.8M

Select item 632814414.

Screening human cell lines for viral infections applying RNA-Seq data analysis

Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans G. Drexler

PLoS One. 2019; 14(1): e0210404. Published online 2019 Jan 10. doi: 10.1371/journal.pone.0210404

PMCID:: PMC6328144

Article PDF–1.5M

Select item 631234815.

Quantitative RNAseq analysis of Ugandan KS tumors reveals KSHV gene expression dominated by transcription from the LTd downstream latency promoter

Timothy M. Rose, A. Gregory Bruce, Serge Barcy, Matt Fitzgibbon, Lisa R. Matsumoto, Minako Ikoma, Corey Casper, Jackson Orem, Warren Phipps

PLoS Pathog. 2018 Dec; 14(12): e1007441. Published online 2018 Dec 17. doi: 10.1371/journal.ppat.1007441

PMCID:: PMC6312348

Article PDF–5.1M

Select item 629491316.

Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

Takanobu Tagawa, Shaojian Gao, Vishal N. Koparde, Mileidy Gonzalez, John L. Spouge, Anna P. Serquiña, Kathryn Lurain, Ramya Ramaswami, Thomas S. Uldrick, Robert Yarchoan, Joseph M. Ziegelbauer

Proc Natl Acad Sci U S A. 2018 Dec 11; 115(50): 12805–12810. Published online 2018 Nov 19. doi: 10.1073/pnas.1816183115

PMCID:: PMC6294913

Article PDF–1.1M

Select item 625468517.

Polymorphisms in KSHV-encoded microRNA sequences affect levels of mature viral microRNA in Kaposi Sarcoma lesions

Vickie A. Marshall, Nazzarena Labo, Joanna Sztuba-Solinska, Elena M. Cornejo Castro, Karen Aleman, Kathleen M. Wyvill, Lynne McNamara, Stuart F.J. Le Grice, Robert Yarchoan, Thomas S. Uldrick, Patrick MacPhail, Mark N. Polizzotto, Denise Whitby

Oncotarget. 2018 Nov 9; 9(88): 35856–35869. Published online 2018 Nov 9. doi: 10.18632/oncotarget.26321