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Items: 1 to 20 of 27

1.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
2.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
3.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
4.
SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors
Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée de Leeuw, Karen E. Knudsen, J. Alan Diehl
Sci Adv. 2019 Sep; 5(9): eaax6352. Published online 2019 Sep 18. doi: 10.1126/sciadv.aax6352
PMCID:
PMC6750908
AbstractArticlePDF–3.1M
5.
The H+-Coupled Electrogenic Lysosomal Amino Acid Transporter LYAAT1 Localizes to the Axon and Plasma Membrane of Hippocampal Neurons
Christopher C. Wreden, Juliette Johnson, Cindy Tran, Rebecca P. Seal, David R. Copenhagen, Richard J. Reimer, Robert H. Edwards
J Neurosci. 2003 Feb 15; 23(4): 1265–1275. doi: 10.1523/JNEUROSCI.23-04-01265.2003
PMCID:
PMC6742289
AbstractArticlePDF–1.1M
6.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
7.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
8.
PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons
Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Léa Huguet, Lucie Gorisse-Hussonnois, Stéphanie Chasseigneaux, Bernadette Allinquant
BMC Neurosci. 2015; 16: 10. Published online 2015 Mar 7. doi: 10.1186/s12868-015-0152-8
PMCID:
PMC4355975
AbstractArticlePDF–3.8M
9.
Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy
Elisa Donnard, Paula F. Asprino, Bruna R. Correa, Fabiana Bettoni, Fernanda C. Koyama, Fabio C.P. Navarro, Rodrigo O. Perez, John Mariadason, Oliver M. Sieber, Robert L. Strausberg, Andrew J.G. Simpson, Denis L.F. Jardim, Luiz Fernando L. Reis, Raphael B. Parmigiani, Pedro A.F. Galante, Anamaria A. Camargo
Oncotarget. 2014 Oct; 5(19): 9199–9213. Published online 2014 Aug 25. doi: 10.18632/oncotarget.2374
PMCID:
PMC4253428
AbstractArticlePDF–1.7M
10.
Identification of 33 candidate oncogenes by screening for base-specific mutations
S Tuupanen, U A Hänninen, J Kondelin, P von Nandelstadh, T Cajuso, A E Gylfe, R Katainen, T Tanskanen, H Ristolainen, J Böhm, J-P Mecklin, H Järvinen, L Renkonen-Sinisalo, C L Andersen, M Taipale, J Taipale, P Vahteristo, K Lehti, E Pitkänen, L A Aaltonen
Br J Cancer. 2014 Oct 14; 111(8): 1657–1662. Published online 2014 Aug 12. doi: 10.1038/bjc.2014.429
PMCID:
PMC4200084
AbstractArticlePDF–740K
11.
Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1‐dependent mechanism in skeletal muscle cells
Dillon K. Walker, Micah J. Drummond, Jared M. Dickinson, Michael S. Borack, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen
Physiol Rep. 2014 Mar; 2(3): e00238. Published online 2014 Mar 20. doi: 10.1002/phy2.238
PMCID:
PMC4002227
AbstractArticlePDF–468K
12.
Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro
C U Nielsen, S Frølund, S Abdulhadi, H Sari, L Langthaler, M K Nøhr, M A Kall, B Brodin, R Holm
Br J Pharmacol. 2013 Nov; 170(5): 1041–1052. Published online 2013 Oct 15. doi: 10.1111/bph.12341
PMCID:
PMC3949652
AbstractArticlePDF–1.1M
13.
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat
Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54
PMCID:
PMC3817404
AbstractArticlePDF–13M
14.
Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes
Margrét H. Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M. Visvalingam, Michael K. Shaw, Deborah C. I. Goberdhan
PLoS One. 2012; 7(5): e36616. Published online 2012 May 4. doi: 10.1371/journal.pone.0036616
PMCID:
PMC3344915
AbstractArticlePDF–2.9M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
Proton-assisted amino acid transporters are conserved regulators of proliferation and amino acid-dependent mTORC1 activation
S Heublein, S Kazi, M H Ögmundsdóttir, E V Attwood, S Kala, C A R Boyd, C Wilson, D C I Goberdhan
Oncogene. Author manuscript; available in PMC 2011 Jan 10.
Published in final edited form as: Oncogene. 2010 Jul 15; 29(28): 4068–4079. Published online 2010 May 24. doi: 10.1038/onc.2010.177
PMCID:
PMC3018277
AbstractArticlePDF–2.3M
17.
Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1
Madlen Dorn, Matthias Weiwad, Fritz Markwardt, Linda Laug, Rainer Rudolph, Matthias Brandsch, Eva Bosse-Doenecke
J Biol Chem. 2009 Aug 14; 284(33): 22123–22132. Published online 2009 Jun 23. doi: 10.1074/jbc.M109.023713
PMCID:
PMC2755936
AbstractArticlePDF–1.8M
18.
Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl−-dependent TauT (SLC6A6)
Catriona M H Anderson, Alison Howard, Julian R F Walters, Vadivel Ganapathy, David T Thwaites
J Physiol. 2009 Feb 15; 587(Pt 4): 731–744. Published online 2008 Dec 22. doi: 10.1113/jphysiol.2008.164228
PMCID:
PMC2669967
AbstractArticlePDF–433K
19.
Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2
Zhong Chen, You-Jun Fei, Catriona M H Anderson, Katherine A Wake, Seiji Miyauchi, Wei Huang, David T Thwaites, Vadivel Ganapathy
J Physiol. 2003 Jan 15; 546(Pt 2): 349–361. Published online 2002 Dec 13. doi: 10.1113/jphysiol.2002.026500
PMCID:
PMC2342508
AbstractArticlePDF–535K
20.
Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1
Emily L Abbot, Danielle S Grenade, David J Kennedy, Kelly M Gatfield, David T Thwaites
Br J Pharmacol. 2006 Feb; 147(3): 298–306. Published online 2005 Dec 5. doi: 10.1038/sj.bjp.0706557
PMCID:
PMC1751303
AbstractArticlePDF–251K

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