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Items: 1 to 20 of 44

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
Tobias Petzold, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin, Manuela Thienel, Lulu Liu, Qurrat Ul Ain, Vincent Ehreiser, Christian Weber, Badr Kilani, Pontus Mertsch, Jeremias Götschke, Sophie Cremer, Wenwen Fu, Michael Lorenz, Hellen Ishikawa-Ankerhold, Elisabeth Raatz, Shaza El-Nemr, Agnes Görlach, Esther Marhuenda, Konstantin Stark, Joachim Pircher, David Stegner, Christian Gieger, Marc Schmidt-Supprian, Florian Gaertner, Isaac Almendros, Malte Kelm, Christian Schulz, Andrés Hidalgo, Steffen Massberg
Immunity. 2022 Dec 13; 55(12): 2285–2299.e7. doi: 10.1016/j.immuni.2022.10.001
PMCID:
PMC9767676
AbstractArticle
3.
Granuloma Formation in a Cyba-Deficient Model of Chronic Granulomatous Disease Is Associated with Myeloid Hyperplasia and the Exhaustion of B-Cell Lineage
Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, María Carmen García-Macías, Carmen Sánchez-Bernal, Ignacio García-Tuñón, Jesús Sánchez-Yagüe, Manuel Sánchez-Martín, Ángel Hernández-Hernández
Int J Mol Sci. 2021 Aug; 22(16): 8701. Published online 2021 Aug 13. doi: 10.3390/ijms22168701
PMCID:
PMC8395996
AbstractArticlePDF–2.8M
4.
Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins
Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Ignacio García-Tuñón, Manuel Sánchez-Martín, Ángel Hernández-Hernández
Haematologica. 2021 Jan 1; 106(1): 142–153. Published online 2020 Jan 9. doi: 10.3324/haematol.2019.233064
PMCID:
PMC7776239
AbstractArticlePDF–2.3M
5.
ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22phox activation in Aβ-induced retinal pigment epithelial cell injury
Junran Sun, Jieqiong Chen, Tong Li, Peirong Huang, Jie Li, Mengxi Shen, Min Gao, Yang Sun, Jian Liang, Xiaomeng Li, Yimin Wang, Yushu Xiao, Xiang Shi, Yifan Hu, Jingyang Feng, Huixun Jia, Te Liu, Xiaodong Sun
Theranostics. 2020; 10(25): 11637–11655. Published online 2020 Sep 19. doi: 10.7150/thno.48064
PMCID:
PMC7546003
AbstractArticlePDF–3.7M
6.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
7.
The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
Anne Wolf, Marc Herb, Michael Schramm, Thomas Langmann
Nat Commun. 2020; 11: 2709. Published online 2020 Jun 1. doi: 10.1038/s41467-020-16400-8
PMCID:
PMC7264151
AbstractArticlePDF–9.3M
8.
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation
Louise van der Weyden, Agnieszka Swiatkowska, Vivek Iyer, Anneliese O. Speak, David J. Adams
G3 (Bethesda) 2020 Jun; 10(6): 1869–1877. Published online 2020 Apr 3. doi: 10.1534/g3.120.401128
PMCID:
PMC7263671
AbstractArticlePDF–1.0M
9.
Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss
Francis Rousset, German Nacher-Soler, Marta Coelho, Sten Ilmjarv, Vivianne Beatrix Christina Kokje, Antoine Marteyn, Yves Cambet, Michael Perny, Marta Roccio, Vincent Jaquet, Pascal Senn, Karl Heinz Krause
Redox Biol. 2020 Feb; 30: 101434. Published online 2020 Jan 20. doi: 10.1016/j.redox.2020.101434
PMCID:
PMC7016250
AbstractArticlePDF–4.6M
10.
Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
Adelaida M Celaya, Isabel Sánchez-Pérez, Jose M Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Laura Pintado-Berninches, Rosario Perona, Silvia Murillo-Cuesta, Isabel Varela-Nieto
eLife. 2019; 8: e39159. Published online 2019 Apr 2. doi: 10.7554/eLife.39159
PMCID:
PMC6464786
AbstractArticlePDF–5.9M
11.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
12.
Pulmonary metastatic colonisation and granulomas in NOX2‐deficient mice
Louise van der Weyden, Anneliese O Speak, Agnieszka Swiatkowska, Simon Clare, Andrea Schejtman, Giorgia Santilli, Mark J Arends, David J Adams
J Pathol. 2018 Nov; 246(3): 300–310. Published online 2018 Sep 19. doi: 10.1002/path.5140
PMCID:
PMC6221033
AbstractArticlePDF–1.8M
13.
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
David C. Thomas, Simon Clare, John M. Sowerby, Mercedes Pardo, Jatinder K. Juss, David A. Goulding, Louise van der Weyden, Daniel Storisteanu, Ananth Prakash, Marion Espéli, Shaun Flint, James C. Lee, Kim Hoenderdos, Leanne Kane, Katherine Harcourt, Subhankar Mukhopadhyay, Yagnesh Umrania, Robin Antrobus, James A. Nathan, David J. Adams, Alex Bateman, Jyoti S. Choudhary, Paul A. Lyons, Alison M. Condliffe, Edwin R. Chilvers, Gordon Dougan, Kenneth G.C. Smith
J Exp Med. 2017 Apr 3; 214(4): 1111–1128. doi: 10.1084/jem.20161382
PMCID:
PMC5379978
AbstractArticlePDF–1.8M
14.
Deletion of p22phox-dependent oxidative stress in the hypothalamus protects against obesity by modulating β3-adrenergic mechanisms
Heinrich E. Lob, Jiunn Song, Chansol Hurr, Alvin Chung, Colin N. Young, Allyn L. Mark, Robin L. Davisson
JCI Insight. 2017 Jan 26; 2(2): e87094. Published online 2017 Jan 26. doi: 10.1172/jci.insight.87094
PMCID:
PMC5256131
AbstractArticlePDF–1.1M
15.
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury
Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa
PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355
PMCID:
PMC5045200
AbstractArticlePDF–2.9M
16.
Optimal ROS signaling is critical for nuclear reprogramming
Gang Zhou, Shu Meng, Yanhui Li, Yohannes T Ghebremariam, John P. Cooke
Cell Rep. Author manuscript; available in PMC 2016 May 4.
Published in final edited form as: Cell Rep. 2016 May 3; 15(5): 919–925. Published online 2016 Apr 21. doi: 10.1016/j.celrep.2016.03.084
PMCID:
PMC4856580
AbstractArticlePDF–922K
17.
Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse
Modar Kassan, Karima Ait-Aissa, Maha Ali, Mohamed Trebak, Khalid Matrougui
Biochim Biophys Acta. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A): 2404–2410. Published online 2015 May 31. doi: 10.1016/j.bbamcr.2015.05.032
PMCID:
PMC4855834
AbstractArticlePDF–339K
18.
Downregulation of p22phox in Retinal Pigment Epithelial Cells Inhibits Choroidal Neovascularization in Mice
Qiuhong Li, Astra Dinculescu, Zhiying Shan, Rehae Miller, Jijing Pang, Alfred S Lewin, Mohan K Raizada, William W Hauswirth
Mol Ther. Author manuscript; available in PMC 2016 Apr 30.
Published in final edited form as: Mol Ther. 2008 Oct; 16(10): 1688–1694. Published online 2008 Jul 29. doi: 10.1038/mt.2008.164
PMCID:
PMC4851833
AbstractArticlePDF–868K
19.
Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox
Matthew R. DiStasi, Julie A. Mund, H. Glenn Bohlen, Steven J. Miller, David A. Ingram, Michael C. Dalsing, Joseph L. Unthank
Am J Physiol Heart Circ Physiol. 2015 Oct; 309(7): H1207–H1217. Published online 2015 Aug 21. doi: 10.1152/ajpheart.00180.2015
PMCID:
PMC4666923
AbstractArticle
20.
Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome
Ji-Youn Youn, Kin Lung Siu, Heinrich E. Lob, Hana Itani, David G. Harrison, Hua Cai
Diabetes. 2014 Jul; 63(7): 2344–2355. Published online 2014 Jun 14. doi: 10.2337/db13-0719
PMCID:
PMC4066332
AbstractArticlePDF–1.6M

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