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Items: 1 to 20 of 40

1.
Impaired retinoic acid signaling in cerebral cavernous malformations
Nastasja Grdseloff, Gwenola Boulday, Claudia J. Rödel, Cécile Otten, Daphné Raphaelle Vannier, Cécile Cardoso, Eva Faurobert, Deepika Dogra, Elisabeth Tournier-Lasserve, Salim Abdelilah-Seyfried
Sci Rep. 2023; 13: 5572. Published online 2023 Apr 5. doi: 10.1038/s41598-023-31905-0
PMCID:
PMC10076292
AbstractArticlePDF–2.1M
2.
Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting
Rui Wang, Shi-Ting Wu, Xi Yang, Yude Qian, Jaesung P. Choi, Rui Gao, Siliang Song, Yixuan Wang, Tao Zhuang, Justin J.L. Wong, Yuzhen Zhang, Zhiming Han, Hua A. Lu, Stephen I. Alexander, Renjing Liu, Yin Xia, Xiangjian Zheng
JCI Insight. 2021 Jun 22; 6(12): e142838. Published online 2021 Jun 22. doi: 10.1172/jci.insight.142838
PMCID:
PMC8262504
AbstractArticlePDF–6.9M
3.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican
Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl F. Wittig, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Lauren M. Goddard, Aileen A. Ren, N. Adrian Leu, Stephanie Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, Lukas E. Dow, Hideto Watanabe, Markus Schwaninger, Wang Min, Douglas A. Marchuk, Xiangjian Zheng, Issam A. Awad, Mark L. Kahn
J Exp Med. 2020 Oct 5; 217(10): e20200140. Published online 2020 Jul 10. doi: 10.1084/jem.20200140
PMCID:
PMC7537394
AbstractArticlePDF–7.2M
4.
Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice
Jia Li, Yang Zhao, Jaesung Choi, Ka Ka Ting, Paul Coleman, Jinbiao Chen, Victoria C. Cogger, Li Wan, Zhongsong Shi, Thorleif Moller, Xiangjian Zheng, Mathew A. Vadas, Jennifer R. Gamble
PLoS Biol. 2020 Jun; 18(6): e3000734. Published online 2020 Jun 5. doi: 10.1371/journal.pbio.3000734
PMCID:
PMC7299406
AbstractArticlePDF–3.1M
5.
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
Alan T. Tang, Katie R. Sullivan, Courtney C. Hong, Lauren M. Goddard, Aparna Mahadevan, Aileen Ren, Heidy Pardo, Amy Peiper, Erin Griffin, Ceylan Tanes, Lisa M. Mattei, Jisheng Yang, Li Li, Patricia Mericko-Ishizuka, Le Shen, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Claudia J. Roedel, Ning Li, Qin Zhu, Kevin J. Whitehead, Xiangjian Zheng, Amy Akers, Leslie Morrison, Helen Kim, Kyle Bittinger, Christopher J. Lengner, Markus Schwaninger, Anna Velcich, Leonard Augenlicht, Salim Abdelilah-Seyfried, Wang Min, Douglas A. Marchuk, Issam A. Awad, Mark L. Kahn
Sci Transl Med. Author manuscript; available in PMC 2019 Dec 31.
Published in final edited form as: Sci Transl Med. 2019 Nov 27; 11(520): eaaw3521. doi: 10.1126/scitranslmed.aaw3521
PMCID:
PMC6937779
AbstractArticlePDF–3.6M
6.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
7.
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
Alan T. Tang, Jaesung P. Choi, Jonathan J. Kotzin, Yiqing Yang, Courtney C. Hong, Nicholas Hobson, Romuald Girard, Hussein A. Zeineddine, Rhonda Lightle, Thomas Moore, Ying Cao, Robert Shenkar, Mei Chen, Patricia Mericko, Jisheng Yang, Li Li, Ceylan Tanes, Dmytro Kobuley, Urmo Võsa, Kevin J. Whitehead, Dean Y. Li, Lude Franke, Blaine Hart, Markus Schwaninger, Jorge Henao-Mejia, Leslie Morrison, Helen Kim, Issam A. Awad, Xiangjian Zheng, Mark L. Kahn
Nature. Author manuscript; available in PMC 2018 Jan 8.
Published in final edited form as: Nature. 2017 May 18; 545(7654): 305–310. Published online 2017 May 10. doi: 10.1038/nature22075
PMCID:
PMC5757866
AbstractArticlePDF–5.1M
8.
Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice
Jaesung P. Choi, Matthew Foley, Zinan Zhou, Weng-Yew Wong, Naveena Gokoolparsadh, J. Simon C. Arthur, Dean Y. Li, Xiangjian Zheng
PLoS One. 2016; 11(8): e0160833. Published online 2016 Aug 11. doi: 10.1371/journal.pone.0160833
PMCID:
PMC4981389
AbstractArticlePDF–6.3M
9.
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling
Zinan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai, Lauren M. Goddard, Robert Shenkar, Su Zhou, Jisheng Yang, Alexander C. Wright, Matthew Foley, J. Simon C. Arthur, Kevin J. Whitehead, Issam A. Awad, Dean Y. Li, Xiangjian Zheng, Mark L. Kahn
Nature. Author manuscript; available in PMC 2016 Sep 30.
Published in final edited form as: Nature. 2016 Apr 7; 532(7597): 122–126. Published online 2016 Mar 30. doi: 10.1038/nature17178
Correction in:
Nature. 2016 May 25; 536(7617): 488.
PMCID:
PMC4864035
AbstractArticlePDF–3.0M
10.
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano, Noemi Rudini, Luca Bravi, Monica Corada, Costanza Giampietro, Eleanna Papa, Marco Francesco Morini, Luigi Maddaluno, Nicolas Baeyens, Ralf H Adams, Mukesh K Jain, Gary K Owens, Martin Schwartz, Maria Grazia Lampugnani, Elisabetta Dejana
EMBO Mol Med. 2016 Jan; 8(1): 6–24. Published online 2015 Nov 26. doi: 10.15252/emmm.201505433
PMCID:
PMC4718159
AbstractArticlePDF–3.3M
11.
Expression of CCM2 and CCM3 during mouse gonadogenesis
Aylin Yaba, N. Ece Gungor Ordueri, Gamze Tanriover, Pinar Sahin, Necdet Demir, Ciler Celik-Ozenci
J Assist Reprod Genet. 2015 Oct; 32(10): 1497–1507. Published online 2015 Sep 19. doi: 10.1007/s10815-015-0559-2
PMCID:
PMC4615919
AbstractArticlePDF–14M
12.
Endothelial Erg expression is required for embryogenesis and vascular integrity
Rong Han, Maurizio Pacifici, Masahiro Iwamoto, Maria Trojanowska
Organogenesis. 2015 Apr; 11(2): 75–86. Published online 2015 Jun 10. doi: 10.1080/15476278.2015.1031435
PMCID:
PMC4594436
AbstractArticlePDF–677K
13.
The cerebral cavernous malformation pathway controls embryonic endocardial gene expression through regulation of MEKK3 signaling and KLF expression
Zinan Zhou, David Rawnsley, Lauren Goddard, Wei Pan, Xing-Jun Cao, Zoltan Jakus, Hui Zheng, Jisheng Yang, Simon Arthur, Kevin J. Whitehead, Dean Li, Bin Zhou, Benjamin A. Garcia, Xiangjian Zheng, Mark L. Kahn
Dev Cell. Author manuscript; available in PMC 2016 Jan 26.
Published in final edited form as: Dev Cell. 2015 Jan 26; 32(2): 168–180. doi: 10.1016/j.devcel.2014.12.009
PMCID:
PMC4589864
AbstractArticlePDF–3.7M
14.
Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex
Oriana S. Fisher, Hanqiang Deng, Dou Liu, Ya Zhang, Rong Wei, Yong Deng, Fan Zhang, Angeliki Louvi, Benjamin E. Turk, Titus J. Boggon, Bing Su
Nat Commun. 2015; 6: 7937. Published online 2015 Aug 3. doi: 10.1038/ncomms8937
PMCID:
PMC4526114
AbstractArticlePDF–2.2M
15.
Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation
Christopher C. Gibson, Weiquan Zhu, Chadwick T. Davis, Jay A. Bowman-Kirigin, Aubrey C. Chan, Jing Ling, Ashley E. Walker, Luca Goitre, Simona Delle Monache, Saverio Francesco Retta, Yan-Ting E. Shiu, Allie H. Grossmann, Kirk R. Thomas, Anthony J. Donato, Lisa A. Lesniewski, Kevin J. Whitehead, Dean Y. Li
Circulation. Author manuscript; available in PMC 2016 Jan 20.
Published in final edited form as: Circulation. 2015 Jan 20; 131(3): 289–299. Published online 2014 Dec 8. doi: 10.1161/CIRCULATIONAHA.114.010403
PMCID:
PMC4356181
AbstractArticlePDF–2.6M
16.
Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth
Xiangjian Zheng, Chong Xu, Annie O. Smith, Amber N. Stratman, Zhiying Zou, Benjamin Kleaveland, Lijun Yuan, Chuka Didiku, Aslihan Sen, Xi Liu, Nicolas Skuli, Alexander Zaslavsky, Mei Chen, Lan Cheng, George E. Davis, Mark L. Kahn
Dev Cell. Author manuscript; available in PMC 2013 Aug 14.
Published in final edited form as: Dev Cell. 2012 Aug 14; 23(2): 342–355. doi: 10.1016/j.devcel.2012.06.004
PMCID:
PMC3743537
AbstractArticlePDF–7.4M
17.
CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling
Eva Faurobert, Claire Rome, Justyna Lisowska, Sandra Manet-Dupé, Gwénola Boulday, Marilyne Malbouyres, Martial Balland, Anne-Pascale Bouin, Michelle Kéramidas, Daniel Bouvard, Jean-Luc Coll, Florence Ruggiero, Elisabeth Tournier-Lasserve, Corinne Albiges-Rizo
J Cell Biol. 2013 Aug 5; 202(3): 545–561. doi: 10.1083/jcb.201303044
PMCID:
PMC3734079
AbstractArticlePDF–5.1M
18.
STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin
Barbara Costa, Michelle J. Kean, Volker Ast, James D. R. Knight, Alice Mett, Zehava Levy, Derek F. Ceccarelli, Beatriz Gonzalez Badillo, Roland Eils, Rainer König, Anne-Claude Gingras, Mike Fainzilber
J Biol Chem. 2012 Aug 24; 287(35): 29285–29289. Published online 2012 Jul 10. doi: 10.1074/jbc.C112.345397
PMCID:
PMC3436191
AbstractArticlePDF–910K
19.
Functional Consequences of Necdin Nucleocytoplasmic Localization
Anat Lavi-Itzkovitz, Marianna Tcherpakov, Zehava Levy, Shalev Itzkovitz, Francoise Muscatelli, Mike Fainzilber
PLoS One. 2012; 7(3): e33786. Published online 2012 Mar 19. doi: 10.1371/journal.pone.0033786
PMCID:
PMC3307762
AbstractArticlePDF–780K
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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