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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 104356672.

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away

Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112125. Published online 2023 Feb 18. doi: 10.1016/j.celrep.2023.112125

PMCID:: PMC10435667

Abstract Article PDF–2.3M

Select item 101516153.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 101330324.

The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia

Swapnil Rohidas Shinde, David U. Mick, Erika Aoki, Rachel B. Rodrigues, Steven P. Gygi, Maxence V. Nachury

Dev Cell. Author manuscript; available in PMC 2024 Apr 24.

Published in final edited form as: Dev Cell. 2023 Apr 24; 58(8): 677–693.e9. Published online 2023 Apr 4. doi: 10.1016/j.devcel.2023.03.003

PMCID:: PMC10133032

Abstract Article PDF–3.4M

Select item 101252595.

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura

Nat Chem Biol. Author manuscript; available in PMC 2023 Apr 24.

Published in final edited form as: Nat Chem Biol. 2022 Apr; 18(4): 412–421. Published online 2022 Feb 24. doi: 10.1038/s41589-022-00971-2

PMCID:: PMC10125259

Abstract Article PDF–2.8M

Select item 100729066.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100408767.

SET7 methylates the deubiquitinase OTUB1 at Lys ¹²² to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis

Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li, Wuhan Xiao, Xing Liu

J Biol Chem. 2023 Apr; 299(4): 103054. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103054

PMCID:: PMC10040876

Abstract Article PDF–3.0M

Select item 100154428.

Tsg101/ESCRT-I Recruitment Regulated by the Dual Binding Modes of K63-Linked Diubiquitin

Madeleine Strickland, Susan Watanabe, Steven M. Bonn, Christina M. Camara, Mary R. Starich, David Fushman, Carol A. Carter, Nico Tjandra

Structure. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: Structure. 2022 Feb 3; 30(2): 289–299.e6. doi: 10.1016/j.str.2021.09.006

PMCID:: PMC10015442

Abstract Article PDF–2.2M

Select item 99982909.

Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication

Xuan Tan, Kun Cai, Jiajia Li, Zhen Yuan, Ruifeng Chen, Hurong Xiao, Chuanrui Xu, Bing Hu, Yali Qin, Binbin Ding

Cell Rep. 2023 Apr 25; 42(4): 112286. Published online 2023 Mar 10. doi: 10.1016/j.celrep.2023.112286

PMCID:: PMC9998290

Abstract Article PDF–7.6M

Select item 995441310.

E2 Partner Tunes the Ubiquitylation Specificity of Arkadia E3 Ubiquitin Ligase

Georgia N. Delegkou, Maria Birkou, Nefeli Fragkaki, Tamara Toro, Konstantinos D. Marousis, Vasso Episkopou, Georgios A. Spyroulias

Cancers (Basel) 2023 Feb; 15(4): 1040. Published online 2023 Feb 7. doi: 10.3390/cancers15041040

PMCID:: PMC9954413

Abstract Article PDF–20M

Select item 990249211.

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition

Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S. Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, Malavika Raman

Nat Commun. 2023; 14: 638. Published online 2023 Feb 6. doi: 10.1038/s41467-023-36298-2

PMCID:: PMC9902492

Abstract Article PDF–4.1M

Select item 988991612.

Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling

Simran Goel, Rosario Oliva, Sadasivam Jeganathan, Verian Bader, Laura J Krause, Simon Kriegler, Isabelle D Stender, Chadwick W Christine, Ken Nakamura, Jan-Erik Hoffmann, Roland Winter, Jörg Tatzelt, Konstanze F Winklhofer

Life Sci Alliance. 2023 Apr; 6(4): e202201607. Published online 2023 Jan 31. doi: 10.26508/lsa.202201607

PMCID:: PMC9889916

Abstract Article PDF–2.9M

Select item 983425213.

The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family

Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg

Nat Commun. 2023; 14: 168. Published online 2023 Jan 11. doi: 10.1038/s41467-023-35871-z

PMCID:: PMC9834252

Abstract Article PDF–4.2M

Select item 979580714.

Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2

Annarita Miluzio, Alessandro Cuomo, Chiara Cordiglieri, Lorena Donnici, Elisa Pesce, Mauro Bombaci, Matteo Conti, Alessandra Fasciani, Luigi Terracciano, Lara Manganaro, Mirco Toccafondi, Alessandra Scagliola, Stefania Oliveto, Sara Ricciardi, Renata Grifantini, Raffaele De Francesco, Sergio Abrignani, Nicola Manfrini, Stefano Biffo

eBioMedicine. 2023 Jan; 87: 104390. Published online 2022 Dec 28. doi: 10.1016/j.ebiom.2022.104390

PMCID:: PMC9795807

Abstract Article PDF–4.6M

Select item 975707415.

Probing protein ubiquitination in live cells

Weihua Qin, Clemens Steinek, Ksenia Kolobynina, Ignasi Forné, Axel Imhof, M Cristina Cardoso, Heinrich Leonhardt

Nucleic Acids Res. 2022 Nov 28; 50(21): e125. Published online 2022 Oct 3. doi: 10.1093/nar/gkac805

PMCID:: PMC9757074

Abstract Article PDF–8.2M

Select item 975347116.

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus

Zhixiao Wu, Lena A Berlemann, Verian Bader, Dominik A Sehr, Eva Dawin, Alberto Covallero, Jens Meschede, Lena Angersbach, Cathrin Showkat, Jonas B Michaelis, Christian Münch, Bettina Rieger, Dmitry Namgaladze, Maria Georgina Herrera, Fabienne C Fiesel, Wolfdieter Springer, Marta Mendes, Jennifer Stepien, Katalin Barkovits, Katrin Marcus, Albert Sickmann, Gunnar Dittmar, Karin B Busch, Dietmar Riedel, Marisa Brini, Jörg Tatzelt, Tito Cali, Konstanze F Winklhofer

EMBO J. 2022 Dec; 41(24): e112006. Published online 2022 Nov 18. doi: 10.15252/embj.2022112006

PMCID:: PMC9753471

Abstract Article PDF–4.3M

Select item 974196717.

DDX24 promotes metastasis by regulating RPL5 in non‐small cell lung cancer

Xinyan Hu, Fangfang Li, Yulan Zhou, Hairun Gan, Tiancheng Wang, Luting Li, Haoyu Long, Bing Li, Pengfei Pang

Cancer Med. 2022 Dec; 11(23): 4513–4525. Published online 2022 Jul 21. doi: 10.1002/cam4.4835

PMCID:: PMC9741967

Abstract Article PDF–25M

Select item 970452718.

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J. 2022 Oct 28; 479(20): 2195–2216. Published online 2022 Oct 21. doi: 10.1042/BCJ20220401

PMCID:: PMC9704527

Abstract Article PDF–7.7M

Select item 952529819.

The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma

Jia-hao Liu, Hui-ling Yang, Shu-ting Deng, Zhe Hu, Wei-feng Chen, Wei-wei Yan, Ren-tao Hou, Yong-hao Li, Rui-ting Xian, Ying-ying Xie, Yun Su, Li-yang Wu, Ping Xu, Zhi-bo Zhu, Xiong Liu, Yu-ling Deng, Yu-bing Wang, Zhen Liu, Wei-yi Fang

Acta Pharmacol Sin. 2022 Oct; 43(10): 2687–2695. Published online 2022 Mar 16. doi: 10.1038/s41401-022-00890-x