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Items: 1 to 20 of 628

1.
Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition
Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen
J Exp Clin Cancer Res. 2024; 43: 65. Published online 2024 Mar 1. doi: 10.1186/s13046-024-02987-z
PMCID:
PMC10905802
AbstractArticlePDF–2.9M
2.
HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia
Mengjia Jing, Xiaofeng Xiong, Xin Mao, Qianben Song, Lumiao Zhang, Yiming Ouyang, Yingzhi Pang, Yu Fu, Wei Yan
Cell Death Dis. 2024 Feb; 15(2): 155. Published online 2024 Feb 20. doi: 10.1038/s41419-024-06536-6
PMCID:
PMC10879213
AbstractArticlePDF–6.5M
3.
The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation
Mitsuyoshi Motizuki, Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa
J Biol Chem. 2024 Jan; 300(1): 105580. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105580
PMCID:
PMC10821601
AbstractArticlePDF–5.5M
4.
LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress
Hongyang Huang, Yu-Man Tsui, Daniel Wai-Hung Ho, Clive Yik-Sham Chung, Karen Man-Fong Sze, Eva Lee, Gary Cheuk-Hang Cheung, Vanilla Xin Zhang, Xia Wang, Xueying Lyu, Irene Oi-Lin Ng
Hepatology. 2024 Feb; 79(2): 323–340. Published online 2023 Aug 7. doi: 10.1097/HEP.0000000000000523
PMCID:
PMC10789379
AbstractArticlePDF–2.4M
5.
Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity
Dong Li, Younhee Park, Hami Hemati, Xia Liu
J Biol Chem. 2023 Dec; 299(12): 105377. Published online 2023 Oct 20. doi: 10.1016/j.jbc.2023.105377
PMCID:
PMC10692920
AbstractArticlePDF–4.3M
6.
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg
Science. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021
PMCID:
PMC10617673
AbstractArticlePDF–3.6M
7.
Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1
Xinyan Gao, Xiaoyan Lin, Mengxin Lin, Yanqin Lan, Yao Wang, Riping Wu, Junde Li, Chuanyong Huang, Dongta Zhong
Turk J Gastroenterol. 2023 Sep; 34(9): 975–981. Published online 2023 Sep 1. doi: 10.5152/tjg.2023.23108
PMCID:
PMC10543419
AbstractArticlePDF–1.4M
8.
Interfering with Rac1-activation during neonatal monocyte-macrophage differentiation influences the inflammatory responses of M1 macrophages
Hang Fu, Ping Zhang, Xiao-Dong Zhao, Xiao-Yun Zhong
Cell Death Dis. 2023 Sep; 14(9): 619. Published online 2023 Sep 21. doi: 10.1038/s41419-023-06150-y
PMCID:
PMC10514032
AbstractArticlePDF–5.2M
9.
MiR-22-3p suppresses NSCLC cell migration and EMT via targeting RAC1 expression
Xuejiao Wang, Xiaobin Wang, Tao Jiang, Zhipei Zhang, Nianlin Xie, Guang Yang
Funct Integr Genomics. 2023; 23(3): 281. Published online 2023 Aug 25. doi: 10.1007/s10142-023-01211-z
PMCID:
PMC10449966
AbstractArticlePDF–4.0M
10.
TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy
Renu A. Kowluru, Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Ghulam Mohammad, Ismail Syed, Julia M. Santos, Manish Mishra
Diabetologia. Author manuscript; available in PMC 2023 Jul 3.
Published in final edited form as: Diabetologia. 2014 May; 57(5): 1047–1056. Published online 2014 Feb 20. doi: 10.1007/s00125-014-3194-z
PMCID:
PMC10317023
AbstractArticlePDF–1.3M
11.
Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling
Siarhei Hladyshau, Jorik P. Stoop, Kosei Kamada, Shuyi Nie, Denis Tsygankov
Cells. 2023 Jun; 12(12): 1638. Published online 2023 Jun 15. doi: 10.3390/cells12121638
PMCID:
PMC10297213
AbstractArticlePDF–7.7M
12.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
13.
Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing
Mingyu Chen, Hanyue Li, Xiaolin Xu, Xunxia Bao, Lei Xue, Xinghao Ai, Jian Xu, Ming Xu, Yong Shi, Timing Zhen, Jie Li, Yi Yang, Yang Ji, Zhiliang Fu, Kaichen Xing, Tao Qing, Qiubo Wang, Ping Zhong, Sibo Zhu
Cell Death Dis. 2023 May; 14(5): 330. Published online 2023 May 18. doi: 10.1038/s41419-023-05823-y
PMCID:
PMC10195834
AbstractArticlePDF–5.8M
14.
ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization
Katarzyna Bogucka-Janczi, Gregory Harms, Marie-May Coissieux, Mohamed Bentires-Alj, Bernd Thiede, Krishnaraj Rajalingam
eLife. 2023; 12: e85167. Published online 2023 Apr 14. doi: 10.7554/eLife.85167
PMCID:
PMC10191626
AbstractArticlePDF–30M
15.
SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion
Sunho An, Tam Thuy Lu Vo, Taekwon Son, Hoon Choi, Jinyoung Kim, Juyeon Lee, Byung Hoon Kim, Misun Choe, Eunyoung Ha, Young-Joon Surh, Kyu-Won Kim, Ji Hae Seo
Exp Mol Med. 2023 Apr; 55(4): 779–793. Published online 2023 Apr 3. doi: 10.1038/s12276-023-00961-x
PMCID:
PMC10167369
AbstractArticlePDF–4.7M
16.
A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells
Ioana Stejerean-Todoran, Phyllis A Gimotty, Andrea Watters, Patricia Brafford, Clemens Krepler, Tetiana Godok, Haiyin Li, Zuriñe Bonilla del Rio, Anke Zieseniss, Dörthe M Katschinski, Sinem M Sertel, Silvio O Rizzoli, Bradley Garman, Katherine L Nathanson, Xiaowei Xu, Qing Chen, Jack H Oswald, Michal Lotem, Gordon B Mills, Michael A Davies, Michael P Schön, Ivan Bogeski, Meenhard Herlyn, Adina Vultur
Neuro Oncol. 2023 Apr; 25(4): 674–686. Published online 2022 Sep 2. doi: 10.1093/neuonc/noac212
PMCID:
PMC10076948
AbstractArticlePDF–40M
17.
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion
Julia Harms, Simona Mareike Lüttgenau, Christin Emming, Justine Guske, Katrin Weber, Thomas Wagner, Larissa Schowe, Pavel Nedvetsky, Michael P. Krahn
Cancer Gene Ther. 2023; 30(3): 497–506. Published online 2022 Dec 9. doi: 10.1038/s41417-022-00570-2
PMCID:
PMC10014575
AbstractArticlePDF–5.0M
18.
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons
Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson
J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888
PMCID:
PMC9978635
AbstractArticlePDF–10M
19.
RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells
Fuhui Chen, Sevim B. Gurler, David Novo, Cigdem Selli, Denis G. Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H. Sims, Neil E. Humphreys, Antony Adamson, Andrew Campbell, Owen J. Sansom, Cathy Tournier, Robert B. Clarke, Keith Brennan, Charles H. Streuli, Ahmet Ucar
Oncogene. 2023; 42(9): 679–692. Published online 2023 Jan 5. doi: 10.1038/s41388-022-02574-6
PMCID:
PMC9957727
AbstractArticlePDF–2.9M
20.
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation
Wen Yih Aw, Crescentia Cho, Hao Wang, Anne Hope Cooper, Elizabeth L. Doherty, David Rocco, Stephanie A. Huang, Sarah Kubik, Chloe P. Whitworth, Ryan Armstrong, Anthony J. Hickey, Boyce Griffith, Matthew L. Kutys, Julie Blatt, William J. Polacheck
Sci Adv. 2023 Feb; 9(7): eade8939. Published online 2023 Feb 15. doi: 10.1126/sciadv.ade8939
PMCID:
PMC9931220
AbstractArticlePDF–3.7M

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