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Select item 110169401.

Mitochondrial dysfunction induced by HIF‐1α under hypoxia contributes to the development of gastric mucosal lesions

Yuelin Xiao, Xianzhi Liu, Kaiduan Xie, Jiajie Luo, Yiwang Zhang, Xiaoli Huang, Jinni Luo, Siwei Tan

Clin Transl Med. 2024 Apr; 14(4): e1653. Published online 2024 Apr 15. doi: 10.1002/ctm2.1653

PMCID:: PMC11016940

Abstract Article PDF–8.7M

Select item 110146662.

Granulocytic myeloid-derived suppressor cell activity during biofilm infection is regulated by a glycolysis/HIF1a axis

Christopher M. Horn, Prabhakar Arumugam, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Blake P. Bertrand, Dhananjay Shinde, Vinai C. Thomas, Svetlana G. Romanova, Tatiana K. Bronich, Curtis W. Hartman, Kevin L. Garvin, Tammy Kielian

J Clin Invest. 2024 Apr 15; 134(8): e174051. Published online 2024 Feb 29. doi: 10.1172/JCI174051

PMCID:: PMC11014666

Abstract Article PDF–3.9M

Select item 109876623.

Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin

Uttkarsh Ayyangar, Aneesh Karkhanis, Heather Tay, Aliya Farissa Binte Afandi, Oindrila Bhattacharjee, Lalitha KS, Sze Han Lee, James Chan, Srikala Raghavan

EMBO J. 2024 Apr; 43(7): 1113–1134. Published online 2024 Feb 28. doi: 10.1038/s44318-024-00039-y

PMCID:: PMC10987662

Abstract Article PDF–12M

Select item 109813204.

Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease

Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yongtao He, Jiayin Zhao, Zishan Wang, Jinghui Wang, Qing Li, Guangchun Fan, Zhaolin Liu, Chenye Shen, Yunhe Zhang, Mei Yu, Jian Fei, Fang Huang

J Neuroinflammation. 2024; 21: 80. Published online 2024 Mar 30. doi: 10.1186/s12974-024-03070-2

PMCID:: PMC10981320

Abstract Article PDF–6.4M

Select item 109697905.

The DUX4–HIF1α Axis in Murine and Human Muscle Cells: A Link More Complex Than Expected

Thuy-Hang Nguyen, Maelle Limpens, Sihame Bouhmidi, Lise Paprzycki, Alexandre Legrand, Anne-Emilie Declèves, Philipp Heher, Alexandra Belayew, Christopher R. S. Banerji, Peter S. Zammit, Alexandra Tassin

Int J Mol Sci. 2024 Mar; 25(6): 3327. Published online 2024 Mar 15. doi: 10.3390/ijms25063327

PMCID:: PMC10969790

Abstract Article PDF–8.2M

Select item 109484856.

Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure

Hana Kolesova, Petra Hrabalova, Romana Bohuslavova, Pavel Abaffy, Valeria Fabriciova, David Sedmera, Gabriela Pavlinkova

Front Endocrinol (Lausanne) 2024; 15: 1344074. Published online 2024 Mar 5. doi: 10.3389/fendo.2024.1344074

PMCID:: PMC10948485

Abstract Article PDF–7.6M

Select item 109332657.

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

Heeseog Kang, Amy L. Strong, Yuxiao Sun, Lei Guo, Conan Juan, Alec C. Bancroft, Ji Hae Choi, Chase A. Pagani, Aysel A. Fernandes, Michael Woodard, Juhoon Lee, Sowmya Ramesh, Aaron W. James, David Hudson, Kevin N. Dalby, Lin Xu, Robert J. Tower, Benjamin Levi

Bone Res. 2024; 12: 17. Published online 2024 Mar 12. doi: 10.1038/s41413-024-00320-0

PMCID:: PMC10933265

Abstract Article PDF–2.4M

Select item 109275168.

Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment

Jingyi Ma, Khatoun Al Moussawi, Hantao Lou, Hok Fung Chan, Yihua Wang, Joseph Chadwick, Chansavath Phetsouphanh, Elizabeth A. Slee, Shan Zhong, Thomas M. Leissing, Andrew Roth, Xiao Qin, Shuo Chen, Jie Yin, Indrika Ratnayaka, Yang Hu, Pakavarin Louphrasitthiphol, Lewis Taylor, Paulo J. G. Bettencourt, Mary Muers, David R. Greaves, Helen McShane, Robert Goldin, Elizabeth J. Soilleux, Mathew L. Coleman, Peter J. Ratcliffe, Xin Lu

Proc Natl Acad Sci U S A. 2024 Mar 5; 121(10): e2309957121. Published online 2024 Feb 29. doi: 10.1073/pnas.2309957121

PMCID:: PMC10927516

Abstract Article PDF–4.9M

Select item 108943039.

DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α

Aidi Gao, Mingxia Zhang, Shuang qi Zhu, Shitao Zou, Hengrui Chen, Xiaoqin Li, Chao He, Liangsu Zhou, Yan Mei, Weiqun Ding, Jundong Zhou, Yue Zhou, Yuandong Cao

Cell Death Dis. 2024 Feb; 15(2): 171. Published online 2024 Feb 24. doi: 10.1038/s41419-024-06552-6

PMCID:: PMC10894303

Abstract Article PDF–3.7M

Select item 1089115410.

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress

Silvia Cardarelli, Martina Biglietto, Tiziana Orsini, Valentina Fustaino, Lucia Monaco, Ana Gabriela de Oliveira do Rêgo, Francesca Liccardo, Silvia Masciarelli, Francesco Fazi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Cell Death Dis. 2024 Feb; 15(2): 169. Published online 2024 Feb 23. doi: 10.1038/s41419-024-06549-1

PMCID:: PMC10891154

Abstract Article PDF–2.6M

Select item 1087163411.

Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex

Feixia Wang, Li Chen, Desong Kong, Xiaojin Zhang, Siwei Xia, Baoyu Liang, Yang Li, Ya Zhou, Zili Zhang, Jiangjuan Shao, Shizhong Zheng, Feng Zhang

Hepatology. 2024 Mar; 79(3): 606–623. Published online 2023 Sep 21. doi: 10.1097/HEP.0000000000000569

PMCID:: PMC10871634

Abstract Article PDF–2.0M

Select item 1079274812.

M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2/HIF-1α axis mediated metabolic reprogramming of macrophages

Yingying Zhang, Liangyu Zhu, Xueqin Li, Chang Ge, Weiya Pei, Mengying Zhang, Min Zhong, Xiaolong Zhu, Kun Lv

Redox Biol. 2024 Feb; 69: 103016. Published online 2023 Dec 28. doi: 10.1016/j.redox.2023.103016

PMCID:: PMC10792748

Abstract Article PDF–8.7M

Select item 1078274113.

PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease

Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao, Guangyi Zhao

Mol Med. 2024; 30: 8. Published online 2024 Jan 10. doi: 10.1186/s10020-023-00759-7

PMCID:: PMC10782741

Abstract Article PDF–9.9M

Select item 1074232114.

HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro

Flaminia Chellini, Alessia Tani, Martina Parigi, Francesco Palmieri, Rachele Garella, Sandra Zecchi-Orlandini, Roberta Squecco, Chiara Sassoli

Cells. 2023 Dec; 12(24): 2851. Published online 2023 Dec 16. doi: 10.3390/cells12242851

PMCID:: PMC10742321

Abstract Article PDF–6.1M

Select item 1068813815.

Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells

Jie Zhang, FangLin Ye, AiHua Ye, BaiCheng He

J Orthop Surg Res. 2023; 18: 911. Published online 2023 Nov 29. doi: 10.1186/s13018-023-04251-0

PMCID:: PMC10688138

Abstract Article PDF–3.6M

Select item 1066753416.

Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death

Nana Yaa Nsiah, Autumn B. Morgan, Nina Donkor, Denise M. Inman

Sci Rep. 2023; 13: 20541. Published online 2023 Nov 23. doi: 10.1038/s41598-023-47942-8

PMCID:: PMC10667534

Abstract Article PDF–2.7M

Select item 1063769917.

The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model

Hui Zhao, Ronald J. Wong, David K. Stevenson

PLoS One. 2023; 18(11): e0294185. Published online 2023 Nov 10. doi: 10.1371/journal.pone.0294185

PMCID:: PMC10637699

Abstract Article PDF–3.6M

Select item 1058348618.

The HIFIA/LINC02913/IGF1R axis promotes the cell function of adipose-derived mesenchymal stem cells under hypoxia via activating the PI3K/AKT pathway

Xiang Xiong, Liqin Yuan, Kai Yang, Xiancheng Wang

J Transl Med. 2023; 21: 732. Published online 2023 Oct 17. doi: 10.1186/s12967-023-04581-x

PMCID:: PMC10583486

Abstract Article PDF–9.6M

Select item 1056825419.

Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α

I-Che Chung, Wei-Ching Huang, Yung-Tsang Huang, Mao-Lin Chen, An-Wei Tsai, Pei-Yu Wu, Ta-Tung Yuan

Oncol Rep. 2023 Nov; 50(5): 205. Published online 2023 Oct 3. doi: 10.3892/or.2023.8642

PMCID:: PMC10568254

Abstract Article PDF–3.8M

Select item 1047568020.

Angiopoietin‐2 Promotes Mechanical Stress‐induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF‐1α/NF‐κB Signaling Pathway

Xiang Ao, Yuan Li, Tao Jiang, Chenglong Li, Zhengnan Lian, Liang Wang, Zhongmin Zhang, Minjun Huang

Orthop Surg. 2023 Sep; 15(9): 2410–2422. Published online 2023 Jul 21. doi: 10.1111/os.13797

PMCID:: PMC10475680

Abstract Article PDF–2.6M

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