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Items: 1 to 20 of 319

1.
Mitochondrial Raf1 Regulates Glutamine Catabolism
Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari
Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297
PMCID:
PMC10942467
AbstractArticlePDF–6.5M
2.
RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome
Jingjing Zheng, Longyun Peng, Ruofei Cheng, Zhiyan Li, Jianjie Xie, Erwen Huang, Jianding Cheng, Qianhao Zhao
Mol Genet Genomic Med. 2024 Jan; 12(1): e2290. Published online 2023 Oct 3. doi: 10.1002/mgg3.2290
PMCID:
PMC10767430
AbstractArticlePDF–8.9M
3.
PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis
Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto
Biomolecules. 2023 Dec; 13(12): 1741. Published online 2023 Dec 4. doi: 10.3390/biom13121741
PMCID:
PMC10741526
AbstractArticlePDF–3.0M
4.
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis
Alexandre Janer, Jordan L Morris, Michiel Krols, Hana Antonicka, Mari J Aaltonen, Zhen-Yuan Lin, Hanish Anand, Anne-Claude Gingras, Julien Prudent, Eric A Shoubridge
Life Sci Alliance. 2024 Jan; 7(1): e202302335. Published online 2023 Nov 6. doi: 10.26508/lsa.202302335
PMCID:
PMC10627786
AbstractArticlePDF–5.2M
5.
Recurrent TRAK1::RAF1 Fusions in pediatric low‐grade gliomas
Jamal K. Benhamida, Hannah J. Harmsen, Deqin Ma, Christopher M. William, Bryan K. Li, Liliana Villafania, Purvil Sukhadia, Kerry A. Mullaney, Michael C. Dewan, Efsevia Vakiani, Matthias A. Karajannis, Matija Snuderl, David Zagzag, Marc Ladanyi, Marc K. Rosenblum, Tejus A. Bale
Brain Pathol. 2023 Sep; 33(5): e13185. Published online 2023 Jul 3. doi: 10.1111/bpa.13185
PMCID:
PMC10467040
AbstractArticlePDF–1.4M
6.
TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1
Xiaowei Fei, Ya-nan Dou, Kai Sun, Jialiang Wei, Qingdong Guo, Li Wang, Xiuquan Wu, Weihao Lv, Xiaofan Jiang, Zhou Fei
Exp Mol Med. 2023 Jun; 55(6): 1203–1217. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01007-y
PMCID:
PMC10318069
AbstractArticlePDF–7.6M
7.
Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues
Saeideh Nakhaei-Rad, Fereshteh Haghighi, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Karolin Kleemann, Anne Schänzer, Andrea Borchardt, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim P. Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian
Commun Biol. 2023; 6: 657. Published online 2023 Jun 21. doi: 10.1038/s42003-023-05013-8
PMCID:
PMC10284840
AbstractArticlePDF–5.2M
8.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
9.
RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status
Coralie Dorard, Claire Madry, Olivier Buhard, Stefanie Toifl, Sebastian Didusch, Toky Ratovomanana, Quentin Letourneur, Helmut Dolznig, Mathew J. Garnett, Alex Duval, Manuela Baccarini
Oncogene. 2023; 42(20): 1649–1660. Published online 2023 Apr 5. doi: 10.1038/s41388-023-02683-w
PMCID:
PMC10181936
AbstractArticlePDF–2.5M
10.
SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus
Wenwen Geng, Meiling Cao, Ke Dong, Junhua An, Haidong Gao
Cancer Biol Ther. 2023; 24(1): 2206362. Published online 2023 May 11. doi: 10.1080/15384047.2023.2206362
PMCID:
PMC10177683
AbstractArticlePDF–2.5M
11.
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Samantha Wong, Yu Xuan Tan, Abigail Yi Ting Loh, Kiat Yi Tan, Hane Lee, Zainab Aziz, Stanley F Nelson, Engin Özkan, Hülya Kayserili, Nathalie Escande‐Beillard, Bruno Reversade
EMBO Mol Med. 2023 May; 15(5): e17078. Published online 2023 Apr 17. doi: 10.15252/emmm.202217078
PMCID:
PMC10165362
AbstractArticlePDF–2.7M
12.
Interactome dynamics of RAF1-BRAF kinase monomers and dimers
Luis F. Iglesias-Martinez, Nora Rauch, Kieran Wynne, Brendan McCann, Walter Kolch, Jens Rauch
Sci Data. 2023; 10: 203. Published online 2023 Apr 12. doi: 10.1038/s41597-023-02115-0
PMCID:
PMC10097620
AbstractArticlePDF–2.6M
13.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
14.
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini
Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3
PMCID:
PMC9950183
AbstractArticlePDF–2.4M
15.
The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade
Yun Qian, Lianxin Zhou, Simson Tsz Yat Luk, Jiaying Xu, Weilin Li, Hongyan Gou, Huarong Chen, Wei Kang, Jun Yu, Chi Chun Wong
Oncogene. 2023; 42(8): 601–612. Published online 2022 Dec 23. doi: 10.1038/s41388-022-02576-4
PMCID:
PMC9937924
AbstractArticlePDF–5.7M
16.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
17.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
18.
S-glutathionylation of Hsp90 enhances its degradation and correlates with favorable prognosis of breast cancer
Yu-Yin Shih, Hsien-Ya Lin, Hau-Ming Jan, Yu-Ju Chen, Lih-Lih Ong, Alice Lin-Tsing Yu, Chun-Hung Lin
Redox Biol. 2022 Nov; 57: 102501. Published online 2022 Oct 15. doi: 10.1016/j.redox.2022.102501
PMCID:
PMC9594641
AbstractArticlePDF–5.4M
19.
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
Zhuoyao Chen, Rafael M. Ioris, Stacey Richardson, Ava N. Van Ess, Iolanda Vendrell, Benedikt M. Kessler, Francesca M. Buffa, Luca Busino, Steven C. Clifford, Alex N. Bullock, Vincenzo D’Angiolella
Cell Death Differ. 2022 Oct; 29(10): 1955–1969. Published online 2022 Apr 4. doi: 10.1038/s41418-022-00983-4
PMCID:
PMC9525703
AbstractArticlePDF–4.4M
20.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M

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