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Items: 1 to 20 of 40

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse
Vijay K. Yadav, Julian M. Berger, Parminder Singh, Perumal Nagarajan, Gerard Karsenty
J Clin Invest. 2022 Feb 15; 132(4): e153752. Published online 2022 Feb 15. doi: 10.1172/JCI153752
PMCID:
PMC8843753
ArticlePDF–4.9M
3.
Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis
Satoru Mukai, Akiko Mizokami, Takahito Otani, Tomomi Sano, Miho Matsuda, Sakura Chishaki, Jing Gao, Tomoyo Kawakubo-Yasukochi, Ronghao Tang, Takashi Kanematsu, Hiroshi Takeuchi, Eijiro Jimi, Masato Hirata
J Biol Chem. 2021 Jan-Jun; 296: 100274. Published online 2021 Jan 9. doi: 10.1016/j.jbc.2021.100274
PMCID:
PMC7949034
ArticlePDF–2.6M
4.
Humanized GPRC6AKGKY is a gain-of-function polymorphism in mice
Min Pi, Fuyi Xu, Ruisong Ye, Satoru K. Nishimoto, Robert A. Kesterson, Robert W. Williams, Lu Lu, L. Darryl Quarles
Sci Rep. 2020; 10: 11143. Published online 2020 Jul 7. doi: 10.1038/s41598-020-68113-z
PMCID:
PMC7341878
ArticlePDF–1.8M
5.
Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice
Min Pi, Fuyi Xu, Ruisong Ye, Satoru K. Nishimoto, Robert W. Williams, Lu Lu, L. Darryl Quarles
Sci Rep. 2020; 10: 7216. Published online 2020 Apr 29. doi: 10.1038/s41598-020-64384-8
PMCID:
PMC7190669
ArticlePDF–2.1M
6.
Mediation of the acute stress response by the skeleton
Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A. Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L. Horvath, Ana I. Domingos, Anna L. Marsland, Vijay Kumal Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty
Cell Metab. Author manuscript; available in PMC 2020 Nov 5.
Published in final edited form as: Cell Metab. 2019 Nov 5; 30(5): 890–902.e8. Published online 2019 Sep 12. doi: 10.1016/j.cmet.2019.08.012
PMCID:
PMC6834912
ArticlePDF–2.8M
7.
Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice
Christinna V. Jørgensen, Sylvia J. Gasparini, Jinwen Tu, Hong Zhou, Markus J. Seibel, Hans Bräuner-Osborne
Sci Rep. 2019; 9: 5995. Published online 2019 Apr 12. doi: 10.1038/s41598-019-41921-8
PMCID:
PMC6461682
ArticlePDF–1.4M
8.
Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice
Yuan-Yu Lin, Ching-Yi Chen, Shih-Torng Ding
PLoS One. 2017; 12(12): e0189063. Published online 2017 Dec 1. doi: 10.1371/journal.pone.0189063
PMCID:
PMC5711023
ArticlePDF–1.3M
9.
Gpr158 mediates osteocalcin’s regulation of cognition
Lori Khrimian, Arnaud Obri, Mariana Ramos-Brossier, Audrey Rousseaud, Stéphanie Moriceau, Anne-Sophie Nicot, Paula Mera, Stylianos Kosmidis, Theodoros Karnavas, Frederic Saudou, Xiao-Bing Gao, Franck Oury, Eric Kandel, Gerard Karsenty
J Exp Med. 2017 Oct 2; 214(10): 2859–2873. doi: 10.1084/jem.20171320
PMCID:
PMC5626410
ArticlePDF–2.0M
10.
GPRC6A: Jack of all metabolism (or master of none)
Min Pi, Satoru Kenneth Nishimoto, L. Darryl Quarles
Mol Metab. 2017 Feb; 6(2): 185–193. Published online 2016 Dec 21. doi: 10.1016/j.molmet.2016.12.006
PMCID:
PMC5279936
ArticlePDF–1.7M
11.
GPRC6A Mediates Responses to Osteocalcin in β-Cells In Vitro and Pancreas In Vivo
Min Pi, Yunpeng Wu, L Darryl Quarles
J Bone Miner Res. Author manuscript; available in PMC 2016 Oct 25.
Published in final edited form as: J Bone Miner Res. 2011 Jul; 26(7): 1680–1683. doi: 10.1002/jbmr.390
PMCID:
PMC5079536
ArticlePDF–1.1M
12.
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Paula Mera, Kathrin Laue, Jianwen Wei, Julian Meyer Berger, Gerard Karsenty
Mol Metab. 2016 Oct; 5(10): 1042–1047. Published online 2016 Jul 16. doi: 10.1016/j.molmet.2016.07.002
Correction in:
Mol Metab. 2017 Aug; 6(8): 941.
PMCID:
PMC5034485
ArticlePDF–696K
13.
L‐arginine promotes gut hormone release and reduces food intake in rodents
A. Alamshah, A. K. McGavigan, E. Spreckley, J. S. Kinsey‐Jones, A. Amin, I. R. Tough, H. C. O'Hara, A. Moolla, K. Banks, R. France, G. Hyberg, M. Norton, W. Cheong, A. Lehmann, S. R. Bloom, H. M. Cox, K. G. Murphy
Diabetes Obes Metab. 2016 May; 18(5): 508–518. Published online 2016 Apr 1. doi: 10.1111/dom.12644
PMCID:
PMC4982043
ArticlePDF–929K
14.
Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise
Paula Mera, Kathrin Laue, Mathieu Ferron, Cyril Confavreux, Jianwen Wei, Marta Galán-Díez, Alain Lacampagne, Sarah J. Mitchell, Julie A. Mattison, Yun Chen, Justine Bacchetta, Pawel Szulc, Richard N. Kitsis, Rafael de Cabo, Richard A. Friedman, Christopher Torsitano, Timothy E. McGraw, Michelle Puchowicz, Irwin Kurland, Gerard Karsenty
Cell Metab. Author manuscript; available in PMC 2017 Jun 14.
Published in final edited form as: Cell Metab. 2016 Jun 14; 23(6): 1078–1092. doi: 10.1016/j.cmet.2016.05.004
PMCID:
PMC4910629
ArticlePDF–2.6M
15.
Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells
Min Pi, Karan Kapoor, Ruisong Ye, Satoru Kenneth Nishimoto, Jeremy C. Smith, Jerome Baudry, Leigh Darryl Quarles
Endocrinology. 2016 May; 157(5): 1866–1880. Published online 2016 Mar 23. doi: 10.1210/en.2015-2010
PMCID:
PMC4870875
Article
16.
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants
Patricia Rueda, Elizabeth Harley, Yao Lu, Gregory D. Stewart, Stewart Fabb, Natalie Diepenhorst, Béatrice Cremers, Marie-Hélène Rouillon, Isabelle Wehrle, Anne Geant, Gwladys Lamarche, Katie Leach, William N. Charman, Arthur Christopoulos, Roger J. Summers, Patrick M. Sexton, Christopher J. Langmead
PLoS One. 2016; 11(1): e0146846. Published online 2016 Jan 19. doi: 10.1371/journal.pone.0146846
PMCID:
PMC4718634
ArticlePDF–2.1M
17.
GPRC6a is not Required for the Effects of a High-Protein Diet on Body Weight in Mice
James S Kinsey-Jones, Amin Alamshah, Anne K McGavigan, Eleanor Spreckley, Katherine Banks, Nicholas Cereceda Monteoliva, Mariana Norton, Gavin A Bewick, Kevin G Murphy
Obesity (Silver Spring) 2015 Jun; 23(6): 1194–1200. Published online 2015 May 9. doi: 10.1002/oby.21083
PMCID:
PMC4692088
ArticlePDF–335K
18.
Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues
Min Pi, Karan Kapoor, Yunpeng Wu, Ruisong Ye, Susan E. Senogles, Satoru K. Nishimoto, Dong-Jin Hwang, Duane D. Miller, Ramesh Narayanan, Jeremy C. Smith, Jerome Baudry, L. Darryl Quarles
Mol Endocrinol. 2015 Dec; 29(12): 1759–1773. Published online 2015 Oct 6. doi: 10.1210/me.2015-1161
PMCID:
PMC4664231
Article
19.
GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses
Dagmar Quandt, Kathrin Rothe, Christoph Baerwald, Manuela Rossol
Sci Rep. 2015; 5: 16719. Published online 2015 Nov 25. doi: 10.1038/srep16719
PMCID:
PMC4658484
ArticlePDF–1.2M
20.
l-cysteine suppresses ghrelin and reduces appetite in rodents and humans
A K McGavigan, H C O'Hara, A Amin, J Kinsey-Jones, E Spreckley, A Alamshah, A Agahi, K Banks, R France, G Hyberg, C Wong, G A Bewick, J V Gardiner, A Lehmann, N M Martin, M A Ghatei, S R Bloom, K G Murphy
Int J Obes (Lond) 2015 Mar; 39(3): 447–455. Prepublished online 2014 Sep 15. Published online 2014 Oct 14. doi: 10.1038/ijo.2014.172
PMCID:
PMC4276721
ArticlePDF–1.9M

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