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Items: 1 to 20 of 36

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration
Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Changwoo Lee, Benjamin Sanders, Paul J. Lee, Yangfei Xiang, Kimberly Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah H. Ro, Hyoungseok Ju, Clara Liao, Sofia Massaro Tieze, Frank Rigo, Paymaan Jafar-Nejad, Janghoo Lim
J Clin Invest. 2023 Aug 15; 133(16): e138207. Published online 2023 Aug 15. doi: 10.1172/JCI138207
PMCID:
PMC10425213
ArticlePDF–19M
3.
Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
Tingting Dong, Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Kimberly Luttik, Terri M. Driessen, Janghoo Lim
JCI Insight. 2021 Nov 22; 6(22): e136147. Published online 2021 Nov 22. doi: 10.1172/jci.insight.136147
PMCID:
PMC8663778
ArticlePDF–2.1M
4.
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare, K. M. Sakamoto
Nat Commun. 2020; 11: 3344. Published online 2020 Jul 3. doi: 10.1038/s41467-020-17100-z
PMCID:
PMC7334220
ArticlePDF–2.4M
5.
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease
Mali Jiang, Xiaoyan Zhang, Hongshuai Liu, Jared LeBron, Athanasios Alexandris, Qi Peng, Hao Gu, Fanghan Yang, Yuchen Li, Ruiling Wang, Zhipeng Hou, Nicolas Arbez, Qianwei Ren, Jen-Li Dong, Emma Whela, Ronald Wang, Tamara Ratovitski, Juan C Troncoso, Susumu Mori, Christopher A Ross, Janghoo Lim, Wenzhen Duan
Hum Mol Genet. 2020 May 28; 29(8): 1340–1352. Published online 2020 Apr 2. doi: 10.1093/hmg/ddaa061
PMCID:
PMC7254850
ArticlePDF–1.3M
6.
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
Shang-Ze Li, Qi-Peng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bing-Xue Jin, Tian-Zi Liuyu, Chao Li, Xi-Chen Huang, Run-Lei Du, Wei Song, Bo Zhong, Xiao-Dong Zhang
Nat Commun. 2019; 10: 3233. Published online 2019 Jul 19. doi: 10.1038/s41467-019-11258-x
PMCID:
PMC6642205
ArticlePDF–2.9M
7.
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
Veerle Fleskens, Carlos M. Minutti, Xingmei Wu, Ping Wei, Cornelieke E.G.M. Pals, James McCrae, Saskia Hemmers, Vincent Groenewold, Harm-Jan Vos, Alexander Rudensky, Fan Pan, Huabin Li, Dietmar M. Zaiss, Paul J. Coffer
Cell Rep. 2019 Mar 26; 26(13): 3600–3612.e6. Published online 2019 Mar 26. doi: 10.1016/j.celrep.2019.02.087
PMCID:
PMC6444001
Article
8.
The Evf2 ultraconserved enhancer lncRNA functionally and spatially organizes multi-megabase distant genes in developing forebrain
Ivelisse Cajigas, Abhijit Chakraborty, Kelsey R. Swyter, Hao Luo, Monique Bastidas, Maximilliano Nigro, Elizabeth R. Morris, Sean Chen, Michael J. W. VanGompel, David Leib, Sara J. Kohtz, Marco Martina, Sooky Koh, Ferhat Ay, Jhumku D. Kohtz
Mol Cell. Author manuscript; available in PMC 2019 Sep 20.
Published in final edited form as: Mol Cell. 2018 Sep 20; 71(6): 956–972.e9. Published online 2018 Aug 23. doi: 10.1016/j.molcel.2018.07.024
PMCID:
PMC6428050
ArticlePDF–2.0M
9.
Correlated evolution between CK1δ Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock
Lijuan Xing, Yang An, Guangsen Shi, Jie Yan, Pancheng Xie, Zhipeng Qu, Zhihui Zhang, Zhiwei Liu, Dejing Pan, Ying Xu
J Biol Chem. 2017 Jan 6; 292(1): 161–171. Published online 2016 Nov 22. doi: 10.1074/jbc.M116.751214
PMCID:
PMC5217676
ArticlePDF–3.0M
10.
Phosphorylation by NLK inhibits YAP‐14‐3‐3‐interactions and induces its nuclear localization
Sungho Moon, Wantae Kim, Soyoung Kim, Youngeun Kim, Yonghee Song, Oleksii Bilousov, Jiyoung Kim, Taebok Lee, Boksik Cha, Minseong Kim, Hanjun Kim, Vladimir L Katanaev, Eek‐hoon Jho
EMBO Rep. 2017 Jan; 18(1): 61–71. Published online 2016 Dec 15. doi: 10.15252/embr.201642683
PMCID:
PMC5210122
ArticlePDF–2.1M
11.
Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart
Ruijie Liu, Hadi Khalil, Suh-Chin J. Lin, Michelle A. Sargent, Allen J. York, Jeffery D. Molkentin
PLoS One. 2016; 11(10): e0164897. Published online 2016 Oct 20. doi: 10.1371/journal.pone.0164897
PMCID:
PMC5072578
ArticlePDF–2.2M
12.
Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells
Hengning Ke, Katarzyna Chmielarska Masoumi, Kristofer Ahlqvist, Michael J. Seckl, Kristina Rydell-Törmänen, Ramin Massoumi
Sci Rep. 2016; 6: 23987. Published online 2016 Apr 1. doi: 10.1038/srep23987
PMCID:
PMC4817507
ArticlePDF–1.5M
13.
Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy
Tiffany W Todd, Hiroshi Kokubu, Helen C Miranda, Constanza J Cortes, Albert R La Spada, Janghoo Lim
eLife. 2015; 4: e08493. Published online 2015 Aug 26. doi: 10.7554/eLife.08493
PMCID:
PMC4577982
ArticlePDF–5.9M
14.
A high resolution spatiotemporal atlas of gene expression of the developing mouse brain
Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones
Neuron. Author manuscript; available in PMC 2015 Jul 16.
Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033
PMCID:
PMC4319559
ArticlePDF–3.0M
15.
NEMO-LIKE KINASE REGULATES POSTNATAL SKELETAL HOMEOSTASIS
Ernesto Canalis, Lauren Kranz, Stefano Zanotti
J Cell Physiol. Author manuscript; available in PMC 2015 Nov 1.
Published in final edited form as: J Cell Physiol. 2014 Nov; 229(11): 1736–1743. doi: 10.1002/jcp.24625
PMCID:
PMC4117815
ArticlePDF–645K
16.
Polyglutamine Disease Toxicity Is Regulated by Nemo-like Kinase in Spinocerebellar Ataxia Type 1
Hyoungseok Ju, Hiroshi Kokubu, Tiffany W. Todd, Juliette J. Kahle, Soeun Kim, Ronald Richman, Karthik Chirala, Harry T. Orr, Huda Y. Zoghbi, Janghoo Lim
J Neurosci. 2013 May 29; 33(22): 9328–9336. doi: 10.1523/JNEUROSCI.3465-12.2013
PMCID:
PMC3710458
ArticlePDF–2.4M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
ArticlePDF–1.1M
18.
NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells
Satoshi Ota, Shizuka Ishitani, Nobuyuki Shimizu, Kunihiro Matsumoto, Motoyuki Itoh, Tohru Ishitani
EMBO J. 2012 Apr 18; 31(8): 1904–1915. Published online 2012 Feb 28. doi: 10.1038/emboj.2012.46
PMCID:
PMC3343332
ArticlePDF–1.5M
19.
NEMO-LIKE KINASE INHIBITS OSTEOBLASTOGENESIS BY SUPPRESSING BONE MORPHOGENETIC PROTEIN AND WNT CANONICAL SIGNALING
Stefano Zanotti, Ernesto Canalis
J Cell Biochem. Author manuscript; available in PMC 2013 Feb 1.
Published in final edited form as: J Cell Biochem. 2012 Feb; 113(2): 449–456. doi: 10.1002/jcb.23365
PMCID:
PMC3253257
ArticlePDF–727K
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
ArticlePDF–1.0M

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