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Select item 103805671.

Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin

Anna Hucke, Rita Schröter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli

Int J Mol Sci. 2023 Jul; 24(14): 11486. Published online 2023 Jul 14. doi: 10.3390/ijms241411486

PMCID:: PMC10380567

Abstract Article PDF–3.5M

Select item 95668992.

In vivo visualization and molecular targeting of the cardiac conduction system

William R. Goodyer, Benjamin M. Beyersdorf, Lauren Duan, Nynke S. van den Berg, Sruthi Mantri, Francisco X. Galdos, Nazan Puluca, Jan W. Buikema, Soah Lee, Darren Salmi, Elise R. Robinson, Stephan Rogalla, Dillon P. Cogan, Chaitan Khosla, Eben L. Rosenthal, Sean M. Wu

J Clin Invest. 2022 Oct 17; 132(20): e156955. Published online 2022 Oct 17. doi: 10.1172/JCI156955

PMCID:: PMC9566899

Abstract Article PDF–9.4M

Select item 91305383.

Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1

Marleen J. Meyer, Pascale C.F. Schreier, Mert Basaran, Stefaniia Vlasova, Tina Seitz, Jürgen Brockmöller, Barbara Zdrazil, Mladen V. Tzvetkov

J Biol Chem. 2022 Jun; 298(6): 101974. Published online 2022 Apr 22. doi: 10.1016/j.jbc.2022.101974

PMCID:: PMC9130538

Abstract Article PDF–4.4M

Select item 81418104.

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

Ole Jensen, Johannes Matthaei, Henry G. Klemp, Marleen J. Meyer, Jürgen Brockmöller, Mladen V. Tzvetkov

Front Pharmacol. 2021; 12: 674559. Published online 2021 May 10. doi: 10.3389/fphar.2021.674559

PMCID:: PMC8141810

Abstract Article PDF–3.6M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 79171856.

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2^−/− Mice

Bridget L. Morse, Lisa Hong Chen, John T. Catlow, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren

Front Pharmacol. 2021; 12: 631793. Published online 2021 Feb 15. doi: 10.3389/fphar.2021.631793

PMCID:: PMC7917185

Abstract Article PDF–1.7M

Select item 77925857.

Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families

Matthias Gorecki, Simon F. Müller, Regina Leidolf, Joachim Geyer

Int J Mol Sci. 2021 Jan; 22(1): 22. Published online 2020 Dec 22. doi: 10.3390/ijms22010022

PMCID:: PMC7792585

Abstract Article PDF–845K

Select item 75598348.

Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction

Saskia Floerl, Annett Kuehne, Yohannes Hagos

Int J Mol Sci. 2020 Sep; 21(18): 6871. Published online 2020 Sep 19. doi: 10.3390/ijms21186871

PMCID:: PMC7559834

Abstract Article PDF–1.7M

Select item 59196929.

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content

Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C. Chen, Qi Luo, Ling Zou, Meiling Piao, Arias Mifune, Ligong Chen, Meredith E. Calvert, Sarah King, Frode Norheim, Janna Abad, Ronald M. Krauss, Kathleen M. Giacomini

PLoS Biol. 2018 Apr; 16(4): e2002907. Published online 2018 Apr 16. doi: 10.1371/journal.pbio.2002907

PMCID:: PMC5919692

Abstract Article PDF–6.4M

Select item 563016210.

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

Hye In Kim, Johannes Raffler, Wenyun Lu, Jung-Jin Lee, Deepti Abbey, Danish Saleheen, Joshua D. Rabinowitz, Michael J. Bennett, Nicholas J. Hand, Christopher Brown, Daniel J. Rader

Am J Hum Genet. 2017 Oct 5; 101(4): 489–502. Published online 2017 Sep 21. doi: 10.1016/j.ajhg.2017.08.008

PMCID:: PMC5630162

Abstract Article PDF–1.6M

Select item 479936211.

A phosphotyrosine switch regulates organic cation transporters

Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Shuiying Hu, Guoqing Du, Wenwei Lin, Lie Li, Shashank Bharill, Rachel A. Ness, Adrian Stecula, Steven M. Offer, Robert B. Diasio, Anne T. Nies, Matthias Schwab, Guido Cavaletti, Eberhard Schlatter, Giuliano Ciarimboli, Jan H. M. Schellens, Ehud Y. Isacoff, Andrej Sali, Taosheng Chen, Sharyn D. Baker, Alex Sparreboom, Navjotsingh Pabla

Nat Commun. 2016; 7: 10880. Published online 2016 Mar 16. doi: 10.1038/ncomms10880

PMCID:: PMC4799362

Abstract Article PDF–1.0M

Select item 441332012.

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

Navjotsingh Pabla, Alice A. Gibson, Mike Buege, Su Sien Ong, Lie Li, Shuiying Hu, Guoqing Du, Jason A. Sprowl, Aksana Vasilyeva, Laura J. Janke, Eberhard Schlatter, Taosheng Chen, Giuliano Ciarimboli, Alex Sparreboom

Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16): 5231–5236. Published online 2015 Apr 6. doi: 10.1073/pnas.1424313112

PMCID:: PMC4413320

Abstract Article PDF–1.1M

Select item 441045513.

Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation

Chelsea Marcho, Ariana Bevilacqua, Kimberly D Tremblay, Jesse Mager

Epigenetics Chromatin. 2015; 8: 10. Published online 2015 Mar 14. doi: 10.1186/s13072-015-0003-y

PMCID:: PMC4410455

Abstract Article PDF–1.7M

Select item 410332414.

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

Ligong Chen, Yan Shu, Xiaomin Liang, Eugene C. Chen, Sook Wah Yee, Arik A. Zur, Shuanglian Li, Lu Xu, Kayvan R. Keshari, Michael J. Lin, Huan-Chieh Chien, Youcai Zhang, Kari M. Morrissey, Jason Liu, Jonathan Ostrem, Noah S. Younger, John Kurhanewicz, Kevan M. Shokat, Kaveh Ashrafi, Kathleen M. Giacomini

Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27): 9983–9988. Published online 2014 Jun 24. doi: 10.1073/pnas.1314939111

PMCID:: PMC4103324

Abstract Article PDF–1.0M

Select item 371631715.

Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes

Tianxiang (Kevin) Han, Ruth S. Everett, William R. Proctor, Chee M. Ng, Chester L. Costales, Kim L. R. Brouwer, Dhiren R. Thakker

Mol Pharmacol. 2013 Aug; 84(2): 182–189. Published online 2013 Aug. doi: 10.1124/mol.112.084517

PMCID:: PMC3716317

Abstract Article PDF–984K

Select item 363786416.

Dynamic regulatory network controlling Th17 cell differentiation

Nir Yosef, Alex K. Shalek, Jellert T. Gaublomme, Hulin Jin, Youjin Lee, Amit Awasthi, Chuan Wu, Katarzyna Karwacz, Sheng Xiao, Marsela Jorgolli, David Gennert, Rahul Satija, Arvind Shakya, Diana Y. Lu, John J. Trombetta, Meenu R. Pillai, Peter J. Ratcliffe, Mathew L. Coleman, Mark Bix, Dean Tantin, Hongkun Park, Vijay K. Kuchroo, Aviv Regev

Nature. Author manuscript; available in PMC 2013 Oct 25.

Published in final edited form as: Nature. 2013 Apr 25; 496(7446): 461–468. Published online 2013 Mar 6. doi: 10.1038/nature11981