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Select item 109051051.

DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response

Minjing Li, Xingli Wu, Meiyang Chen, Shiyu Hao, Yue Yu, Xiang Li, Erdi Zhao, Ming Xu, Zhenhai Yu, Zhiqiang Wang, Ning Xu, Changzhu Jin, Yancun Yin

Haematologica. 2024 Mar 1; 109(3): 751–764. Published online 2023 Jul 27. doi: 10.3324/haematol.2023.282691

PMCID:: PMC10905105

Article PDF–3.8M

Select item 107649922.

Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice

Jooyeop Lee, Min Joo Kim, Seoil Moon, Ji Yoon Lim, Kyong Soo Park, Hye Seung Jung

Endocrinol Metab (Seoul) 2023 Dec; 38(6): 782–787. Published online 2023 Nov 13. doi: 10.3803/EnM.2023.1738

PMCID:: PMC10764992

Article PDF–821K

Select item 107212783.

Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation

Suravi Majumder, Abhijnan Chattopadhyay, Jamie M. Wright, Pujun Guan, L. Maximilian Buja, Callie S. Kwartler, Dianna M. Milewicz

JCI Insight. 2023 Nov 8; 8(21): e173247. Published online 2023 Nov 8. doi: 10.1172/jci.insight.173247

PMCID:: PMC10721278

Article PDF–21M

Select item 104248024.

PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy

Shuizhen Shi, Chun Ding, Shuang Zhu, Fan Xia, Seth E. Buscho, Shengguo Li, Massoud Motamedi, Hua Liu, Wenbo Zhang

Invest Ophthalmol Vis Sci. 2023 Aug; 64(11): 17. Published online 2023 Aug 11. doi: 10.1167/iovs.64.11.17

PMCID:: PMC10424802

Article PDF–6.1M

Select item 104155445.

Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis

Xiaohua Zhu, Linjie Yang, Xu Han, Chen Huang, Gongcheng Huang, Tingju Wei, Liliang Shu, Jing Xu

Aging (Albany NY) 2023 Jul 31; 15(14): 6834–6847. Published online 2023 Jul 17. doi: 10.18632/aging.204875

PMCID:: PMC10415544

Article PDF–1.1M

Select item 101928216.

Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

Bipul R Acharya, Jennifer S Fang, Erin D Jeffery, Nicholas W Chavkin, Gael Genet, Hema Vasavada, Elizabeth A Nelson, Gloria M Sheynkman, Martin J Humphries, Karen K Hirschi

Life Sci Alliance. 2023 Aug; 6(8): e202201685. Published online 2023 May 17. doi: 10.26508/lsa.202201685

PMCID:: PMC10192821

Article PDF–3.0M

Select item 101906077.

The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway

Yankun Shao, Yilin Xu, Huang Di, Xinxiu Shi, Yingying Wang, Hongyu Liu, Lina Song

IET Nanobiotechnol. 2023 May; 17(3): 182–196. Published online 2023 Jan 20. doi: 10.1049/nbt2.12113

PMCID:: PMC10190607

Article PDF–4.2M

Select item 99682978.

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Eun-Ji Park, Hyun-Soo Kim, Do-Hyoung Lee, Su-Min Kim, Joon-Sup Yoon, Ji-Min Lee, Se Jin Im, Ho Lee, Min-Woo Lee, Chang-Woo Lee

Nat Commun. 2023; 14: 1097. Published online 2023 Feb 25. doi: 10.1038/s41467-023-36836-y

PMCID:: PMC9968297

Article PDF–4.4M

Select item 98705779.

PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice

Shaunaci A. Stevens, Maria K. Gonzalez Aguiar, Allyson L. Toro, Esma I. Yerlikaya, Siddharth Sunilkumar, Ashley M. VanCleave, Jessica Pfleger, Elisa A. Bradley, Scot R. Kimball, Michael D. Dennis

Am J Physiol Endocrinol Metab. 2023 Jan 1; 324(1): E62–E72. Published online 2022 Nov 16. doi: 10.1152/ajpendo.00238.2022

PMCID:: PMC9870577

Article

Select item 972262610.

Stress-mediated attenuation of translation undermines T-cell activity in cancer

Brian P. Riesenberg, Elizabeth G. Hunt, Megan D. Tennant, Katie E. Hurst, Alex M. Andrews, Lee R. Leddy, David M. Neskey, Elizabeth G. Hill, Guillermo O. Rangel Rivera, Chrystal M. Paulos, Peng Gao, Jessica E. Thaxton

Cancer Res. Author manuscript; available in PMC 2023 Jun 2.

Published in final edited form as: Cancer Res. 2022 Dec 2; 82(23): 4386–4399. doi: 10.1158/0008-5472.CAN-22-1744

PMCID:: PMC9722626

Article PDF–2.3M

Select item 956106711.

Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

Jessica K. Mandula, Shiun Chang, Eslam Mohamed, Rachel Jimenez, Rosa A. Sierra-Mondragon, Darwin C. Chang, Alyssa N. Obermayer, Carlos M. Moran-Segura, Satyajit Das, Julio A. Vazquez-Martinez, Karol Prieto, Ann Chen, Keiran S.M. Smalley, Brian Czerniecki, Peter Forsyth, Richard C. Koya, Brian Ruffell, Juan R. Cubillos-Ruiz, David H. Munn, Timothy I. Shaw, Jose R. Conejo-Garcia, Paulo C. Rodriguez

Cancer Cell. Author manuscript; available in PMC 2023 Oct 10.

Published in final edited form as: Cancer Cell. 2022 Oct 10; 40(10): 1145–1160.e9. Published online 2022 Sep 22. doi: 10.1016/j.ccell.2022.08.016

PMCID:: PMC9561067

Article PDF–1.7M

Select item 955086312.

Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota

Nat Commun. 2022; 13: 5859. Published online 2022 Oct 10. doi: 10.1038/s41467-022-33605-1

PMCID:: PMC9550863

Article PDF–2.1M

Select item 931146313.

Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation

Abhijnan Chattopadhyay, Pujun Guan (关蒲骏), Suravi Majumder, Kaveeta Kaw, Zhen Zhou (周桢), Chen Zhang, Siddharth K. Prakash, Anita Kaw, L. Maximillian Buja, Callie S. Kwartler, Dianna M. Milewicz

Arterioscler Thromb Vasc Biol. 2022 Aug; 42(8): 1005–1022. Published online 2022 Jun 16. doi: 10.1161/ATVBAHA.121.317451

PMCID:: PMC9311463

Article PDF–1.6M

Select item 911228814.

PERK is a critical metabolic hub for immunosuppressive function in macrophages

Lydia N. Raines, Haoxin Zhao, Yuzhu Wang, Heng-Yi Chen, Hector Gallart-Ayala, Pei-Chun Hsueh, Wei Cao, Yeojung Koh, Ana Alamonte-Loya, Pu-Ste Liu, Julijana Ivanisevic, Chan-Wang Jerry Lio, Ping-Chih Ho, Stanley Ching-Cheng Huang

Nat Immunol. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Nat Immunol. 2022 Mar; 23(3): 431–445. Published online 2022 Feb 28. doi: 10.1038/s41590-022-01145-x

PMCID:: PMC9112288

Article PDF–2.4M

Select item 900912415.

Inhibition of unfolded protein response prevents post‐anesthesia neuronal hyperactivity and synapse loss in aged mice

Kai Chen, Qiuping Hu, Riya Gupta, Jessie Stephens, Zhongcong Xie, Guang Yang

Aging Cell. 2022 Apr; 21(4): e13592. Published online 2022 Mar 17. doi: 10.1111/acel.13592

PMCID:: PMC9009124

Article PDF–2.2M

Select item 896549916.

Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche

Cui Liu, Qiuyun Chen, Yinghui Shang, Lechuang Chen, Jay Myers, Amad Awadallah, Jinger Sun, Shuiliang Yu, Katharine Umphred-Wilson, Danian Che, Yingtong Dou, Luoyi Li, Pamela Wearsch, Diana Ramírez-Bergeron, Rose Beck, Wei Xin, Ge Jin, Stanley Adoro, Lan Zhou

Theranostics. 2022; 12(6): 2894–2907. Published online 2022 Mar 21. doi: 10.7150/thno.67710

PMCID:: PMC8965499

Article PDF–2.6M

Select item 891961617.

PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen

Mingyu Liu, Chong Wu, Shufeng Luo, Qiaomin Hua, Hai-Tian Chen, Yulan Weng, Junyu Xu, Huiling Lin, Lu Wang, Jinheng Li, Lan Zhu, Zhenhong Guo, Shi-Mei Zhuang, Tiebang Kang, Limin Zheng

J Exp Med. 2022 Apr 4; 219(4): e20211498. Published online 2022 Mar 10. doi: 10.1084/jem.20211498

Correction in:: J Exp Med. 2022 Jul 4; 219(7): jem.2021149805312022c.

PMCID:: PMC8919616

Article PDF–8.8M

Select item 875422818.

The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation

Junchao Shi, Zi Li, Rongyi Xu, Jing Zhang, Qianyu Zhou, Rui Gao, Huijun Lu, Yungang Lan, Kui Zhao, Hongbin He, Feng Gao, Wenqi He

J Virol. 2022 Jan; 96(1): e01695-21. Prepublished online 2021 Oct 13. Published online 2022 Jan 12. doi: 10.1128/JVI.01695-21

PMCID:: PMC8754228

Article PDF–6.3M

Select item 856344419.

Integrated Stress Response Couples Mitochondrial Protein Translation with Oxidative Stress Control

Guangyu Zhang, Xiaoding Wang, Chao Li, Qinfeng Li, Yu A. An, Xiang Luo, Yingfeng Deng, Thomas G. Gillette, Philipp E. Scherer, Zhao V. Wang

Circulation. Author manuscript; available in PMC 2022 Nov 2.

Published in final edited form as: Circulation. 2021 Nov 2; 144(18): 1500–1515. Published online 2021 Sep 29. doi: 10.1161/CIRCULATIONAHA.120.053125

PMCID:: PMC8563444

Article PDF–2.8M

Select item 853315020.

Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium

Rafael Moreno-Gómez-Toledano, Sandra Sánchez-Esteban, Alberto Cook, Marta Mínguez-Moratinos, Rafael Ramírez-Carracedo, Paula Reventún, María Delgado-Marín, Ricardo J. Bosch, Marta Saura

Biomolecules. 2021 Oct; 11(10): 1429. Published online 2021 Sep 29. doi: 10.3390/biom11101429

PMCID:: PMC8533150

Article PDF–3.1M

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