PMC Links for GEO Profiles (Select 115142623) - PMC

Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers

Nat Commun. 2024; 15: 1564. Published online 2024 Feb 20. doi: 10.1038/s41467-024-45012-9

PMCID:: PMC10879116

Abstract Article PDF–3.7M

Select item 105117905.

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells

Melanie R. Shapiro, Leeana D. Peters, Matthew E. Brown, Cecilia Cabello-Kindelan, Amanda L. Posgai, Allison L. Bayer, Todd M. Brusko

J Immunol. 2023 Oct 1; 211(7): 1108–1122. Published online 2023 Aug 18. doi: 10.4049/jimmunol.2200651

PMCID:: PMC10511790

Abstract Article PDF–3.3M

Select item 102886206.

Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells

Trang T. T. Nguyen, Wen Lu, Wandi S. Zhu, K. Mark Ansel, Hong-Erh Liang, Arthur Weiss

Proc Natl Acad Sci U S A. 2023 Jun 20; 120(25): e2300987120. Published online 2023 Jun 12. doi: 10.1073/pnas.2300987120

PMCID:: PMC10288620

Abstract Article PDF–2.0M

Select item 101200617.

Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2

Claire E. Depew, Jordan A. Rixon, Stephen J. McSorley

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2214699120. Published online 2023 Apr 11. doi: 10.1073/pnas.2214699120

PMCID:: PMC10120061

Abstract Article PDF–3.6M

Select item 99772738.

Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek

eLife. 2023; 12: e79342. Published online 2023 Jan 27. doi: 10.7554/eLife.79342

PMCID:: PMC9977273

Abstract Article PDF–3.2M

Select item 96990719.

Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression

Chengyi Huang, Fucheng Zhang, Peng Li, Cai Song

Int J Mol Sci. 2022 Nov; 23(22): 13856. Published online 2022 Nov 10. doi: 10.3390/ijms232213856

PMCID:: PMC9699071

Abstract Article PDF–3.1M

Select item 968827610.

Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model

Ornella Chovar-Vera, Ernesto López, Felipe Gálvez-Cancino, Carolina Prado, Dafne Franz, Diego A. Figueroa, Alexandra Espinoza, Claudio Figueroa, Alvaro Lladser, Rodrigo Pacheco

Cells. 2022 Nov; 11(22): 3536. Published online 2022 Nov 9. doi: 10.3390/cells11223536

PMCID:: PMC9688276

Abstract Article PDF–1.7M

Select item 965912111.

Diversity-Oriented Synthesis of a Molecular Library of Immunomodulatory α-Galactosylceramides with Fluorous-Tag-Assisted Purification and Evaluation of Their Bioactivities in Regard to IL-2 Secretion

Yeng-Nan Chen, Jung-Tung Hung, Fan-Dan Jan, Yung-Yu Su, Jih-Ru Hwu, Alice L. Yu, Avijit K. Adak, Chun-Cheng Lin

Int J Mol Sci. 2022 Nov; 23(21): 13403. Published online 2022 Nov 2. doi: 10.3390/ijms232113403

PMCID:: PMC9659121

Abstract Article PDF–4.1M

Select item 949526112.

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4⁺Foxp3⁺ regulatory T lymphocytes

Cécile Apert, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Héloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Holländer, Saulius Žuklys, Jérémy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk

Front Immunol. 2022; 13: 965303. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.965303

PMCID:: PMC9495261

Abstract Article PDF–6.3M

Select item 942882713.

The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8⁺ T lymphocyte/Treg cell balance

Tania Carmenate, Galia Montalvo, Sum Lai Lozada, Yaretnis Rodriguez, Yaquelin Ortiz, Claudia Díaz, Janet Avellanet, Juhee Kim, Charles D. Surh, Luis Graça, Kalet León

Front Immunol. 2022; 13: 974188. Published online 2022 Aug 17. doi: 10.3389/fimmu.2022.974188

PMCID:: PMC9428827

Abstract Article PDF–1.2M

Select item 920272014.

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y.F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston

J Exp Med. 2022 Jul 4; 219(7): e20212391. Published online 2022 Jun 14. doi: 10.1084/jem.20212391

Correction in:: J Exp Med. 2022 Aug 1; 219(8): jem.2021149805312022c.

PMCID:: PMC9202720

Abstract Article PDF–9.2M

Select item 892323815.

Intrinsic IL-2 Production by Effector CD8 T Cells Affects IL-2 Signaling and Promotes Fate Decisions, Stemness, and Protection

Shannon M. Kahan, Rakesh K. Bakshi, Jennifer T. Ingram, R. Curtis Hendrickson, Elliot J. Lefkowitz, David K. Crossman, Laurie E. Harrington, Casey T. Weaver, Allan J. Zajac

Sci Immunol. Author manuscript; available in PMC 2023 Feb 11.

Published in final edited form as: Sci Immunol. 2022 Feb 11; 7(68): eabl6322. Published online 2022 Feb 11. doi: 10.1126/sciimmunol.abl6322

PMCID:: PMC8923238

Abstract Article PDF–3.1M

Select item 880334716.

Selective delivery of low-affinity IL-2 to PD-1⁺ T cells rejuvenates antitumor immunity with reduced toxicity

Zhenhua Ren, Anli Zhang, Zhichen Sun, Yong Liang, Jianfeng Ye, Jian Qiao, Bo Li, Yang-Xin Fu

J Clin Invest. 2022 Feb 1; 132(3): e153604. Published online 2022 Feb 1. doi: 10.1172/JCI153604

PMCID:: PMC8803347

Abstract Article PDF–4.6M

Select item 866415817.

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Francesco Marangoni, Ademi Zhakyp, Michela Corsini, Shannon N. Geels, Esteban Carrizosa, Martin Thelen, Vinidhra Mani, Jasper N. Prüßmann, Ross D. Warner, Aleksandra J. Ozga, Mauro Di Pilato, Shivashankar Othy, Thorsten R. Mempel

Cell. Author manuscript; available in PMC 2022 Jul 22.

Published in final edited form as: Cell. 2021 Jul 22; 184(15): 3998–4015.e19. Published online 2021 Jun 21. doi: 10.1016/j.cell.2021.05.027

PMCID:: PMC8664158

Abstract Article PDF–2.6M

Select item 863575618.

The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role

Jorge Nihei, Fabiola Cardillo, Jose Mengel

Front Cell Infect Microbiol. 2021; 11: 758273. Published online 2021 Nov 17. doi: 10.3389/fcimb.2021.758273

PMCID:: PMC8635756

Abstract Article PDF–3.5M

Select item 852991419.

Enhanced IL-2 in early life limits the development of T_FH and protective antiviral immunity

Chloe J. Pyle, Lucia Labeur-Iurman, Helen T. Groves, Franz Puttur, Clare M. Lloyd, John S. Tregoning, James A. Harker

J Exp Med. 2021 Dec 6; 218(12): e20201555. Published online 2021 Oct 19. doi: 10.1084/jem.20201555

PMCID:: PMC8529914

Abstract Article PDF–6.3M

Select item 831750820.

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

Stanislav Dikiy, Jun Li, Lu Bai, Menglin Jiang, Laura Janke, Xinying Zong, Xiaolei Hao, Beatrice Hoyos, Zhong-Min Wang, Beisi Xu, Yiping Fan, Alexander Y. Rudensky, Yongqiang Feng

Immunity. Author manuscript; available in PMC 2021 Aug 11.

Published in final edited form as: Immunity. 2021 May 11; 54(5): 931–946.e11. Published online 2021 Apr 9. doi: 10.1016/j.immuni.2021.03.020

PMCID:: PMC8317508

Abstract Article PDF–3.2M

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