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Select item 110580181.

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation

Amy Erica Lin, Aneesh C. Bapat, Ling Xiao, Abhishek Niroula, Jiangchuan Ye, Waihay J. Wong, Mridul Agrawal, Christopher J. Farady, Andreas Boettcher, Christopher B. Hergott, Marie McConkey, Patricio Flores-Bringas, Veronica Shkolnik, Alexander G. Bick, David Milan, Pradeep Natarajan, Peter Libby, Patrick T. Ellinor, Benjamin L. Ebert

Circulation. 2024 Apr 30; 149(18): 1419–1434. Published online 2024 Feb 15. doi: 10.1161/CIRCULATIONAHA.123.065597

PMCID:: PMC11058018

Abstract Article PDF–1.6M

Select item 110042972.

Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity

Emily Dennis, Maria Murach, Cassidy M.R. Blackburn, Melissa Marshall, Katherine Root, Tanyaporn Pattarabanjird, Justine Deroissart, Loren D. Erickson, Christoph J. Binder, Stefan Bekiranov, Coleen A. McNamara

Front Immunol. 2024; 15: 1380641. Published online 2024 Mar 27. doi: 10.3389/fimmu.2024.1380641

PMCID:: PMC11004297

Abstract Article PDF–16M

Select item 109851123.

A negative feedback loop between TET2 and leptin in adipocyte regulates body weight

Qin Zeng, Jianfeng Song, Xiaoxiao Sun, Dandan Wang, Xiyan Liao, Yujin Ding, Wanyu Hu, Yayi Jiao, Wuqian Mai, Wufuer Aini, Fanqi Wang, Hui Zhou, Limin Xie, Ying Mei, Yuan Tang, Zhiguo Xie, Haijing Wu, Wei Liu, Tuo Deng

Nat Commun. 2024; 15: 2825. Published online 2024 Apr 1. doi: 10.1038/s41467-024-46783-x

PMCID:: PMC10985112

Abstract Article PDF–2.5M

Select item 109436914.

Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency

Patrick A. Flynn, Mark D. Long, Yoko Kosaka, Nicola Long, Jessica S. Mulkey, Jesse L. Coy, Anupriya Agarwal, Evan F. Lind

Front Immunol. 2024; 15: 1297338. Published online 2024 Mar 1. doi: 10.3389/fimmu.2024.1297338

PMCID:: PMC10943691

Abstract Article PDF–6.1M

Select item 108782745.

Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis

Rachel Matrenec, Claudia E. Oropeza, Eddie Dekoven, Grant Tarnow, Mark Maienschein-Cline, Cecilia S. Chau, Stefan J. Green, Alan McLachlan

J Virol. 2024 Feb; 98(2): e01721-23. Published online 2024 Jan 5. doi: 10.1128/jvi.01721-23

PMCID:: PMC10878274

Currently embargoed: Free in PMC on Jul 5, 2024; PubMed

Select item 107669526.

TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

Hongwei Lv, Qianni Zong, Cian Chen, Guishuai Lv, Wei Xiang, Fuxue Xing, Guoqing Jiang, Bing Yan, Xiaoyan Sun, Yue Ma, Liang Wang, Zixin Wu, Xiuliang Cui, Hongyang Wang, Wen Yang

Nat Commun. 2024; 15: 6. Published online 2024 Jan 4. doi: 10.1038/s41467-023-43743-9

PMCID:: PMC10766952

Abstract Article PDF–9.2M

Select item 107502687.

Microenvironmental CXCL12 Deletion Enhances Flt3-ITD Acute Myeloid Leukemia Stem Cell Response to Therapy by Reducing p38 MAPK Signaling

Nicholas R. Anderson, Vipul Sheth, Hui Li, Mason W. Harris, Shaowei Qiu, David K. Crossman, Harish Kumar, Puneet Agarwal, Takashi Nagasawa, Andrew J. Paterson, Robert S. Welner, Ravi Bhatia

Leukemia. Author manuscript; available in PMC 2023 Dec 26.

Published in final edited form as: Leukemia. 2023 Mar; 37(3): 560–570. Published online 2022 Dec 22. doi: 10.1038/s41375-022-01798-5

PMCID:: PMC10750268

Abstract Article PDF–1.3M

Select item 106802768.

TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice

Ziang Gao, Hao Lv, Yunfei Wang, Yulie Xie, Mengting Guan, Yu Xu

Mol Med. 2023; 29: 160. Published online 2023 Nov 27. doi: 10.1186/s10020-023-00757-9

PMCID:: PMC10680276

Abstract Article PDF–9.5M

Select item 106530219.

Clonal germinal center B cells function as a niche for T-cell lymphoma

Manabu Fujisawa, Tran B. Nguyen, Yoshiaki Abe, Yasuhito Suehara, Kota Fukumoto, Sakurako Suma, Kenichi Makishima, Chihiro Kaneko, Yen T.M. Nguyen, Kensuke Usuki, Kentaro Narita, Kosei Matsue, Naoya Nakamura, Shumpei Ishikawa, Fumihito Miura, Takashi Ito, Ayako Suzuki, Yutaka Suzuki, Seiya Mizuno, Satoru Takahashi, Shigeru Chiba, Mamiko Sakata-Yanagimoto

Blood. 2022 Nov 3; 140(18): 1937–1950. Published online 2022 Aug 5. doi: 10.1182/blood.2022015451

PMCID:: PMC10653021

Abstract Article

Select item 1057954110.

DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell

Zihang Zeng, Tiao Li, Xiangming Liu, Yiming Ma, Lijuan Luo, ZuLi Wang, Zhiqi Zhao, Herui Li, Xue He, Huihui Zeng, Yongguang Tao, Yan Chen

Redox Biol. 2023 Nov; 67: 102916. Published online 2023 Oct 4. doi: 10.1016/j.redox.2023.102916

PMCID:: PMC10579541

Abstract Article PDF–28M

Select item 1048364011.

Tet2 deletion in CD4+ T cells disrupts Th1 lineage commitment in memory cells and enhances T follicular helper cell recall responses to viral rechallenge

Andrew Baessler, Bryce Fuchs, Bryant Perkins, Andrew W. Richens, Camille L. Novis, Malia Harrison-Chau, Linda M. Sircy, Kendall A. Thiede, J. Scott Hale

Proc Natl Acad Sci U S A. 2023 Sep 5; 120(36): e2218324120. Published online 2023 Aug 28. doi: 10.1073/pnas.2218324120

PMCID:: PMC10483640

Abstract Article PDF–3.8M

Select item 1032605412.

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

Ihab Ansari, Llorenç Solé-Boldo, Meshi Ridnik, Julian Gutekunst, Oliver Gilliam, Maria Korshko, Timur Liwinski, Birgit Jickeli, Noa Weinberg-Corem, Michal Shoshkes-Carmel, Eli Pikarsky, Eran Elinav, Frank Lyko, Yehudit Bergman

Nat Commun. 2023; 14: 4005. Published online 2023 Jul 6. doi: 10.1038/s41467-023-39512-3

PMCID:: PMC10326054

Abstract Article PDF–11M

Select item 1015737513.

DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

Athmane Teghanemt, Kara Misel‐Wuchter, Jace Heath, Andrew Thurman, Priyanjali Pulipati, Garima Dixit, Ramasatya Geesala, David K Meyerholz, Thorsten Maretzky, Alejandro Pezzulo, Priya D Issuree

EMBO Rep. 2023 May; 24(5): e55543. Published online 2023 Mar 7. doi: 10.15252/embr.202255543

PMCID:: PMC10157375

Abstract Article PDF–9.7M

Select item 1015103714.

MicroRNA-210 downregulates TET2 and contributes to neuroinflammation in ischemic stroke of adult mice

Yong Li, Rui Song, Guofang Shen, Lei Huang, DaLiao Xiao, Qingyi Ma, Lubo Zhang

Stroke. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Stroke. 2023 Mar; 54(3): 857–867. Published online 2023 Feb 3. doi: 10.1161/STROKEAHA.122.041651

PMCID:: PMC10151037

Abstract Article PDF–1.8M

Select item 1010326215.

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak

J Am Soc Nephrol. 2023 Apr; 34(4): 572–589. Published online 2022 Dec 15. doi: 10.1681/ASN.2022040460

PMCID:: PMC10103262

Abstract Article

Select item 1003294116.

Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

Karishma J.B. Pratt, Jeremy M. Shea, Laura Remesal-Gomez, Gregor Bieri, Lucas K. Smith, Julien Couthouis, Christopher P. Chen, Irena J. Roy, Geraldine Gontier, Saul A. Villeda

Cell Rep. Author manuscript; available in PMC 2023 Mar 22.

Published in final edited form as: Cell Rep. 2022 Nov 8; 41(6): 111612. doi: 10.1016/j.celrep.2022.111612

Correction in:: Cell Rep. 2023 Jan 30; 42(2): 111926.

PMCID:: PMC10032941

Abstract Article PDF–1.9M

Select item 999192317.

BET inhibitors rescue anti-PD1 resistance by enhancing TCF7 accessibility in leukemia-derived terminally exhausted CD8⁺ T cells

Kyle A. Romine, Kevin MacPherson, Hyun-jun Cho, Yoko Kosaka, Patrick A. Flynn, Kaelan H. Byrd, Jesse L. Coy, Matthew T. Newman, Ravina Pandita, Christopher P. Loo, Jaime Scott, Andrew C. Adey, Evan F. Lind

Leukemia. 2023; 37(3): 580–592. Published online 2023 Jan 21. doi: 10.1038/s41375-023-01808-0

PMCID:: PMC9991923

Abstract Article PDF–3.4M

Select item 994285018.

Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells

Jerome Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, François Lemonnier, Wanda Y. Li, Miki S. Gams, Takashi Sakamoto, Mandy Chu, Chantal Tobin, Eric Laugesen, Troy M. Robinson, Annick You-Ten, Daniel J. Butler, Thorsten Berger, Mark D. Minden, Ross L. Levine, Cynthia J. Guidos, Ari M. Melnick, Christopher E. Mason, Tak W. Mak

Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4): e2208176120. Published online 2023 Jan 18. doi: 10.1073/pnas.2208176120

PMCID:: PMC9942850

Abstract Article PDF–9.0M

Select item 989472819.

PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation

Maria M. Aivalioti, Boris A. Bartholdy, Kith Pradhan, Tushar D. Bhagat, Aliona Zintiridou, Jong Jin Jeong, Victor J. Thiruthuvanathan, Mario Pujato, Aditi Paranjpe, Chi Zhang, Ross L. Levine, Aaron D. Viny, Amittha Wickrema, Amit Verma, Britta Will

Blood Cancer Discov. 2022 Sep 6; 3(5): 444–467. Published online 2022 Aug 12. doi: 10.1158/2643-3230.BCD-21-0226

PMCID:: PMC9894728

Abstract Article PDF–10M

Select item 984131820.

Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

Surya P. Pandey, Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Luzmariel Medina Sanchez, Mohit Rana, Lee Hedden, Kishan A. Sangani, Li Chen, Jake H. Shapira, Magdalena Siller, Chhavi Goel, Elena F. Verdú, Bana Jabri, Alexander Chang, Uma R. Chandran, Steven J. Mullett, Stacy G. Wendell, Aatur D. Singhi, Jeremy S. Tilstra, Joseph F. Pierre, Gavin E. Arteel, Reinhard Hinterleitner, Marlies Meisel

Cell Host Microbe. Author manuscript; available in PMC 2023 Jan 16.

Published in final edited form as: Cell Host Microbe. 2022 Jul 13; 30(7): 1003–1019.e10. Published online 2022 Jun 2. doi: 10.1016/j.chom.2022.05.006

PMCID:: PMC9841318

Abstract Article PDF–2.4M

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