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Items: 1 to 20 of 42

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis
Xiaobo Fu, Siming Liu, Dan Cao, Chonghui Li, Hongbin Ji, Gang Wang
Br J Cancer. 2024 Mar 23; 130(5): 716–727. Published online 2024 Jan 9. doi: 10.1038/s41416-023-02556-9
PMCID:
PMC10912217
AbstractArticlePDF–7.3M
3.
An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities
Yenan Yang, Chonghui Li, Ziyin Chen, Yiyang Zhang, Qing Tian, Meiling Sun, Shuai Zhang, Miao Yu, Gang Wang
Nucleic Acids Res. 2023 Mar 21; 51(5): 2137–2150. Published online 2023 Jan 31. doi: 10.1093/nar/gkad025
Correction in:
Nucleic Acids Res. 2023 Mar 21; 51(5): 2499.
PMCID:
PMC10018335
AbstractArticlePDF–14M
4.
Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models
Hamid Meziane, Marie-Christine Birling, Olivia Wendling, Sophie Leblanc, Aline Dubos, Mohammed Selloum, Guillaume Pavlovic, Tania Sorg, Vera M. Kalscheuer, Pierre Billuart, Frédéric Laumonnier, Jamel Chelly, Hans van Bokhoven, Yann Herault
Biomedicines. 2022 Dec; 10(12): 3148. Published online 2022 Dec 6. doi: 10.3390/biomedicines10123148
PMCID:
PMC9775489
AbstractArticlePDF–2.8M
5.
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression
Yenan Yang, Qi Xiao, Jingwen Yin, Chonghui Li, Decai Yu, Yulong He, Zhongzhou Yang, Gang Wang
Commun Biol. 2022; 5: 374. Published online 2022 Apr 19. doi: 10.1038/s42003-022-03332-w
PMCID:
PMC9019027
AbstractArticlePDF–6.9M
6.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
7.
Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network
Changming Tan, Siting Zhu, Zee Chen, Canzhao Liu, Yang E. Li, Mason Zhu, Zhiyuan Zhang, Zhiwei Zhang, Lunfeng Zhang, Yusu Gu, Zhengyu Liang, Thomas G. Boyer, Kunfu Ouyang, Sylvia M. Evans, Xi Fang
PLoS Genet. 2021 Sep; 17(9): e1009785. Published online 2021 Sep 10. doi: 10.1371/journal.pgen.1009785
PMCID:
PMC8432849
AbstractArticlePDF–3.4M
8.
Med23 Regulates Sox9 Expression during Craniofacial Development
S. Dash, S. Bhatt, K.T. Falcon, L.L. Sandell, P.A. Trainor
J Dent Res. 2021 Apr; 100(4): 406–414. Published online 2020 Nov 6. doi: 10.1177/0022034520969109
PMCID:
PMC7989139
AbstractArticlePDF–4.0M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
The Mediator Subunit, Med23 Is Required for Embryonic Survival and Regulation of Canonical WNT Signaling During Cranial Ganglia Development
Soma Dash, Shachi Bhatt, Lisa L. Sandell, Christopher W. Seidel, Youngwook Ahn, Robb E. Krumlauf, Paul A. Trainor
Front Physiol. 2020; 11: 531933. Published online 2020 Oct 22. doi: 10.3389/fphys.2020.531933
PMCID:
PMC7642510
AbstractArticlePDF–11M
11.
Mediator Med23 Regulates Adult Hippocampal Neurogenesis
Guo-Yan Chen, Shuai Zhang, Chong-Hui Li, Cong-Cong Qi, Ya-Zhou Wang, Jia-Yin Chen, Gang Wang, Yu-Qiang Ding, Chang-Jun Su
Front Cell Dev Biol. 2020; 8: 699. Published online 2020 Jul 29. doi: 10.3389/fcell.2020.00699
PMCID:
PMC7403405
AbstractArticlePDF–5.0M
12.
Mediator MED23 regulates inflammatory responses and liver fibrosis
Zhichao Wang, Dan Cao, Chonghui Li, Lihua Min, Gang Wang
PLoS Biol. 2019 Dec; 17(12): e3000563. Published online 2019 Dec 5. doi: 10.1371/journal.pbio.3000563
PMCID:
PMC6917294
AbstractArticlePDF–5.0M
13.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
14.
Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
Yu Xu, Yang Sun, Hao Shen, Yuling Dai, Haifeng Liu, Ronghong Li, Hongdao Zhang, Ligang Wu, Xiaoyan Zhu, Xiaolong Liu
Nat Commun. 2018; 9: 3875. Published online 2018 Sep 24. doi: 10.1038/s41467-018-06372-1
PMCID:
PMC6155209
AbstractArticlePDF–2.2M
15.
Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
Xufeng Chen, Jingyao Zhao, Chan Gu, Yu Cui, Yuling Dai, Guangrong Song, Haifeng Liu, Hao Shen, Yuanhua Liu, Yuya Wang, Huayue Xing, Xiaoyan Zhu, Pei Hao, Fan Guo, Xiaolong Liu
Nat Commun. 2018; 9: 3746. Published online 2018 Sep 14. doi: 10.1038/s41467-018-06282-2
PMCID:
PMC6138688
AbstractArticlePDF–1.2M
16.
Placentation defects are highly prevalent in embryonic lethal mouse mutants
Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun, Myriam Hemberger
Nature. Author manuscript; available in PMC 2018 Sep 14.
Published in final edited form as: Nature. 2018 Mar 22; 555(7697): 463–468. Published online 2018 Mar 14. doi: 10.1038/nature26002
PMCID:
PMC5866719
AbstractArticlePDF–7.4M
17.
MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
Beatriz Aranda-Orgilles, Ricardo Saldaña-Meyer, Eric Wang, Eirini Trompouki, Anne Fassl, Stephanie Lau, Jasper Mullenders, Pedro P. Rocha, Ramya Raviram, María Guillamot, María Sánchez-Díaz, Kun Wang, Clarisse Kayembe, Nan Zhang, Leonela Amoasii, Avik Choudhuri, Jane A. Skok, Markus Schober, Danny Reinberg, Piotr Sicinski, Heinrich Schrewe, Aristotelis Tsirigos, Leonard I. Zon, Iannis Aifantis
Cell Stem Cell. Author manuscript; available in PMC 2017 Jan 26.
Published in final edited form as: Cell Stem Cell. 2016 Dec 1; 19(6): 784–799. Published online 2016 Aug 25. doi: 10.1016/j.stem.2016.08.004
PMCID:
PMC5268820
AbstractArticlePDF–1.7M
18.
Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
Zhen Liu, Xiao Yao, Guang Yan, YiChi Xu, Jun Yan, Weiguo Zou, Gang Wang
Nat Commun. 2016; 7: 11149. Published online 2016 Apr 1. doi: 10.1038/ncomms11149
PMCID:
PMC4821994
AbstractArticlePDF–2.8M
19.
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPa N-terminal leukemia
Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V. M. Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J. Brown, Johannes Zuber, Keiryn L. Bennett, Rima Al-awar, Ruud Delwel, Claus Nerlov, Cheryl H. Arrowsmith, Giulio Superti-Furga
Nat Chem Biol. Author manuscript; available in PMC 2016 Feb 1.
Published in final edited form as: Nat Chem Biol. 2015 Aug; 11(8): 571–578. Published online 2015 Jul 13. doi: 10.1038/nchembio.1859
PMCID:
PMC4511833
AbstractArticlePDF–2.2M
20.
Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity
Yajing Chu, Leonardo Gómez Rosso, Ping Huang, Zhichao Wang, Yichi Xu, Xiao Yao, Menghan Bao, Jun Yan, Haiyun Song, Gang Wang
Cell Res. 2014 Oct; 24(10): 1250–1265. Published online 2014 Sep 16. doi: 10.1038/cr.2014.120
PMCID:
PMC4185346
AbstractArticlePDF–1.6M

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