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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103317252.

A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction

Chun Chou, Gregory L. Martin, Gayani Perera, Junya Awata, Amy Larson, Robert Blanton, Michael T. Chin

Front Cardiovasc Med. 2023; 10: 1223244. Published online 2023 Jun 26. doi: 10.3389/fcvm.2023.1223244

PMCID:: PMC10331725

Abstract Article PDF–6.9M

Select item 101914283.

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

Olivia G. Thomas, Mattias Bronge, Katarina Tengvall, Birce Akpinar, Ola B. Nilsson, Erik Holmgren, Tara Hessa, Guro Gafvelin, Mohsen Khademi, Lars Alfredsson, Roland Martin, André Ortlieb Guerreiro-Cacais, Hans Grönlund, Tomas Olsson, Ingrid Kockum

Sci Adv. 2023 May; 9(20): eadg3032. Published online 2023 May 17. doi: 10.1126/sciadv.adg3032

PMCID:: PMC10191428

Abstract Article PDF–1.4M

Select item 97437584.

HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage

Justin Knapp, Marsela Braunstein, Spencer Iner Thomas Berg, Cody Shirriff

Arthritis Res Ther. 2022; 24: 267. Published online 2022 Dec 12. doi: 10.1186/s13075-022-02958-9

PMCID:: PMC9743758

Abstract Article PDF–3.3M

Select item 96038605.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 92973706.

Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts

Jessica B. Martin, Kenneth Herman, Nathalie S. Houssin, Wade Rich, Matthew A. Reilly, Timothy F. Plageman, Jr.

Front Cell Dev Biol. 2022; 10: 840129. Published online 2022 Jul 6. doi: 10.3389/fcell.2022.840129

PMCID:: PMC9297370

Abstract Article PDF–5.2M

Select item 91618817.

The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-β (TGF-β1)-Smad3/4 signaling

Tianwen Wei, Yingqiang Du, Tiankai Shan, Jiawen Chen, Dongwei Shi, Tongtong Yang, Jiankang Wang, Jun Zhang, Yafei Li

Bioengineered. 2022; 13(4): 8836–8849. Published online 2022 Mar 25. doi: 10.1080/21655979.2022.2054913

PMCID:: PMC9161881

Abstract Article PDF–4.1M

Select item 84463388.

ACAA2 is a Ligand-dependent Coactivator for Thyroid Hormone Receptor β1

Wesley Wang, Dolena Ledee

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 22.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Oct 22; 576: 15–21. Published online 2021 Aug 28. doi: 10.1016/j.bbrc.2021.08.073

PMCID:: PMC8446338

Abstract Article PDF–830K

Select item 83278569.

Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons

Jeremiah Tsyporin, David Tastad, Xiaokuang Ma, Antoine Nehme, Thomas Finn, Liora Huebner, Guoping Liu, Daisy Gallardo, Amr Makhamreh, Jacqueline M. Roberts, Solomon Katzman, Nenad Sestan, Susan K. McConnell, Zhengang Yang, Shenfeng Qiu, Bin Chen

Cell Rep. Author manuscript; available in PMC 2021 Aug 2.

Published in final edited form as: Cell Rep. 2021 Jun 22; 35(12): 109269. doi: 10.1016/j.celrep.2021.109269

PMCID:: PMC8327856

Abstract Article PDF–4.2M

Select item 825962110.

Role of Cell and Matrix-Bound VEGF Isoforms in Lens Development

Magali Saint-Geniez, Tomoki Kurihara, Patricia A. D’Amore

Invest Ophthalmol Vis Sci. Author manuscript; available in PMC 2021 Jul 6.

Published in final edited form as: Invest Ophthalmol Vis Sci. 2009 Jan; 50(1): 311–321. Published online 2008 Aug 29. doi: 10.1167/iovs.08-2461

PMCID:: PMC8259621

Abstract Article PDF–1.8M

Select item 799279811.

Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury

Erin-Mai F. Lim, Vahid Hoghooghi, Kathleen M. Hagen, Kunal Kapoor, Ariana Frederick, Trisha M. Finlay, Shalina S. Ousman

J Neuroinflammation. 2021; 18: 82. Published online 2021 Mar 24. doi: 10.1186/s12974-021-02108-z

PMCID:: PMC7992798

Abstract Article PDF–5.6M

Select item 799109312.

αB-Crystallin Alleviates Endotoxin-Induced Retinal Inflammation and Inhibits Microglial Activation and Autophagy

Fangyu Wang, Zhaoxin Jiang, Bingsheng Lou, Fang Duan, Suo Qiu, Zhixing Cheng, Xinqi Ma, Yao Yang, Xiaofeng Lin

Front Immunol. 2021; 12: 641999. Published online 2021 Mar 11. doi: 10.3389/fimmu.2021.641999

PMCID:: PMC7991093

Abstract Article PDF–3.2M

Select item 797977613.

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi

Commun Biol. 2021; 4: 355. Published online 2021 Mar 19. doi: 10.1038/s42003-021-01864-1

PMCID:: PMC7979776

Abstract Article PDF–5.3M

Select item 793877014.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 748374715.

Transcriptional analysis of cleft palate in TGFβ3 mutant mice

J. Liu, S. K. Chanumolu, K. M. White, M. Albahrani, H. H. Otu, A. Nawshad

Sci Rep. 2020; 10: 14940. Published online 2020 Sep 10. doi: 10.1038/s41598-020-71636-0

PMCID:: PMC7483747

Abstract Article PDF–4.1M

Select item 744683516.

Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts

Cheryl Frankfater, Stephanie L. Bozeman, Fong-Fu Hsu, Usha P. Andley

PLoS One. 2020; 15(8): e0238081. Published online 2020 Aug 24. doi: 10.1371/journal.pone.0238081

Correction in:: PLoS One. 2020; 15(11): e0242951.

PMCID:: PMC7446835

Abstract Article PDF–1.9M

Select item 737783817.

The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression

Ling Wang, Qian Nie, Meng Gao, Lan Yang, Jia-Wen Xiang, Yuan Xiao, Fang-Yuan Liu, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Quan Dong Nguyen, Yizhi Liu, Mugen Liu, David Wan-Cheng Li

Aging (Albany NY) 2020 Jul 15; 12(13): 13594–13617. Published online 2020 Jun 17. doi: 10.18632/aging.103474

PMCID:: PMC7377838

Abstract Article PDF–2.2M

Select item 733118518.

Changes in relative histone abundance and heterochromatin in αA-crystallin and αB-crystallin knock-in mutant mouse lenses

Usha P. Andley, Brittney N. Naumann, Paul D. Hamilton, Stephanie L. Bozeman

BMC Res Notes. 2020; 13: 315. Published online 2020 Jul 2. doi: 10.1186/s13104-020-05154-7

PMCID:: PMC7331185

Abstract Article PDF–1.1M

Select item 685269919.

An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Wenxuan Cai, Jianhua Zhang, Willem J. de Lange, Zachery R. Gregorich, Hannah Karp, Emily T. Farrell, Stanford D. Mitchell, Trisha Tucholski, Ziqing Lin, Mitch Biermann, Sean J. McIlwain, J. Carter Ralphe, Timothy J. Kamp, Ying Ge

Circ Res. Author manuscript; available in PMC 2020 Nov 8.

Published in final edited form as: Circ Res. 2019 Nov 8; 125(11): 936–953. Published online 2019 Oct 1. doi: 10.1161/CIRCRESAHA.119.315305

PMCID:: PMC6852699

Abstract Article PDF–2.8M

Select item 667692420.

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

Kathleen S. Molnar, Bryan M. Dunyak, Bonnie Su, Yevgeniy Izrayelit, Brittney McGlasson-Naumann, Paul D. Hamilton, Mingxing Qian, Douglas F. Covey, Jason E. Gestwicki, Leah N. Makley, Usha P. Andley

Invest Ophthalmol Vis Sci. 2019 Aug; 60(10): 3320–3331. doi: 10.1167/iovs.18-25647

PMCID:: PMC6676924

Abstract Article PDF–1.8M

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