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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 108376282.

NOTCH2 promotes osteoclast maturation and metabolism and modulates the transcriptome profile during osteoclastogenesis

Ernesto Canalis, Lauren Schilling, Jungeun Yu, Emily Denker

J Biol Chem. 2024 Feb; 300(2): 105613. Published online 2023 Dec 28. doi: 10.1016/j.jbc.2023.105613

PMCID:: PMC10837628

Article PDF–6.6M

Select item 106468183.

TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice

Xiaoling Xie, Wuju Zhang, Min Xiao, Tiantian Wei, Yingqi Qiu, Jingyang Qiu, Hao Wang, Zeyou Qiu, Sheng Zhang, Yating Pan, Linlin Mao, Yuhua Li, Bin Guo, Wanwen Yang, Yuxing Hu, Shujie Hu, Yan Gong, Jun Yang, Guozhi Xiao, Yue Zhang, Xiaochun Bai

Blood. 2023 Jun 29; 141(26): 3184–3198. Published online 2023 Apr 5. doi: 10.1182/blood.2022018619

PMCID:: PMC10646818

Article

Select item 104998794.

Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development

Yongzhen Lai, Yan Guo, Caiyu Liao, Chuanqing Mao, Jing Liu, Chengyan Ren, Wen Yang, Lin Luo, Weihui Chen

Sci Rep. 2023; 13: 15170. Published online 2023 Sep 13. doi: 10.1038/s41598-023-42423-4

PMCID:: PMC10499879

Article PDF–6.8M

Select item 94897165.

Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis

Yuyu Chen, Jinna Wu, Shun Zhang, Wenjie Gao, Zhiheng Liao, Taifeng Zhou, Yongyong Li, Deying Su, Hengyu Liu, Xiaoming Yang, Peiqiang Su, Caixia Xu

Cell Death Dis. 2022 Sep; 13(9): 803. Published online 2022 Sep 20. doi: 10.1038/s41419-022-05239-0

PMCID:: PMC9489716

Article PDF–8.5M

Select item 94748706.

Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice

Takeru Kondo, Hiroko Okawa, Akishige Hokugo, Bhumika Shokeen, Oskar Sundberg, Yiying Zheng, Charles E. McKenna, Renate Lux, Ichiro Nishimura

Commun Biol. 2022; 5: 962. Published online 2022 Sep 14. doi: 10.1038/s42003-022-03896-7

PMCID:: PMC9474870

Article PDF–5.4M

Select item 94616757.

Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis

Guochun Zhu, Wei Chen, Chen-Yi Tang, Abigail McVicar, Diep Edwards, Jinwen Wang, Matthew McConnell, Shuying Yang, Yang Li, Zhijie Chang, Yi-Ping Li

Int J Biol Sci. 2022; 18(14): 5522–5538. Published online 2022 Aug 29. doi: 10.7150/ijbs.72211

PMCID:: PMC9461675

Article PDF–5.3M

Select item 93523538.

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

Bhaba K Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J Krager, Renny Lan, Samuel G Mackintosh, Ricky Edmondson, Michael L Jennings, Xiaofang Wang, Jian Q Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao

eLife. 2022; 11: e73539. Published online 2022 Jun 27. doi: 10.7554/eLife.73539

PMCID:: PMC9352353

Article PDF–13M

Select item 93461929.

Beclin1 modulates bone homeostasis by regulating osteoclast and chondrocyte differentiation

Atsushi Arai, Sol Kim, Vadim Goldshteyn, Terresa Kim, No-Hee Park, Cun-Yu Wang, Reuben Kim

J Bone Miner Res. Author manuscript; available in PMC 2022 Aug 3.

Published in final edited form as: J Bone Miner Res. 2019 Sep; 34(9): 1753–1766. Published online 2019 Jul 30. doi: 10.1002/jbmr.3756

PMCID:: PMC9346192

Article PDF–1.7M

Select item 929399110.

Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron, Hiroshi Takayanagi

Nat Commun. 2022; 13: 4166. Published online 2022 Jul 18. doi: 10.1038/s41467-022-31592-x

PMCID:: PMC9293991

Article PDF–11M

Select item 927870511.

Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress

Xueling Yue, Limei Piao, Hailong Wang, Zhe Huang, Xiangkun Meng, Takeshi Sasaki, Aiko Inoue, Kae Nakamura, Ying Wan, Shengnan Xu, Guo-Ping Shi, Weon Kim, Toyoaki Murohara, Masafumi Kuzuya, Xian Wu Cheng

Hypertension. 2022 Aug; 79(8): 1713–1723. Published online 2022 Jun 21. doi: 10.1161/HYPERTENSIONAHA.122.19137

PMCID:: PMC9278705

Article PDF–2.0M

Select item 897800712.

Cathepsin K activity controls cachexia‐induced muscle atrophy via the modulation of IRS1 ubiquitination

Xiangkun Meng, Zhe Huang, Aiko Inoue, Hailong Wang, Ying Wan, Xueling Yue, Shengnan Xu, Xueying Jin, Guo‐Ping Shi, Masafumi Kuzuya, Xian Wu Cheng

J Cachexia Sarcopenia Muscle. 2022 Apr; 13(2): 1197–1209. Published online 2022 Jan 30. doi: 10.1002/jcsm.12919

PMCID:: PMC8978007

Article PDF–5.8M

Select item 863368813.

Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function

Jungeun Yu, Lauren Schilling, Tabitha Eller, Ernesto Canalis

J Biol Chem. 2021 Dec; 297(6): 101376. Published online 2021 Nov 3. doi: 10.1016/j.jbc.2021.101376

PMCID:: PMC8633688

Article PDF–5.1M

Select item 858686214.

活化的Mir-30a-wnt/β-catenin信号轴通过上调组织蛋白酶K的表达促进牙周膜干细胞向成牙骨质细胞分化

刘芬, 周志斐, 薛洋, 朱斌, 吴补领, 陈发明

Nan Fang Yi Ke Da Xue Xue Bao. 2021 Oct 20; 41(10): 1439–1447. Chinese. doi: 10.12122/j.issn.1673-4254.2021.10.01

PMCID:: PMC8586862

Article PDF–1.4M

Select item 848801515.

The CD200-CD200R axis promotes squamous cell carcinoma metastasis via regulation of cathepsin K

Iasha Z. Khan, Christina A. Del Guzzo, Anqi Shao, Jiyoon Cho, Rong Du, Adrienne O. Cohen, David M. Owens

Cancer Res. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Cancer Res. 2021 Oct 1; 81(19): 5021–5032. Published online 2021 Jun 28. doi: 10.1158/0008-5472.CAN-20-3251

PMCID:: PMC8488015

Article PDF–1.5M

Select item 831400216.

Fluorescence-Based Real-Time Analysis of Osteoclast Development

Áron Pánczél, Simon P. Nagy, János Farkas, Zoltán Jakus, Dávid S. Győri, Attila Mócsai

Front Cell Dev Biol. 2021; 9: 657935. Published online 2021 Jul 13. doi: 10.3389/fcell.2021.657935

PMCID:: PMC8314002

Article PDF–3.3M

Select item 831323917.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Article PDF–1.6M

Select item 819833218.

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice

Vaishnavi Venugopalan, Alaa Al-Hashimi, Jonas Weber, Maren Rehders, Maria Qatato, Eva K. Wirth, Ulrich Schweizer, Heike Heuer, François Verrey, Klaudia Brix

Int J Mol Sci. 2021 Jun; 22(11): 5776. Published online 2021 May 28. doi: 10.3390/ijms22115776

PMCID:: PMC8198332

Article PDF–5.4M

Select item 802111319.

JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice

David W. Dodington, Jenalyn L. Yumol, Jiaqi Yang, Evan Pollock-Tahiri, Tharini Sivasubramaniyam, Sandra M. Sacco, Stephanie A. Schroer, Yujin E. Li, Helen Le, Wendy E. Ward, Minna Woo

JCI Insight. 2021 Mar 8; 6(5): e137045. Published online 2021 Mar 8. doi: 10.1172/jci.insight.137045

PMCID:: PMC8021113

Article PDF–3.6M

Select item 792793120.

Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion

Wenbin Yang, Zheng Zhu, Longjiang Li, Abigail McVicar, Ning Gao, Lin Wang, Yi-Ping Li, Wei Chen

Infect Immun. 2021 Jan; 89(1): e00436-20. Prepublished online 2020 Oct 19. Published online 2020 Dec 15. doi: 10.1128/IAI.00436-20

PMCID:: PMC7927931

Article PDF–5.9M

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