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Select item 102354211.

Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

Jacob M. Hull, Nicholas Denomme, Yukun Yuan, Victoria Booth, Lori L. Isom

Sci Rep. 2023; 13: 8887. Published online 2023 Jun 1. doi: 10.1038/s41598-023-36036-0

PMCID:: PMC10235421

Article PDF–10M

Select item 99382162.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Article PDF–5.3M

Select item 95791453.

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini

Nat Commun. 2022; 13: 6166. Published online 2022 Oct 18. doi: 10.1038/s41467-022-33303-y

PMCID:: PMC9579145

Article PDF–11M

Select item 92208234.

Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation

Roberto Ramos-Mondragon, Nnamdi Edokobi, Samantha L. Hodges, Shuyun Wang, Alexandra A. Bouza, Chandrika Canugovi, Caroline Scheuing, Lena Juratli, William R. Abel, Sami F. Noujaim, Nageswara R. Madamanchi, Marschall S. Runge, Luis F. Lopez-Santiago, Lori L. Isom

JCI Insight. 2022 May 23; 7(10): e152050. Published online 2022 May 23. doi: 10.1172/jci.insight.152050

PMCID:: PMC9220823

Article PDF–2.1M

Select item 90764215.

Scn1b expression in the adult mouse heart modulates Na⁺ influx in myocytes and reveals a mechanistic link between Na⁺ entry and diastolic function

Daniel O. Cervantes, Emanuele Pizzo, Harshada Ketkar, Sreema P. Parambath, Samantha Tang, Eleonora Cianflone, Antonio Cannata, Govindaiah Vinukonda, Sudhir Jain, Jason T. Jacobson, Marcello Rota

Am J Physiol Heart Circ Physiol. 2022 Jun 1; 322(6): H975–H993. Published online 2022 Apr 8. doi: 10.1152/ajpheart.00465.2021

PMCID:: PMC9076421

Article

Select item 83132396.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Article PDF–1.6M

Select item 79348437.

Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling

Alexandra A. Bouza, Nnamdi Edokobi, Samantha L. Hodges, Alexa M. Pinsky, James Offord, Lin Piao, Yan-Ting Zhao, Anatoli N. Lopatin, Luis F. Lopez-Santiago, Lori L. Isom

JCI Insight. 2021 Feb 8; 6(3): e141776. Published online 2021 Feb 8. doi: 10.1172/jci.insight.141776

PMCID:: PMC7934843

Article PDF–2.1M

Select item 76642748.

Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52

Jacob M. Hull, Heather A. O’Malley, Chunling Chen, Yukun Yuan, Nicholas Denomme, Alexandra A. Bouza, Charles Anumonwo, Luis F. Lopez‐Santiago, Lori L. Isom

Ann Clin Transl Neurol. 2020 Nov; 7(11): 2137–2149. Published online 2020 Sep 26. doi: 10.1002/acn3.51205

PMCID:: PMC7664274

Article PDF–3.3M

Select item 73833829.

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis

Alexandra A. Bouza, Julie M. Philippe, Nnamdi Edokobi, Alexa M. Pinsky, James Offord, Jeffrey D. Calhoun, Mariana Lopez-Florán, Luis F. Lopez-Santiago, Paul M. Jenkins, Lori L. Isom

J Biol Chem. 2020 Jul 24; 295(30): 10380–10393. Published online 2020 Jun 5. doi: 10.1074/jbc.RA120.013978

PMCID:: PMC7383382

Article PDF–2.0M

Select item 672942710.

Mice Lacking Sodium Channel β1 Subunits Display Defects in Neuronal Excitability, Sodium Channel Expression, and Nodal Architecture

Chunling Chen, Ruth E. Westenbroek, Xiaorong Xu, Chris A. Edwards, Dorothy R. Sorenson, Yuan Chen, Dyke P. McEwen, Heather A. O'Malley, Vandana Bharucha, Laurence S. Meadows, Gabriel A. Knudsen, Alex Vilaythong, Jeffrey L. Noebels, Thomas L. Saunders, Todd Scheuer, Peter Shrager, William A. Catterall, Lori L. Isom

J Neurosci. 2004 Apr 21; 24(16): 4030–4042. doi: 10.1523/JNEUROSCI.4139-03.2004

PMCID:: PMC6729427

Article PDF–1.0M

Select item 667069711.

Voltage-Gated Na⁺ Channel β1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo

William J. Brackenbury, Tigwa H. Davis, Chunling Chen, Emily A. Slat, Matthew J. Detrow, Travis L. Dickendesher, Barbara Ranscht, Lori L. Isom

J Neurosci. 2008 Mar 19; 28(12): 3246–3256. doi: 10.1523/JNEUROSCI.5446-07.2008

PMCID:: PMC6670697

Article PDF–477K

Select item 663462412.

Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel β Subunits via Paradoxical Effects on Persistent Sodium Currents

Mischa Uebachs, Thoralf Opitz, Michel Royeck, Gesa Dickhof, Marie-Therese Horstmann, Lori L. Isom, Heinz Beck

J Neurosci. 2010 Jun 23; 30(25): 8489–8501. doi: 10.1523/JNEUROSCI.1534-10.2010

PMCID:: PMC6634624

Article PDF–2.7M

Select item 647017013.

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

Yukun Yuan, Heather A. O’Malley, Melissa A. Smaldino, Alexandra A. Bouza, Jacob M. Hull, Lori L. Isom

Sci Rep. 2019; 9: 6210. Published online 2019 Apr 17. doi: 10.1038/s41598-019-42191-0

PMCID:: PMC6470170

Article PDF–2.4M

Select item 611519414.

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice

Ikuo Ogiwara, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Tetsushi Yamagata, Tojo Nakayama, Nafiseh Atapour, Eriko Miura, Emi Mazaki, Sara J. Ernst, Dezhi Cao, Hideyuki Ohtani, Shigeyoshi Itohara, Yuchio Yanagawa, Mauricio Montal, Michisuke Yuzaki, Yushi Inoue, Takao K. Hensch, Jeffrey L. Noebels, Kazuhiro Yamakawa

Commun Biol. 2018; 1: 96. Published online 2018 Jul 19. doi: 10.1038/s42003-018-0099-2

PMCID:: PMC6115194

Article PDF–3.5M

Select item 609383815.

Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy

Chunling Chen, Jerrah K. Holth, Rosie Bunton‐Stasyshyn, Charles K. Anumonwo, Miriam H. Meisler, Jeffrey L. Noebels, Lori L. Isom

Ann Clin Transl Neurol. 2018 Aug; 5(8): 982–987. Published online 2018 Jul 5. doi: 10.1002/acn3.599

PMCID:: PMC6093838

Article PDF–222K

Select item 537732716.

SCN1B gene variants in Brugada Syndrome: a study of 145 SCN5A-negative patients

Maria Teresa Ricci, Silvia Menegon, Simona Vatrano, Giorgia Mandrile, Natascia Cerrato, Paula Carvalho, Mario De Marchi, Fiorenzo Gaita, Carla Giustetto, Daniela Francesca Giachino

Sci Rep. 2014; 4: 6470. Published online 2014 Sep 25. doi: 10.1038/srep06470

PMCID:: PMC5377327

Article PDF–566K

Select item 489952417.

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function

Larisa C. Kruger, Heather A. O'Malley, Jacob M. Hull, Amanda Kleeman, Gustavo A. Patino, Lori L. Isom

J Neurosci. 2016 Jun 8; 36(23): 6213–6224. doi: 10.1523/JNEUROSCI.0405-16.2016

PMCID:: PMC4899524

Article PDF–3.4M

Select item 474436118.

SCN1A and SCN1B gene polymorphisms and their association with plasma concentrations of carbamazepine and carbamazepine 10, 11 epoxide in Iranian epileptic patients

Soha Namazi, Negar Azarpira, Katayoon Javidnia, Mehrdad Emami, Rahimeh Rahjoo, Razieh Berahmand, Afshin Borhani-Haghighi

Iran J Basic Med Sci. 2015 Dec; 18(12): 1215–1220.

PMCID:: PMC4744361

Article

Select item 463813519.

Late Na⁺ current and protracted electrical recovery are critical determinants of the aging myopathy

Sergio Signore, Andrea Sorrentino, Giulia Borghetti, Antonio Cannata, Marianna Meo, Yu Zhou, Ramaswamy Kannappan, Francesco Pasqualini, Heather O'Malley, Mark Sundman, Nikolaos Tsigkas, Eric Zhang, Christian Arranto, Chiara Mangiaracina, Kazuya Isobe, Brena F. Sena, Junghyun Kim, Polina Goichberg, Matthias Nahrendorf, Lori L. Isom, Annarosa Leri, Piero Anversa, Marcello Rota

Nat Commun. 2015; 6: 8803. Published online 2015 Nov 6. doi: 10.1038/ncomms9803