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Select item 106982731.

GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity

Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu

Mol Metab. 2024 Jan; 79: 101839. Published online 2023 Nov 17. doi: 10.1016/j.molmet.2023.101839

PMCID:: PMC10698273

Article PDF–4.9M

Select item 101154422.

AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis

Carlos P Descovich, Kendall J Lough, Akankshya Jena, Jessica J Wu, Jina Yom, Danielle C Spitzer, Manuela Uppalapati, Katarzyna M Kedziora, Scott E Williams

eLife. 2023; 12: e80403. Published online 2023 Apr 5. doi: 10.7554/eLife.80403

PMCID:: PMC10115442

Article PDF–5.5M

Select item 97008143.

GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages

Jing Yan, Yuemei Zhang, Hairong Yu, Yicen Zong, Daixi Wang, Jiangfei Zheng, Li Jin, Xiangtian Yu, Caizhi Liu, Yi Zhang, Feng Jiang, Rong Zhang, Xiangnan Fang, Ting Xu, Mingyu Li, Jianzhong Di, Yan Lu, Xinran Ma, Jian Zhang, Weiping Jia, Cheng Hu

Nat Commun. 2022; 13: 7260. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34998-9

PMCID:: PMC9700814

Article PDF–6.3M

Select item 83132394.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Article PDF–1.6M

Select item 80988145.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Article PDF–7.7M

Select item 63825636.

Gα_i2 signaling regulates inflammasome priming and cytokine production by biasing macrophage phenotype determination

Ali Vural, Neel R. Nabar, Il-Young Hwang, Silke Sohn, Chung Park, Mikael C. I. Karlsson, Joe B. Blumer, John H. Kehrl

J Immunol. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: J Immunol. 2019 Mar 1; 202(5): 1510–1520. Published online 2019 Jan 25. doi: 10.4049/jimmunol.1801145

PMCID:: PMC6382563

Article PDF–1.2M

Select item 55793747.

Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3

Mehdi Saadaoui, Daijiro Konno, Karine Loulier, Rosette Goiame, Vaibhav Jadhav, Marina Mapelli, Fumio Matsuzaki, Xavier Morin

EMBO Rep. 2017 Sep; 18(9): 1509–1520. Published online 2017 Jul 6. doi: 10.15252/embr.201643048

PMCID:: PMC5579374

Article PDF–1.8M

Select item 52958218.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Article PDF–3.0M

Select item 48113379.

Activator of G-protein Signaling 3 (AGS3)-induced lysosomal biogenesis limits macrophage intracellular bacterial infection

Ali Vural, Souhaila Al Khodor, Gordon Y.C. Cheung, Chong-Shan Shi, Lalitha Srinivasan, Travis J. McQuiston, Il-Young Hwang, Anthony J. Yeh, Joe B. Blumer, Volker Briken, Peter R. Williamson, Michael Otto, Iain D.C. Fraser, John H. Kehrl

J Immunol. Author manuscript; available in PMC 2017 Jan 15.

Published in final edited form as: J Immunol. 2016 Jan 15; 196(2): 846–856. Published online 2015 Dec 14. doi: 10.4049/jimmunol.1501595

PMCID:: PMC4811337

Article PDF–1.9M

Select item 403619010.

Defective Chemokine Signal Integration in Leukocytes Lacking Activator of G Protein Signaling 3 (AGS3)

Melissa Branham-O'Connor, William G. Robichaux, III, Xian-Kui Zhang, Hyeseon Cho, John H. Kehrl, Stephen M. Lanier, Joe B. Blumer

J Biol Chem. 2014 Apr 11; 289(15): 10738–10747. Published online 2014 Feb 26. doi: 10.1074/jbc.M113.515031

PMCID:: PMC4036190

Article PDF–1.2M

Select item 396495511.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Article PDF–5.7M

Select item 395096712.

G-protein-coupled receptor kinase-6 interacts with Activator of G-protein signaling-3 to regulate CXCR2-mediated cellular functions

Vandana Singh, Sandeep K. Raghuwanshi, Nikia Smith, Elizabeth J. Rivers, Ricardo M. Richardson

J Immunol. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: J Immunol. 2014 Mar 1; 192(5): 2186–2194. Published online 2014 Feb 7. doi: 10.4049/jimmunol.1301875

PMCID:: PMC3950967

Article PDF–1.4M

Select item 384297913.

Normal Autophagic Activity in Macrophages from Mice Lacking Gα_i3, AGS3, or RGS19

Ali Vural, Travis J. McQuiston, Joe B. Blumer, Chung Park, Il-Young Hwang, Yolanda Williams-Bey, Chong-Shan Shi, Dzwokai Zach Ma, John H. Kehrl

PLoS One. 2013; 8(11): e81886. Published online 2013 Nov 28. doi: 10.1371/journal.pone.0081886

PMCID:: PMC3842979

Article PDF–1.5M

Select item 357241014.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Article PDF–1.1M

Select item 353566315.

G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease

Michelle Kwon, Tengis S. Pavlov, Kandai Nozu, Shauna A. Rasmussen, Daria V. Ilatovskaya, Alexandra Lerch-Gaggl, Lauren M. North, Hyunho Kim, Feng Qian, William E. Sweeney, Jr., Ellis D. Avner, Joe B. Blumer, Alexander Staruschenko, Frank Park

Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52): 21462–21467. Published online 2012 Dec 10. doi: 10.1073/pnas.1216830110

PMCID:: PMC3535663

Article PDF–680K

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

Select item 310103417.

Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents

Kevin R. Regner, Kandai Nozu, Stephen M. Lanier, Joe B. Blumer, Ellis D. Avner, William E. Sweeney, Jr, Frank Park

FASEB J. 2011 Jun; 25(6): 1844–1855. doi: 10.1096/fj.10-169797

PMCID:: PMC3101034

Article

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Article PDF–3.8M

Select item 260547919.

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives

Owen J Tamplin, Doris Kinzel, Brian J Cox, Christine E Bell, Janet Rossant, Heiko Lickert

BMC Genomics. 2008; 9: 511. Published online 2008 Oct 30. doi: 10.1186/1471-2164-9-511

PMCID:: PMC2605479

Article PDF–1.7M

Select item 248824320.

Activator of G Protein Signaling 3 Null Mice: I. Unexpected Alterations in Metabolic and Cardiovascular Function

Joe B. Blumer, Kevin Lord, Thomas L. Saunders, Alejandra Pacchioni, Cory Black, Eric Lazartigues, Kurt J. Varner, Thomas W. Gettys, Stephen M. Lanier

Endocrinology. 2008 Aug; 149(8): 3842–3849. Published online 2008 May 1. doi: 10.1210/en.2008-0050

PMCID:: PMC2488243

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