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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 67414692.

HIV-1 Gag-Virus-Like Particles Induce Natural Killer Cell Immune Responses via Activation and Maturation of Dendritic Cells

Myint Oo Chang, Tomoyuki Suzuki, Hitoshi Suzuki, Hiroshi Takaku

J Innate Immun. 2012 Feb; 4(2): 187–200. Published online 2011 Jul 22. doi: 10.1159/000329226

PMCID:: PMC6741469

Abstract Article PDF–990K

Select item 61666823.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 55316114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 49740945.

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

Yukinori Okada, Akari Suzuki, Katsunori Ikari, Chikashi Terao, Yuta Kochi, Koichiro Ohmura, Koichiro Higasa, Masato Akiyama, Kyota Ashikawa, Masahiro Kanai, Jun Hirata, Naomasa Suita, Yik-Ying Teo, Huji Xu, Sang-Cheol Bae, Atsushi Takahashi, Yukihide Momozawa, Koichi Matsuda, Shigeki Momohara, Atsuo Taniguchi, Ryo Yamada, Tsuneyo Mimori, Michiaki Kubo, Matthew A. Brown, Soumya Raychaudhuri, Fumihiko Matsuda, Hisashi Yamanaka, Yoichiro Kamatani, Kazuhiko Yamamoto

Am J Hum Genet. 2016 Aug 4; 99(2): 366–374. Published online 2016 Aug 2. doi: 10.1016/j.ajhg.2016.06.019

PMCID:: PMC4974094

Abstract Article PDF–1.7M

Select item 47952146.

Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking

Nicola Pirastu, Maarten Kooyman, Michela Traglia, Antonietta Robino, Sara M Willems, Giorgio Pistis, Najaf Amin, Cinzia Sala, Lennart C Karssen, Cornelia M van Duijn, Daniela Toniolo, Paolo Gasparini

Eur J Hum Genet. 2015 Dec; 23(12): 1717–1722. Published online 2015 Mar 11. doi: 10.1038/ejhg.2015.34

PMCID:: PMC4795214

Abstract Article PDF–2.9M

Select item 46615247.

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity

Wei Jiang, Michael J. Strohman, Sriram Somasundaram, Sashi Ayyangar, Tieying Hou, Nan Wang, Elizabeth D. Mellins

Sci Rep. 2015; 5: 17333. Published online 2015 Nov 27. doi: 10.1038/srep17333

PMCID:: PMC4661524

Abstract Article PDF–1.9M

Select item 44719948.

Association of Granulomatosis With Polyangiitis (Wegener’s) With HLA–DPB1*04 and SEMA6A Gene Variants Evidence From Genome-Wide Analysis

Gang Xie, Delnaz Roshandel, Richard Sherva, Paul A. Monach, Emily Yue Lu, Tabitha Kung, Keisha Carrington, Steven S. Zhang, Sara L. Pulit, Stephan Ripke, Simon Carette, Paul F. Dellaripa, Jeffrey C. Edberg, Gary S. Hoffman, Nader Khalidi, Carol A. Langford, Alfred D. Mahr, E. William St.Clair, Philip Seo, Ulrich Specks, Robert F. Spiera, John H. Stone, Steven R. Ytterberg, Soumya Raychaudhuri, Paul I. W. de Bakker, Lindsay A. Farrer, Christopher I. Amos, Peter A. Merkel, Katherine A. Siminovitch

Arthritis Rheum. Author manuscript; available in PMC 2015 Jun 18.

Published in final edited form as: Arthritis Rheum. 2013 Sep; 65(9): 2457–2468. doi: 10.1002/art.38036

PMCID:: PMC4471994

Abstract Article PDF–1.0M

Select item 44471409.

Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA

Izortze Santin, Ainara Castellanos-Rubio, Ana María Aransay, Galder Gutierrez, Sonia Gaztambide, Itxaso Rica, Jose Luis Vicario, Janelle A. Noble, Luis Castaño, Jose Ramon Bilbao

Genes Immun. Author manuscript; available in PMC 2015 May 28.

Published in final edited form as: Genes Immun. 2009 Sep; 10(6): 596–600. Published online 2009 May 21. doi: 10.1038/gene.2009.41

PMCID:: PMC4447140

Abstract Article PDF–316K

Select item 439524810.

Association of Polymorphisms in HLA Antigen Presentation-Related Genes with the Outcomes of HCV Infection

Peng Huang, Yuanyuan Zhang, Xiaomei Lu, Yin Xu, Jie Wang, Yun Zhang, Rongbin Yu, Jing Su

PLoS One. 2015; 10(4): e0123513. Published online 2015 Apr 13. doi: 10.1371/journal.pone.0123513

PMCID:: PMC4395248

Abstract Article PDF–180K

Select item 431072611.

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Satoru Doi, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Takehiko Miyagawa, Mitsuru Adachi, Hiroshi Tanaka, Akio Niimi, Hisako Matsumoto, Isao Ito, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Masami Taniguchi, John J. Lima, Charles G. Irvin, Stephen P. Peters, Blanca E. Himes, Augusto A. Litonjua, Kelan G. Tantisira, Scott T. Weiss, Naoyuki Kamatani, Yusuke Nakamura, Mayumi Tamari

Nat Genet. Author manuscript; available in PMC 2015 Jan 29.

Published in final edited form as: Nat Genet. 2011 Sep; 43(9): 893–896. Published online 2011 Jul 31. doi: 10.1038/ng.887

PMCID:: PMC4310726

Article PDF–376K

Select item 426658812.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 403304313.

The activity of Nef on HIV-1 infectivity

Stéphane Basmaciogullari, Massimo Pizzato

Front Microbiol. 2014; 5: 232. Published online 2014 May 20. doi: 10.3389/fmicb.2014.00232

PMCID:: PMC4033043

Abstract Article PDF–1.2M

Select item 353788614.

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

Abigail I Guce, Sarah E Mortimer, Taejin Yoon, Corrie A Painter, Wei Jiang, Elizabeth D Mellins, Lawrence J Stern

Nat Struct Mol Biol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 Jan; 20(1): 90–98. Published online 2012 Dec 9. doi: 10.1038/nsmb.2460

PMCID:: PMC3537886

Abstract Article PDF–2.2M

Select item 340844315.

Strategy for Identifying Dendritic Cell-Processed CD4⁺ T Cell Epitopes from the HIV Gag p24 Protein

Leonia Bozzacco, Haiqiang Yu, Jörn Dengjel, Christine Trumpfheller, Henry A. Zebroski, III, Nawei Zhang, Victoria Küttner, Beatrix M. Ueberheide, Haiteng Deng, Brian T. Chait, Ralph M. Steinman, Svetlana Mojsov, David Fenyö

PLoS One. 2012; 7(7): e41897. Published online 2012 Jul 30. doi: 10.1371/journal.pone.0041897

PMCID:: PMC3408443

Abstract Article PDF–1.4M

Select item 339651716.

Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis

Taejin Yoon, Henriette Macmillan, Sarah E. Mortimer, Wei Jiang, Cornelia H. Rinderknecht, Lawrence J. Stern, Elizabeth D. Mellins

Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11276–11281. Published online 2012 Jun 25. doi: 10.1073/pnas.1113966109

PMCID:: PMC3396517

Abstract Article PDF–1.2M

Select item 333529617.

New gene functions in megakaryopoiesis and platelet formation

Christian Gieger, Aparna Radhakrishnan, Ana Cvejic, Weihong Tang, Eleonora Porcu, Giorgio Pistis, Jovana Serbanovic-Canic, Ulrich Elling, Alison H. Goodall, Yann Labrune, Lorna M. Lopez, Reedik Mägi, Stuart Meacham, Yukinori Okada, Nicola Pirastu, Rossella Sorice, Alexander Teumer, Katrin Voss, Weihua Zhang, Ramiro Ramirez-Solis, Joshua C. Bis, David Ellinghaus, Martin Gögele, Jouke-Jan Hottenga, Claudia Langenberg, Peter Kovacs, Paul F. O’Reilly, So-Youn Shin, Tõnu Esko, Jaana Hartiala, Stavroula Kanoni, Federico Murgia, Afshin Parsa, Jonathan Stephens, Pim van der Harst, C. Ellen van der Schoot, Hooman Allayee, Antony Attwood, Beverley Balkau, François Bastardot, Saonli Basu, Sebastian E. Baumeister, Ginevra Biino, Lorenzo Bomba, Amélie Bonnefond, François Cambien, John C. Chambers, Francesco Cucca, Pio D’Adamo, Gail Davies, Rudolf A. de Boer, Eco J. C. de Geus, Angela Döring, Paul Elliott, Jeanette Erdmann, David M. Evans, Mario Falchi, Wei Feng, Aaron R. Folsom, Ian H. Frazer, Quince D. Gibson, Nicole L. Glazer, Chris Hammond, Anna-Liisa Hartikainen, Susan R. Heckbert, Christian Hengstenberg, Micha Hersch, Thomas Illig, Ruth J. F. Loos, Jennifer Jolley, Kay Tee Khaw, Brigitte Kühnel, Marie-Christine Kyrtsonis, Vasiliki Lagou, Heather Lloyd-Jones, Thomas Lumley, Massimo Mangino, Andrea Maschio, Irene Mateo Leach, Barbara McKnight, Yasin Memari, Braxton D. Mitchell, Grant W. Montgomery, Yusuke Nakamura, Matthias Nauck, Gerjan Navis, Ute Nöthlings, Ilja M. Nolte, David J. Porteous, Anneli Pouta, Peter P. Pramstaller, Janne Pullat, Susan M. Ring, Jerome I. Rotter, Daniela Ruggiero, Aimo Ruokonen, Cinzia Sala, Nilesh J. Samani, Jennifer Sambrook, David Schlessinger, Stefan Schreiber, Heribert Schunkert, James Scott, Nicholas L. Smith, Harold Snieder, John M. Starr, Michael Stumvoll, Atsushi Takahashi, W. H. Wilson Tang, Kent Taylor, Albert Tenesa, Swee Lay Thein, Anke Tönjes, Manuela Uda, Sheila Ulivi, Dirk J. van Veldhuisen, Peter M. Visscher, Uwe Völker, H.-Erich Wichmann, Kerri L. Wiggins, Gonneke Willemsen, Tsun-Po Yang, Jing Hua Zhao, Paavo Zitting, John R. Bradley, George V. Dedoussis, Paolo Gasparini, Stanley L. Hazen, Andres Metspalu, Mario Pirastu, Alan R. Shuldiner, L. Joost van Pelt, Jaap-Jan Zwaginga, Dorret I. Boomsma, Ian J. Deary, Andre Franke, Philippe Froguel, Santhi K. Ganesh, Marjo-Riitta Jarvelin, Nicholas G. Martin, Christa Meisinger, Bruce M. Psaty, Timothy D. Spector, Nicholas J. Wareham, Jan-Willem N. Akkerman, Marina Ciullo, Panos Deloukas, Andreas Greinacher, Steve Jupe, Naoyuki Kamatani, Jyoti Khadake, Jaspal S. Kooner, Josef Penninger, Inga Prokopenko, Derek Stemple, Daniela Toniolo, Lorenz Wernisch, Serena Sanna, Andrew A. Hicks, Augusto Rendon, Manuel A. Ferreira, Willem H. Ouwehand, Nicole Soranzo

Nature. Author manuscript; available in PMC 2012 Apr 24.

Published in final edited form as: Nature. 2011 Nov 30; 480(7376): 201–208. Published online 2011 Nov 30. doi: 10.1038/nature10659

PMCID:: PMC3335296

Abstract Article PDF–862K

Select item 329077218.

One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

Alessia Landi, Veronica Iannucci, Anouk Van Nuffel, Pieter Meuwissen, Bruno Verhasselt

Curr HIV Res. 2011 Oct; 9(7): 496–504. Published online 2011 Oct. doi: 10.2174/157016211798842116

PMCID:: PMC3290772

Abstract Article PDF–247K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317365620.

Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence

Andrey Tokarev, John Guatelli

Cell Logist. 2011 May-Jun; 1(3): 90–102. Published online May-Jun 2011. doi: 10.4161/cl.1.3.16708

PMCID:: PMC3173656

Abstract Article PDF–619K

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