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Items: 1 to 20 of 32

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons
Quynh Nguyen, Caleb A. Wood, Peter J. Kim, Joanna L. Jankowsky
Front Neurosci. 2023; 17: 1275959. Published online 2023 Oct 13. doi: 10.3389/fnins.2023.1275959
PMCID:
PMC10603297
AbstractArticlePDF–1.3M
3.
TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury
Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff
Cells. 2023 Jul; 12(13): 1734. Published online 2023 Jun 27. doi: 10.3390/cells12131734
PMCID:
PMC10340176
AbstractArticlePDF–19M
4.
TMEM106B regulates microglial proliferation and survival in response to demyelination
Tingting Zhang, Weilun Pang, Tuancheng Feng, Jennifer Guo, Kenton Wu, Mariela Nunez Santos, Akshayakeerthi Arthanarisami, Alissa L. Nana, Quynh Nguyen, Peter J. Kim, Joanna L. Jankowsky, William W. Seeley, Fenghua Hu
Sci Adv. 2023 May; 9(18): eadd2676. Published online 2023 May 5. doi: 10.1126/sciadv.add2676
PMCID:
PMC10162677
AbstractArticlePDF–2.9M
5.
Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration
Anne-Sophie Cabron, Uwe Borgmeyer, Julia Richter, Helga Peisker, Katharina Gutbrod, Peter Dörmann, Anja Capell, Markus Damme
Acta Neuropathol Commun. 2023; 11: 21. Published online 2023 Jan 27. doi: 10.1186/s40478-023-01510-3
PMCID:
PMC9881268
AbstractArticlePDF–4.5M
6.
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M. Van Deerlin, John Q. Trojanowski, Edward B. Lee, Fenghua Hu
Acta Neuropathol Commun. 2022; 10: 33. Published online 2022 Mar 14. doi: 10.1186/s40478-022-01334-7
PMCID:
PMC8919601
AbstractArticlePDF–3.5M
7.
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β
Sarah Helena Nies, Hideyuki Takahashi, Charlotte S. Herber, Anita Huttner, Alison Chase, Stephen M. Strittmatter
J Biol Chem. 2021 Oct; 297(4): 101159. Published online 2021 Sep 2. doi: 10.1016/j.jbc.2021.101159
PMCID:
PMC8477193
AbstractArticlePDF–6.8M
8.
Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non‐motor dysfunction
Stijn Stroobants, Rudi D’Hooge, Markus Damme
Brain Pathol. 2021 Mar; 31(2): 223–238. Published online 2020 Nov 1. doi: 10.1111/bpa.12903
PMCID:
PMC8018119
AbstractArticlePDF–1.4M
9.
Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders
Azucena Perez-Canamas, Hideyuki Takahashi, Jane A Lindborg, Stephen M Strittmatter
Brain Commun. 2021; 3(1): fcaa200. Published online 2020 Nov 16. doi: 10.1093/braincomms/fcaa200
PMCID:
PMC7990118
AbstractArticlePDF–1.7M
10.
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice
Xiaolai Zhou, Mieu Brooks, Peizhou Jiang, Shunsuke Koga, Aamir R Zuberi, Matthew C Baker, Tammee M Parsons, Monica Castanedes‐Casey, Virginia Phillips, Ariston L Librero, Aishe Kurti, John D Fryer, Guojun Bu, Cathleen Lutz, Dennis W Dickson, Rosa Rademakers
EMBO Rep. 2020 Oct 5; 21(10): e50197. Published online 2020 Aug 5. doi: 10.15252/embr.202050197
PMCID:
PMC7534638
AbstractArticlePDF–6.3M
11.
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
Tuancheng Feng, Shuyi Mai, Jenn Marie Roscoe, Rory R Sheng, Mohammed Ullah, Junke Zhang, Isabel Iscol Katz, Haiyuan Yu, Wenjun Xiong, Fenghua Hu
EMBO Rep. 2020 Oct 5; 21(10): e50219. Published online 2020 Aug 10. doi: 10.15252/embr.202050219
PMCID:
PMC7534636
AbstractArticlePDF–11M
12.
Progranulin and TMEM106B: when two become wan
Emma L Clayton, Adrian M Isaacs
EMBO Rep. 2020 Oct 5; 21(10): e51668. Published online 2020 Sep 28. doi: 10.15252/embr.202051668
PMCID:
PMC7534635
AbstractArticlePDF–562K
13.
Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell
EMBO Rep. 2020 Oct 5; 21(10): e50241. Published online 2020 Sep 14. doi: 10.15252/embr.202050241
PMCID:
PMC7534633
AbstractArticlePDF–4.5M
14.
A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination
Tuancheng Feng, Rory R Sheng, Santiago Solé-Domènech, Mohammed Ullah, Xiaolai Zhou, Christina S Mendoza, Laura Camila Martinez Enriquez, Isabel Iscol Katz, Daniel H Paushter, Peter M Sullivan, Xiaochun Wu, Frederick R Maxfield, Fenghua Hu
Brain. 2020 Jul; 143(7): 2255–2271. Published online 2020 Jun 23. doi: 10.1093/brain/awaa154
PMCID:
PMC7363491
AbstractArticlePDF–1.5M
15.
Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies
Xiaolai Zhou, Alexandra M Nicholson, Yingxue Ren, Mieu Brooks, Peizhou Jiang, Aamir Zuberi, Hung Nguyen Phuoc, Ralph B Perkerson, Billie Matchett, Tammee M Parsons, NiCole A Finch, Wenlang Lin, Wenhui Qiao, Monica Castanedes-Casey, Virginia Phillips, Ariston L Librero, Yan Asmann, Guojun Bu, Melissa E Murray, Cathleen Lutz, Dennis W Dickson, Rosa Rademakers
Brain. 2020 Jun; 143(6): 1905–1919. Published online 2020 Jun 5. doi: 10.1093/brain/awaa141
PMCID:
PMC7296855
AbstractArticlePDF–1.3M
16.
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown
Emma L Clayton, Carmelo Milioto, Bhavana Muralidharan, Frances E Norona, James R Edgar, Armand Soriano, Paymaan Jafar-nejad, Frank Rigo, John Collinge, Adrian M Isaacs
Brain. 2018 Dec; 141(12): 3428–3442. Published online 2018 Nov 29. doi: 10.1093/brain/awy284
PMCID:
PMC6262218
AbstractArticlePDF–1.4M
17.
TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons
Nat Commun. 2018; 9: 2731. Published online 2018 Jul 16. doi: 10.1038/s41467-018-05013-x
PMCID:
PMC6048095
AbstractArticlePDF–8.9M
18.
Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
Andrew E. Arrant, Alexandra M. Nicholson, Xiaolai Zhou, Rosa Rademakers, Erik D. Roberson
Mol Neurodegener. 2018; 13: 32. Published online 2018 Jun 22. doi: 10.1186/s13024-018-0264-6
PMCID:
PMC6013889
AbstractArticlePDF–2.2M
19.
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity
Alexandra M. Nicholson, Xiaolai Zhou, Ralph B. Perkerson, Tammee M. Parsons, Jeannie Chew, Mieu Brooks, Mariely DeJesus-Hernandez, NiCole A. Finch, Billie J. Matchett, Aishe Kurti, Karen R. Jansen-West, Emilie Perkerson, Lillian Daughrity, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips, Fenghua Hu, Tania F. Gendron, Melissa E. Murray, Dennis W. Dickson, John D. Fryer, Leonard Petrucelli, Rosa Rademakers
Acta Neuropathol Commun. 2018; 6: 42. Published online 2018 May 31. doi: 10.1186/s40478-018-0545-x
PMCID:
PMC5984311
AbstractArticlePDF–2.9M
20.
Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice
Zoe A. Klein, Hideyuki Takahashi, Mengxiao Ma, Massimiliano Stagi, Melissa Zhou, TuKiet T. Lam, Stephen M. Strittmatter
Neuron. Author manuscript; available in PMC 2018 Jul 19.
Published in final edited form as: Neuron. 2017 Jul 19; 95(2): 281–296.e6. doi: 10.1016/j.neuron.2017.06.026
PMCID:
PMC5558861
AbstractArticlePDF–2.3M

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